公开(公告)号：US08558009B2

公开(公告)日：2013-10-15

申请号：US13066807

申请日：2011-04-25

Applicant: Braj Bhushan Lohray ,  Vidya Bhushan Lohray ,  Vijay Kumar Barot ,  Saurin Khimshankar Raval ,  Preeti Saurin Raval ,  Sujay Basu

Inventor： Braj Bhushan Lohray ,  Vidya Bhushan Lohray ,  Vijay Kumar Barot ,  Saurin Khimshankar Raval ,  Preeti Saurin Raval ,  Sujay Basu

IPC: C07D207/30 ,  A61K31/40

CPC classification number: C07D207/325 ,  C07D207/33 ,  C07D207/333 ,  C07D207/335 ,  C07D207/36 ,  C07D207/48 ,  C07D401/04 ,  C07D405/04 ,  C07D409/04 ,  G06F3/14 ,  G06F3/1438 ,  G09G5/363 ,  G09G2360/122

Abstract: The present invention relates to compounds of the general formula (I) their derivatives, their analogs, their tautomeric forms, their pharmaceutically acceptable salts, wherein all variables are as defined in the specification.

Abstract translation: 本发明涉及通式（I）化合物的衍生物，它们的类似物，它们的互变异构形式及其药学上可接受的盐，其中所有变量如说明书中所定义。

公开(公告)号：US08053579B2

公开(公告)日：2011-11-08

申请号：US12760523

申请日：2010-04-14

Applicant: Braj Bhushan Lohray ,  Vidya Bhushan Lohray ,  Mayank Ghanshyambhai Dave

Inventor： Braj Bhushan Lohray ,  Vidya Bhushan Lohray ,  Mayank Ghanshyambhai Dave

IPC: C07D513/02

CPC classification number: C07D495/04

Abstract: Disclosed are new salts of Clopidogrel viz. Clopidogrel mesylate, Clopidogrel besylate and Clopidogrel tosylate, methods for their preparation and pharmaceutical compositions containing them and their use in medicine.

Abstract translation: 公开了氯吡格雷的新盐 甲磺酸氯吡格雷，苯磺酸氯吡格雷和甲磺酸氯吡格雷，其制备方法和含有它们的药物组合物及其在医学中的应用。

公开(公告)号：US07863300B2

公开(公告)日：2011-01-04

申请号：US12010473

申请日：2008-01-25

Applicant: Bipin Pandey ,  Vidya Bhushan Lohray ,  Braj Bhushan Lohray

Inventor： Bipin Pandey ,  Vidya Bhushan Lohray ,  Braj Bhushan Lohray

IPC: A61K31/4436 ,  C07D417/12

CPC classification number: C07D213/30 ,  C07D213/34 ,  C07D417/12

Abstract: A novel process for preparing thiazolidinediones, preferably Pioglitazone, as described. Also described are novel intermediates involved in its synthesis and process for their preparation and use in medicine.

Abstract translation: 如所述制备噻唑烷二酮类，优选吡格列酮的新方法。 还描述了涉及其合成的新型中间体及其在医药中的制备和应用的方法。

公开(公告)号：US20100273791A1

公开(公告)日：2010-10-28

申请号：US12769861

申请日：2010-04-29

Applicant: Braj Bhushan LOHRAY ,  Vidya Bhushan Lohray ,  Brijesh Srivastava

Inventor： Braj Bhushan LOHRAY ,  Vidya Bhushan Lohray ,  Brijesh Srivastava

IPC: A61K31/416 ,  C07D231/54 ,  C07D491/044 ,  C07D495/04 ,  A61K31/454 ,  A61K31/4162 ,  A61K31/5377 ,  A61K31/496 ,  C07C69/738 ,  C07D313/08 ,  C07D337/08

CPC classification number: C07D495/14 ,  C07D495/04

Abstract: The present invention relates to novel compounds of general formula (I), their regioisomers, tautomeric forms, novel intermediates involved in their synthesis. The present invention also relates to a process of preparing compounds of general formula (I), their regioisomers, their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.

Abstract translation: 本发明涉及通式（I）的新型化合物，其区域异构体，互变异构体，涉及其合成的新型中间体。 本发明还涉及制备通式（I）的化合物，其区域异构体，其互变异构形式，其药学上可接受的盐，含有它们的药物组合物以及参与其合成的新中间体的方法。

公开(公告)号：US20090192191A1

公开(公告)日：2009-07-30

申请号：US10585420

申请日：2005-01-07

Applicant: Braj Bhushan Lohray ,  Vidya Bhushan Lohray ,  Mukul R. Jain ,  Pravin S. Thombare

Inventor： Braj Bhushan Lohray ,  Vidya Bhushan Lohray ,  Mukul R. Jain ,  Pravin S. Thombare

IPC: A61K31/4709 ,  C07D401/12 ,  C07D207/38 ,  C07D405/14 ,  C07D409/14 ,  A61K31/4015 ,  A61P19/02

CPC classification number: C07D409/14 ,  C07D401/12 ,  C07D405/14

Abstract: The present invention relates to novel compounds of formula (I) and their pharmaceutically useful compositions as MMP and TNF inhibitors.

Abstract translation: 本发明涉及新的式（I）化合物及其药学上有用的组合物作为MMP和TNF抑制剂。

公开(公告)号：US20090171091A1

公开(公告)日：2009-07-02

申请号：US12374089

申请日：2007-07-27

Applicant: Pravin S. Thombare ,  Braj Bhushan Lohray ,  Vidya Bhushan Lohray ,  Pankaj Ramanbhai Patel

Inventor： Pravin S. Thombare ,  Braj Bhushan Lohray ,  Vidya Bhushan Lohray ,  Pankaj Ramanbhai Patel

IPC: C07D215/48

CPC classification number: C07C237/30 ,  C07C2601/14 ,  C07D215/48 ,  C07D405/12

Abstract: Disclosed herein in the embodiments of the present invention are the compounds suitable as modulators of HDL having general formula (1), novel intermediates involved in their synthesis, their pharmaceutically acceptable salts and pharmaceutical compositions containing them. The present invention also relates to a process of preparing compounds of general formula (1), their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.

Abstract translation: 在本发明的实施方案中公开的是适合作为具有通式（1）的HDL的调节剂的化合物，涉及其合成的新中间体，其药学上可接受的盐和含有它们的药物组合物。 本发明还涉及制备通式（1）的化合物，其互变异构形式，其药学上可接受的盐，含有它们的药物组合物和参与其合成的新中间体的方法。

公开(公告)号：US20080181946A1

公开(公告)日：2008-07-31

申请号：US11596371

申请日：2005-05-05

Applicant: Braj Bhushan Lohray ,  Sandip B. Tiwari

Inventor： Braj Bhushan Lohray ,  Sandip B. Tiwari

IPC: A61K9/36 ,  A61K31/155 ,  A61K31/4439 ,  A61P7/00 ,  A61K31/402

CPC classification number: A61K9/2013 ,  A61K9/2054 ,  A61K31/155

Abstract: The invention relates to a controlled release delivery system for Metformin comprising of (a) therapeutically effective amount of Metformin or pharmaceutically acceptable salts there of; (b) hydrophilic polymers and (c) hydrophobic lubricating agent(s). The invention also relates to a method of making the said solid dosage form.

Abstract translation: 本发明涉及二甲双胍的控制释放递送系统，其包含（a）治疗有效量的二甲双胍或其药学上可接受的盐; （b）亲水性聚合物和（c）疏水性润滑剂。 本发明还涉及制备所述固体剂型的方法。

公开(公告)号：US6130214A

公开(公告)日：2000-10-10

申请号：US179141

申请日：1998-10-26

Applicant: Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Rao Bheema Paraselli ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti

Inventor： Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Rao Bheema Paraselli ,  Rajagopalan Ramanujam ,  Ranjan Chakrabarti

IPC: C07C235/48 ,  C07C323/62 ,  C07C327/48 ,  C07D239/90 ,  C07D265/22 ,  C07D279/08 ,  A61K31/54 ,  A61K31/535 ,  C07D265/12 ,  C07D279/16

CPC classification number: C07C323/62 ,  C07C235/48 ,  C07C327/48 ,  C07D239/90 ,  C07D265/22 ,  C07D279/08

Abstract: The present invention relates to novel antiobesity and hypocholesterolemic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. More particularly, the present invention relates to novel .beta.-aryl-.alpha.-oxysubstituted alkylcarboxylic acids of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. ##STR1##

Abstract translation: 本发明涉及新型抗肥胖和低胆固醇血症化合物，其衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂合物和含有它们的药学上可接受的组合物。 更具体地说，本发明涉及通式（I）的新型β-芳基-α-氧基取代的烷基羧酸，其衍生物，它们的类似物，它们的互变异构形式，它们的立体异构体，它们的多晶型物，它们的药学上可接受的盐，它们的药学上可接受的 溶剂合物和含有它们的药学上可接受的组合物。

公开(公告)号：US6051570A

公开(公告)日：2000-04-18

申请号：US41191

申请日：1998-03-10

Applicant: Braj Bhushan Lohray ,  Vidya Bhushan Lohray ,  Prasuna Guntupalli ,  Narayan Reddy Kommireddi ,  Prem Kumar Mamnoor ,  Rajagopalan Ramanujam

Inventor： Braj Bhushan Lohray ,  Vidya Bhushan Lohray ,  Prasuna Guntupalli ,  Narayan Reddy Kommireddi ,  Prem Kumar Mamnoor ,  Rajagopalan Ramanujam

IPC: C07D491/113 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/55 ,  A61P1/04 ,  C07D235/28 ,  C07D401/12 ,  C07D401/14 ,  C07D491/10 ,  C07D491/107 ,  C07D521/00 ,  A61K31/535 ,  C07D403/14 ,  C07D413/14

CPC classification number: C07D231/12 ,  C07D233/56 ,  C07D235/28 ,  C07D249/08 ,  C07D401/12 ,  C07D401/14 ,  C07D491/10

Abstract: This invention particularly relates to novel pyridylmethylsulfinyl benzimidazole represented by the general formula (I), its tautomers, its derivatives, its analogs, its stereoisomers, its polymorphs, its pharmaceutically acceptable salts, its pharmaceutically acceptable solvates and pharmaceutical compositions containing them and the use thereof. ##STR1## The present invention also relates to a process for the preparation of the above said novel pyridylmethylsulfinyl benzimidazoles and pharmaceutical compositions containing them.

Abstract translation: 本发明特别涉及由通式（I）表示的新型吡啶基甲基亚磺酰基苯并咪唑，其互变异构体，其衍生物，其类似物，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂合物和含有它们的药物组合物及其用途 。 本发明还涉及制备上述新的吡啶基甲基亚磺酰基苯并咪唑的方法和含有它们的药物组合物。

公开(公告)号：US5885997A

公开(公告)日：1999-03-23

申请号：US777627

申请日：1996-12-31

Applicant: Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Rao Bheema Paraselli

Inventor： Vidya Bhushan Lohray ,  Braj Bhushan Lohray ,  Rao Bheema Paraselli

IPC: C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D495/04 ,  A61K31/425

CPC classification number: C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D495/04

Abstract: The present invention relates to novel antidiabetic compounds, their tautomeric forms, their derivatives, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. This invention particularly relates to novel azolidinedione derivatives of the general formula (I), and their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutical compositions containing them. ##STR1##

Abstract translation: 本发明涉及新的抗糖尿病化合物，其互变异构形式，其衍生物，其立体异构体，其多晶型物，其药学上可接受的盐，其药学上可接受的溶剂合物和含有它们的药学上可接受的组合物。 本发明特别涉及通式（I）的新的唑来二酮衍生物及其药学上可接受的盐，药学上可接受的溶剂合物和含有它们的药物组合物。 （一）