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110 条记录 (耗时 0.069 秒)

    Modulators of metabolism and the treatment of disorders related thereto
    33.
    发明申请
    Modulators of metabolism and the treatment of disorders related thereto 审中-公开
    代谢调节剂和与之有关的疾病的治疗

    公开(公告)号：US20100004272A1

    公开(公告)日：2010-01-07

    申请号：US12307545

    申请日：2007-07-05

    申请人： Robert M. Jones ,  Juerg Lehmann

    发明人： Robert M. Jones ,  Juerg Lehmann

    IPC分类号： A61K31/506 ,  C07D401/14 ,  A61P3/10 ,  A61P3/06 ,  A61P3/08 ,  A61P3/04

    CPC分类号： C07D401/14

    摘要： The present invention relates to 4-[6-(6-methanesulfonyl-2-methyl-pyridin-3-ylamino)-5-methyl-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid isopropyl ester, pharmaceutically acceptable salts, solvates and hydrates thereof that are modulators of glucose metabolism. Accordingly, compounds of the present invention are useful in the treatment of metabolic-related disorders and complications thereof, such as, diabetes and obesity.

    摘要翻译： 本发明涉及4- [6-（6-甲磺酰基-2-甲基 - 吡啶-3-基氨基）-5-甲基 - 嘧啶-4-基氧基] - 哌啶-1-甲酸异丙酯，其药学上可接受的盐， 其是葡萄糖代谢调节剂的溶剂合物和水合物。 因此，本发明的化合物可用于治疗代谢相关疾病及其并发症，例如糖尿病和肥胖症。

    MODULATORS OF METABOLISM AND THE TREATMENT OF DISORDERS RELATED THERETO
    35.
    发明申请
    MODULATORS OF METABOLISM AND THE TREATMENT OF DISORDERS RELATED THERETO 审中-公开
    代谢调节剂和相关疾病的治疗

    公开(公告)号：US20090286816A1

    公开(公告)日：2009-11-19

    申请号：US12307549

    申请日：2007-07-05

    申请人： Robert M. Jones ,  Juerg Lehmann ,  Amy Siu-Ting Wong

    发明人： Robert M. Jones ,  Juerg Lehmann ,  Amy Siu-Ting Wong

    IPC分类号： A61K31/506 ,  C07D401/14 ,  A61P3/00

    CPC分类号： C07D401/14

    摘要： The present invention relates to 4-[5-Methoxy-6-(2-methyl-6-[1,2,4]triazol-1-yl-pyridin-3-ylamino)-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid isopropyl ester, pharmaceutically acceptable salts, solvates and hydrates thereof that are modulators of glucose metabolism. Accordingly, compounds of the present invention are useful in the treatment of metabolic-related disorders and complications thereof, such as, diabetes and obesity. (Formula I)

    摘要翻译： 本发明涉及4- [5-甲氧基-6-（2-甲基-6- [1,2,4]三唑-1-基 - 吡啶-3-基氨基） - 嘧啶-4-基氧基] 1-羧酸异丙酯，其药学上可接受的盐，溶剂化物和水合物，其是葡萄糖代谢的调节剂。 因此，本发明的化合物可用于治疗代谢相关疾病及其并发症，例如糖尿病和肥胖症。 （式I）

    METHODS OF USING A G PROTEIN-COUPLED RECEPTOR TO IDENTIFY PEPTIDE YY (PYY) SECRETAGOGUES AND COMPOUNDS USEFUL IN THE TREATMENT OF CONDITIONS MODULATED BY PYY
    36.
    发明申请
    METHODS OF USING A G PROTEIN-COUPLED RECEPTOR TO IDENTIFY PEPTIDE YY (PYY) SECRETAGOGUES AND COMPOUNDS USEFUL IN THE TREATMENT OF CONDITIONS MODULATED BY PYY 有权
    使用G蛋白偶联受体鉴定PYY（PYY）秘密肽和化合物的方法可用于治疗由PYY调节的病症

    公开(公告)号：US20090253153A1

    公开(公告)日：2009-10-08

    申请号：US12391097

    申请日：2009-02-23

    申请人： ZHI-LIANG CHU ,  James N. Leonard ,  Robert M. Jones

    发明人： ZHI-LIANG CHU ,  James N. Leonard ,  Robert M. Jones

    IPC分类号： G01N33/53

    CPC分类号： G01N33/68 ,  G01N33/5044 ,  G01N2333/726 ,  G01N2800/042 ,  G01N2800/044 ,  G01N2800/065 ,  G01N2800/108 ,  G01N2800/323

    摘要： The present invention relates to methods of using GPR119 receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditions modulated by PYY, such as conditions modulated by stimulation of NPY Y2 receptor (Y2R). Agonists of GPR119 receptor are useful as therapeutic agents for treating or preventing a condition modulated by PYY, such as a condition modulated by stimulation of Y2R. Conditions modulated by PYY such as may be a condition modulated by stimulation of Y2R include bone-related conditions, metabolic disorders, angiogenesis-related conditions, ischemia-related conditions, convulsive disorders, malabsorptive disorders, cancers, and inflammatory disorders.

    摘要翻译： 本发明涉及使用GPR119受体鉴定肽YY（PYY）促分泌素和可用于治疗由PYY调节的病症的化合物的方法，例如通过刺激NPY Y2受体（Y2R）调节的病症。 GPR119受体的激动剂可用作治疗或预防由PYY调节的病症的治疗剂，例如通过刺激Y2R调节的病症。 由PYY调节的病症例如可能是通过Y2R刺激调节的病症包括骨相关病症，代谢紊乱，血管生成相关病症，缺血相关病症，惊厥症，吸收不良障碍，癌症和炎症性疾病。

    Differential for a lightweight vehicle
    37.
    发明申请
    Differential for a lightweight vehicle 审中-公开
    微型车轻型

    公开(公告)号：US20090014223A1

    公开(公告)日：2009-01-15

    申请号：US11825846

    申请日：2007-07-09

    申请人： Robert M. Jones ,  Bruce L. VanHoozen ,  Jesse H. Sims

    发明人： Robert M. Jones ,  Bruce L. VanHoozen ,  Jesse H. Sims

    IPC分类号： B60K17/16 ,  B60K1/02

    CPC分类号： B60K17/16 ,  B60L50/15 ,  B60L2200/22 ,  Y02T10/7077

    摘要： A differential for a vehicle having a suspension includes a first axle shaft, and a second axle shaft. The first axle shaft and the second axle shaft are disposed along a first axis of rotation. A first electric motor is disposed along a second axis of rotation. The second axis of rotation is spaced from the first axis of rotation. A housing is configured to support the first and second axle shafts. The shafts are disposed in a transverse manner through the housing. The first electric motor is also disposed in a transverse manner through the housing. The housing is configured to support the first electric motor as sprung weight, and in a location below the vehicle.

    摘要翻译： 具有悬架的车辆的差速器包括第一车轴和第二车轴。 第一车轴和第二车轴沿着第一旋转轴线设置。 第一电动机沿着第二旋转轴设置。 第二旋转轴线与第一旋转轴线间隔开。 壳体构造成支撑第一和第二车轴。 轴以横向方式设置穿过壳体。 第一电动机也以横向方式设置穿过壳体。 壳体构造成将第一电动机支撑为弹簧重量，并且在车辆下方的位置。

    Automatic winder for an inside brushless stator
    38.
    发明申请
    Automatic winder for an inside brushless stator 有权
    内置无刷定子自动络筒机

    公开(公告)号：US20080017746A1

    公开(公告)日：2008-01-24

    申请号：US11827830

    申请日：2007-07-13

    申请人： Robert M. Jones ,  Joseph M. Lisiecki

    发明人： Robert M. Jones ,  Joseph M. Lisiecki

    IPC分类号： H02K15/085

    CPC分类号： H02K15/085 ,  Y10T29/49009 ,  Y10T29/49071 ,  Y10T29/53143

    摘要： An apparatus for manufacturing an internal wound stator includes a winding arbor configured to receive a conductive wire. The apparatus also has a stator loader, and receives a stator having a generally cylindrical shape with an interior opening and having a plurality of axial slots formed therein. The interior dimension of the stator is larger than the exterior dimension of the winding arbor such that the winding arbor and stator may traverse with respect to one another. The apparatus also has a first movable member configured for moving at least one of the winding arbor and the stator. The apparatus also has a second rotating member configured to rotate at least one of the stator and the winding arbor. The conductive wire is introduced through an interior of the winding arbor. The first movable member is configured to move at least one of the winding arbor and the stator relative to one another to wind the conductive wire in a first longitudinal manner and into a first of the plurality of axial slots. The second rotating member is configured to rotate at least one of the first winding arbor or the stator relative to one another to align the wire relative to a second axial slot of the plurality of axial slots. The first movable member is configured to move at least one of the winding arbor and the stator relative to one another to wind the conductive wire in a second opposite longitudinal manner and into the second axial slot.

    摘要翻译： 一种用于制造内部缠绕定子的装置包括构造成接纳导线的绕线轴。 该装置还具有定子装载器，并且接收具有大致圆柱形形状的定子，其具有内部开口并且在其中形成有多个轴向槽。 定子的内部尺寸大于绕组心轴的外部尺寸，使得绕组心轴和定子可以相对于彼此横越。 该装置还具有构造成用于移动绕组轴和定子中的至少一个的第一可动构件。 该装置还具有构造成旋转定子和绕组心轴中的至少一个的第二旋转构件。 导线通过绕组心轴的内部引入。 第一可移动构件被构造成相对于彼此移动至少一个绕组心轴和定子，以使第一纵向方式缠绕导线并进入多个轴向槽中的第一个。 第二旋转构件被配置为相对于彼此旋转第一卷绕心轴或定子中的至少一个，以使线相对于多个轴向槽中的第二轴向槽对准。 第一可移动部件构造成相对于彼此移动绕组轴和定子中的至少一个，以使第二相对纵向方式缠绕导线并进入第二轴向槽。

    β-Superfamily conotoxins
    39.
    发明授权
    β-Superfamily conotoxins 有权
    β-超家族芋螺毒素

    公开(公告)号：US07115708B2

    公开(公告)日：2006-10-03

    申请号：US11198847

    申请日：2005-08-08

    申请人： Robert M. Jones ,  Baldomero M. Olivera ,  Maren Watkins ,  James E. Garrett

    发明人： Robert M. Jones ,  Baldomero M. Olivera ,  Maren Watkins ,  James E. Garrett

    IPC分类号： C07K4/12 ,  A61K51/08

    CPC分类号： C07K14/43504

    摘要： The present invention is directed to β-superfamily conotoxin peptides, derivatives or pharmaceutically acceptable salts thereof. The present invention is further directed to the use of this peptide, derivatives thereof and pharmaceutically acceptable salts thereof for the treatment of disorders associated with voltage-gated ion channels, ligand gated channels and other receptors. The invention is further directed to nucleic acid sequences encoding the β-superfamily conotoxin peptides and encoding β-superfamily conotoxin propeptides, as well as the β-superfamily conotoxin propeptides.

    摘要翻译： 本发明涉及β-超家族荚果毒素肽，其衍生物或药学上可接受的盐。 本发明进一步涉及该肽，其衍生物和其药学上可接受的盐在治疗与电压门控离子通道，配体门控通道和其它受体相关的病症中的用途。 本发明还涉及编码β-超家族荚果毒素肽和编码β-超家族荚果毒素前肽以及β-超家族荚果毒素前肽的核酸序列。

    Recuperator duct assembly line
    40.
    发明授权
    Recuperator duct assembly line 有权
    换热器管道装配线

    公开(公告)号：US06668446B2

    公开(公告)日：2003-12-30

    申请号：US10001510

    申请日：2001-10-31

    申请人： Charles W. Bucey ,  Steven W. Clayton ,  Douglas R. Ervin ,  Robert M. Jones ,  Chad Miars

    发明人： Charles W. Bucey ,  Steven W. Clayton ,  Douglas R. Ervin ,  Robert M. Jones ,  Chad Miars

    IPC分类号： B23P1526

    CPC分类号： F28D9/0018 ,  B23P15/26 ,  Y10T29/49357 ,  Y10T29/5188 ,  Y10T29/53052 ,  Y10T29/53087 ,  Y10T29/53113

    摘要： An assembly line for economically and efficiently assembling a core into a recuperator. The assembly line has an inlet end, an assembly station, a welding station, a control station and an outlet end. The inlet end has a plurality of the cores to be used for assembly thereat. The core is positioned within the assembly station and an assembly fixture locates a ducting structure in a preestablished relationship to the core. The control station using a plurality of sensors sends an input to a controller and the welding station performs a weld fixedly securing the ducting structure to the core.

    摘要翻译： 一种用于经济有效地将核心组装成换热器的装配线。 装配线具有入口端，组装站，焊接站，控制站和出口端。 入口端具有用于组装的多个芯。 芯部位于组装工位内，并且组装夹具将管道结构定位成与芯部预先建立的关系。 使用多个传感器的控制站向控制器发送输入，并且焊接站执行将导管结构固定地固定到芯的焊接。