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公开(公告)号：US5235039A
公开(公告)日：1993-08-10
申请号：US712828
申请日：1991-06-10
申请人： William F. Heath, Jr. , Mei-Huei T. Lai , Joseph V. Manetta , John R. Sportsman , Sau-Chi B. Yan
发明人： William F. Heath, Jr. , Mei-Huei T. Lai , Joseph V. Manetta , John R. Sportsman , Sau-Chi B. Yan
IPC分类号： C07K7/08 , C07K7/06 , C07K7/22 , C07K14/16 , C07K14/78 , C12Q1/34 , C12Q1/37 , G01N21/78 , G01N33/573
CPC分类号： C07K14/005 , C07K14/78 , C07K7/22 , C12Q1/37 , G01N33/573 , C12N2740/16222 , G01N2333/16 , G01N2333/78
摘要： An assay method for the rapid determination of hydrolytic enzyme activity in large numbers of samples is provided which comprises bonding a resin-binding compound, such as biotin, to one side of the scissile bond of the substrate and a reporter molecule, such as a fluorescence marker, to the opposite side of the scissile bond, incubating the modified substrate and the enzyme in multiple well plates, e.g. 96-well plates, optionally in the presence if a test inhibitor or activator compound transferring the incubation solutions to a second multiple well plate having upper and lower chambers separated by a porous membrane the upper chamber of which contains resin beads capable of binding with the resin-binding compound, filtering and washing the wells of the second plate and reading the emission from the plates. The invention also provides protease substrates for HIV-1 protease, vertebrate stromelysin and derivatives thereof which are useful in the assay method.
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公开(公告)号：US5594104A
公开(公告)日：1997-01-14
申请号：US384492
申请日：1995-02-06
申请人： Margret B. Basinski , Richard D. DiMarchi , David B. Flora , William F. Heath, Jr. , James A. Hoffmann , Brigitte E. Schoner , James E. Shields , David L. Smiley
发明人： Margret B. Basinski , Richard D. DiMarchi , David B. Flora , William F. Heath, Jr. , James A. Hoffmann , Brigitte E. Schoner , James E. Shields , David L. Smiley
IPC分类号： A61K38/00 , C07K14/575 , C07K7/00 , C07K7/10
CPC分类号： C07K14/5759 , A61K38/00
摘要： The present invention provides anti-obesity proteins, which when administered to a patient regulate fat tissue. Accordingly, such agents allow patients to overcome their obesity handicap and live normal lives with much reduced risk for type II diabetes, cardiovascular disease and cancer.
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公开(公告)号：US5580954A
公开(公告)日：1996-12-03
申请号：US381057
申请日：1995-01-31
申请人： Richard D. DiMarchi , David B. Flora , William F. Heath, Jr. , James A. Hoffmann , James E. Shields , David L. Smiley
发明人： Richard D. DiMarchi , David B. Flora , William F. Heath, Jr. , James A. Hoffmann , James E. Shields , David L. Smiley
IPC分类号： A61K38/00 , C07K14/575 , C07K14/00
CPC分类号： C07K14/5759 , A61K38/00
摘要： The present invention provides anti-obesity proteins, which when administered to a patient regulate fat tissue. Accordingly, such agents allow patients to overcome their obesity handicap and live normal lives with much reduced risk for type II diabetes, cardiovascular disease and cancer.
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公开(公告)号：US5552524A
公开(公告)日：1996-09-03
申请号：US384292
申请日：1995-02-06
IPC分类号： A61K38/00 , C07K14/575 , C07K7/00 , C07K7/10
CPC分类号： C07K14/5759 , A61K38/00 , C07K2319/00
摘要： The present invention provides anti-obesity proteins, which when administered to a patient regulate fat tissue. Accordingly, such agents allow patients to overcome their obesity handicap and live normal lives with much reduced risk for type II diabetes, cardiovascular disease and cancer.
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公开(公告)号：US5532336A
公开(公告)日：1996-07-02
申请号：US381034
申请日：1995-01-31
申请人： Richard D. DiMarchi , David B. Flora , William F. Heath, Jr. , James A. Hoffmann , James E. Shields , David L. Smiley
发明人： Richard D. DiMarchi , David B. Flora , William F. Heath, Jr. , James A. Hoffmann , James E. Shields , David L. Smiley
IPC分类号： A61K38/00 , C07K14/575 , C07K14/00
CPC分类号： C07K14/5759 , A61K38/00
摘要： The present invention provides anti-obesity proteins, which when administered to a patient regulate fat tissue. Accordingly, such agents allow patients to overcome their obesity handicap and live normal lives with much reduced risk for type II diabetes, cardiovascular disease and cancer.
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公开(公告)号：US5441984A
公开(公告)日：1995-08-15
申请号：US338994
申请日：1994-11-14
IPC分类号： A61K31/17 , C07C275/28 , C07C323/44 , C07C335/16 , A61K31/155 , A61K31/335 , A61K31/38
CPC分类号： C07C335/16 , A61K31/17 , C07C275/28 , C07C323/44 , Y10S514/866
摘要： The present invention provides novel urea, thiourea and guanidine derivatives, pharmaceutical formulations thereof and a method of using same to prevent diabetic complications.
摘要翻译： 本发明提供新型尿素，硫脲和胍衍生物，其药物制剂及其用于预防糖尿病并发症的方法。
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公开(公告)号：US5691309A
公开(公告)日：1997-11-25
申请号：US383650
申请日：1995-02-06
申请人： Margret B. Basinski , Richard D. DiMarchi , David B. Flora , William F. Heath, Jr. , James A. Hoffmann , Brigitte E. Schoner , James E. Shields , David L. Smiley
发明人： Margret B. Basinski , Richard D. DiMarchi , David B. Flora , William F. Heath, Jr. , James A. Hoffmann , Brigitte E. Schoner , James E. Shields , David L. Smiley
IPC分类号： A61K38/00 , C07K14/575 , C07K1/00 , C07K5/00 , C07K7/00
CPC分类号： C07K14/5759 , A61K38/00
摘要： The present invention provides anti-obesity proteins, which when administered to a patient regulate fat tissue. Accordingly, such agents allow patients to overcome their obesity handicap and live normal lives with much reduced risk for type II diabetes, cardiovascular disease and cancer.
摘要翻译： 本发明提供了抗肥胖蛋白质，其在施用于患者时调节脂肪组织。 因此，这样的药物允许患者克服其肥胖障碍和生活正常生活，其中II型糖尿病，心血管疾病和癌症风险大大降低。
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公开(公告)号：US5567803A
公开(公告)日：1996-10-22
申请号：US383649
申请日：1995-02-06
申请人： Margret Basinski , Richard D. DiMarchi , David B. Flora , William F. Heath, Jr. , James A. Hoffmann , Brigitte E. Schoner , James E. Shields , David L. Smiley
发明人： Margret Basinski , Richard D. DiMarchi , David B. Flora , William F. Heath, Jr. , James A. Hoffmann , Brigitte E. Schoner , James E. Shields , David L. Smiley
IPC分类号： A61K38/00 , C07K14/575 , C07K14/00
CPC分类号： C07K14/5759 , A61K38/00
摘要： The present invention provides anti-obesity proteins, which when administered to a patient regulate fat tissue. Accordingly, such agents allow patients to overcome their obesity handicap and live normal lives with much reduced risk for type II diabetes, cardiovascular disease and cancer.
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公开(公告)号：US5563244A
公开(公告)日：1996-10-08
申请号：US381050
申请日：1995-01-31
申请人： Richard D. DiMarchi , David B. Flora , William F. Heath, Jr. , James A. Hoffmann , James E. Shields , David L. Smiley
发明人： Richard D. DiMarchi , David B. Flora , William F. Heath, Jr. , James A. Hoffmann , James E. Shields , David L. Smiley
IPC分类号： A61K38/00 , C07K14/575 , C07K7/10
CPC分类号： C07K14/5759 , A61K38/00
摘要： The present invention provides anti-obesity proteins, which when administered to a patient regulate fat tissue. Accordingly, such agents allow patients to overcome their obesity handicap and live normal lives with much reduced risk for type II diabetes, cardiovascular disease and cancer.
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公开(公告)号：US5552523A
公开(公告)日：1996-09-03
申请号：US384183
申请日：1995-02-06
IPC分类号： A61K38/00 , C07K14/575 , C07K7/00 , C07K7/10
CPC分类号： C07K14/5759 , A61K38/00
摘要： The present invention provides anti-obesity proteins, which when administered to a patient regulate fat tissue. Accordingly, such agents allow patients to overcome their obesity handicap and live normal lives with much reduced risk for type II diabetes, cardiovascular disease and cancer.
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