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公开(公告)号：US09056061B2
公开(公告)日：2015-06-16
申请号：US11525977
申请日：2006-09-22
申请人： Robert M. Gale , Jay Audett , Rama V. Padmanabhan , Michel J. N. Cormier , Allison Luciano , Eric N. Silverberg , Paul B. Foreman
发明人： Robert M. Gale , Jay Audett , Rama V. Padmanabhan , Michel J. N. Cormier , Allison Luciano , Eric N. Silverberg , Paul B. Foreman
IPC分类号： A61K31/4439 , A61K9/70 , A61K31/56
CPC分类号： A61K9/7061 , A61K31/4439 , A61K31/56 , C09J7/255 , C09J7/385 , C09J133/06 , C09J2467/006
摘要： A transdermal nicotine salt delivery system to an individual. The system has a high nicotine salt loading to effect therapeutic flux rate. Acrylate polymeric drug reservoir with the high nicotine salt dissolved therein provides desirable adhesive characteristics and effective transdermal therapeutic properties.
摘要翻译： 向个体透皮的尼古丁盐输送系统。 该系统具有高尼古丁盐负荷以实现治疗通量。 溶解有高尼古丁盐的丙烯酸酯聚合物药物储库提供了所需的粘合特性和有效的经皮治疗性质。
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公开(公告)号：US20090105634A1
公开(公告)日：2009-04-23
申请号：US12252731
申请日：2008-10-16
CPC分类号： A61N1/30 , A61N1/0436 , A61N1/0448 , Y10T29/49002
摘要： An electrotransport system for delivery of a cationic drug. The system has a donor anodic reservoir having an insoluble biocompatible polymeric anion source embedded in the reservoir. The anion source has precipitating anions that can precipitate out metal ions generated from sacrificial metal of the anode during electrotransport.
摘要翻译： 用于递送阳离子药物的电转运系统。 该系统具有供体阳极储存器，其具有嵌入储存器中的不溶性生物相容性聚合阴离子源。 阴离子源具有沉淀阴离子，其可以在电输送期间沉淀出由阳极的牺牲金属产生的金属离子。
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公开(公告)号：US20090105632A1
公开(公告)日：2009-04-23
申请号：US12246856
申请日：2008-10-07
IPC分类号： A61K31/437 , A61N1/30 , H01S4/00 , A61P25/16
CPC分类号： A61N1/30 , A61N1/0448 , Y10T29/49002
摘要： An electrotransport system for delivery of lisuride or a pharmaceutically acceptable salt thereof. The system has a donor electrode assembly, a counter electrode assembly, and a controller electrically connected to the donor electrode assembly and the counter electrode assembly. The donor electrode assembly has a donor reservoir that contains a lisuride salt. The controller is electrically connected to the donor and counter electrode assemblies and is operatable for controlling current for the electrotransport.
摘要翻译： 一种用于递送黎西汀或其药学上可接受的盐的电转运系统。 该系统具有供体电极组件，对电极组件和电连接到施主电极组件和对电极组件的控制器。 供体电极组件具有含有碘化物盐的供体储存器。 控制器电连接到供体和对电极组件，并且可操作用于控制电输送的电流。
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公开(公告)号：US20070249988A1
公开(公告)日：2007-10-25
申请号：US11691005
申请日：2007-03-26
IPC分类号： A61N1/30
CPC分类号： A61N1/0444 , A61N1/0424 , A61N1/044 , A61N1/325 , A61N1/327
摘要： The present invention provides methods and devices for the non-invasive, transdermal administration by electrotransport of nesiritide, or pharmaceutically acceptable nesiritide salts, to patients in need of treatment with nesiritide. The present invention also provides methods for the treatment of congestive heart failure that involve the administration of nesiritide, or pharmaceutically acceptable nesiritide salts, by electrotransport to patients that suffer from congestive heart failure.
摘要翻译： 本发明提供了用于通过电转运奈西立肽或药学上可接受的奈西瑞肽盐对需要用奈西立肽治疗的患者进行非侵入性，透皮给药的方法和装置。 本发明还提供了通过电转运给患有充血性心力衰竭的患者来治疗充血性心力衰竭的方法，其涉及给予奈西立肽或药学上可接受的奈西立肽盐。
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5.发明申请公开(公告)号：US20080058703A1
公开(公告)日：2008-03-06
申请号：US11893732
申请日：2007-08-17
IPC分类号： A61N1/30
CPC分类号： A61K9/0009 , A61K47/32 , A61K47/34 , A61N1/0424 , A61N1/044 , A61N1/30 , A61N1/327
摘要： A transdermal electrotransport drug delivery system with hydratable reservoir and method for drug delivery to an individual. The system has a hydratable reservoir with impedance measurement means for determining level of hydration in the reservoir.
摘要翻译： 具有可水合储存器的透皮电运输药物递送系统和用于向个体递送药物的方法。 该系统具有用于确定储层中水合水平的阻抗测量装置的可水合储存器。
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