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公开(公告)号：US20240390671A1
公开(公告)日：2024-11-28
申请号：US18795674
申请日：2024-08-06
Inventor： Saurav Paul , Troy T. Tegg , Israel A. Byrd , Riki Thao , Harry A. Puryear , Linda Nemec
Abstract: Catheter systems include direction-sensitive, multi-polar tip electrode assemblies for electroporation-mediated therapy, electroporation-induced primary necrosis therapy and electric field-induced apoptosis therapy, including configurations for producing narrow, linear lesions as well as distributed, wide area lesions. A monitoring system for electroporation therapy includes a mechanism for delivering electrochromic dyes to a tissue site as well as a fiber optic arrangement to optically monitor the progress of the therapy as well as to confirm success post-therapy. A fiber optic temperature sensing electrode catheter includes a tip electrode having a cavity whose inner surface is impregnated or coated with thermochromic/thermotropic material that changes color with changes in temperature. An optic fiber/detector arrangement monitors the thermochromic or thermotropic materials, acquiring a light signal and generating an output signal indicative of the spectrum of the light signal. An analyzer determines an electrode temperature based on the detector output and predetermined spectrum versus temperature calibration data.
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公开(公告)号：US11628286B2
公开(公告)日：2023-04-18
申请号：US14948645
申请日：2015-11-23
Inventor： Arthur G. Erdman , Saurav Paul , Troy T. Tegg
IPC: A61M39/10 , A61B5/00 , A61M25/00 , A61M25/01 , A61B18/14 , A61B5/06 , A61B5/107 , A61B18/24 , A61B17/00 , A61B90/00
Abstract: Coupler assemblies and methods are disclosed as the coupler assemblies may be used with a catheter. An exemplary coupler assembly includes a spherical linkage coupler for a catheter. The coupler comprises a first cylinder portion for connecting to a structure, and a second cylinder portion for connecting to a distal end of a body of the catheter. The coupler also comprises a spherical linkage including at least two link arms. Each of the two link arms are connected on one end to the first cylinder portion and on the other end to the second cylinder portion. The two link arms connect a portion of the structure to the distal end of the catheter and enable the structure to move relative to the distal end of the catheter in response to an external force exerted on the structure.
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公开(公告)号：US11517372B2
公开(公告)日：2022-12-06
申请号：US16712817
申请日：2019-12-12
Inventor： Stephan P. Miller , Don Curtis Deno , Saurav Paul , Liane R. Teplitsky
Abstract: A method and system for assessing lesion formation in tissue is provided. The system includes an electronic control unit (ECU). The ECU is configured to acquire values for first and second components of a complex impedance between the electrode and the tissue, and to calculate an index responsive to the first and second values. The ECU is further configured to process the ECI to assess lesion formation in the tissue.
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公开(公告)号：US11331136B2
公开(公告)日：2022-05-17
申请号：US15589652
申请日：2017-05-08
Inventor： Saurav Paul , Troy T. Tegg , Chou Thao , Harry A. Puryear
Abstract: An electrode for use on a medical device is disclosed. The electrode may have a main body of electrically conductive material extending along an axis and may have a proximal end and a distal end. The electrode may also include a magnetic resonance imaging (MRI) tracking coil disposed in the body. The MRI tracking coil may comprise electrically insulated wire. A catheter including an electrode, as well as a method for determining the location of an electrode, are also disclosed.
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公开(公告)号：US20200269038A1
公开(公告)日：2020-08-27
申请号：US15931240
申请日：2020-05-13
Inventor： Saurav Paul , Troy T. Tegg , Israel A. Byrd , Riki Thao , Harry A. Puryear , Linda Nemec
Abstract: Catheter systems include direction-sensitive, multi-polar tip electrode assemblies for electroporation-mediated therapy, electroporation-induced primary necrosis therapy and electric field-induced apoptosis therapy, including configurations for producing narrow, linear lesions as well as distributed, wide area lesions. A monitoring system for electroporation therapy includes a mechanism for delivering electrochromic dyes to a tissue site as well as a fiber optic arrangement to optically monitor the progress of the therapy as well as to confirm success post-therapy. A fiber optic temperature sensing electrode catheter includes a tip electrode having a cavity whose inner surface is impregnated or coated with thermochromic/thermotropic material that changes color with changes in temperature. An optic fiber/detector arrangement monitors the thermochromic or thermotropic materials, acquiring a light signal and generating an output signal indicative of the spectrum of the light signal. An analyzer determines an electrode temperature based on the detector output and predetermined spectrum versus temperature calibration data.
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Patent Agency Ranking
公开(公告)号：US10595937B2
公开(公告)日：2020-03-24
申请号：US14369645
申请日：2012-12-27
Inventor： Reed R. Heimbecher , Saurav Paul , Prathyusha Marri , Steven C. Christian , William M. Sutton , Paul H. McDowall
Abstract: A system for diagnosis or treatment of tissue in a body is provided. The system includes an ablation catheter having a deformable, elongate shaft having proximal and distal ends. The catheter further includes an ablation delivery member disposed proximate the distal end of the shaft and configured to deliver ablation energy to ablate the tissue. In one embodiment, the ablation delivery member comprises an ablation electrode and may also be configured to generate a signal indicative of electrical activity in the tissue. The catheter further includes one or more sensing electrodes disposed proximate the ablation delivery member. The sensing electrodes are configured to generate signals indicative of electrical activity in the tissue. The system further includes an electronic control unit configured to control delivery of ablation energy from the ablation delivery member responsive to one or more of the generated signals indicative of electrical activity in the tissue.
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公开(公告)号：US10314641B2
公开(公告)日：2019-06-11
申请号：US14948687
申请日：2015-11-23
Inventor： Saurav Paul , Todd R. Stangenes , Riki Thao
Abstract: A medical device utilizing temperature sensing to identify or assess anatomical bodies or structures includes an elongate tubular member, at least one electrode, a thermal sensor, and a temperature response assessment system or component. The at least one electrode may be connected to the distal portion of the elongate tubular member, and the one or more electrode can be configured to provide energy or heat to a portion of an anatomical body or structure. The thermal sensor may be configured to measure the thermal response of the portion of an anatomical body or structure, e.g., tissue or blood pools. The temperature response assessment system or component can be coupled to the thermal sensor. In embodiments, the device may include a lumen and port opening, which may accommodate a tool, such as a needle. Methods for using temperature sensing to identify an anatomical body or structure are also disclosed.
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公开(公告)号：US20180271593A1
公开(公告)日：2018-09-27
申请号：US15923489
申请日：2018-03-16
Inventor： Saurav Paul , Harry A. Puryear , Riki Chou Thao , Hong Cao
CPC classification number: A61B18/1492 , A61B18/1206 , A61B2018/00023 , A61B2018/00577 , A61B2018/00875
Abstract: The present invention is directed to bipolar ablation systems. A bipolar electrode system for ablation therapy is disclosed, including a pressure-sensitive conducting composite layer and a pair of electrodes in electrical conductive contact or communication with the pressure-sensitive conducting composite layer. Energy (e.g., ablation energy) is delivered via the pressure-sensitive conductive composition when sufficient pressure is applied to transform the pressure-sensitive conductive composite to an electrical conductor. An electrically insulative flexible layer, which may include a passageway for a fill material is also disclosed. In some embodiments, the systems can also be used for targeted delivery of compounds, such as drugs, using a bipolar electrode.
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公开(公告)号：US09814860B2
公开(公告)日：2017-11-14
申请号：US13740624
申请日：2013-01-14
Inventor： Troy T. Tegg , Saurav Paul
CPC classification number: A61M25/0054 , A61B5/067 , A61B2034/2048 , A61B2562/0219 , A61M25/00 , A61M2025/0166 , A61N1/36542 , A61N1/36578
Abstract: A catheter system including an accelerometer-based sensing assembly is provided. In particular the present teachings relate to an accelerometer based assembly used to determine contact between a catheter and surrounding proximate tissue, such as cardiac tissue. An embodiment of such a system may, for example, be used for visualization, mapping, ablation, or other methods of diagnosis and treatment of tissue and/or surrounding areas.
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公开(公告)号：US20170312009A1
公开(公告)日：2017-11-02
申请号：US15646914
申请日：2017-07-11
Inventor： Saurav Paul , Hong Cao
CPC classification number: A61B18/1233 , A61B18/1206 , A61B18/1492 , A61B2018/00678 , A61B2018/00702 , A61B2018/00779 , A61B2018/00791 , A61B2018/00827 , A61B2018/00869 , A61B2018/00892 , A61B2090/065
Abstract: Disclosed herein are ablation systems and methods for providing feedback on lesion formation in real-time. The methods and systems assess absorptivity of tissue based on a degree of electric coupling or contact between an ablation electrode and the tissue. The absorptivity can then be used, along with other information, including, power levels and activation times, to provide real-time feedback on the lesions being created. Feedback may be provided, for example, in the form of estimated lesion volumes and other lesion characteristics. The methods and systems can provide estimated treatment times to achieve a desired lesion characteristic for a given degree of contact, as well as depth of a lesion being created. The degree of contact may be measured using different techniques, including the phase angle techniques and a coupling index.
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