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公开(公告)号：US20220370491A1
公开(公告)日：2022-11-24
申请号：US17760908
申请日：2020-09-16
申请人： National University Corporation Tokyo Medical and Dental University , Takeda Pharmaceutical Company Limited
发明人： Takanori Yokota , Testuya Nagata , Hideki Furukawa , Takatoshi Yogo , Yasuo Nakagawa , Shigekazu Sasaki , Ryosuke Tokunoh , Tomohiro Seki , Kosuke Hidaka , Fumiaki Kikuchi , Osamu Kubo , Takahito Kasahara , Takuto Kojima , Junsi Wang , Norihito Tokunaga
IPC分类号： A61K31/713 , A61K47/54 , A61P25/00 , A61K9/00
摘要： The object of the present invention is to provide a nucleic acid agent that is efficiently delivered to the nervous system, for example, the central nervous system to which drug delivery can be prevented by BBB, and produces an antisense effect on the target transcriptional product at the delivery site, and a composition comprising the same. In an embodiment, the present invention provides a double-stranded nucleic acid complex formed by annealing a first nucleic acid strand that hybridizes to a part of a target transcriptional product and has an antisense effect on the target transcriptional product, and a second nucleic acid strand that comprises a base sequence complementary to the first nucleic acid strand and is bound to a C22-35 alkyl group optionally substituted with a hydroxy group or an analog thereof.
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公开(公告)号：US20210137962A9
公开(公告)日：2021-05-13
申请号：US16185258
申请日：2018-11-09
发明人： Masato Yoshikawa , Morihisa Saitoh , Taisuke Kato , Yayoi Yoshitomi , Tomohiro Seki , Yasuo Nakagawa , Yusuke Tominari , Masaki Seto , Akito Shibuya , Kosuke Hidaka , Zenyu Shiokawa , Yoshihisa Nakada , Michiyo Mochizuki
IPC分类号： A61K31/7084 , A61P35/00 , A61K47/68 , A61K31/7076
摘要： The present disclosure provides a compound having a STING agonistic activity, which may be expected to be useful as an agent for the prophylaxis or treatment of STING-related diseases.
The present disclosure relates to a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof.-
公开(公告)号：US20210024929A1
公开(公告)日：2021-01-28
申请号：US16980191
申请日：2019-03-13
申请人： National University Corporation Tokyo Medical and Dental University , Takeda Pharmaceutical Company Limited
发明人： Takanori Yokota , Tetsuya Nagata , Hideki Furukawa , Yasuo Nakagawa , Takatoshi Yogo , Ryosuke Tokunoh , Shigekazu Sasaki , Kosuke Hidaka , Tomohiro Seki , Kenichi Miyata , Akio Uchida
IPC分类号： C12N15/113 , A61P25/00
摘要： Developed and provided is: a nucleic acid agent that is efficiently delivered to the central nervous system, to which drug delivery is inhibited by the blood brain barrier mechanism, and that provides an antisense effect to a target transcription product at the delivery site; and a composition containing such a nucleic acid agent.
Provided is a double-stranded nucleic acid complex consisting of a first nucleic acid strand and a second nucleic acid strand that are annealed to each other; wherein the first nucleic acid strand hybridizes with part of a target transcription product and has an antisense effect on the target transcription product; and wherein the second nucleic acid strand includes a base sequence complementary to the first nucleic acid strand and is conjugated to a phosphatidylethanolamine or an analog thereof.-
公开(公告)号：US11666594B2
公开(公告)日：2023-06-06
申请号：US17065242
申请日：2020-10-07
发明人： Masato Yoshikawa , Morihisa Saitoh , Taisuke Kato , Yayoi Nakayama , Tomohiro Seki , Yasuo Nakagawa , Yusuke Tominari , Masaki Seto , Yusuke Sasaki , Masanori Okaniwa , Tsuneo Oda , Akito Shibuya , Kosuke Hidaka , Zenyu Shiokawa , Shumpei Murata , Atsutoshi Okabe , Yoshihisa Nakada , Michiyo Mochizuki , Brian Scott Freeze , Taisuke Tawaraishi , Yasufumi Wada , Paul D. Greenspan
IPC分类号： A61K31/7084 , A61P35/00 , C07H21/00 , C07H21/02 , A61K47/68 , A61K31/7076
CPC分类号： A61K31/7084 , A61K31/7076 , A61K47/6807 , A61P35/00 , C07H21/00 , C07H21/02
摘要： The present disclosure provides a compound having a STING agonistic activity, which may be expected to be useful as an agent for the prophylaxis or treatment of STING-related diseases.
The present disclosure relates to a compound represented by the formula (I):
wherein each symbol is as defined in the description, or a salt thereof.-
公开(公告)号：US20210106607A1
公开(公告)日：2021-04-15
申请号：US17065242
申请日：2020-10-07
发明人： MASATO YOSHIKAWA , Morihisa Saitoh , Taisuke Kato , Yayoi Nakayama , Tomohiro Seki , Yasuo Nakagawa , Yusuke Tominari , Masaki Seto , Yusuke Sasaki , Masanori Okaniwa , Tsuneo Oda , Akito Shibuya , Kosuke Hidaka , Zenyu Shiokawa , Shumpei Murata , Atsutoshi Okabe , Yoshihisa Nakada , Michiyo Mochizuki , Brian Scott Freeze , Taisuke Tawaraishi , Yasufumi Wada , Paul D. Greenspan
IPC分类号： A61K31/7084 , A61P35/00 , C07H21/00 , C07H21/02 , A61K47/68 , A61K31/7076
摘要： The present disclosure provides a compound having a STING agonistic activity, which may be expected to be useful as an agent for the prophylaxis or treatment of STING-related diseases.
The present disclosure relates to a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof.-
公开(公告)号：US20230295628A1
公开(公告)日：2023-09-21
申请号：US18163506
申请日：2023-02-02
申请人： National University Corporation Tokyo Medical and Dental University , Takeda Pharmaceutical Company Limited
发明人： Takanori Yokota , Tetsuya Nagata , Hideki Furukawa , Yasuo Nakagawa , Takatoshi Yogo , Ryosuke Tokunoh , Shigekazu Sasaki , Kosuke Hidaka , Tomohiro Seki , Kenichi Miyata , Akio Uchida
IPC分类号： C12N15/113 , A61P25/00
CPC分类号： C12N15/113 , A61P25/00 , C12N2310/11 , C12N2310/341
摘要： Developed and provided is: a nucleic acid agent that is efficiently delivered to the central nervous system, to which drug delivery is inhibited by the blood brain barrier mechanism, and that provides an antisense effect to a target transcription product at the delivery site; and a composition containing such a nucleic acid agent. Provided is a double-stranded nucleic acid complex consisting of a first nucleic acid strand and a second nucleic acid strand that are annealed to each other; wherein the first nucleic acid strand hybridizes with part of a target transcription product and has an antisense effect on the target transcription product; and wherein the second nucleic acid strand includes a base sequence complementary to the first nucleic acid strand and is conjugated to a phosphatidylethanolamine or an analog thereof.
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公开(公告)号：US11597928B2
公开(公告)日：2023-03-07
申请号：US16980191
申请日：2019-03-13
申请人： National University Corporation Tokyo Medical and Dental University , Takeda Pharmaceutical Company Limited
发明人： Takanori Yokota , Tetsuya Nagata , Hideki Furukawa , Yasuo Nakagawa , Takatoshi Yogo , Ryosuke Tokunoh , Shigekazu Sasaki , Kosuke Hidaka , Tomohiro Seki , Kenichi Miyata , Akio Uchida
IPC分类号： C07H21/04 , C12N15/113 , A61P25/00
摘要： Developed and provided is: a nucleic acid agent that is efficiently delivered to the central nervous system, to which drug delivery is inhibited by the blood brain barrier mechanism, and that provides an antisense effect to a target transcription product at the delivery site; and a composition containing such a nucleic acid agent.
Provided is a double-stranded nucleic acid complex consisting of a first nucleic acid strand and a second nucleic acid strand that are annealed to each other; wherein the first nucleic acid strand hybridizes with part of a target transcription product and has an antisense effect on the target transcription product; and wherein the second nucleic acid strand includes a base sequence complementary to the first nucleic acid strand and is conjugated to a phosphatidylethanolamine or an analog thereof.-
公开(公告)号：US10980825B2
公开(公告)日：2021-04-20
申请号：US16185258
申请日：2018-11-09
发明人： Masato Yoshikawa , Morihisa Saitoh , Taisuke Kato , Yayoi Nakayama , Tomohiro Seki , Yasuo Nakagawa , Yusuke Tominari , Masaki Seto , Akito Shibuya , Kosuke Hidaka , Zenyu Shiokawa , Yoshihisa Nakada , Michiyo Mochizuki
IPC分类号： A61K31/7084 , A61K31/7076 , A61K47/68 , A61P35/00 , C07H21/00 , C07H21/02
摘要： The present disclosure provides a compound having a STING agonistic activity, which may be expected to be useful as an agent for the prophylaxis or treatment of STING-related diseases.
The present disclosure relates to a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof.-
公开(公告)号：US20190192549A1
公开(公告)日：2019-06-27
申请号：US16185258
申请日：2018-11-09
发明人： MASATO YOSHIKAWA , Morihisa Saitoh , Taisuke Kato , Yayoi Yoshitomi , Tomohiro Seki , Yasuo Nakagawa , Yusuke Tominari , Masaki Seto , Yusuke Sasaki , Masanori Okaniwa , Tsuneo Oda , Akito Shibuya , Kosuke Hidaka , Zenyu Shiokawa , Shumpei Murata , Atsutoshi Okabe , Yoshihisa Nakada , Michiyo Mochizuki , Brian Scott Freeze , Taisuke Tawaraishi , Yasufumi Wada , Paul D. Greenspan
IPC分类号： A61K31/7084 , A61P35/00 , A61K47/68 , A61K31/7076
CPC分类号： A61K31/7084 , A61K31/7076 , A61K47/6807 , A61P35/00 , C07H21/00 , C07H21/02
摘要： The present disclosure provides a compound having a STING agonistic activity, which may be expected to be useful as an agent for the prophylaxis or treatment of STING-related diseases.The present disclosure relates to a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof.
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