公开(公告)号：US20190293615A1

公开(公告)日：2019-09-26

申请号：US16438787

申请日：2019-06-12

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Dieter Heindl ,  Uwe Kobold ,  Martin Rempt ,  Christoph Seidel

IPC: G01N30/86 ,  G01N30/72 ,  G01N30/34 ,  G01N30/88

Abstract: A method for tracking a sample identity during a process in an analysis system is disclosed. The analysis system comprises a liquid chromatograph and a mass spectrometer. The method comprises providing a sample, adding a composition of different chemical substances to the sample with a concentration being above a detection level of the mass spectrometer, processing the sample together with the composition with the analysis system, detecting and measuring a component and/or components of the sample with the mass spectrometer, detecting and measuring the composition or parts of the composition of different chemical substances with the mass spectrometer, and identifying the sample based on a detection of a substance detection signal pattern of the mass spectrometer including substance detection signals representing the composition of chemical substances.

公开(公告)号：US20190250158A1

公开(公告)日：2019-08-15

申请号：US16389066

申请日：2019-04-19

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Uwe Kobold ,  Robert Lang ,  Andreas Leinenbach

IPC: G01N33/566 ,  G01N33/573 ,  G01N33/68

CPC classification number: G01N33/566 ,  G01N33/543 ,  G01N33/573 ,  G01N33/6848

Abstract: The present disclosure relates to a method for detecting an analyte involving a) contacting the analyte, a capture agent and a solid surface to form a capture complex attached to a solid surface, b) cleaving at least one covalent bond within the analyte and/or within said capture agent in the capture complex and, thereby, releasing the analyte or a fragment thereof from the capture complex, and c) detecting at least one fragment of the analyte and, thereby, detecting the analyte. The present disclosure further relates to a kit having i) a capture agent binding to an analyte; and ii) an agent cleaving at least one covalent bond within the analyte and/or within the capture agent; and to the use of a protease for releasing fragments of an analyte for detecting the analyte, wherein the analyte is bound to a solid surface via a capture agent.