公开(公告)号：US20180169015A1

公开(公告)日：2018-06-21

申请号：US15878131

申请日：2018-01-23

Applicant: TRANSLATE BIO, INC.

Inventor： Frank DeRosa ,  Braydon Charles Guild ,  Michael Heartlein

IPC: A61K9/127 ,  A61K38/44 ,  A61K47/28 ,  C12N15/11 ,  A61K48/00

CPC classification number: A61K9/1277 ,  A61K9/1271 ,  A61K9/1272 ,  A61K38/44 ,  A61K47/28 ,  A61K48/00 ,  C12N15/111 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/16 ,  C12N2310/3515 ,  C12N2320/32 ,  C12Y113/12007

Abstract: Disclosed herein are novel lipids and liposomal compositions prepared using such compounds and related methods of neutralizing or otherwise modifying such liposomal compositions. The lipids described herein are useful for example, as liposomal vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and the subsequent transfection of such target cells. In certain embodiments, one or more of the compounds that comprise the liposomal delivery vehicle may be neutralized or further modified such that the properties of the liposomal delivery vehicle are modified.

公开(公告)号：US09877919B2

公开(公告)日：2018-01-30

申请号：US14389165

申请日：2013-03-29

Applicant: TRANSLATE BIO, INC.

Inventor： Frank DeRosa ,  Braydon Charles Guild ,  Michael Heartlein

IPC: A61K47/28 ,  A61K9/127 ,  C12N15/11 ,  A61K38/44 ,  A61K48/00

CPC classification number: A61K9/1277 ,  A61K9/1271 ,  A61K9/1272 ,  A61K38/44 ,  A61K47/28 ,  A61K48/00 ,  C12N15/111 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/16 ,  C12N2310/3515 ,  C12N2320/32 ,  C12Y113/12007

Abstract: Disclosed herein are novel lipids and liposomal compositions prepared using such compounds and related methods of neutralizing or otherwise modifying such liposomal compositions. The lipids described herein are useful for example, as liposomal vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and the subsequent transfection of such target cells. In certain embodiments, one or more of the compounds that comprise the liposomal delivery vehicle may be neutralized or further modified such that the properties of the liposomal delivery vehicle are modified.

公开(公告)号：US20250161221A1

公开(公告)日：2025-05-22

申请号：US19027437

申请日：2025-01-17

Applicant: Translate Bio, Inc.

Inventor： Braydon Charles Guild ,  Michael Heartlein ,  Frank DeRosa ,  Jerry Chi Zhang

IPC: A61K9/19 ,  A61K9/1271 ,  A61K9/1272 ,  A61K9/51 ,  A61K31/7088 ,  A61K38/45 ,  A61K38/46 ,  A61K38/47 ,  A61K38/50 ,  C07C323/25 ,  C07C323/27 ,  C07C323/44 ,  C07D233/64 ,  C07J41/00 ,  C07J43/00 ,  C12N15/88

Abstract: Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use. The compounds described herein are useful, e.g., as liposomal delivery vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and subsequent transfection of said target cells, and in certain embodiments are characterized as having one or more properties that afford such compounds advantages relative to other similarly classified lipids.

公开(公告)号：US20240425442A1

公开(公告)日：2024-12-26

申请号：US18646567

申请日：2024-04-25

Applicant: Translate Bio, Inc.

Inventor： Frank DeRosa ,  Braydon Charles Guild ,  Michael Heartlein

IPC: C07C211/21 ,  A61K9/127 ,  A61K9/50 ,  A61K38/18 ,  A61K38/47 ,  C12N15/85

Abstract: Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use. The compounds described herein are useful, e.g., as liposomal delivery vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and subsequent transfection of said target cells, and in certain embodiments are characterized as having one or more properties that afford such compounds advantages relative to other similarly classified lipids.

公开(公告)号：US20240342307A1

公开(公告)日：2024-10-17

申请号：US18431597

申请日：2024-02-02

Applicant: Translate Bio, Inc.

Inventor： Braydon Charles Guild ,  Frank DeRosa ,  Michael Heartlein

IPC: A61K48/00 ,  A61K9/00 ,  A61K9/127 ,  A61K31/7105 ,  C07J43/00 ,  C12N15/67

CPC classification number: A61K48/0033 ,  A61K9/0019 ,  A61K9/1271 ,  A61K9/1272 ,  A61K31/7105 ,  A61K48/0008 ,  A61K48/005 ,  C07J43/003 ,  C12N15/67

Abstract: Disclosed herein are compositions and methods of modulating the expression of gene or the production of a protein by transfecting target cells with nucleic acids. The compositions disclosed herein demonstrate a high transfection efficacy and are capable of ameliorating diseases associated with protein or enzyme deficiencies.

公开(公告)号：US11951180B2

公开(公告)日：2024-04-09

申请号：US18295152

申请日：2023-04-03

Applicant: Translate Bio, Inc.

Inventor： Frank DeRosa ,  Braydon Charles Guild ,  Michael Heartlein

IPC: C12Q1/00 ,  A61K9/00 ,  A61K9/127 ,  A61K9/51 ,  A61K31/7105 ,  A61K31/713 ,  A61K38/18 ,  A61K38/47 ,  A61K38/48 ,  A61K38/57 ,  A61K48/00 ,  C07K14/505 ,  C07K14/81 ,  C12N9/40 ,  C12N9/64 ,  C12N15/52 ,  C12N15/85

CPC classification number: A61K48/0008 ,  A61K9/0019 ,  A61K9/0073 ,  A61K9/1271 ,  A61K9/1272 ,  A61K9/5123 ,  A61K31/713 ,  A61K38/1816 ,  A61K38/47 ,  A61K38/4846 ,  A61K38/57 ,  A61K48/0075 ,  A61K48/0091 ,  C07K14/505 ,  C07K14/8125 ,  C12N9/2465 ,  C12N9/644 ,  C12N15/52 ,  C12N15/85 ,  C12Y302/01022 ,  C12Y304/21022 ,  A61K48/00

Abstract: Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.

公开(公告)号：US20230293723A1

公开(公告)日：2023-09-21

申请号：US18295139

申请日：2023-04-03

Applicant: Translate Bio, Inc.

Inventor： Frank DeRosa ,  Braydon Charles Guild ,  Michael Heartlein

IPC: A61K48/00 ,  A61K38/18 ,  A61K38/47 ,  A61K38/48 ,  A61K38/57 ,  A61K31/713 ,  A61K9/00 ,  A61K9/127 ,  C07K14/505 ,  C07K14/81 ,  C12N9/40 ,  C12N9/64 ,  C12N15/52 ,  C12N15/85 ,  A61K9/51

CPC classification number: A61K48/0008 ,  A61K38/1816 ,  A61K38/47 ,  A61K38/4846 ,  A61K38/57 ,  A61K31/713 ,  A61K9/0019 ,  A61K9/0073 ,  A61K9/1271 ,  A61K9/1272 ,  C07K14/505 ,  C07K14/8125 ,  C12N9/2465 ,  C12N9/644 ,  C12N15/52 ,  C12N15/85 ,  A61K9/5123 ,  A61K48/0075 ,  A61K48/0091 ,  C12Y302/01022 ,  C12Y304/21022 ,  A61K48/00

Abstract: Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.

公开(公告)号：US11497716B2

公开(公告)日：2022-11-15

申请号：US17003105

申请日：2020-08-26

Applicant: TRANSLATE BIO, INC.

Inventor： Frank DeRosa ,  Braydon Charles Guild ,  Michael Heartlein

IPC: A61K9/127 ,  C12N15/11 ,  A61K38/44 ,  A61K47/28 ,  A61K48/00

Abstract: Disclosed herein are novel lipids and liposomal compositions prepared using such compounds and related methods of neutralizing or otherwise modifying such liposomal compositions. The lipids described herein are useful for example, as liposomal vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and the subsequent transfection of such target cells. In certain embodiments, one or more of the compounds that comprise the liposomal delivery vehicle may be neutralized or further modified such that the properties of the liposomal delivery vehicle are modified.

公开(公告)号：US20220226236A1

公开(公告)日：2022-07-21

申请号：US17389016

申请日：2021-07-29

Applicant: TRANSLATE BIO, INC. ,  Ethris GmbH

Inventor： Michael Heartlein ,  Braydon Charles Guild ,  Frank DeRosa ,  Carsten Rudolph ,  Christian Plank

IPC: A61K9/00 ,  C12N15/88 ,  A61K31/7088 ,  A61M15/00 ,  A61M16/14

Abstract: Compositions comprising mRNA formulated for pulmonary administration and related methods for delivery of the mRNA and/or encoded protein to a non-lung cell or tissue. The compositions and methods may be used to prevent or ameliorate the symptoms of diseases associated with the mRNA encoded protein.

公开(公告)号：US11338044B2

公开(公告)日：2022-05-24

申请号：US17556974

申请日：2021-12-20

Applicant: Translate Bio, Inc.

Inventor： Braydon Charles Guild ,  Frank DeRosa ,  Michael Heartlein

IPC: B82Y5/00 ,  A61K38/18 ,  A61K48/00 ,  A61K9/19 ,  A61K9/00 ,  A61K9/127 ,  A61K9/51 ,  A61K38/47 ,  A61K38/48 ,  C12N15/85 ,  A61K31/713 ,  A61K38/57 ,  A61K31/7105 ,  A61K31/7115 ,  C07K14/505 ,  C07K14/81 ,  C12N9/40 ,  C12N9/64 ,  C12N15/52

Abstract: Disclosed herein are compositions and methods for modulating the production of a protein in a target cell. The compositions and methods disclosed herein are capable of ameliorating diseases associated with protein or enzyme deficiencies.