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    Matrix composition for transdermal therapeutic system
    1.
    发明授权
    Matrix composition for transdermal therapeutic system 失效
    透皮治疗系统的基质组成

    公开(公告)号：US4559222A

    公开(公告)日：1985-12-17

    申请号：US491490

    申请日：1983-05-04

    申请人： David J. Enscore ,  Robert M. Gale

    发明人： David J. Enscore ,  Robert M. Gale

    IPC分类号： A61K35/08 ,  A61K9/70 ,  A61F13/00 ,  A61K31/745 ,  A61L15/03

    CPC分类号： A61K9/7053 ,  A61K9/7084

    摘要： Mineral oil (MO) polyisobutylene (PIB), colloidal silicon dioxide (CSD) mixtures suitable for use as drug containing matrices in transdermal delivery systems are disclosed. Preferred systems for dispensing moderately mineral oil soluble drugs contain at least about 6% CSD, have a MO/PIB of at least 1.0 and a viscosity of at least 1.5.times.10.sup.7 poises. Preferred systems for dispensing clonidine have a clonidine permeability of at least 1.0.times.10.sup.-4 .mu.g/cm sec and a MO/PIB of at least 1.2.

    摘要翻译： 公开了适用于透皮递送系统中含药基质的矿物油（MO）聚异丁烯（PIB），胶体二氧化硅（CSD）混合物。 用于分配适度矿物油溶性药物的优选系统含有至少约6％的CSD，具有至少1.0的MO / PIB和至少1.5×10 7泊的粘度。 用于分配可乐定的优选体系具有至少1.0×10 -4μg/ cm 2秒的可乐定渗透性和至少1.2的MO / PIB。

    Subsaturated nicotine transdermal therapeutic system
    4.
    发明授权
    Subsaturated nicotine transdermal therapeutic system 失效
    亚饱和尼古丁透皮治疗系统

    公开(公告)号：US6165497A

    公开(公告)日：2000-12-26

    申请号：US662857

    申请日：1991-03-01

    申请人： James L. Osborne ,  Melinda Nelson ,  David J. Enscore ,  Su Il Yum ,  Robert M. Gale

    发明人： James L. Osborne ,  Melinda Nelson ,  David J. Enscore ,  Su Il Yum ,  Robert M. Gale

    IPC分类号： A61K9/70 ,  A61K31/465 ,  A61F13/02 ,  A61F13/00

    CPC分类号： A61K9/7084 ,  A61K9/7053 ,  A61K9/7069 ,  A61K31/465 ,  Y10S514/813

    摘要： Rate controlled transdermal nicotine delivery systems are disclosed which utilize an in-line adhesive to maintain the systems on the skin. The initial equilibrated concentration of nicotine in the nicotine reservoir and the adhesive is below saturation, preferably at a thermodynamic activity no greater than 0.50, and the reservoir comprises the nicotine dissolved in a polymer with respect to which the rate controlling element of the device is substantially impermeable. In preferred embodiments the initial loading of nicotine in the reservoir is sufficient to prevent the activity of the nicotine in the reservoir from decreasing by more than about 75% and preferably no more than about 25% during the predetermined period of administration; and the thicknesses of the adhesive, rate controlling membrane and reservoir layers are selected so that at least 50% and, preferably at least 75% initial equilibrated nicotine loading is in the reservoir layer.

    摘要翻译： 公开了速率控制的透皮尼古丁递送系统，其利用直列粘合剂将系统保持在皮肤上。 尼古丁储存器和粘合剂中尼古丁的初始平衡浓度低于饱和度，优选在不大于0.50的热力学活性下，并且储存器包括溶解在聚合物中的尼古丁，装置的速率控制元件基本上与其相对 不渗透 在优选的实施方案中，储存器中尼古丁的初始加载量足以防止储存器中的尼古丁的活性在给定的给药期间减少超过约75％，优选不超过约25％; 并且选择粘合剂，速率控制膜和储存器层的厚度，使得至少50％，优选至少75％的初始平衡的尼古丁负载在储层中。

    Subsaturated nicotine transdermal therapeutic system
    5.
    发明授权
    Subsaturated nicotine transdermal therapeutic system 失效
    亚饱和尼古丁透皮治疗系统

    公开(公告)号：US5004610A

    公开(公告)日：1991-04-02

    申请号：US537672

    申请日：1990-06-14

    申请人： James L. Osborne ,  Melinda Nelson ,  David J. Enscore ,  Su I. Yum ,  Robert M. Gale

    发明人： James L. Osborne ,  Melinda Nelson ,  David J. Enscore ,  Su I. Yum ,  Robert M. Gale

    IPC分类号： A61K9/70 ,  A61K31/465

    CPC分类号： A61K9/7084 ,  A61K31/465 ,  A61K9/7053 ,  A61K9/7069 ,  Y10S514/813

    摘要： Rate controlled transdermal nicotine delivery systems are disclosed which utilize an in-line adhesive to maintain the systems on the skin. The initial equilibrated concentration of nicotine in the nicotine reservoir and the adhesive is below saturation, preferably at a thermodynamic activity no greater than 0.50, and the reservoir comprises the nicotine dissolved in a material with respect to which the rate controlling element of the device is substantially impermeable. In preferred embodiments the initial loading of nicotine in the reservoir is sufficient to prevent the activity of the nicotine in the reservoir from decreasing by more than about 75% and preferably no more than about 25% during the predetermined period of administration; and the thickness of the adhesive, rate controlling membrane and reservoir layers are selected so that at least 50% and, preferably at least 75% of the initial equilibrated nicotine loading is in the reservoir layer.

    摘要翻译： 公开了速率控制的透皮尼古丁递送系统，其利用直列粘合剂将系统保持在皮肤上。 尼古丁储存器和粘合剂中尼古丁的初始平衡浓度低于饱和度，优选在不大于0.50的热力学活性下，并且储存器包含溶解在该装置的速率控制元件基本相当于的材料中的尼古丁 不渗透 在优选的实施方案中，储存器中尼古丁的初始加载量足以防止储存器中的尼古丁的活性在给定的给药期间减少超过约75％，优选不超过约25％; 并且选择粘合剂，速率控制膜和储存层的厚度，使得初始平衡的尼古丁负载的至少50％，优选至少75％在储层中。

    Transdermal delivery of drugs from an aqueous reservoir
    6.
    发明授权
    Transdermal delivery of drugs from an aqueous reservoir 失效
    从水性储存器透皮输送药物

    公开(公告)号：US4904475A

    公开(公告)日：1990-02-27

    申请号：US17649

    申请日：1987-02-24

    申请人： Robert M. Gale ,  David J. Enscore

    发明人： Robert M. Gale ,  David J. Enscore

    IPC分类号： A61K9/70

    CPC分类号： A61K9/7084

    摘要： A transdermal delivery device for delivering drugs, typically ionized drugs, from an aqueous reservoir is described. The device comprises an aqueous drug reservoir in the form of a gel confined between an impermeable backing member and a porous support structure. In preferred embodiments the support structure is the substrate to which is applied a porous or patterned in-line adhesive. A strippable release liner is preferably provided on the adhesive while in the package. The devices are usable to deliver drugs such as chlorpheniramine maelate, brompheneiramine maleate and scopolamine hydrobromide.

    摘要翻译： 描述了用于从水性储存器输送药物（通常为电离药物）的透皮递送装置。 该装置包括凝胶形式的凝胶形式的含水药物储存器，其限制在不透水背衬构件和多孔支撑结构之间。 在优选实施例中，支撑结构是施加有多孔或图案化的在线粘合剂的基底。 可剥离的剥离衬垫优选在包装中在粘合剂上提供。 该装置可用于递送药物如氯苯那敏，马来酸溴噻嗪和东莨菪碱氢溴酸盐。

    Subsaturated nicotine transdermal therapeutic system
    8.
    发明授权
    Subsaturated nicotine transdermal therapeutic system 失效
    亚饱和尼古丁透皮治疗系统

    公开(公告)号：US5364630A

    公开(公告)日：1994-11-15

    申请号：US80280

    申请日：1993-06-21

    申请人： James L. Osborne ,  Melinda Nelson ,  David J. Enscore ,  Su I. Yum ,  Robert M. Gale

    发明人： James L. Osborne ,  Melinda Nelson ,  David J. Enscore ,  Su I. Yum ,  Robert M. Gale

    IPC分类号： A61K9/70 ,  A61K31/465 ,  A61F13/00

    CPC分类号： A61K31/465 ,  A61K9/7084

    摘要： Rate controlled transdermal nicotine delivery systems are disclosed which utilize an in-line adhesive to maintain the systems on the skin. The initial equilibrated concentration of nicotine in the nicotine reservoir and the adhesive is below saturation, preferably at a thermodynamic activity no greater than 0.50, and the reservoir comprises the nicotine dissolved in a material with respect to which the rate controlling element of the device is substantially impermeable. In preferred embodiments the initial loading of nicotine in the reservoir is sufficient to prevent the activity of the nicotine in the reservoir from decreasing by more than about 75% and preferably no more than about 25% during the predetermined period of administration; and the thickness of the adhesive, rate controlling membrane and reservoir layers are selected so that at least 50% and, preferably at least 75% of the initial equilibrated nicotine loading is in the reservoir layer.

    摘要翻译： 公开了速率控制的透皮尼古丁递送系统，其利用直列粘合剂将系统保持在皮肤上。 尼古丁储存器和粘合剂中尼古丁的初始平衡浓度低于饱和度，优选在不大于0.50的热力学活性下，并且储存器包含溶解在该装置的速率控制元件基本相当于的材料中的尼古丁 不渗透 在优选的实施方案中，储存器中尼古丁的初始加载量足以防止储存器中的尼古丁的活性在给定的给药期间减少超过约75％，优选不超过约25％; 并且选择粘合剂，速率控制膜和储存层的厚度，使得初始平衡的尼古丁负载的至少50％，优选至少75％在储层中。

    Transdermal delivery of highly ionized fat insoluble drugs
    9.
    发明授权
    Transdermal delivery of highly ionized fat insoluble drugs 失效
    透皮递送高度电离的脂肪不溶性药物

    公开(公告)号：US4645502A

    公开(公告)日：1987-02-24

    申请号：US730713

    申请日：1985-05-03

    申请人： Robert M. Gale ,  David J. Enscore

    发明人： Robert M. Gale ,  David J. Enscore

    IPC分类号： A61M37/00 ,  A61K9/70 ,  A61K9/00

    CPC分类号： A61K9/7084

    摘要： A medical device for the transdermal delivery of highly ionized, fat insoluble drugs comprises an aqueous drug reservoir having a physiological pH, said reservoir preferably being a gel maintained in an impermeable receptacle by a highly permeable support member disposed between the gel and a permeable contact adhesive. A permeation enhancer reservoir delivers a permeation enhancer to the skin through the aqueous reservoir and through a permeation enhancer release rate controlling membrane which is permeable to the permeation enhancer and impermeable to the drug and water. In a preferred embodiment the permeation enhancer release rate controlling membrane forms at least a portion of said receptacle.

    摘要翻译： 用于透皮递送高度电离的脂肪不溶性药物的医疗装置包括具有生理pH的水性药物储存器，所述储存器优选地是通过设置在凝胶和可渗透接触粘合剂之间的高度可渗透的支撑构件保持在不可渗透的容器中的凝胶 。 渗透增强剂储库通过水性储存器通过渗透促进剂释放速率控制膜向渗透促进剂递送渗透促进剂，所述渗透促进剂释放速率控制膜对渗透促进剂是可渗透的并且对于药物和水是不可渗透的。 在优选的实施方案中，渗透促进剂释放速率控制膜形成所述容器的至少一部分。