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公开(公告)号：US20240336949A1
公开(公告)日：2024-10-10
申请号：US18628860
申请日：2024-04-08
发明人： CHRISTOPHE QUIRING , CHRISTINE FAVIER , PATRICE SARFATI , JEAN FRANCOIS MOUSCADET , RONALD LEBOFSKY , REBECCA DIEVART
CPC分类号： C12Q1/06 , C12N9/2428 , C12N9/2445 , C12N9/2465 , C12N9/2471 , C12N9/2474 , C12N9/485 , C12Q1/04 , C12Q1/045 , C12Y302/01003 , C12Y302/01022 , C12Y302/01035 , C12Y304/11
摘要： Methods, compositions, and kits are provided for rapidly analyzing microbial growth and/or number in a plurality of water-in-oil emulsion droplets.
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公开(公告)号：US20240240195A1
公开(公告)日：2024-07-18
申请号：US18584965
申请日：2024-02-22
CPC分类号： C12N15/8243 , A23F5/02 , C12N9/2465 , C12N15/8213 , C12Y302/01022
摘要： A coffee plant comprising a genome comprising a loss of function mutation in a nucleic acid sequence encoding alpha-D-galactosidase. Also provided is a method of increasing extractability of solids from coffee beans. In addition there is provided a method of producing soluble coffec.
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公开(公告)号：US20240218342A1
公开(公告)日：2024-07-04
申请号：US18556642
申请日：2022-04-25
申请人： Lai-Xi WANG , Xiao ZHANG
发明人： Lai-Xi WANG , Xiao ZHANG
CPC分类号： C12N9/2465 , C07H17/00 , C12N9/2402 , C12Y302/01022 , C12Y302/01096 , A61K38/00
摘要： The present disclosure provides compounds useful for enzymatic glycan remodeling of a glycoprotein. Also provided is a method for remodeling a glycoprotein using M6P-glycan oxazolines in a one-pot deglycosylation/transglycosylation process, which may enable site selective M6P-glycan remodeling of glycoproteins to obtain homogeneous products. The remodeled glycoprotein (such as a recombinant human acid α-glucosidase) may have enhanced affinity for the CI-MPR, increased uptake by a cell, and improved therapeutic efficacy compared to the original glycoprotein. A method of treating Pompe disease using a glycan remodeled lysosomal enzyme is also provided.
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公开(公告)号：US20240035056A1
公开(公告)日：2024-02-01
申请号：US18274770
申请日：2021-05-06
发明人： Caoxing HUANG , Qiang YONG , Yuheng TAO , Chenhuan LAI , Yong XU , Xin LI
CPC分类号： C12P19/04 , C12N9/2465 , C12Y302/01022 , C12N9/2491 , C12Y302/01025
摘要： A method and special complex enzyme for hydrolyzing a galactomannan (GM) to prepare a small-molecule GM and a galactomannan oligosaccharide (GMOS) is provided. The method includes: conducting fermentation with microcrystalline cellulose (MCC) and melibiose as carbon sources and Trichoderma reesei (T. reesei) as an enzyme-producing strain to obtain a supernatant, which is a complex enzyme solution with enzymatic activities of β-mannanase and α-galactosidase; and directly using the complex enzyme solution for enzymatic hydrolysis of a GM as a substrate to prepare the small-molecule GM and the GMOS.
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公开(公告)号：US20240025943A1
公开(公告)日：2024-01-25
申请号：US17769570
申请日：2020-10-16
申请人： eleva GmbH
CPC分类号： C07K1/145 , C12N9/2465 , C12Y302/01022
摘要： The invention concerns a method for detaching expressed material from the surface or from the apoplast of plant cells, wherein the plant cells are treated with a rotor-stator in a liquid medium, wherein the specific heat from the rotor-stator introduced by rotation of the rotor is a maximum of 3 kJ per kg of the liquid medium and per g/L dry weight of the plant cells and the specific heat capacity introduced into the medium is a maximum of 1.5 kJ per kg of the liquid medium per minute and per g/L dry weight of the plant cells.
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公开(公告)号：US11751584B2
公开(公告)日：2023-09-12
申请号：US17340271
申请日：2021-06-07
申请人： Novozymes A/S
发明人： Lone Carstensen , Nikolaj Spodsberg , Morten Gjermansen , Jesper Salomon , Kristian Bertel Roemer M. Krogh , Eduardo Antonio Della Pia
IPC分类号： A61K38/00 , A23K20/189 , A23K20/174 , A23K20/22 , A23K20/24 , A23K20/20 , A23K40/10 , A23K10/30 , C12N9/40
CPC分类号： A23K20/189 , A23K10/30 , A23K20/174 , A23K20/22 , A23K20/24 , A23K20/30 , A23K40/10 , C12N9/2465 , C12Y302/01022
摘要： The present invention relates to methods of releasing galactose from legumes using polypeptides having alpha-galactosidase activity. The invention also relates to polypeptides having alpha-galactosidase activity, polynucleotides encoding the polypeptides, nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing the polypeptides. The invention also relates to compositions comprising the polypeptides of the invention and the use of the polypeptides in animal feed.
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公开(公告)号：US20230203465A1
公开(公告)日：2023-06-29
申请号：US18111321
申请日：2023-02-17
发明人： Russell Gotschall , Hung V. Do
CPC分类号： C12N9/2465 , C12Y302/0102 , A61K48/005 , C12N15/09 , C12N2510/02
摘要： Recombinant human alpha glucosidase (rhGAA) composition derived from CHO cells that contains a more optimized glycan composition consisting of a higher amount of rhGAA containing N-glycans carrying mannose-6-phosphate (M6P) or bis-M6P than conventional rhGAAs, along with low amount of non-phosphorylated high mannose glycans, and low amount of terminal galactose on complex oligosaccharides. Compositions containing the rhGAA, and methods of use are described.
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公开(公告)号：US11685912B2
公开(公告)日：2023-06-27
申请号：US16978417
申请日：2019-03-05
发明人： Brian Dwyer , Bohong Zhang , Jun Hu , Muthuraman Meiyappan , Thomas Miller , Paul McLean , Clark Pan
IPC分类号： C12N9/40 , B01J20/286 , B01J20/289 , B01J20/32
CPC分类号： C12N9/2465 , B01J20/286 , B01J20/289 , B01J20/3219 , B01J20/3253 , B01J20/3255 , C12Y302/01022
摘要： The invention relates to an affinity resin functionalized with small molecule inhibitors of glycoside-cleaving enzymes, e.g., α-galactosidase A (α-Gal A), glucocerebrosidase (GCB), β-galactosidase, and acid alpha-glucosidase (GAA), and a method for purifying glycoside-cleaving enzymes produced in a cell line using the small molecule inhibitor-functionalized affinity resin.
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公开(公告)号：US20230158123A1
公开(公告)日：2023-05-25
申请号：US17838741
申请日：2022-06-13
发明人： Russell Gotschall
IPC分类号： A61K38/47 , A61K31/445 , C12N9/40 , C12P21/00
CPC分类号： A61K38/47 , A61K31/445 , C12N9/2465 , C12P21/005 , C12Y302/01022
摘要： Described are compositions comprising α-galactosidase A enzymes with unique carbohydrate profiles, as well as methods for manufacturing and purifying such enzymes. Also described methods of treating, preventing, and/or ameliorating Fabry Disease by administering such enzymes to a subject in need thereof. Also described are compositions comprising migalastat in combination with such α-galactosidase A enzymes.
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公开(公告)号：US20190203239A1
公开(公告)日：2019-07-04
申请号：US16356138
申请日：2019-03-18
发明人： David N. Thompson , William A. Apel , Vicki S. Thompson , David W. Reed , Jeffrey A. Lacey , Emily D. Henriksen
IPC分类号： C12P19/14 , C12N9/10 , C12P19/02 , C12P19/00 , C12N15/52 , C12N9/88 , C12N9/80 , C12N9/24 , C12N9/38 , C12N9/40 , C12N9/42 , C12N9/34 , C12N9/26 , C12N9/18 , C12N9/16
CPC分类号： C12P19/14 , C12N9/1051 , C12N9/16 , C12N9/18 , C12N9/2402 , C12N9/2408 , C12N9/2428 , C12N9/2434 , C12N9/2437 , C12N9/2445 , C12N9/2465 , C12N9/2471 , C12N9/248 , C12N9/2482 , C12N9/2494 , C12N9/80 , C12N9/88 , C12N15/52 , C12P19/00 , C12P19/02 , C12Y204/0102 , C12Y301/01001 , C12Y301/01006 , C12Y301/01073 , C12Y301/02004 , C12Y302/01008 , C12Y302/01015 , C12Y302/0102 , C12Y302/01021 , C12Y302/01022 , C12Y302/01037 , C12Y302/01055 , C12Y302/01078 , C12Y302/01091 , C12Y302/01131 , C12Y302/01133 , C12Y302/01139 , C12Y305/01 , C12Y402/01007 , C12Y402/01008
摘要： Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods of at least partially degrading, cleaving, or removing polysaccharides, lignocellulose, cellulose, hemicellulose, lignin, starch, chitin, polyhydroxybutyrate, heteroxylans, glycosides, xylan-, glucan-, galactan-, or mannan-decorating groups using isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius.
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