摘要:
Provided herein are methods and compositions related to a retinoid receptor-selective pathway. As described herein, this pathway can be targeted to manipulate a tumor microenvironment. For example, the methods and compositions described herein can be used to induce apoptosis in a cancer cell. Further, the compositions described herein, including Sulindac and analogs thereof, can be used to target this pathway for the treatment or prevention of cancer in human patients.
摘要:
The present invention, pertaining to the field of mobile broadcast television technologies, discloses a method and apparatus for generating a broadcast positioning signal, and a positioning method. According to the present invention, a broadcast positioning signal is generated by inserting a spread spectrum signal and a first spread spectrum signal in an orthogonal frequency-division multiplexing (OFDM) signal, and a receiver is positioned according to broadcast positioning signals from at least three different senders.
摘要:
This invention relates to methods for identifying agents useful for treatment of diseases and pathological conditions affected by Retinoid X Receptor apoptosis. The invention also relates to methods for treating diseases and pathological conditions affected by RXR apoptosis. The invention includes compositions that are useful in the study and treatment of diseases and pathological conditions affected by RXR apoptosis.
摘要:
In one embodiment a gait training system includes a patient interface adapted to attach to a patient's thigh, the patient interface defining a channel, a cord that passes through the channel of the patient interface, and connecting means attached to a first end of the cord for connecting the cord to the patient's forefoot, wherein pulling of the cord pulls the patient interface forward and upward to emulate hip flexion and simultaneously pulls the connecting means upward to emulate ankle dorsiflexion.
摘要:
The invention is a method of reducing catalyst dissolution in the cathode of a membrane electrode assembly fuel cell, the method comprising the steps of: (a) preparing a membrane electrode assembly comprising an anode, a cathode and a polymer electrolyte membrane interposed between the anode and the cathode; (b) assembling a fuel cell using the membrane electrode assembly; (c) applying a fluid comprising an oxidant to the cathode of the membrane electrode assembly; (d) applying a fluid comprising a fuel to the anode of the membrane electrode assembly; and (e) supplying a sufficient quantity of reducing agent to the cathode to maintain the average open-circuit voltage of the cathode at less than about 0.98 V.
摘要:
Provided is a process for the preparation of 2(R)-(3-Chloro-4-methanesulfonyl-phenyl)-3-((R)-3-oxo-cyclopentyl)-N-pyrazin-2-yl-propionamide and its isopropanol solvate as a glucokinase activator which increases insulin secretion in the treatment of, for example, type II diabetes.
摘要:
A variable polarization independent optical power splitter is disclosed. An input light beam “A” is split into two output light beams “M” and “N” where the optical power ratio of the two output light beams “M” and “N” is adjusted to a desired ratio by controlling a variable polarization rotator, e.g. a liquid crystal unit. The polarization components “P” and “S” of the input light beam “A” are separated in a first polarization separator, then processed through the variable polarization rotator, and a second polarization separator. The polarization independence of the power split is thus achieved through the stratagem of processing the “P” and “S” polarized components of the input light beam “A” separately, resulting in four light beams “H”, “I”, “L” and “K”, which are appropriately combined in the polarization combiner to yield the output light beams “M” and “N” having the desired optical power ratio “R”.
摘要:
This invention provides nucleic acid sequences and characterization of the gene cluster responsible for the biosynthesis of the enediyne C-1027 (produced by Streptomyces globisporus). The pathway comprises a nonriobsomal peptide synthetase (NRPS). Methods are provided for the biosynthesis of enediynes, enediyne analogs and other biological molecules.
摘要:
This invention provides nucleic acid sequences and characterization of the gene cluster responsible for the biosynthesis of the enediyne C-1027 (produced by Streptomyces globisporus). Methods are provided for the biosynthesis of enediynes, enediyne analogs and other biological molecules. This invention also provides enediyne and enediyne analogs biosynthesized by manipulation of the C-1027 gene pathway.
摘要:
The invention discloses a bidirectional OADM device, comprising a main body, on which a first fiber ferrule, a first filter, a Lens, a second filter, a second fiber ferrule arranged along a transverse optical axis of the device, and a Laser and a Pin-TIA vertical to the transverse optical axis, wherein the Laser and the Pin-TIA are located at either the same side or at each side of the transverse optical axis, respectively, and the normal of Laser and the first filter intersect with each other in an angle of about 45 degree, the normal of Pin-TIA and the second filter intersect with each other in an angle of about 45 degree, and the first filter offers total reflection to an optical signal transmitted by the Laser and gives total transmission of an received optical signal into Pin-TIA and an CATV signal, the second filter offers total reflection to an optical signal received by Pin-TIA and gives total transmission of CATV signal.