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68 条记录 (耗时 0.041 秒)

    Subsaturated nicotine transdermal therapeutic system
    31.
    发明授权
    Subsaturated nicotine transdermal therapeutic system 失效
    亚饱和尼古丁透皮治疗系统

    公开(公告)号：US5004610A

    公开(公告)日：1991-04-02

    申请号：US537672

    申请日：1990-06-14

    申请人： James L. Osborne ,  Melinda Nelson ,  David J. Enscore ,  Su I. Yum ,  Robert M. Gale

    发明人： James L. Osborne ,  Melinda Nelson ,  David J. Enscore ,  Su I. Yum ,  Robert M. Gale

    IPC分类号： A61K9/70 ,  A61K31/465

    CPC分类号： A61K9/7084 ,  A61K31/465 ,  A61K9/7053 ,  A61K9/7069 ,  Y10S514/813

    摘要： Rate controlled transdermal nicotine delivery systems are disclosed which utilize an in-line adhesive to maintain the systems on the skin. The initial equilibrated concentration of nicotine in the nicotine reservoir and the adhesive is below saturation, preferably at a thermodynamic activity no greater than 0.50, and the reservoir comprises the nicotine dissolved in a material with respect to which the rate controlling element of the device is substantially impermeable. In preferred embodiments the initial loading of nicotine in the reservoir is sufficient to prevent the activity of the nicotine in the reservoir from decreasing by more than about 75% and preferably no more than about 25% during the predetermined period of administration; and the thickness of the adhesive, rate controlling membrane and reservoir layers are selected so that at least 50% and, preferably at least 75% of the initial equilibrated nicotine loading is in the reservoir layer.

    摘要翻译： 公开了速率控制的透皮尼古丁递送系统，其利用直列粘合剂将系统保持在皮肤上。 尼古丁储存器和粘合剂中尼古丁的初始平衡浓度低于饱和度，优选在不大于0.50的热力学活性下，并且储存器包含溶解在该装置的速率控制元件基本相当于的材料中的尼古丁 不渗透 在优选的实施方案中，储存器中尼古丁的初始加载量足以防止储存器中的尼古丁的活性在给定的给药期间减少超过约75％，优选不超过约25％; 并且选择粘合剂，速率控制膜和储存层的厚度，使得初始平衡的尼古丁负载的至少50％，优选至少75％在储层中。

    Method for treating nocturnal angina
    32.
    发明授权
    Method for treating nocturnal angina 失效
    治疗夜间心绞痛的方法

    公开(公告)号：US4954344A

    公开(公告)日：1990-09-04

    申请号：US269835

    申请日：1988-11-10

    申请人： Robert M. Gale

    发明人： Robert M. Gale

    IPC分类号： A61K9/70

    CPC分类号： A61K9/703 ,  A61K9/7069 ,  A61K9/7084 ,  Y10S514/929

    摘要： A medical bandage is disclosed comprising a reservoir containing a gelled fluid, rheological agent and a drug. A method of using the bandage for producing a beneficial effect is disclosed also.

    摘要翻译： 公开了一种医用绷带，其包括含有凝胶流体，流变剂和药物的贮存器。 还公开了使用绷带产生有益效果的方法。

    Transdermal delivery of drugs from an aqueous reservoir
    33.
    发明授权
    Transdermal delivery of drugs from an aqueous reservoir 失效
    从水性储存器透皮输送药物

    公开(公告)号：US4904475A

    公开(公告)日：1990-02-27

    申请号：US17649

    申请日：1987-02-24

    申请人： Robert M. Gale ,  David J. Enscore

    发明人： Robert M. Gale ,  David J. Enscore

    IPC分类号： A61K9/70

    CPC分类号： A61K9/7084

    摘要： A transdermal delivery device for delivering drugs, typically ionized drugs, from an aqueous reservoir is described. The device comprises an aqueous drug reservoir in the form of a gel confined between an impermeable backing member and a porous support structure. In preferred embodiments the support structure is the substrate to which is applied a porous or patterned in-line adhesive. A strippable release liner is preferably provided on the adhesive while in the package. The devices are usable to deliver drugs such as chlorpheniramine maelate, brompheneiramine maleate and scopolamine hydrobromide.

    摘要翻译： 描述了用于从水性储存器输送药物（通常为电离药物）的透皮递送装置。 该装置包括凝胶形式的凝胶形式的含水药物储存器，其限制在不透水背衬构件和多孔支撑结构之间。 在优选实施例中，支撑结构是施加有多孔或图案化的在线粘合剂的基底。 可剥离的剥离衬垫优选在包装中在粘合剂上提供。 该装置可用于递送药物如氯苯那敏，马来酸溴噻嗪和东莨菪碱氢溴酸盐。

    Medical bandage for administering vasodilator drug
    35.
    发明授权
    Medical bandage for administering vasodilator drug 失效
    用于管理血管扩张剂药物的医用绷带

    公开(公告)号：US4661105A

    公开(公告)日：1987-04-28

    申请号：US872369

    申请日：1986-06-09

    申请人： Robert M. Gale

    发明人： Robert M. Gale

    IPC分类号： A61K9/70 ,  A61K9/00

    CPC分类号： A61K9/703 ,  A61K9/7069 ,  A61K9/7084

    摘要： A medical bandage is disclosed comprising a reservoir containing a gelled fluid, rheological agent and a drug. A method of using the bandage for producing a beneficial effect is disclosed also.

    摘要翻译： 公开了一种医用绷带，其包括含有凝胶流体，流变剂和药物的贮存器。 还公开了使用绷带产生有益效果的方法。

    Transdermal warfarin system
    40.
    发明授权
    Transdermal warfarin system 有权
    透皮华法林系统

    公开(公告)号：US07323191B2

    公开(公告)日：2008-01-29

    申请号：US10900804

    申请日：2004-07-27

    申请人： Robert M. Gale

    发明人： Robert M. Gale

    IPC分类号： A61F13/00

    CPC分类号： A61K9/7053 ,  A61K9/7084 ,  A61K31/366

    摘要： Composition of matter for application to a body surface or membrane to administer warfarin by permeation through the body surface or membrane, the composition comprising warfarin to be administered, at a therapeutically effective rate, alone or in combination with a permeation enhancer or mixture. Also disclosed are drug delivery devices containing the warfarin or warfarin and enhancer composition and methods for the transdermal administration of the warfarin and warfarin/enhancer composition.

    摘要翻译： 用于通过身体表面或膜渗透来施用于身体表面或膜以施用华法林的物质的组成，所述组合物包含以治疗有效速率单独或与渗透增强剂或混合物组合施用的华法林。 还公开了含有华法林或华法林的药物递送装置和用于透皮给药华法林和华法林/增强剂组合物的增强剂组合物和方法。