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31.发明申请GLUCOPYRANOSYL-SUBSTITUTED DIFLUOROBENZYL-BENZENE DERIVATES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR MANUFACTURE 有权葡聚糖取代的二氟硼酸苄酯衍生物，含有这些化合物的药物，其使用及其制造方法公开(公告)号：US20090318547A1
公开(公告)日：2009-12-24
申请号：US12441968
申请日：2007-09-20
IPC分类号： A61K31/351 , C07D315/00 , A61P3/10 , A61P9/10 , A61P3/04 , A61P9/04
CPC分类号： C07H7/04 , C07D309/10
摘要： Glucopyranosyl-substituted difluorobenzyl-benzene derivatives of general formula (I) as defined according to claim 1, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabolic disorders.
摘要翻译： 包括互变异构体，其立体异构体，其混合物及其盐的如权利要求1所定义的通式（I）的吡喃葡糖基取代的二氟苄基 - 苯衍生物。 根据本发明的化合物适用于治疗代谢性疾病。
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32.发明授权D-xylopyranosyl-phenyl-substituted cycles, medicaments containing such compounds, their use and process for their manufacture 有权D-吡喃木糖基 - 苯基取代的周期，含有这些化合物的药物，它们的用途和制造方法公开(公告)号：US07417032B2
公开(公告)日：2008-08-26
申请号：US11190315
申请日：2005-07-27
CPC分类号： C07H7/04 , C07D309/10 , C07D309/12 , C07D309/22 , C07D405/10 , C07D405/12 , C07D407/10 , C07D407/12
摘要： D-Glucopyranosyl-phenyl-substituted cycles of general formula I wherein the groups R1 to R6, Z, Cy and R7a, R7b, R7c, R7d are defined as in claim 1, have an inhibiting effect on the sodium-dependent glucose cotransporter SGLT. The present invention also relates to pharmaceutical compositions for the treatment of metabolic disorders.
摘要翻译： 通式I的D-吡喃葡糖基 - 苯基取代的环，其中基团R 1至R 6，Z，Cy和R 7a，R R 7，R 7，R 7，R 7，如权利要求1中所定义，对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用。 本发明还涉及用于治疗代谢紊乱的药物组合物。
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33.发明申请Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing such compounds, their use and process for their manufacture 有权吡喃葡糖基取代的苄腈衍生物，含有这些化合物的药物组合物，它们的用途和制备方法公开(公告)号：US20080058379A1
公开(公告)日：2008-03-06
申请号：US11674839
申请日：2007-02-14
IPC分类号： A61K31/351 , A61K31/453 , A61P3/00 , C07D309/10 , C07D401/10
CPC分类号： C07D309/10 , C07H7/04
摘要： Glucopyranosyl-substituted benzonitrile derivatives as defined herein, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabolic disorders.
摘要翻译： 本文定义的吡喃葡糖基取代的苄腈衍生物，包括互变异构体，其立体异构体，其混合物及其盐。 根据本发明的化合物适用于治疗代谢性疾病。
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34.发明申请Glucopyranosyl-substituted ((hetero)cycloalkylethynyl-benzyl)-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture 有权吡喃葡糖基取代的（（杂）环烷基乙炔基 - 苄基） - 苯衍生物，含有这些化合物的药物，它们的用途和制备方法公开(公告)号：US20070027092A1
公开(公告)日：2007-02-01
申请号：US11494162
申请日：2006-07-27
CPC分类号： C07H15/203 , A61K31/7034
摘要： Glucopyranosyl-substituted ((hetero)cycloalkylethynyl-benzyl)-benzene derivatives of the general formula I where the groups R1 to R6 as well as R7a, R7b, R7c are defined according to claim 1, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabolic disorders.
摘要翻译： 基团R 1至R 6的通式I的吡喃葡糖基取代的（（杂）环烷基乙炔基 - 苄基） - 苯衍生物以及R 7a， 根据权利要求1定义，R 7b，R 7c，R 7c，其包括互变异构体，其立体异构体，其混合物及其盐。 根据本发明的化合物适用于治疗代谢性疾病。
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35.发明申请Glucopyranosyl-substituted (heteroaryloxy-benzyl)-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture 有权吡喃葡糖基取代的（杂芳氧基 - 苄基） - 苯衍生物，含有这些化合物的药物，它们的用途和制造方法公开(公告)号：US20060234953A1
公开(公告)日：2006-10-19
申请号：US11403444
申请日：2006-04-13
CPC分类号： C07H7/06
摘要： Glucopyranosyloxy-substituted (heteroaryloxy-benzyl)-benzene compounds of the general formula I where the groups R1 to R6 as well as R7a, R7b, R7c are defined according to claim 1, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabolic disorders.
摘要翻译： 基团R 1至R 6以及R 7a的通式I的吡喃葡糖氧基取代的（杂芳氧基 - 苄基） - 苯化合物， 根据权利要求1定义，R 7b，R 7c，其包括互变异构体，其立体异构体，其混合物及其盐。 根据本发明的化合物适用于治疗代谢性疾病。
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36.发明申请Glucopyranosyl-substituted benzene derivatives, medicaments containing such compounds, their use and process for their manufacture 有权吡喃葡萄糖基取代的苯衍生物，含有这些化合物的药物，它们的用途和制备方法公开(公告)号：US20060142210A1
公开(公告)日：2006-06-29
申请号：US11304284
申请日：2005-12-15
IPC分类号： A61K31/7034
CPC分类号： C07H7/04
摘要： Glucopyranosyl-substituted benzene derivatives defined according to claim 1, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabolic disorders.
摘要翻译： 根据权利要求1所述的吡喃葡萄糖基取代的苯衍生物，包括互变异构体，其立体异构体，其混合物及其盐。 根据本发明的化合物适用于治疗代谢性疾病。
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37.发明申请D-pyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture 有权D-吡喃糖基取代的苯基衍生物，含有这些化合物的药物，它们的用途和制备方法公开(公告)号：US20060074031A1
公开(公告)日：2006-04-06
申请号：US11239917
申请日：2005-09-30
IPC分类号： A61K31/7052 , A61K31/70 , C07H17/00 , C07H15/04
CPC分类号： C07H7/04
摘要： D-pyranosyl-substituted phenyls of general formula I wherein the groups R1 to R5, X, Z and R7a, R7b, R7c are defined as in claim 1, have an inhibiting effect on the sodium-dependent glucose cotransporter SGLT. The present invention also relates to pharmaceutical compositions for the treatment of metabolic disorders.
摘要翻译： D-吡喃糖基取代的通式I的苯基，其中基团R 1至R 5，X，Z和R 7a，R SUP 如权利要求1所定义，R 7，R 7c对钠依赖性葡萄糖转运蛋白SGLT具有抑制作用。 本发明还涉及用于治疗代谢紊乱的药物组合物。
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38.发明授权Glucopyranosyl-substituted ((hetero)arylethynyl-benzyl)-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture 有权吡喃葡糖基取代的（（杂）芳基乙炔基 - 苄基） - 苯衍生物，含有这些化合物的药物，它们的用途和制造方法公开(公告)号：US07772378B2
公开(公告)日：2010-08-10
申请号：US11359846
申请日：2006-02-22
IPC分类号： A61K31/351 , A61K31/7004 , C07H7/04 , C07D367/20
CPC分类号： C07D309/10 , C07D405/10 , C07D409/10 , C07D413/10 , C07D417/10
摘要： Glucopyranosyl-substituted (hetero)arylethynyl-benzene derivatives of the general formula I where the groups R1 to R6 as well as R7a, R7b, R7c are defined according to claim 1, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabolic disorders.
摘要翻译： 其中基团R 1至R 6以及R 7a，R 7b，R 7c根据权利要求1定义的通式I的吡喃葡糖基取代的（杂）芳基乙炔基 - 苯衍生物，包括互变异构体，其立体异构体，其混合物和盐 其中。 根据本发明的化合物适用于治疗代谢性疾病。
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39.发明授权Glucopyranosyl-substituted benzyl-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture 有权吡喃葡萄糖基取代的苄基苯衍生物，含有这些化合物的药物，其用途和制备方法公开(公告)号：US07683160B2
公开(公告)日：2010-03-23
申请号：US11468074
申请日：2006-08-29
IPC分类号： C07H1/00 , C07H7/04 , A61K31/7004
CPC分类号： C07D309/10 , C07D407/12
摘要： Glucopyranosyl-substituted benzyl-benzene derivatives of the general formula I where the groups R1 to R6 as well as R7a, R7b, R7c are defined according to claim 1, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabolic disorders.
摘要翻译： 其中基团R1至R6以及R7a，R7b，R7c的通式I的吡喃葡糖基取代的苄基 - 苯衍生物包括互变异构体，其立体异构体，其混合物及其盐。 根据本发明的化合物适用于治疗代谢性疾病。
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40.发明授权Glucopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture 有权吡喃葡糖基取代的苯基衍生物，含有这些化合物的药物，它们的用途和制备方法公开(公告)号：US07579449B2
公开(公告)日：2009-08-25
申请号：US11080150
申请日：2005-03-15
IPC分类号： A61K31/70 , A61K31/7004 , A61K31/351 , C07H7/04 , C07H309/10
CPC分类号： C07H23/00 , A61K9/0019 , A61K9/02 , A61K9/2018 , A61K9/4866 , C07D309/10 , C07H15/04 , C07H15/20 , C07H15/26
摘要： Glucopyranosyl-substituted benzene derivatives of general formula I where the groups R1 to R6 as well as R7a, R7b, R7c are defined herein and the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabolic disorders.
摘要翻译： 其中基团R 1至R 6以及R 7a，R 7b，R 7c在本文中定义的通式I的吡喃葡糖基取代的苯衍生物以及互变异构体，其立体异构体，其混合物及其盐。 根据本发明的化合物适用于治疗代谢性疾病。
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