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120 条记录 (耗时 0.04 秒)

    Antibacterial 8-cyano-1-cyclopropyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids
    35.
    发明授权
    Antibacterial 8-cyano-1-cyclopropyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids 失效
    抗菌8-氰基-1-环丙基-1,4-二氢-4-氧代-3-喹啉羧酸

    公开(公告)号：US4908366A

    公开(公告)日：1990-03-13

    申请号：US144884

    申请日：1988-01-14

    申请人： Michael Schriewer ,  Klaus Grohe ,  Uwe Petersen ,  Ingo Haller ,  Karl G. Metzger ,  Rainer Endermann ,  Hans-Joachim Zeiler

    发明人： Michael Schriewer ,  Klaus Grohe ,  Uwe Petersen ,  Ingo Haller ,  Karl G. Metzger ,  Rainer Endermann ,  Hans-Joachim Zeiler

    IPC分类号： A61K31/47 ,  A61K31/495 ,  A61P31/04 ,  C07D215/56 ,  C07D401/04 ,  C07D487/08

    CPC分类号： C07D215/56 ,  C07D401/04 ,  C07D487/08

    摘要： Antibacterial 8-cyano-1-cyclopropyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid derivatives of the formula ##STR1## in which Y represents a carboxyl group, a nitrile group, an ester group --COOR.sup.1 or an acid amide group --CONR.sup.2 R.sup.3,X.sup.1 represents hydrogen nitro, alkyl or halogenX.sup.4 can be hydrogen or halogen, or alkyl,R.sup.4 and R.sup.5, together with the nitrogen atom to which they are bonded, form a 5- or 6-membered heterocyclic ring which can additionally contain the atoms or groups --O--, --S--, --SO--, --SO.sub.2 --, ##STR2## as ring members or the group ##STR3## can also represent a ring system of the structure ##STR4## which can optionally be substituted on the ring carbons by methyl and pharmaceutically usable hydrates, salts or esters thereof.These compounds have a high antibacterial activity and are therefore suitable as active compounds for human and veterinary medicine.

    摘要翻译： 其中Y表示羧基，腈基，酯基-COOR1或酸的式“IMAGE”的抗菌8-氰基-1-环丙基-1,4-二氢-4-氧代-3-喹啉羧酸衍生物 酰胺基-CONR2R3，X1表示氢硝基，烷基或卤素X4可以是氢或卤素，或烷基，R4和R5与它们所键合的氮原子一起形成5-或6-元杂环，其可以 另外还包含原子或基团-O - ， - S - ， - SO - ， - SO 2 - ，作为环成员或组也可以表示结构 + TR

    6-fluoro-7-chloro-1-cyclopropyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid
    37.
    发明授权
    6-fluoro-7-chloro-1-cyclopropyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid 失效
    6-氟-7-氯-1-环丙基-4-氧代-1,4-二氢 - 喹啉-3-羧酸

    公开(公告)号：US4620007A

    公开(公告)日：1986-10-28

    申请号：US807554

    申请日：1985-12-11

    申请人： Klaus Grohe ,  Hans-Joachim Zeiler ,  Karl G. Metzger

    发明人： Klaus Grohe ,  Hans-Joachim Zeiler ,  Karl G. Metzger

    IPC分类号： C07D215/56 ,  C07D471/04 ,  C07D215/14

    CPC分类号： C07D471/04 ,  C07D215/56

    摘要： The invention relates to 7-amino-1-cyclo-propyl-4-oxo-1,4-dihydro-naphthyridine (or quinoline)-3-carboxylic acids of Formula I as defined in the specifications. Also included in the invention is a process for the preparation of said compounds of Formula I and Ia. Further, the invention includes compositions containing the compounds of Formula I or Ia and the use of said compounds and compositions as antibacterial agents.

    摘要翻译： 本发明涉及规格中定义的式I的7-氨基-1-环丙基-4-氧代-1,4-二氢 - 萘啶（或喹啉）-3-羧酸。 本发明还包括制备所述式I和Ia化合物的方法。 此外，本发明包括含有式I或Ia化合物的组合物以及所述化合物和组合物作为抗菌剂的用途。

    7-(3-aryl-1-piperazinyl)- and 7-(3-cyclohexyl-1-piperazinyl)-3-quinolonecarboxylic acid antibacterials
    38.
    发明授权
    7-(3-aryl-1-piperazinyl)- and 7-(3-cyclohexyl-1-piperazinyl)-3-quinolonecarboxylic acid antibacterials 失效
    7-（3-芳基-1-哌嗪基） - 和7-（3-环己基-1-哌嗪基）-3-喹诺酮羧酸抗菌剂

    公开(公告)号：US4599334A

    公开(公告)日：1986-07-08

    申请号：US735493

    申请日：1985-05-17

    申请人： Uwe Petersen ,  Klaus Grohe ,  Hans-Joachim Zeiler ,  Karl G. Metzger

    发明人： Uwe Petersen ,  Klaus Grohe ,  Hans-Joachim Zeiler ,  Karl G. Metzger

    IPC分类号： A61K31/495 ,  A61P3/00 ,  A61P31/04 ,  C07D215/56 ,  C07D333/00 ,  C07D401/04 ,  C07D409/14

    CPC分类号： C07D215/56 ,  C07D401/04 ,  C07D409/14

    摘要： Novel 1-cyclopropyl-4-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid antibacterials of the formula ##STR1## in which R.sup.1 is hydrogen, alkyl with 1 to 4 carbon atoms and optionally substituted by hydroxyl, methoxy, amino, dimethylamino, halogen, cyano or alkoxycarbonyl having 1 or 2 carbon atoms in the alkyl moiety, or is oxoalkyl having up to 4 carbon atoms, phenacyl, or acyl having 1 to 4 carbon atoms, phenacyl, or acyl having 1 to 4 carbon atoms,R.sup.2 is phenyl or cyclohexyl optionally substituted up to three times by halogen, methyl, phenyl, cyano, hydroxyl, methoxy, benzyloxy, amino, methylamino, dimethylamino, piperidino or nitro, or is methylenedioxyphenyl, methylenedioxycyclohexyl, furyl, tetrahydrofuryl or thienyl, andX.sup.1 is hydrogen or fluorine,or pharmaceutically ultizable hydrates, acid addition salts, alkali metal salts or alkaline earth metal salts thereof.

    摘要翻译： 具有式“IMAGE”的新颖的1-环丙基-4-氟-1,4-二氢-4-氧代-7-（1-哌嗪基）-3-喹啉羧酸抗菌剂，其中R 1是氢，具有1至4个的烷基 任选地被羟基，甲氧基，氨基，二甲基氨基，卤素，氰基或在烷基部分中具有1或2个碳原子的烷氧基羰基取代，或具有至多4个碳原子的氧代烷基，苯甲酰甲基或具有1至4个碳原子的酰基 ，苯甲酰基或具有1至4个碳原子的酰基，R 2是苯基或任选被卤素，甲基，苯基，氰基，羟基，甲氧基，苄氧基，氨基，甲基氨基，二甲基氨基，哌啶子基或硝基取代至多三次的苯基或环己基， 亚甲二氧基苯基，亚甲二氧基环己基，呋喃基，四氢呋喃基或噻吩基，X 1为氢或氟，或其药学上可接受的水合物，酸加成盐，碱金属盐或碱土金属盐。