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31.发明授权Method and apparatus for device controlled gene expression for cardiac protection 失效心脏保护装置控制基因表达的方法和装置公开(公告)号：US08538520B2
公开(公告)日：2013-09-17
申请号：US12830534
申请日：2010-07-06
申请人： Joseph M. Pastore , Jeffrey Ross , Tamara Colette Baynham , Rodney W. Salo , Andrew P. Kramer , Julio C. Spinelli
发明人： Joseph M. Pastore , Jeffrey Ross , Tamara Colette Baynham , Rodney W. Salo , Andrew P. Kramer , Julio C. Spinelli
IPC分类号： A61N1/36
CPC分类号： A61N1/3627 , A61K48/0083 , A61N1/36514
摘要： A gene regulatory system detects ischemia events and is capable of delivering a biologic therapy in response to the detection of an ischemic event or the reception of a command. The biologic therapy protects the heart from ischemic damage by regulating the expression of an exogenously introduced gene product. In one embodiment, the gene regulatory system includes an implantable system that emits at least one gene regulatory signal in response to the detection of the ischemic event or the reception of the command. The gene regulatory signal directly or indirectly regulates gene expression of the gene product.
摘要翻译： 基因调控系统检测缺血事件，并且能够响应于缺血事件的检测或命令的接收而递送生物疗法。 生物治疗通过调节外源基因产物的表达来保护心脏免于缺血性损伤。 在一个实施方案中，基因调控系统包括可植入系统，其可以响应于缺血事件的检测或命令的接收而发射至少一个基因调节信号。 基因调控信号直接或间接调控基因产物的基因表达。
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32.发明授权公开(公告)号：US08121684B2
公开(公告)日：2012-02-21
申请号：US12268170
申请日：2008-11-10
申请人： Jeffrey Ross , Julio C. Spinelli , Rodney W. Salo
发明人： Jeffrey Ross , Julio C. Spinelli , Rodney W. Salo
IPC分类号： A61N1/05
CPC分类号： A61N1/3627
摘要： A cardiac rhythm management device is configured to deliver pre-excitation pacing to one or more sites in proximity to an infarcted region of the ventricular myocardium. The pre-excitation pacing in conjunction with counterpulsation therapy serves to either prevent or minimize post-infarct remodeling.
摘要翻译： 心律管理装置被配置为将预激励起搏递送到心室心肌梗塞区域附近的一个或多个部位。 预激励起搏结合反搏疗法可预防或最小化梗死后重塑。
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33.发明授权公开(公告)号：US07450988B2
公开(公告)日：2008-11-11
申请号：US10862011
申请日：2004-06-04
申请人： Jeffrey Ross , Julio C. Spinelli , Rodney W. Salo
发明人： Jeffrey Ross , Julio C. Spinelli , Rodney W. Salo
IPC分类号： A61N1/00
CPC分类号： A61N1/3627
摘要： A cardiac rhythm management device is configured to deliver pre-excitation pacing to one or more sites in proximity to an infarcted region of the ventricular myocardium. The pre-excitation pacing in conjunction with counterpulsation therapy serves to either prevent or minimize post-infarct remodeling.
摘要翻译： 心律管理装置被配置为将预激励起搏递送到心室心肌梗塞区域附近的一个或多个部位。 预激励起搏结合反搏疗法可预防或最小化梗死后重塑。
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公开(公告)号：US5584868A
公开(公告)日：1996-12-17
申请号：US281476
申请日：1994-07-27
CPC分类号： A61N1/3962 , A61N1/3622 , A61N1/3627 , A61N1/3682
摘要： A cardiac rhythm management device and method includes a dual-chamber pacemaker especially designed for treating congestive heart failure and a defibrillator as a back-up measure. The device incorporates a programmed microcontroller which is operative to adjust the AV delay of the pacemaker to a minimum or maximum length consistent with optimal cardiac function. The cardiac stimulator includes apparatus for sensing cardiac function from cycle-to-cycle and determining whether incremental changes made to the AV delay interval enhances or worsens the measured cardiac function. On each iterative cycle, the AV delay interval is changed, either incremented or decremented, until a cross-over point is reached in which it is noted that the cardiac function ceases to improve and this is followed with a further incremental adjustment in an opposite direction to compensate for any overshoot. By providing a cardiac defibrillator in combination with the pacing device with closed-loop control of the AV interval, incidences of sudden death due to lethal arrhythmias is reduced.
摘要翻译： 心律管理装置和方法包括一个双室心脏起搏器，特别设计用于治疗充血性心力衰竭和除颤器作为后备措施。 该装置包括编程的微控制器，其可操作以将起搏器的AV延迟调整到与最佳心脏功能一致的最小或最大长度。 心脏刺激器包括用于从周期到周期感测心脏功能的装置，以及确定对AV延迟间隔做出的增量变化是否增强或恶化测量的心脏功能。 在每个迭代循环中，AV延迟间隔被改变，递增或递减，直到达到交叉点，其中注意到心脏功能不再改善，并且随后在相反方向上进一步增量调整 以补偿任何过冲。 通过与AV间隔的闭环控制提供与起搏装置组合的心脏除颤器，减少了因致命性心律失常引起的猝死的发生。
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公开(公告)号：US07627373B2
公开(公告)日：2009-12-01
申请号：US10723258
申请日：2003-11-25
IPC分类号： A61N1/00
CPC分类号： A61N1/362
摘要： A method for cell and electrical therapy of living tissue including administration of exogenous cells into a region of injured tissue and application of electrical energy. In one application the combined cell and electrical therapy is applied in vivo to damaged heart tissue. In such applications, minimally invasive procedures are used to apply the cell therapy and the electrical therapy is provided via an implantable pulse generator. In one application an implantable pacemaker is used in the VDD mode with an atrioventricular delay kept relatively short when compared to the intrinsic atrioventricular delay.
摘要翻译： 一种用于生物组织的细胞和电疗法的方法，包括将外源细胞施用到损伤组织的区域中并施加电能。 在一个应用中，组合的细胞和电疗法在体内应用于损伤的心脏组织。 在这样的应用中，使用微创手术来应用细胞治疗，并且通过可植入脉冲发生器提供电疗法。 在一个应用中，可以使用植入式起搏器进行VDD模式，与内在房室延迟相比，房室延迟保持相对较短。
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公开(公告)号：US07194307B2
公开(公告)日：2007-03-20
申请号：US10744952
申请日：2003-12-22
IPC分类号： A61N1/368
CPC分类号： A61N1/3627 , A61N1/3684
摘要： An implantable device for delivering cardiac pacing therapy in order to improve cardiac function is programmed to allow some amount of intrinsic activity to occur without otherwise the disturbing the pacing algorithm used to deliver therapy. Intrinsic cardiac cycles utilize the heart's native conduction system and thus serve to prevent the atrophy which may otherwise result from continuous pacing.
摘要翻译： 用于递送心脏起搏治疗以改善心脏功能的可植入装置被编程为允许发生一定量的内在活动，而无需另外打扰用于递送治疗的起搏算法。 内在心脏周期利用心脏的天然传导系统，从而用于预防由连续起搏引起的萎缩。
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公开(公告)号：US08046070B2
公开(公告)日：2011-10-25
申请号：US11557202
申请日：2006-11-07
申请人： Rodney W. Salo , Robert Shipley
发明人： Rodney W. Salo , Robert Shipley
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/36564
摘要： Described herein are methods and apparatus for treating hypertension with electrical pre-excitation pacing therapy. Electrical pre-excitation of a hypertrophic region advances the timing of the regional contraction and reduces its contribution to the overall contraction. Such pre-excitation pacing therapy may be beneficial to hypertensive patients with an abnormal distribution of ventricular wall stress/strain.
摘要翻译： 本文描述了用电预激发起步疗法治疗高血压的方法和装置。 增生区域的电预激发促进了区域收缩的时机，并减少了其对整体收缩的贡献。 这种预激励起搏治疗可能有益于心室壁应力/应变异常分布的高血压患者。
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38.发明授权Method and apparatus for control of cardiac therapy using non-invasive hemodynamic sensor 有权使用非侵入性血液动力学传感器控制心脏治疗的方法和装置公开(公告)号：US08046069B2
公开(公告)日：2011-10-25
申请号：US11315032
申请日：2005-12-22
IPC分类号： A61N1/00
CPC分类号： A61N1/36557 , A61B5/6816 , A61B5/6826 , A61B5/6829 , A61B5/6838 , A61N1/36114 , A61N1/36564
摘要： A cardiac rhythm management (CRM) system includes a non-invasive hemodynamic sensing device and an implantable medical device to sense a hemodynamic signal and derive one or more cardiac performance parameters from the hemodynamic signal. The non-invasive hemodynamic sensing device includes at least a portion configured for external attachment to a body in which the implantable medical device is implanted. The one or more cardiac performance parameters are used for various diagnostic, monitoring, and therapy control purposes.
摘要翻译： 心律管理（CRM）系统包括非侵入性血液动力学感测装置和可植入医疗装置，用于感测血液动力学信号并从血流动力学信号导出一个或多个心脏性能参数。 非侵入式血流动力学检测装置包括至少一部分，其构造成用于外部附接到其中植入可植入医疗装置的主体。 一个或多个心脏性能参数用于各种诊断，监测和治疗控制目的。
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公开(公告)号：US20110213436A1
公开(公告)日：2011-09-01
申请号：US13103477
申请日：2011-05-09
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/3684
摘要： A method and device for treating myocardial ischemia are described in which the stress experienced by a myocardial region identified as vulnerable to becoming ischemic is varied with pre-excitation pacing. In an unloading mode, pacing is applied in proximity to the vulnerable region to reduce stress and the metabolic demand of the region. In a loading mode, pacing is applied to a region remote from the vulnerable region in order to produce a conditioning effect.
摘要翻译： 描述了一种用于治疗心肌缺血的方法和装置，其中被认为易于变得缺血的心肌区域所经受的压力随着预激发起搏而变化。 在卸载模式下，起搏应用于脆弱区域附近，以减少该地区的压力和代谢需求。 在加载模式中，起搏应用于远离脆弱区域的区域，以产生调节效果。
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40.发明申请公开(公告)号：US20110144575A1
公开(公告)日：2011-06-16
申请号：US13034560
申请日：2011-02-24
申请人： Rodney W. Salo
发明人： Rodney W. Salo
CPC分类号： A61N1/3627 , A61N1/0587 , A61N1/3684
摘要： A cardiac rhythm management device for in which pre-excitation pacing is applied to one or more sites in proximity to an infarcted region of the ventricular myocardium. Such pacing servers to either prevent or minimize post-infarct remodeling.
摘要翻译： 一种心律管理装置，其中预激发起搏应用于心室心肌梗塞区域附近的一个或多个部位。 这种起搏服务器可以预防或最小化梗死后重塑。
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