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公开(公告)号：US20070155696A1
公开(公告)日：2007-07-05
申请号：US10587042
申请日：2005-01-28
IPC分类号： A61K31/724 , C08B30/18 , C08B37/16
CPC分类号： C12N1/20 , C07D313/00 , C12P17/162
摘要： The present invention provides a method for stabilizing a macrolide compound, and an efficient method for producing the compound. Specifically, it provides a method for stabilizing a macrolide compound, in which a 12-membered ring macrolide compound, such as a compound expressed by the formula (1) and a cyclodextrin are both present, and a method for producing a macrolide compound, in which a cyclodextrin is made to be present in a culture broth of actinomycetes having an ability of producing the macrolide compound.
摘要翻译： 本发明提供了一种稳定大环内酯类化合物的方法和一种制备该化合物的有效方法。 具体地说，提供了稳定大环内酯类化合物的方法，其中存在12元环大环内酯化合物，如式（1）表示的化合物和环糊精两者，以及大环内酯类化合物的制备方法， 使得环糊精存在于具有产生大环内酯化合物的能力的放线菌的培养肉汤中。
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公开(公告)号：US20060141589A1
公开(公告)日：2006-06-29
申请号：US10532412
申请日：2003-11-27
申请人： Akifumi Okuda , Satoshi Yamamoto , Takashi Sakai , Susumu Takeda , Takashi Nakashima , Katsura Kaneko , Tomohiro Sameshima , Taira Kato , Naoto Kawamura
发明人： Akifumi Okuda , Satoshi Yamamoto , Takashi Sakai , Susumu Takeda , Takashi Nakashima , Katsura Kaneko , Tomohiro Sameshima , Taira Kato , Naoto Kawamura
CPC分类号： C07D407/06 , A61K31/336 , C12P17/162
摘要： The present invention provides a novel method of producing the 12-membered ring macrolide compound 11107D having an antitumor activity by biological transformation. Starting material which is the 12-membered ring macrolide compound 11107B represented by the formula (I) is incubated in the presence of a strain belonging to the genus Mortierella, the genus Streptomyces or the family Micromonosporaceae (for example, Streptomyces sp. AB-1704 strain (FERM BP-8551)), each of which has the ability of transforming the 12-membered ring macrolide compound 11107B into a 11107D substance represented by the formula (II), or a preparation of its cultured mycelia and oxygen, and then 11107D substance which is a target material is collected from the treating solution.
摘要翻译： 本发明提供了通过生物转化制备具有抗肿瘤活性的12元环大环内酯化合物11107D的新方法。 作为式（I）所示的12元环大环内酯化合物11107B的起始原料在属于被孢霉属（Mortierella），链霉菌属（Streptomyces）属或小单孢菌属（Micromonosporaceae）的菌株（例如，链霉菌属AB-1704 菌株（FERM BP-8551）），其各自具有将12元环大环内酯化合物11107B转化为由式（II）表示的11107D物质或其培养的菌丝体和氧气的制剂的能力，然后将11107D 从处理液中收集作为目标物质的物质。
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公开(公告)号：US07059156B2
公开(公告)日：2006-06-13
申请号：US10523298
申请日：2002-08-06
申请人： Daisuke Takeda , Susumu Takeda
发明人： Daisuke Takeda , Susumu Takeda
IPC分类号： D04B9/20
CPC分类号： A41B11/004 , D04B1/108 , D04B1/26
摘要： When knitting the sole section and instep section of the toe section, knitting is performed while sequentially decreasing the number of stitches on the small-toe side of the toes by a specified number, and after the number of stitches on the large-toe side has been decreased by a ratio larger than the ratio of decreasing the number of stitches on the small-toe side, the number is increased by the same ratio, and by doing this, on the small-toe side, the side edge section goes toward the tip end and deviates to the inside at a specified ratio, and on the large-toe side, side edge section is nearly a straight line toward the tip end, and by doing this, the shape of the tip end of the toe section protrudes such that it gradually extends to the front of the toes going from the small-toe side to the large-toe side, and that shape is such that it runs along the curve that is obtained by connecting the tip ends of the toes.
摘要翻译： 当编织脚趾部的鞋底部和脚背部时，在脚趾的小脚趾侧的针数依次减少指定的次数的同时进行编织，在大脚趾侧的针数为 减小比小脚趾侧的线圈数减少的比例增加相同的比例，并且通过这样做，在小脚趾侧，侧边缘部分朝向 尖端部以规定的比例向内侧偏移，在大趾侧，侧边缘部分朝向前端几乎是直线，由此，脚趾部的前端的形状突出， 它逐渐延伸到从小脚趾侧到大脚趾侧的脚趾的前部，并且该形状使得其沿着通过连接脚趾的末端而获得的曲线延伸。
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公开(公告)号：US6000247A
公开(公告)日：1999-12-14
申请号：US69816
申请日：1998-04-30
申请人： Susumu Takeda , Tsutomu Harada
发明人： Susumu Takeda , Tsutomu Harada
摘要： A hosiery, whose shape is quite similar to that of a foot of a man and which never presses the big toe, the hosiery includes a cylindrical section; a toe section being forwardly extended from a front end of the cylindrical section, wherein a front tip point of the toe section is located on a big toe side with respect to a center line of the hosiery; and an additional section being formed in the toe section, wherein thickness of the toe section including the additional section is thicker than that of other parts of the toe section and the additional section is located on the big toe side with respect to the center line of the hosiery.
摘要翻译： 一个袜子，其形状与一只脚的形状非常相似，并且不会挤压大脚趾，袜子包括一个圆柱形部分; 从所述圆筒部的前端向前方延伸的脚趾部，其中，所述脚趾部的前端部相对于所述针织品的中心线位于大脚趾侧; 以及在所述趾部中形成的附加部分，其中包括所述附加部分的所述趾部的厚度比所述趾部的其他部分的厚度厚，并且所述附加部位相对于所述趾部的中心线位于所述大脚趾侧 袜子。
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公开(公告)号：US5277504A
公开(公告)日：1994-01-11
申请号：US942174
申请日：1992-09-09
申请人： Susumu Takeda
发明人： Susumu Takeda
CPC分类号： B41J35/36
摘要： A printing apparatus is capable of detecting the end of an ink ribbon and verifying normal mounting of a ribbon cassette. When a portion of ink ribbon sufficient for printing one character is transported, an actuator in the ribbon cassette is rotated by a predetermined amount. The rotating actuator turns on and off a switch. The number of times the switch status is changed is detected. Determining the switch ON-OFF count makes it possible to detect the ink ribbon end and to check for any abnormal winding operation of the ink ribbon. Thus a single switch arrangement permits detection of both the ink ribbon end and an abnormal ink ribbon winding operation that may occur.
摘要翻译： 打印装置能够检测色带的端部并且验证色带盒的正常安装。 当一部分色带足以印刷一个字符时，色带盒中的致动器旋转预定量。 旋转执行器打开和关闭开关。 检测到切换状态发生变化的次数。 确定开关ON-OFF计数使得能够检测墨带端部并检查墨带的任何异常卷绕操作。 因此，单个开关装置允许检测墨带端部和可能发生的异常墨带卷绕操作。
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公开(公告)号：US4903013A
公开(公告)日：1990-02-20
申请号：US139809
申请日：1987-12-30
申请人： Susumu Takeda
发明人： Susumu Takeda
CPC分类号： G09G1/007
摘要： A display system for displaying characters on a screen which is divided into a plurality of display areas and for allowing a scroll within each of the display areas with one chip of display data RAM without image confusion between the display area. The display data RAM is also divided into plural areas corresponding to the display areas. This system includes address conversion circuit provided between a display controller and the display data RAM for converting a virtual address outputted from the display controller into an actual address of the display data RAM. Here the virtual address is an address out of actual address of the display data RAM.
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公开(公告)号：US4223992A
公开(公告)日：1980-09-23
申请号：US898077
申请日：1978-04-20
申请人： Susumu Takeda , Kiyoaki Hazama , Nobuo Ichitsuka
发明人： Susumu Takeda , Kiyoaki Hazama , Nobuo Ichitsuka
CPC分类号： G03B17/38
摘要： There is disclosed a release device of a camera simple in structure and enabling the camera of "one shot" and successive photographings.The release device comprises a conventional self-cocking mechanism and a locking and unlocking member in addition. The locking and unlocking member is operated by a member movable in response to film winding operation and actuates a shutter release member to release the release member when the film winding operation is completed.
摘要翻译： 公开了一种照相机的释放装置，其结构简单，并使相机“一次”和连续拍摄。 释放装置还包括常规的自动起动机构和锁定和解锁构件。 锁定和解锁构件由可响应于胶片卷绕操作移动的构件操作，并且当胶片卷绕操作完成时致动快门释放构件以释放释放构件。
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