公开(公告)号：US20150266872A1

公开(公告)日：2015-09-24

申请号：US14435899

申请日：2013-10-15

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Tatsuki Koike ,  Masato Yoshikawa ,  Izumi Nomura ,  Yoshiteru Ito ,  Eiji Kimura ,  Tomoaki Hasui ,  Haruhi Ando ,  Hiromi Fukuda ,  Toshiya Nishi

IPC: C07D471/04 ,  C07D519/00 ,  C07D413/04

CPC classification number: C07D471/04 ,  C07D413/04 ,  C07D519/00

Abstract: The present invention provides a compound or a salt thereof useful for an agent for the prophylaxis or treatment of neurodegenerative disease and the like. The present invention relates to a compound represented by the formula wherein each symbol is as defined in the present specification, or a salt thereof.

Abstract translation: 本发明提供可用于预防或治疗神经变性疾病等的药剂的化合物或其盐。 本发明涉及由下式表示的化合物，其中每个符号如本说明书中所定义，或其盐。

公开(公告)号：US20230037538A1

公开(公告)日：2023-02-09

申请号：US17847456

申请日：2022-06-23

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Dennis Solas ,  Anatoliy Kitaygorodskyy ,  Kumar Paulvannan ,  Vishwanath R. Lingappa ,  Masato Yoshikawa ,  Masahiro Ito ,  Yuta Tanaka ,  Keiko Kakegawa ,  Tomohiro Ohashi ,  Takuto Kojima ,  Akinori Toita ,  Osamu Kubo ,  Fumiaki Kikuchi ,  Florian Pünner ,  Junsi Wang

IPC: C07D217/20 ,  C07D405/06 ,  C07D471/04 ,  C07D401/10 ,  C07D405/10 ,  C07D413/10 ,  C07D405/12 ,  C07D401/12 ,  A61P25/28

Abstract: The present invention relates to compounds expected to be useful in the prevention and/or treatment of diseases such as amyotrophic lateral sclerosis, frontotemporal dementia, chronic traumatic encephalopathy, Alzheimer's disease, frontotemporal lobar degeneration, multisystem proteinopathy and the like, a method for preventing or treating such diseases, and the like.

公开(公告)号：US20210137962A9

公开(公告)日：2021-05-13

申请号：US16185258

申请日：2018-11-09

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Masato Yoshikawa ,  Morihisa Saitoh ,  Taisuke Kato ,  Yayoi Yoshitomi ,  Tomohiro Seki ,  Yasuo Nakagawa ,  Yusuke Tominari ,  Masaki Seto ,  Akito Shibuya ,  Kosuke Hidaka ,  Zenyu Shiokawa ,  Yoshihisa Nakada ,  Michiyo Mochizuki

IPC: A61K31/7084 ,  A61P35/00 ,  A61K47/68 ,  A61K31/7076

Abstract: The present disclosure provides a compound having a STING agonistic activity, which may be expected to be useful as an agent for the prophylaxis or treatment of STING-related diseases.
The present disclosure relates to a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof.

公开(公告)号：US10144743B2

公开(公告)日：2018-12-04

申请号：US15424075

申请日：2017-02-03

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Tatsuki Koike ,  Masato Yoshikawa ,  Haruhi Ando ,  William John Farnaby

IPC: C07D498/08 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D401/10 ,  C07D413/10 ,  C07D417/14 ,  C07D405/10

Abstract: The present invention provides a compound useful as an agent for the prophylaxis or treatment of neurodegenerative disease and the like, or a salt thereof.The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：US09440990B2

公开(公告)日：2016-09-13

申请号：US14847703

申请日：2015-09-08

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Tatsuki Koike ,  Masato Yoshikawa ,  Haruhi Ando ,  William John Farnaby ,  Toshiya Nishi

IPC: C07D498/08 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D401/10 ,  C07D413/10 ,  C07D417/14

CPC classification number: C07D498/08 ,  C07D401/10 ,  C07D401/14 ,  C07D405/10 ,  C07D405/14 ,  C07D413/10 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention provides a compound useful as an agent for the prophylaxis or treatment of neurodegenerative disease and the like, or a salt thereof. The present invention relates to a compound represented by the formula (I) wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：US20140228373A1

公开(公告)日：2014-08-14

申请号：US14349201

申请日：2012-10-03

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Tatsuki Koike ,  Masato Yoshikawa ,  Haruhi Ando ,  William John Farnaby

IPC: C07D417/14 ,  C07D413/10 ,  C07D401/14 ,  C07D405/14 ,  C07D401/10 ,  C07D413/14

CPC classification number: C07D498/08 ,  C07D401/10 ,  C07D401/14 ,  C07D405/10 ,  C07D405/14 ,  C07D413/10 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention provides a compound useful as an agent for the prophylaxis or treatment of neurodegenerative disease and the like, or a salt thereof. The present invention relates to a compound represented by the formula (I) wherein each symbol is as defined in the specification, or a salt thereof.

Abstract translation: 本发明提供可用作预防或治疗神经变性疾病等的药剂或其盐。 本发明涉及由式（I）表示的化合物，其中每个符号如说明书中所定义，或其盐。