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21 条记录 (耗时 0.028 秒)

    Expandable osmotic composition and coating suspension
    3.
    发明授权
    Expandable osmotic composition and coating suspension 有权
    可膨胀的渗透组合物和涂层悬浮液

    公开(公告)号：US07338663B2

    公开(公告)日：2008-03-04

    申请号：US10609061

    申请日：2003-06-28

    申请人： Shaoling Li ,  Liang-Chang Dong ,  Padmaja Shivanand ,  Patrick S. L. Wong

    发明人： Shaoling Li ,  Liang-Chang Dong ,  Padmaja Shivanand ,  Patrick S. L. Wong

    IPC分类号： A61K9/00

    CPC分类号： A61K9/0004 ,  A61K31/085

    摘要： The present invention includes an expandable osmotic layer and a coating suspension for providing an expandable osmotic layer, both of which are useful for the manufacture of controlled release dosage forms. The expandable osmotic layer of the present invention may be produced using the coating suspension of the present invention. Advantageously, the coating suspension of the present invention can be used to coat expandable osmotic layers under both wet and dry process conditions without sacrificing the quality of the expandable osmotic layers produced, and therefore provides a relatively robust coating suspension that facilitates commercial production of controlled release dosage forms including a coated expandable osmotic layer.

    摘要翻译： 本发明包括可膨胀渗透层和用于提供可膨胀渗透层的涂层悬浮液，两者都可用于制造控释剂型。 本发明的可膨胀渗透层可以使用本发明的涂布悬浮液来制造。 有利地，本发明的涂层悬浮液可用于在湿法和干法处理条件下涂覆可膨胀渗透层，而不会牺牲所生产的可膨胀渗透层的质量，因此提供了有利于商业生产受控释放的相对坚固的涂层悬浮液 剂型，包括涂覆的可扩张渗透层。

    Dosage form comprising liquid formulation
    6.
    发明授权
    Dosage form comprising liquid formulation 失效
    包含液体制剂的剂型

    公开(公告)号：US07803401B2

    公开(公告)日：2010-09-28

    申请号：US11589558

    申请日：2006-10-30

    申请人： Liang-Chang Dong ,  Steven Espinal ,  Patrick S. L. Wong

    发明人： Liang-Chang Dong ,  Steven Espinal ,  Patrick S. L. Wong

    IPC分类号： A61K9/48 ,  A61K9/66

    CPC分类号： A61K9/4858 ,  A61K9/0004 ,  A61K9/1075 ,  A61K9/4866

    摘要： A sustained release dosage form includes a capsule made of a thermoplastic polymer having a softening point below 200° C. and an orifice formed or formable within the capsule, an emulsion formulation contained within the capsule, and an expandable composition within the capsule remote from the orifice. The emulsion formulation comprises a drug, an emulsifying surfactant, and an oil. The expandable composition is configured to expand and expel the emulsion formulation through the orifice.

    摘要翻译： 持续释放剂型包括由软化点低于200℃的热塑性聚合物制成的胶囊，以及在胶囊内形成或可形成的孔，包含在胶囊内的乳剂，以及远离胶囊内的胶囊内的可膨胀组合物 孔。 乳液制剂包含药物，乳化表面活性剂和油。 可膨胀组合物构造成通过孔膨胀和排出乳液制剂。

    Prolonged release active agent dosage form adapted for gastric retention
    10.
    发明授权
    Prolonged release active agent dosage form adapted for gastric retention 失效
    延长释放活性剂剂型适合胃潴留

    公开(公告)号：US06548083B1

    公开(公告)日：2003-04-15

    申请号：US09615110

    申请日：2000-07-13

    申请人： Patrick S.-L. Wong ,  Liang-Chang Dong ,  David E. Edgren ,  Felix Theeuwes ,  Phyllis I. Gardner ,  Francisco Jao ,  Jason J. Wan

    发明人： Patrick S.-L. Wong ,  Liang-Chang Dong ,  David E. Edgren ,  Felix Theeuwes ,  Phyllis I. Gardner ,  Francisco Jao ,  Jason J. Wan

    IPC分类号： A61K922

    CPC分类号： A61K9/0065 ,  A61K9/2072

    摘要： The present invention is directed to an active agent dosage form which is adapted for retention in the stomach and useful for the prolonged delivery of an active agent formulation to a fluid environment of use. The active agent dosage form is a polymer matrix that swells upon contact with the fluids of the stomach. A portion of the polymer matrix is surrounded by a band of insoluble material that prevents the covered portion of the polymer matrix from swelling and provides a segment of the dosage form that is of sufficient rigidity to withstand the contractions of the stomach and delay expulsion of the dosage form from the stomach until substantially all of the active agent has been dispensed.

    摘要翻译： 本发明涉及一种活性剂剂型，其适于保留在胃中并且可用于将活性剂制剂延长递送至使用的流体环境。 活性剂剂型是与胃液接触时膨胀的聚合物基质。 聚合物基质的一部分由不溶性材料带包围，其阻止聚合物基质的被覆盖部分膨胀，并提供具有足够刚性以抵抗胃收缩和延迟排出的部分的剂型 剂型，直到基本上所有的活性剂已被分配。