公开(公告)号：US06972132B1

公开(公告)日：2005-12-06

申请号：US10009265

申请日：2000-06-09

申请人： Yumio Kudo ,  Hiroki Ueshima ,  Kazuya Sakai

发明人： Yumio Kudo ,  Hiroki Ueshima ,  Kazuya Sakai

IPC分类号： A61K9/48 ,  A61K9/56 ,  A61K9/70 ,  A61K9/36 ,  A61K9/16 ,  A61K9/62

CPC分类号： A61K9/4891 ,  A61K9/7007

摘要： A system whereby a substance which is orally taken and to be delivered into the lower digestive tract is selectively delivered into the lower digestive tract. More particularly, a system which makes it possible to surely and quickly deliver the aimed substance to the lower digestive tract without being affected by pH change in the digestive tract due to change in bacterial flora. Compositions disintegrating in the lower digestive tract characterized by containing a compound , which has a molecular weight of 1000 or less and has a disulfide bond, and a polymer , which has a molecular weight exceeding 1000 and is digested by enteric bacteria and/or undergoes softening, swelling or dissolution due to a decrease in pH; molded products with the use of these compositions; and preparations with the use of these molded products.

摘要翻译： 将口服并被输送到下消化道的物质选择性地输送到下消化道中的系统。 更具体地，涉及一种能够将目标物质可靠地快速地输送到下消化道而不受细菌菌群变化引起的消化道pH变化的影响的系统。 在下消化道中分解的组合物，其特征在于含有分子量为1000以下且具有二硫键的化合物和分子量超过1000的聚合物B，并被肠溶 细菌和/或由于pH降低而发生软化，溶胀或溶解; 使用这些组合物的成型产品; 以及使用这些模制产品的制备。

公开(公告)号：US6030951A

公开(公告)日：2000-02-29

申请号：US308710

申请日：1999-07-08

申请人： Takashi Nakashima ,  Tadashi Fujii ,  Kazuya Sakai ,  Tomohiro Sameshima ,  Hiroyuki Kumagai ,  Takeo Yoshioka

发明人： Takashi Nakashima ,  Tadashi Fujii ,  Kazuya Sakai ,  Tomohiro Sameshima ,  Hiroyuki Kumagai ,  Takeo Yoshioka

IPC分类号： C07D311/78 ,  C07D407/04 ,  C12P17/06 ,  A61K31/70 ,  C07H7/04

CPC分类号： C07D407/04 ,  C07D311/78 ,  C12P17/06

摘要： Disclosed are the novel C-glycoside compounds Mer-1020dA, Mer-1020dB, Mer-1020dC and Mer-1020dD which have a chromophore group in common with well-known chrysomycins A and B, but can be distinguished from the chrysomycins and the like in that the novel C-glycoside compounds have a sugar residue having a higher degree of oxidation, as well as the compound Mer-1020dE comprising only the chromophore thereof. Among these compounds, the C-glycoside compounds are antibiotics which have low toxicity and can strongly inhibit the growth of solid cancer cells in particular.

摘要翻译： PCT No.PCT / JP97 / 04007 Sec。 371日期：1999年7月8日 102（e）1999年7月8日PCT PCT 1997年11月4日PCT公布。 公开号WO98 / 22612 PCT 日期1998年5月28日公开了具有发色团组的新颖的C-糖苷化合物Mer-1020dA，Mer-1020dB，Mer-1020dC和Mer-1020dD，与着名的科莫昔霉素A和B相同，但可以区别于科莫昔霉素 因为新型C-糖苷化合物具有较高氧化度的糖残基以及仅包含其发色团的化合物Mer-1020dE。 在这些化合物中，C-糖苷化合物是具有低毒性并特别强烈地抑制固体癌细胞生长的抗生素。