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175 条记录 (耗时 0.05 秒)

    Adipocyte-specific protein homologs
    32.
    发明授权
    Adipocyte-specific protein homologs 失效

    公开(公告)号：US06566499B1

    公开(公告)日：2003-05-20

    申请号：US09506852

    申请日：2000-02-17

    申请人： Paul O. Sheppard

    发明人： Paul O. Sheppard

    IPC分类号： C07K1700

    CPC分类号： C07K14/4702 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00 ,  C12N2799/022

    摘要： The present invention relates to polynucleotide and polypeptide molecules for zsig37, a novel member of the family of proteins bearing a collagen-like domain and a globular domain. The polypeptides, and polynucleotides encoding them, are involved in dimerization or oligomerization and may be used in the study thereof. The present invention also includes antibodies to the zsig37 polypeptides.

    Zace1: a human metalloenzyme
    33.
    发明授权
    Zace1: a human metalloenzyme 失效

    公开(公告)号：US06524836B2

    公开(公告)日：2003-02-25

    申请号：US09846996

    申请日：2001-05-01

    申请人： Paul O. Sheppard

    发明人： Paul O. Sheppard

    IPC分类号： C12N964

    CPC分类号： C12N9/6489 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00 ,  C12Y304/15001

    摘要： Angiotensin-converting enzyme is a zinc metallopeptidase that plays roles in blood pressure regulation and fertility. The catalytic activities of angiotensin converting enzymes include the production of the potent vasopressor angiotensin II from angiotensin I, and the inactivation of the vasodilatory peptide bradykinin. Zace1 is a new form of human zinc metallopeptidase, which includes one zinc-dependent catalytic domain containing the motif “HEXXH” and one downstream “EX(I/V)X(D/S)” motif.

    Antibodies to motilin homologs
    34.
    发明授权
    Antibodies to motilin homologs 失效
    胃动素同系物的抗体

    公开(公告)号：US06291653B1

    公开(公告)日：2001-09-18

    申请号：US09046479

    申请日：1998-03-23

    申请人： Paul O. Sheppard ,  Theresa A. Deisher

    发明人： Paul O. Sheppard ,  Theresa A. Deisher

    IPC分类号： C07K1626

    CPC分类号： C07K14/575 ,  A61K38/00

    摘要： The present invention is directed to polynucleotides, polypeptides and peptide fragments thereof, and uses thereof for a novel cDNA sequence which has homology to motilin. Tissue distribution of the mRNA for the novel polypeptide is specific to the stomach, small intestine and pancreas. The present invention further includes agonists, antagonists, antibodies, host cells expressing the cDNA encoding the novel motilin homologs and methods for increasing gastric motility using the novel molecules.

    摘要翻译： 本发明涉及多核苷酸，多肽及其肽片段及其与胃动素同源性的新cDNA序列的用途。 新型多肽的mRNA的组织分布特异于胃，小肠和胰腺。 本发明还包括激动剂，拮抗剂，抗体，表达编码新型胃动素同系物的cDNA的宿主细胞和使用新分子增加胃动力的方法。

    Methods of purifying zsig33
    36.
    发明授权
    Methods of purifying zsig33 失效
    zsig33纯化方法

    公开(公告)号：US08124356B2

    公开(公告)日：2012-02-28

    申请号：US13016537

    申请日：2011-01-28

    申请人： Paul O. Sheppard ,  Darrell C. Conklin

    发明人： Paul O. Sheppard ,  Darrell C. Conklin

    IPC分类号： G01N33/68 ,  A61K38/10

    CPC分类号： C07K14/575 ,  A61K38/00

    摘要： The present invention relates to a method of forming a peptide-receptor complex with zsig33 polypeptides and their receptors as well as antibodies. Methods of modulating gastric contractility, nutrient uptake, growth hormones, the secretion of digestive enzymes and hormones, and/or secretion of enzymes and/or hormones in the pancreas are also included.

    摘要翻译： 本发明涉及与zsig33多肽及其受体以及抗体形成肽 - 受体复合物的方法。 还包括调节胃收缩力，营养摄取，生长激素，消化酶和激素分泌和/或胰腺中酶和/或激素分泌的方法。