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公开(公告)号：US08124356B2
公开(公告)日：2012-02-28
申请号：US13016537
申请日：2011-01-28
CPC分类号： C07K14/575 , A61K38/00
摘要： The present invention relates to a method of forming a peptide-receptor complex with zsig33 polypeptides and their receptors as well as antibodies. Methods of modulating gastric contractility, nutrient uptake, growth hormones, the secretion of digestive enzymes and hormones, and/or secretion of enzymes and/or hormones in the pancreas are also included.
摘要翻译： 本发明涉及与zsig33多肽及其受体以及抗体形成肽 - 受体复合物的方法。 还包括调节胃收缩力，营养摄取，生长激素，消化酶和激素分泌和/或胰腺中酶和/或激素分泌的方法。
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公开(公告)号：US5989866A
公开(公告)日：1999-11-23
申请号：US951822
申请日：1997-10-16
申请人： Theresa A. Deisher , Darrell C. Conklin , Fenella Raymond , Thomas R. Bukowski , Susan D. Holderman , Birgit Hansen , Paul O. Sheppard
发明人： Theresa A. Deisher , Darrell C. Conklin , Fenella Raymond , Thomas R. Bukowski , Susan D. Holderman , Birgit Hansen , Paul O. Sheppard
IPC分类号： C12N15/09 , A61K38/00 , A61P9/10 , A61P19/08 , A61P21/00 , C07K14/50 , C07K16/22 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/077 , C12N5/10 , C12N15/18 , C12P21/02 , C12P21/08 , C12N5/00 , C12N15/63
CPC分类号： A61K47/48238 , A61K47/48507 , C07K14/50 , C07K16/22 , C12N5/0657 , A61K38/00 , C07K2319/00 , C12N2501/119
摘要： The present invention relates to polynucleotide and polypeptide molecules for zFGF-5 a novel member of the FGF family. The polypeptides, and polynucleotides encoding them, are proliferative for muscle cells and may be used for remodelling cardiac tissue and improving cardiac function. The present invention also includes antibodies to the zFGF-5 polypeptides.
摘要翻译： 本发明涉及用于zFGF-5的FGF家族的新成员的多核苷酸和多肽分子。 多肽和编码它们的多核苷酸对于肌肉细胞是增殖性的，并且可以用于重塑心脏组织和改善心脏功能。 本发明还包括对zFGF-5多肽的抗体。
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公开(公告)号：US20110151480A1
公开(公告)日：2011-06-23
申请号：US13016537
申请日：2011-01-28
CPC分类号： C07K14/575 , A61K38/00
摘要： The present invention relates to a method of forming a peptide-receptor complex with zsig33 polypeptides and their receptors as well as antibodies. Methods of modulating gastric contractility, nutrient uptake, growth hormones, the secretion of digestive enzymes and hormones, and/or secretion of enzymes and/or hormones in the pancreas are also included.
摘要翻译： 本发明涉及与zsig33多肽及其受体以及抗体形成肽 - 受体复合物的方法。 还包括调节胃收缩力，营养摄取，生长激素，消化酶和激素分泌和/或胰腺中酶和/或激素分泌的方法。
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公开(公告)号：US20090081168A1
公开(公告)日：2009-03-26
申请号：US12147187
申请日：2008-06-26
CPC分类号： C07K14/575 , A61K38/00
摘要： The present invention relates to a method of forming a peptide-receptor complex with zsig33 polypeptides and their receptors as well as antibodies. Methods of modulating gastric contractility, nutrient uptake, growth hormones, the secretion of digestive enzymes and hormones, and/or secretion of enzymes and/or hormones in the pancreas are also included.
摘要翻译： 本发明涉及与zsig33多肽及其受体以及抗体形成肽 - 受体复合物的方法。 还包括调节胃收缩力，营养摄取，生长激素，消化酶和激素分泌和/或胰腺中酶和/或激素分泌的方法。
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公开(公告)号：US06518236B1
公开(公告)日：2003-02-11
申请号：US09229947
申请日：1999-01-13
申请人： Theresa A. Deisher , Darrell C. Conklin , Fenella Raymond , Thomas R. Bukowski , Susan D. Holderman , Birgit Hansen , Paul O. Sheppard
发明人： Theresa A. Deisher , Darrell C. Conklin , Fenella Raymond , Thomas R. Bukowski , Susan D. Holderman , Birgit Hansen , Paul O. Sheppard
IPC分类号： C07K1450
CPC分类号： C07K14/50 , A61K38/00 , C07K2319/00
摘要： The present invention relates to polynucleotide and polypeptide molecules for zFGF5 a novel member of the FGF family. The polypeptides, and polynucleotides encoding them, are proliferative for muscle cells, in particular cardiac cells and may be used for remodeling cardiac tissue and improving cardiac function. The present invention also includes antibodies to the zFGF5 polypeptides.
摘要翻译： 本发明涉及zFGF5的多核苷酸和多肽分子，其是FGF家族的新成员。 多肽和编码它们的多核苷酸对于肌肉细胞，特别是心脏细胞是增殖性的，并且可以用于重建心脏组织和改善心脏功能。 本发明还包括对zFGF5多肽的抗体。
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公开(公告)号：US07247608B2
公开(公告)日：2007-07-24
申请号：US10037922
申请日：2001-10-19
申请人： Theresa A. Deisher , Darrell C. Conklin , Fenella Raymond , Thomas R. Bukowski , Susan D. Holderman , Birgit Hansen , Paul O. Sheppard
发明人： Theresa A. Deisher , Darrell C. Conklin , Fenella Raymond , Thomas R. Bukowski , Susan D. Holderman , Birgit Hansen , Paul O. Sheppard
CPC分类号： C12N5/0657 , A61K38/00 , A61K47/62 , A61K47/6835 , C07K14/50 , C07K16/22 , C07K2319/00 , C12N2501/119
摘要： The present invention relates to polynucleotide and polypeptide molecules for zFGF-5 a novel member of the FGF family. The polypeptides, and polynucleotides encoding them, are proliferative for muscle cells and may be used for remodelling cardiac tissue and improving cardiac function. The present invention also includes antibodies to the zFGF-5 polypeptides.
摘要翻译： 本发明涉及用于zFGF-5的FGF家族的新成员的多核苷酸和多肽分子。 多肽和编码它们的多核苷酸对于肌肉细胞是增殖性的，并且可以用于重塑心脏组织和改善心脏功能。 本发明还包括对zFGF-5多肽的抗体。
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公开(公告)号：US07888056B2
公开(公告)日：2011-02-15
申请号：US12147187
申请日：2008-06-26
CPC分类号： C07K14/575 , A61K38/00
摘要： The present invention relates to a method of forming a peptide-receptor complex with zsig33 polypeptides and their receptors as well as antibodies. Methods of modulating gastric contractility, nutrient uptake, growth hormones, the secretion of digestive enzymes and hormones, and/or secretion of enzymes and/or hormones in the pancreas are also included.
摘要翻译： 本发明涉及与zsig33多肽及其受体以及抗体形成肽 - 受体复合物的方法。 还包括调节胃收缩力，营养摄取，生长激素，消化酶和激素分泌和/或胰腺中酶和/或激素分泌的方法。
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公开(公告)号：US07563438B2
公开(公告)日：2009-07-21
申请号：US11752197
申请日：2007-05-22
申请人： Theresa A. Deisher , Darrell C. Conklin , Fenella C. Raymond , Thomas R. Bukowski , Susan D. Holderman , Paul O. Sheppard
发明人： Theresa A. Deisher , Darrell C. Conklin , Fenella C. Raymond , Thomas R. Bukowski , Susan D. Holderman , Paul O. Sheppard
IPC分类号： A61K39/395 , C07K16/00 , C07K16/22
CPC分类号： C07K14/50 , A61K38/00 , C07K2319/00
摘要： The present invention relates to antibodies and fragments thereof, polynucleotide and polypeptide molecules for zFGF5 a novel member of the FGF family. The polypeptides, and polynucleotides encoding them, are proliferative for muscle cells, in particular cardiac cells and may be used for remodeling cardiac tissue and improving cardiac function. The present invention also includes antibodies to the zFGF5 polypeptides.
摘要翻译： 本发明涉及抗体及其片段，用于zFGF5的多核苷酸和多肽分子是FGF家族的新成员。 多肽和编码它们的多核苷酸对于肌肉细胞，特别是心脏细胞是增殖性的，并且可以用于重建心脏组织和改善心脏功能。 本发明还包括对zFGF5多肽的抗体。
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公开(公告)号：US20080233114A1
公开(公告)日：2008-09-25
申请号：US11752197
申请日：2007-05-22
申请人： Theresa A. Deisher , Darrell C. Conklin , Fenella C. Raymond , Thomas R. Bukowski , Susan D. Holderman , Paul O. Sheppard
发明人： Theresa A. Deisher , Darrell C. Conklin , Fenella C. Raymond , Thomas R. Bukowski , Susan D. Holderman , Paul O. Sheppard
IPC分类号： A61K39/395 , C07K16/00 , A61P29/00
CPC分类号： C07K14/50 , A61K38/00 , C07K2319/00
摘要： The present invention relates to polynucleotide and polypeptide molecules for zFGF5 a novel member of the FGF family. The polypeptides, and polynucleotides encoding them, are proliferative for muscle cells, in particular cardiac cells and may be used for remodeling cardiac tissue and improving cardiac function. The present invention also includes antibodies to the zFGF5 polypeptides.
摘要翻译： 本发明涉及zFGF5的多核苷酸和多肽分子，其是FGF家族的新成员。 多肽和编码它们的多核苷酸对于肌肉细胞，特别是心脏细胞是增殖性的，并且可以用于重建心脏组织和改善心脏功能。 本发明还包括对zFGF5多肽的抗体。
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公开(公告)号：US06372889B1
公开(公告)日：2002-04-16
申请号：US09294531
申请日：1999-04-19
申请人： Paul O. Sheppard , Darrell C. Conklin , Theresa M. Farrah , Mark F. Maurer , Angelika Grossmann
发明人： Paul O. Sheppard , Darrell C. Conklin , Theresa M. Farrah , Mark F. Maurer , Angelika Grossmann
IPC分类号： C07K1447
摘要： The present invention relates to polynucleotide and polypeptide molecules for ZTMPO-1, a novel soluble protein with homology to emerin and the thymopoietins. The polypeptides, and polynucleotides encoding them are useful for modulating cellular proliferation and differentiation and may be used for diagnostic purposes. The present invention also includes antibodies to the ZTMPO-1 polypeptides.
摘要翻译： 本发明涉及用于ZTMPO-1的多核苷酸和多肽分子，其与emerin和胸腺细胞生成素具有同源性的新型可溶性蛋白质。 多肽和编码它们的多核苷酸可用于调节细胞增殖和分化，并可用于诊断目的。 本发明还包括针对ZTMPO-1多肽的抗体。
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