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公开(公告)号：US07884102B2
公开(公告)日：2011-02-08
申请号：US12110915
申请日：2008-04-28
IPC分类号： A61K31/535 , A61K31/425 , C07D405/00 , C07D211/32
CPC分类号： C07D401/04 , C07D211/34 , C07D211/58 , C07D401/06 , C07D401/10 , C07D401/14 , C07D409/14 , C07D413/14
摘要： 3,4-Disubstituted-4-aryl-piperidine compounds are disclosed. Pharmaceutical compositions containing the 3,4-disubstituted-4-aryl-piperidine compounds and methods of their pharmaceutical uses are also disclosed. The compounds disclosed are useful, inter alia, as antagonists of opioid receptors.
摘要翻译： 公开了3,4-二取代-4-芳基 - 哌啶化合物。 还公开了含有3,4-二取代-4-芳基 - 哌啶化合物的药物组合物及其药物用途的方法。 所公开的化合物尤其可用作阿片受体的拮抗剂。
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32.发明申请公开(公告)号：US20100311782A1
公开(公告)日：2010-12-09
申请号：US12795095
申请日：2010-06-07
IPC分类号： A61K31/485 , C07D211/34 , A61K31/451 , A61K31/452 , A61K31/454 , A61K31/4748 , A61K31/4545 , A61P1/04 , A61P1/06 , A61P1/10 , A61P29/00 , C12N5/02
CPC分类号： C07D211/34
摘要： Novel 3,4-disubstituted-4-(3-carbamoylphenyl)-piperidinylpropanoic acid compounds and their salts, including pharmaceutically acceptable salts, pharmaceutical compositions and methods of their use are disclosed. The novel compounds are useful, inter alia, as antagonists of opioid receptors.
摘要翻译： 公开了新的3,4-二取代-4-（3-氨基甲酰基苯基） - 哌啶基丙酸化合物及其盐，包括其药学上可接受的盐，药物组合物及其使用方法。 新化合物尤其可用作阿片受体的拮抗剂。
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公开(公告)号：US07820827B2
公开(公告)日：2010-10-26
申请号：US11217528
申请日：2005-09-01
IPC分类号： C07D213/00 , A61K31/445
CPC分类号： C07D401/06 , C07D211/22 , C07D401/12 , C07F9/59
摘要： Novel 3,4-disubstituted-4-aryl-piperidine compounds are disclosed. Pharmaceutical compositions containing the 3,4-disubstituted-4-aryl-piperidine compounds and methods of their pharmaceutical uses are also disclosed. The compounds disclosed are useful, inter alia, as antagonists of opioid receptors.
摘要翻译： 公开了新的3,4-二取代-4-芳基 - 哌啶化合物。 还公开了含有3,4-二取代-4-芳基 - 哌啶化合物的药物组合物及其药物用途的方法。 所公开的化合物尤其可用作阿片受体的拮抗剂。
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公开(公告)号：US08022060B2
公开(公告)日：2011-09-20
申请号：US12542302
申请日：2009-08-17
IPC分类号： A61K31/55 , C07D491/107
CPC分类号： C07D491/10 , C07D221/20 , C07D223/14 , C07D311/96 , C07D493/10 , C07D495/10
摘要： Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the δ opioid receptor and may be useful, inter alia, for treating and/or preventing pain, anxiety, gastrointestinal disorders, and other δ opioid receptor-mediated conditions.
摘要翻译： 公开了螺环杂环衍生物，含有这些化合物的药物组合物及其制药方法。 在某些实施方案中，螺环杂环衍生物是δ阿片样受体的配体，尤其可用于治疗和/或预防疼痛，焦虑，胃肠道疾病和其他δ阿片受体介导的病症。
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公开(公告)号：US20110034417A1
公开(公告)日：2011-02-10
申请号：US12897824
申请日：2010-10-05
IPC分类号： A61K31/451 , C07D211/34 , C07D401/06 , C07D401/12 , C07D413/12 , C07F9/38 , A61K31/454 , A61K31/4725 , A61K31/5377 , A61K31/675 , A61K31/485 , A61K31/4468 , A61K31/435 , A61K31/4545 , A61P1/00 , A61P1/10 , A61P1/08 , A61P29/00
CPC分类号： C07D401/06 , C07D211/22 , C07D401/12 , C07F9/59
摘要： Novel 3,4-disubstituted-4-aryl-piperidine compounds are disclosed. Pharmaceutical compositions containing the 3,4-disubstituted-4-aryl-piperidine compounds and methods of their pharmaceutical uses are also disclosed. The compounds disclosed are useful, inter alia, as antagonists of opioid receptors.
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公开(公告)号：US07829576B2
公开(公告)日：2010-11-09
申请号：US12750558
申请日：2010-03-30
IPC分类号： A61K31/4353 , A61P25/00
CPC分类号： A61K31/4353
摘要： This present disclosure provides methods of treating pain with beloxepin and/or beloxepin analogs.
摘要翻译： 本公开内容提供了用贝洛塞平和/或贝洛塞平类似物治疗疼痛的方法。
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公开(公告)号：US20100222374A1
公开(公告)日：2010-09-02
申请号：US12718439
申请日：2010-03-05
IPC分类号： A61K31/444 , A61P25/24
CPC分类号： C07D491/107 , C07D221/20 , C07D311/96 , C07D401/04 , C07D493/10 , C07D495/10
摘要： Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the δ opioid receptor and may be useful, inter alia, for treating and/or preventing pain, anxiety, gastrointestinal disorders, and other δ opioid receptor-mediated conditions.
摘要翻译： 公开了螺环杂环衍生物，含有这些化合物的药物组合物及其制药方法。 在某些实施方案中，螺环杂环衍生物是δ阿片样受体的配体，尤其可用于治疗和/或预防疼痛，焦虑，胃肠道疾病和其他δ阿片受体介导的病症。
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公开(公告)号：US20100029614A1
公开(公告)日：2010-02-04
申请号：US12542302
申请日：2009-08-17
IPC分类号： A61K31/438 , C07D491/107 , C07D307/94 , A61K31/496 , A61K31/5377 , A61K31/55 , A61K31/352
CPC分类号： C07D491/10 , C07D221/20 , C07D223/14 , C07D311/96 , C07D493/10 , C07D495/10
摘要： Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the δ opioid receptor and may be useful, inter alia, for treating and/or preventing pain, anxiety, gastrointestinal disorders, and other δ opioid receptor-mediated conditions.
摘要翻译： 公开了螺环杂环衍生物，含有这些化合物的药物组合物及其制药方法。 在某些实施方案中，螺环杂环衍生物是δ阿片受体受体的配体，尤其可用于治疗和/或预防疼痛，焦虑，胃肠道疾病和其他δ阿片受体介导的病症。
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公开(公告)号：US07598261B2
公开(公告)日：2009-10-06
申请号：US11393133
申请日：2006-03-30
IPC分类号： A61K31/438 , C07D491/107
CPC分类号： C07D491/10 , C07D221/20 , C07D223/14 , C07D311/96 , C07D493/10 , C07D495/10
摘要： Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the δ opioid receptor and may be useful, inter alia, for treating and/or preventing pain, anxiety, gastrointestinal disorders, and other δ opioid receptor-mediated conditions.
摘要翻译： 公开了螺环杂环衍生物，含有这些化合物的药物组合物及其制药方法。 在某些实施方案中，螺环杂环衍生物是δ阿片受体受体的配体，尤其可用于治疗和/或预防疼痛，焦虑，胃肠道疾病和其他δ阿片受体介导的病症。
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公开(公告)号：US20090221562A1
公开(公告)日：2009-09-03
申请号：US12463814
申请日：2009-05-11
IPC分类号： A61K31/551 , C07D471/04 , A61K31/4985
CPC分类号： A61K31/4985 , A61K31/198 , C07D471/04
摘要： Certain quinolizidine and octahydropyridopyrazine compounds, pharmaceutical compositions, and methods of their use, inter alia, as opioid receptor antagonists are disclosed.
摘要翻译： 公开了某些喹嗪基和八氢吡啶并吡嗪化合物，药物组合物及其用途的方法，尤其是作为阿片受体拮抗剂。
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