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22 条记录 (耗时 0.031 秒)

    GLUTARIMIDE-CONTAINING POLYKETIDE ANALOGS AND METHODS THEREOF
    1.
    发明申请
    GLUTARIMIDE-CONTAINING POLYKETIDE ANALOGS AND METHODS THEREOF 审中-公开
    含谷氨酰胺的聚合物模拟物及其方法

    公开(公告)号：US20060211736A1

    公开(公告)日：2006-09-21

    申请号：US11275556

    申请日：2006-01-13

    申请人： Ben Shen

    发明人： Ben Shen

    IPC分类号： A61K31/452 ,  A61K31/445 ,  C07H21/04 ,  C12P17/00 ,  C07D405/02 ,  C12N1/21 ,  C07D211/76

    CPC分类号： C12P17/02 ,  C07D211/88 ,  C07D405/06 ,  C12P7/42 ,  C12P17/16

    摘要： The present invention provides library of glutarimide-containing polyketide analogs, such as analogs of migrastatin, iso-migrastatin, dorrigocin A and B, epi-dorrigocin, NK30424 A and B and lactimidomycin, methods of synthesizing and using these analogs and further methods of creating a combinatorial library of these compounds through chemical modifications.

    摘要翻译： 本发明提供了含有戊二酰亚胺的聚酮化合物类似物的文库，例如migrastatin，异伐米他汀，dorrigocin A和B，epi-dorrigocin，NK30424A和B以及类似物的类似物，合成和使用这些类似物的方法以及进一步的创造方法 这些化合物的组合文库通过化学修饰。

    Electro-chemical deposition system and method
    3.
    发明授权
    Electro-chemical deposition system and method 失效
    电化学沉积系统及方法

    公开(公告)号：US06254760B1

    公开(公告)日：2001-07-03

    申请号：US09263649

    申请日：1999-03-05

    申请人： Ben Shen ,  Yezdi Dordi ,  George Birkmaier

    发明人： Ben Shen ,  Yezdi Dordi ,  George Birkmaier

    IPC分类号： G01F164

    CPC分类号： C25D7/12 ,  C25D17/001 ,  H01L21/2885 ,  H05K3/241

    摘要： The present invention generally provides an electro-chemical deposition system that is designed with a flexible architecture that is expandable to accommodate future designs rules and gap fill requirements and provides satisfactory throughput to meet the demands of other processing systems. The electro-chemical deposition system generally comprises a front-end loading station, a mainframe including one or more processing cells, and an electrolyte replenishing system fluidly connected to the one or more electrical processing cells. The electrolyte replenishing system comprises a main electrolyte supply tank and an analyzer module and dosing module coupled thereto. The analyzer module includes one or more chemical analyzers to monitor the concentrations of various chemicals in the main electrolyte supply tank. Information provided by the analyzer module is transmitted via a central control system to the dosing module. Source tanks in the dosing module communicate with the main supply tank to deliver the desired proportions of chemicals thereto. Preferably, the electrolyte analysis is performed continuously during processing to provide real-time data and electrolyte adjustments.

    摘要翻译： 本发明通常提供一种电化学沉积系统，其被设计成具有可扩展以适应未来设计规则和间隙填充要求的柔性结构，并提供令人满意的吞吐量以满足其它处理系统的需求。 电化学沉积系统通常包括前端加载站，包括一个或多个处理单元的主框架和与该一个或多个电处理单元流体连接的电解质补充系统。 电解质补充系统包括主要电解质供应罐和与其耦合的分析器模块和计量模块。 分析仪模块包括一个或多个化学分析仪，用于监测主要电解质供应罐中各种化学物质的浓度。 由分析器模块提供的信息经由中央控制系统传送到计量模块。 计量模块中的来源罐与主供应罐连通，以将所需比例的化学品运送到其上。 优选地，在处理期间连续执行电解质分析以提供实时数据和电解质调节。

    Targeted delivery to the brain of magnetically labeled stem cells
    6.
    发明申请
    Targeted delivery to the brain of magnetically labeled stem cells 审中-公开
    靶向到磁性标记干细胞的大脑

    公开(公告)号：US20110070202A1

    公开(公告)日：2011-03-24

    申请号：US12807999

    申请日：2010-09-17

    申请人： Paul Yarowsky ,  Paul Fishman ,  Adam Puche ,  Wei-Ben Shen

    发明人： Paul Yarowsky ,  Paul Fishman ,  Adam Puche ,  Wei-Ben Shen

    IPC分类号： A61K35/12 ,  A61P25/00

    CPC分类号： C12N5/0623 ,  A61K9/0009 ,  A61K9/0019 ,  A61K9/5115 ,  A61K48/0075

    摘要： Provided herein is a method of targeting stem cells to a specific region of the central nervous system of an individual in need of such treatment, comprising the steps of administering stem cells containing a superparamagnetic nanoparticles to said individual; and applying an external source of a magnetic field to the exterior of said individual's brain so as to advance and maneuver said stem cells. Also provided is a composition for targeting cells to a specific region of the central nervous system of an individual in need of such treatment, comprising stem cells containing a superparamagnetic nanoparticles.

    摘要翻译： 本文提供了将干细胞靶向需要这种治疗的个体的中枢神经系统的特定区域的方法，包括以下步骤：向所述个体施用含有超顺磁性纳米颗粒的干细胞; 以及将外部磁场源施加到所述个人的大脑的外部，以便前进和操纵所述干细胞。 还提供了用于将细胞靶向需要这种治疗的个体的中枢神经系统的特定区域的组合物，其包含含有超顺磁性纳米颗粒的干细胞。

    Methods of directing C-O bond formation utilizing a type II polyketide synthase system
    8.
    发明授权
    Methods of directing C-O bond formation utilizing a type II polyketide synthase system 失效
    使用II型聚酮化合物合成酶系统引导C-O键形成的方法

    公开(公告)号：US07416870B2

    公开(公告)日：2008-08-26

    申请号：US10646664

    申请日：2003-08-22

    申请人： Ben Shen ,  Hyung-Jin Kwon

    发明人： Ben Shen ,  Hyung-Jin Kwon

    IPC分类号： C12N9/02 ,  C07H21/04

    CPC分类号： C12P7/62 ,  C07H21/04 ,  C12N9/1029 ,  C12N15/52 ,  C12P17/08

    摘要： The present invention provides methods of modifying a biological molecule by C—O bond formation utilizing a type II polyketide synthase (PKS) system from the nonactin biosynthesis gene cluster. The type II PKS responsible for biosynthesis of the macrotetralide nonactin includes polypeptides encoded by the nonJK genes. The NonJ and NonK polypeptides have been identified by the inventors as ketoacyl synthases capable of directly catalyzing C—O bond formation between substrate molecules. This invention increases the scope and diversity of chemical syntheses available for drug design and combinatorial biosynthesis.

    摘要翻译： 本发明提供了利用来自非活性生物合成基因簇的II型聚酮化合物合酶（PKS）系统通过C-O键形成修饰生物分子的方法。 负责大分子左旋非激素的生物合成的II型PKS包括由非JK基因编码的多肽。 本发明人已经将NonJ和NonK多肽鉴定为能够直接催化底物分子之间的C-O键形成的酮酰基合成酶。 本发明增加了可用于药物设计和组合生物合成的化学合成的范围和多样性。

    Oxidative activation and episulfonium ion-mediated DNA alkylation-based anticancer
    9.
    发明授权
    Oxidative activation and episulfonium ion-mediated DNA alkylation-based anticancer 失效
    氧化活化和锍离子介导的基于DNA烷基化的抗癌剂

    公开(公告)号：US07345069B2

    公开(公告)日：2008-03-18

    申请号：US11097972

    申请日：2005-04-01

    申请人： Ben Shen

    发明人： Ben Shen

    IPC分类号： C07D513/08 ,  A61K31/381

    CPC分类号： A61K31/428 ,  C07D513/08

    摘要： The present invention relates to TG-25 and/or analogs thereof and their use of TG-25 in the treatment of cancer. TG-25 inhibits the growth of prostate cells by inhibiting DNA synthesis, more particularly by DNA cleavage.

    摘要翻译： 本发明涉及TG-25和/或其类似物及其在治疗癌症中的用途。 TG-25通过抑制DNA合成来抑制前列腺细胞的生长，更特别地通过DNA裂解来抑制前列腺细胞的生长。

    Targeted carrier fusions for delivery of chemotherapeutic agents
    10.
    发明授权
    Targeted carrier fusions for delivery of chemotherapeutic agents 有权
    靶向载体融合用于递送化学治疗剂

    公开(公告)号：US07122353B2

    公开(公告)日：2006-10-17

    申请号：US10912764

    申请日：2004-08-05

    申请人： Ben Shen

    发明人： Ben Shen

    IPC分类号： C12P19/00

    CPC分类号： C07K14/36 ,  A61K47/64 ,  C07K2319/01 ,  C07K2319/20 ,  G01N2500/04

    摘要： The present invention provides for fusion proteins that act as targeted drug carries. The proteins are derived from molecules that possess natural drug-binding capabilities that are further engineered to target specific cell types, and optionally to have altered/improved drug binding characteristics. These fusion proteins are useful in, for example, delivery of chemotherapeutic compounds to cancer cells.

    摘要翻译： 本发明提供用作靶向药物载体的融合蛋白。 蛋白质衍生自具有天然药物结合能力的分子，其进一步工程化以靶向特定细胞类型，并且任选具有改变/改善的药物结合特征。 这些融合蛋白可用于例如将化疗化合物递送至癌细胞。