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    Osmotic drug delivery devices with hydrophobic wall materials
    32.
    发明授权
    Osmotic drug delivery devices with hydrophobic wall materials 失效
    具有疏水壁材料的渗透性药物输送装置

    公开(公告)号：US5795591A

    公开(公告)日：1998-08-18

    申请号：US299867

    申请日：1994-09-01

    申请人： Eun Soo Lee ,  Scott A. Bura ,  Su Il Yum ,  Patrick S.-L. Wong ,  Felix Theeuwes

    发明人： Eun Soo Lee ,  Scott A. Bura ,  Su Il Yum ,  Patrick S.-L. Wong ,  Felix Theeuwes

    IPC分类号： A61M37/00 ,  A61K9/00 ,  A61K9/52 ,  A61K9/26

    CPC分类号： A61K9/0004

    摘要： Osmotically driven drug delivery devices with walls of porous hydrophobic material as the sole diffusion-limiting wall component are disclosed. Despite pores which are considerably larger than the molecular dimensions of osmotically active species in the interior of the device, despite pores which by their hydrophobic character do not permit the passage of liquid water, and despite the absence of a cellulosic semi-permeable membrane, the devices absorb water by osmosis without loss of the osmotically active species, and function in a manner analogous to osmotic pumps of the prior art. By permitting the use of hydrophobic substances as the wall material, the invention permits the device to be constructed entirely from biodegradable materials.

    摘要翻译： 公开了具有作为唯一扩散限制壁部件的多孔疏水材料壁的渗透驱动药物输送装置。 尽管孔远远大于装置内部的渗透活性物质的分子尺寸，尽管孔具有疏水性，但不允许液态水通过，尽管不存在纤维素半透膜， 装置通过渗透吸收水分而不损失渗透活性物质，并且以类似于现有技术的渗透泵的方式起作用。 通过允许使用疏水物质作为壁材料，本发明允许该装置完全由可生物降解的材料构成。

    Osmotic device for delayed delivery of agent
    38.
    发明授权
    Osmotic device for delayed delivery of agent 失效

    公开(公告)号：US5531736A

    公开(公告)日：1996-07-02

    申请号：US424692

    申请日：1995-04-19

    申请人： Patrick S.-L. Wong ,  Felix Theeuwes ,  Steven D. Larsen ,  Liang C. Dong

    发明人： Patrick S.-L. Wong ,  Felix Theeuwes ,  Steven D. Larsen ,  Liang C. Dong

    IPC分类号： A61K9/00 ,  A61K9/22 ,  A61K9/48

    CPC分类号： A61K9/0004 ,  A61K9/4808

    摘要： The present invention is directed to a fluid-imbibing dispensing device for the initially delayed delivery of an active agent to a fluid environment of use and to a method of using the dispensing device. The dispenser comprises a housing having a first wall section and a second wall section in reversibly sliding telescopic arrangement with each other, which housing maintains its integrity in the environment of use; an internal compartment surrounded and defined by the housing; at least one active agent formulation in the compartment; and expansion means and a push plate in the compartment for separating apart the first and second wall sections of the housing after exposure to the environment of use to expose the active agent formulation to the environment of use.