公开(公告)号：US11406594B2

公开(公告)日：2022-08-09

申请号：US16761901

申请日：2018-11-28

Applicant: University of Florida Research Foundation, Inc.

Inventor： Anuj Chauhan ,  Russell Macoon

IPC: A61K9/06 ,  A61K9/00 ,  A61K31/5377 ,  A61K47/10 ,  A61K47/12 ,  A61K47/38 ,  A61K47/44

Abstract: In one aspect, the disclosure relates to compositions for the extended release of drugs in the retina. In a further aspect, the present disclosure provides methods of preparing extended release compositions comprising a therapeutic agent for use in retinal drug delivery. In various other aspects, the present disclosure provides methods for delivery of the disclosed compositions comprising a therapeutic agent to the retina via intravitreal injection. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

公开(公告)号：US11260612B2

公开(公告)日：2022-03-01

申请号：US16690324

申请日：2019-11-21

Applicant: University of Florida Research Foundation, Inc.

Inventor： Anuj Chauhan ,  Phillip J. Dixon ,  Poorvajan Sekar

IPC: B29D11/00 ,  G02C7/04

Abstract: In general, the disclosure relates to methods and compositions for preparing colorants useful for preparing pigmented hydrogels. The disclosure further relates to pigmented hydrogels comprising the disclosed colorants. In some instances, the colorant is an alcohol extract of an agro-material, such as turmeric, paprika, spinach, and/or woad or the colorants comprise one or more of: a carotenoid, chlorophyll-a, chlorophyll-b, a curcumoid, or indigorubin. Alternatively, the colorant can be carbon black. The disclosure further relates to contact lenses comprising the disclosed pigmented hydrogels.

公开(公告)号：US20210338527A1

公开(公告)日：2021-11-04

申请号：US17231233

申请日：2021-04-15

Applicant: University of Florida Research Foundation, Inc.

Inventor： Anuj Chauhan ,  Phillip J. Dixon ,  Poorvajan Sekar

IPC: A61J1/14 ,  B01J20/26 ,  B01J20/28

Abstract: A particulate plug for removing a preservative from a solution, suspension, or emulsion comprising a drug is presented. The plug comprises microparticles of a homopolymer comprising a hydrophilic repeating unit or of a copolymer comprising at least one hydrophilic repeating unit and at least one hydrophobic repeating unit. The microparticles are irregular-shaped rigid aggregates and are sized and packed to yield a hydraulic permeability greater than 0.01 Da. The homopolymers have absorbed portions of a preservative to be removed and/or a drug for delivery in solution, as can the copolymer.

公开(公告)号：US20210169796A1

公开(公告)日：2021-06-10

申请号：US16761901

申请日：2018-11-28

Applicant: University of Florida Research Foundation, Inc.

Inventor： Anuj Chauhan ,  Russell Macoon

IPC: A61K9/06 ,  A61K47/38 ,  A61K47/12 ,  A61K31/5377 ,  A61K47/10 ,  A61K47/44 ,  A61K9/00

Abstract: In one aspect, the disclosure relates to compositions for the extended release of drugs in the retina. In a further aspect, the present disclosure provides methods of preparing extended release compositions comprising a therapeutic agent for use in retinal drug delivery. In various other aspects, the present disclosure provides methods for delivery of the disclosed compositions comprising a therapeutic agent to the retina via intravitreal injection. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

公开(公告)号：US20190247277A1

公开(公告)日：2019-08-15

申请号：US16391588

申请日：2019-04-23

Applicant: University of Florida Research Foundation, Inc.

Inventor： Anuj Chauhan ,  Phillip J. Dixon ,  Poorvajan Sekar

IPC: A61J1/14 ,  B01D39/16

Abstract: A BAK removal device is constructed as a plug of microparticles of a hydrophilic polymeric gel that displays a hydraulic permeability greater than 0.01 Da. The polymer hydrophilic polymeric gel comprises poly(2-hydroxyethyl methacrylate) (pHEMA). The particles are 2 to 100 μm and the plug has a surface area of 30 mm2 to 2 mm2 and a length of 2 mm to 25 mm and wherein the microparticles of a hydrophilic polymeric gel has a pore radius of 3 to 60 μm.

公开(公告)号：US20190117450A1

公开(公告)日：2019-04-25

申请号：US16166787

申请日：2018-10-22

Applicant: University of Florida Research Foundation, Inc.

Inventor： Anuj Chauhan ,  Kuan-Hui Hsu

IPC: A61F9/00 ,  A61J1/05 ,  A61K47/18 ,  A61J1/14 ,  C08J9/28 ,  B01J20/26 ,  B01D15/00 ,  A61K9/00 ,  A61K31/382 ,  A61K31/5377 ,  A61K31/5575 ,  A61K31/573

Abstract: A BAK removal device is constructed as a plug of microparticles of a hydrophilic polymeric gel that displays a hydraulic permeability greater than 0.01 Da. The polymer hydrophilic polymeric gel comprises poly(2-hydroxyethyl methacrylate) (pHEMA). The particles are 2 to 100 μm and the plug has a surface area of 30 mm2 to 2 mm2 and a length of 2 mm to 25 mm and wherein the microparticles of a hydrophilic polymeric gel has a pore radius of 3 to 60 μm.

公开(公告)号：US20160354240A1

公开(公告)日：2016-12-08

申请号：US15238111

申请日：2016-08-16

Applicant: Carrie Chauhan ,  University of Florida Research Foundation, Inc.

Inventor： Anuj Chauhan ,  Carrie Chauhan

IPC: A61F9/00

CPC classification number: A61F9/0026 ,  A61F9/0008 ,  A61F2009/0043

Abstract: A device for the delivery of eye drops to one or both eyes of a patient includes a frame for placement over the patient's eyes, a holder for a commercially available eye drop bottle and a fluid delivery means. The eye drop delivery device can include a video camera to monitor the opening and closing of the eyes and a processor or a connector to a remote processor with software to receive input from the camera and deliver output to the delivery means to start and stop delivery of eye drops to the patient's eye.

Abstract translation: 用于将滴眼剂递送到患者的一只或两只眼睛的装置包括用于放置在患者眼睛上的框架，用于市售的滴眼瓶的支架和流体输送装置。 眼药水传送装置可以包括摄像机，用于通过软件监视眼睛的打开和关闭以及处理器或连接器到远程处理器，以从摄像机接收输入并将输出传送到传送装置以开始和停止传送 眼睛滴到病人的眼睛。