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31.发明授权Pyrroles having hypolipidemic hypocholesteremic activities, process for their preparation and pharmaceutical compositions containing them and their use in medicine 有权具有降血脂低胆固醇活性的吡咯，其制备方法和含有它们的药物组合物及其在药物中的用途公开(公告)号：US08558009B2
公开(公告)日：2013-10-15
申请号：US13066807
申请日：2011-04-25
申请人： Braj Bhushan Lohray , Vidya Bhushan Lohray , Vijay Kumar Barot , Saurin Khimshankar Raval , Preeti Saurin Raval , Sujay Basu
发明人： Braj Bhushan Lohray , Vidya Bhushan Lohray , Vijay Kumar Barot , Saurin Khimshankar Raval , Preeti Saurin Raval , Sujay Basu
IPC分类号： C07D207/30 , A61K31/40
CPC分类号： C07D207/325 , C07D207/33 , C07D207/333 , C07D207/335 , C07D207/36 , C07D207/48 , C07D401/04 , C07D405/04 , C07D409/04 , G06F3/14 , G06F3/1438 , G09G5/363 , G09G2360/122
摘要： The present invention relates to compounds of the general formula (I) their derivatives, their analogs, their tautomeric forms, their pharmaceutically acceptable salts, wherein all variables are as defined in the specification.
摘要翻译： 本发明涉及通式（I）化合物的衍生物，它们的类似物，它们的互变异构形式及其药学上可接受的盐，其中所有变量如说明书中所定义。
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公开(公告)号：US08053579B2
公开(公告)日：2011-11-08
申请号：US12760523
申请日：2010-04-14
IPC分类号： C07D513/02
CPC分类号： C07D495/04
摘要： Disclosed are new salts of Clopidogrel viz. Clopidogrel mesylate, Clopidogrel besylate and Clopidogrel tosylate, methods for their preparation and pharmaceutical compositions containing them and their use in medicine.
摘要翻译： 公开了氯吡格雷的新盐 甲磺酸氯吡格雷，苯磺酸氯吡格雷和甲磺酸氯吡格雷，其制备方法和含有它们的药物组合物及其在医学中的应用。
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公开(公告)号：US07863300B2
公开(公告)日：2011-01-04
申请号：US12010473
申请日：2008-01-25
IPC分类号： A61K31/4436 , C07D417/12
CPC分类号： C07D213/30 , C07D213/34 , C07D417/12
摘要： A novel process for preparing thiazolidinediones, preferably Pioglitazone, as described. Also described are novel intermediates involved in its synthesis and process for their preparation and use in medicine.
摘要翻译： 如所述制备噻唑烷二酮类，优选吡格列酮的新方法。 还描述了涉及其合成的新型中间体及其在医药中的制备和应用的方法。
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公开(公告)号：US20090192191A1
公开(公告)日：2009-07-30
申请号：US10585420
申请日：2005-01-07
IPC分类号： A61K31/4709 , C07D401/12 , C07D207/38 , C07D405/14 , C07D409/14 , A61K31/4015 , A61P19/02
CPC分类号： C07D409/14 , C07D401/12 , C07D405/14
摘要： The present invention relates to novel compounds of formula (I) and their pharmaceutically useful compositions as MMP and TNF inhibitors.
摘要翻译： 本发明涉及新的式（I）化合物及其药学上有用的组合物作为MMP和TNF抑制剂。
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公开(公告)号：US20090171091A1
公开(公告)日：2009-07-02
申请号：US12374089
申请日：2007-07-27
IPC分类号： C07D215/48
CPC分类号： C07C237/30 , C07C2601/14 , C07D215/48 , C07D405/12
摘要： Disclosed herein in the embodiments of the present invention are the compounds suitable as modulators of HDL having general formula (1), novel intermediates involved in their synthesis, their pharmaceutically acceptable salts and pharmaceutical compositions containing them. The present invention also relates to a process of preparing compounds of general formula (1), their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.
摘要翻译： 在本发明的实施方案中公开的是适合作为具有通式（1）的HDL的调节剂的化合物，涉及其合成的新中间体，其药学上可接受的盐和含有它们的药物组合物。 本发明还涉及制备通式（1）的化合物，其互变异构形式，其药学上可接受的盐，含有它们的药物组合物和参与其合成的新中间体的方法。
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36.发明授权Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases 失效杂环化合物，其制备方法和含有它们的药物组合物及其在治疗糖尿病和相关疾病中的用途
公开(公告)号：US5885997A
公开(公告)日：1999-03-23
申请号：US777627
申请日：1996-12-31
IPC分类号： C07D413/12 , C07D417/12 , C07D471/04 , C07D495/04 , A61K31/425
CPC分类号： C07D413/12 , C07D417/12 , C07D471/04 , C07D495/04
摘要： The present invention relates to novel antidiabetic compounds, their tautomeric forms, their derivatives, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. This invention particularly relates to novel azolidinedione derivatives of the general formula (I), and their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutical compositions containing them. ##STR1##
摘要翻译： 本发明涉及新的抗糖尿病化合物，其互变异构形式，其衍生物，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂合物和含有它们的药学上可接受的组合物。 本发明特别涉及通式（I）的新的唑来二酮衍生物及其药学上可接受的盐，药学上可接受的溶剂合物和含有它们的药物组合物。 （一）
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公开(公告)号：US20090012069A1
公开(公告)日：2009-01-08
申请号：US11658990
申请日：2005-06-24
IPC分类号： C07D319/06 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , A61K31/422 , A61K31/4025 , A61K31/404 , A61K31/517 , A61K31/536 , A61K31/5415 , A61K31/366 , A61P3/04 , A61P3/06 , A61P3/10
CPC分类号： C07D405/14 , C07D319/06 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Disclosed are novel compounds of general formula (I) where the symbols are as defined in the specification, their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, methods for their preparation, use of these compounds in medicine and the intermediates involved in their preparation. The compounds are useful in the treatment of diabetes and related diseases.
摘要翻译： 公开了通式（I）的新化合物，其中符号如说明书中所定义，其互变异构形式，其立体异构体，其药学上可接受的盐，含有它们的药物组合物，其制备方法，这些化合物在医药中的用途以及 涉及中间体的制备。 该化合物可用于治疗糖尿病和相关疾病。
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38.发明授权Processes for preparing different forms of (S)-(+)-Clopidogrel bisulfate 有权制备不同形式的（S） - （+） - 氯吡格雷硫酸氢盐的方法公开(公告)号：US08907090B2
公开(公告)日：2014-12-09
申请号：US10577940
申请日：2004-11-02
申请人： Braj Bhushan Lohray , Vidya Bhushan Lohray , Bipin Pandey , Mayank Ghanshyambhai Dave , Parind Dholakia
发明人： Braj Bhushan Lohray , Vidya Bhushan Lohray , Bipin Pandey , Mayank Ghanshyambhai Dave , Parind Dholakia
IPC分类号： C07D471/04 , C07D495/04
CPC分类号： C07D495/04
摘要： The invention provides improved processes for the preparation of hydrated form of (S)-(+)-Clopidogrel bisulfate as well as improved processes for the preparation of form-I and form-II of (S)-(+)-Clopidogrel bisulfate.
摘要翻译： 本发明提供了（S） - （+） - 氯吡格雷硫酸氢盐的水合形式的改进方法以及（S） - （+） - 氯吡格雷硫酸氢盐的形式I和形式II的改进方法。
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39.发明申请NOVEL PROCESS TO PREPARE PIOGLITAZONE VIA SEVERAL NOVEL INTERMEDIATES 有权通过几个新的中介来制备PIOGLITAZONE的新工艺公开(公告)号：US20120077848A1
公开(公告)日：2012-03-29
申请号：US13305295
申请日：2011-11-28
IPC分类号： A61K31/4439 , C07D213/46 , A61K31/44 , A61P3/06 , A61P3/04 , C07D417/12 , A61P3/10
CPC分类号： C07D213/30 , C07D213/34 , C07D417/12
摘要： A novel process for preparing thiazolidinediones, preferably Pioglitazone, as described. Also described are novel intermediates involved in its synthesis and process for their preparation and use in medicine.
摘要翻译： 如所述制备噻唑烷二酮类，优选吡格列酮的新方法。 还描述了涉及其合成的新型中间体及其在医药中的制备和应用的方法。
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公开(公告)号：US08030345B2
公开(公告)日：2011-10-04
申请号：US11632236
申请日：2005-07-08
IPC分类号： A61K31/38 , C07D495/02
CPC分类号： C07D495/14 , C07D495/04
摘要： The present invention relates to novel compounds of general formula (I), their regioisomers, tautomeric forms, novel intermediates involved in their synthesis. The present invention also relates to a process of preparing compounds of general formula (I), their regioisomers, their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.
摘要翻译： 本发明涉及通式（I）的新型化合物，其区域异构体，互变异构体，涉及其合成的新型中间体。 本发明还涉及制备通式（I）的化合物，其区域异构体，其互变异构形式，其药学上可接受的盐，含有它们的药物组合物以及参与其合成的新中间体的方法。
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