公开(公告)号：US5567803A

公开(公告)日：1996-10-22

申请号：US383649

申请日：1995-02-06

申请人： Margret Basinski ,  Richard D. DiMarchi ,  David B. Flora ,  William F. Heath, Jr. ,  James A. Hoffmann ,  Brigitte E. Schoner ,  James E. Shields ,  David L. Smiley

发明人： Margret Basinski ,  Richard D. DiMarchi ,  David B. Flora ,  William F. Heath, Jr. ,  James A. Hoffmann ,  Brigitte E. Schoner ,  James E. Shields ,  David L. Smiley

IPC分类号： A61K38/00 ,  C07K14/575 ,  C07K14/00

CPC分类号： C07K14/5759 ,  A61K38/00

摘要： The present invention provides anti-obesity proteins, which when administered to a patient regulate fat tissue. Accordingly, such agents allow patients to overcome their obesity handicap and live normal lives with much reduced risk for type II diabetes, cardiovascular disease and cancer.

公开(公告)号：US5594104A

公开(公告)日：1997-01-14

申请号：US384492

申请日：1995-02-06

申请人： Margret B. Basinski ,  Richard D. DiMarchi ,  David B. Flora ,  William F. Heath, Jr. ,  James A. Hoffmann ,  Brigitte E. Schoner ,  James E. Shields ,  David L. Smiley

发明人： Margret B. Basinski ,  Richard D. DiMarchi ,  David B. Flora ,  William F. Heath, Jr. ,  James A. Hoffmann ,  Brigitte E. Schoner ,  James E. Shields ,  David L. Smiley

IPC分类号： A61K38/00 ,  C07K14/575 ,  C07K7/00 ,  C07K7/10

CPC分类号： C07K14/5759 ,  A61K38/00

摘要： The present invention provides anti-obesity proteins, which when administered to a patient regulate fat tissue. Accordingly, such agents allow patients to overcome their obesity handicap and live normal lives with much reduced risk for type II diabetes, cardiovascular disease and cancer.

公开(公告)号：US5605886A

公开(公告)日：1997-02-25

申请号：US442916

申请日：1995-05-17

申请人： Margret B. Basinski ,  Richard D. DiMarchi ,  David B. Flora ,  William F. Heath, Jr. ,  James A. Hoffmann ,  Brigitte E. Schoner ,  James E. Shields ,  David L. Smiley

发明人： Margret B. Basinski ,  Richard D. DiMarchi ,  David B. Flora ,  William F. Heath, Jr. ,  James A. Hoffmann ,  Brigitte E. Schoner ,  James E. Shields ,  David L. Smiley

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61P3/00 ,  A61P3/08 ,  A61P3/10 ,  C07K14/47 ,  C07K14/575 ,  C12P21/02 ,  C12R1/19

CPC分类号： C07K14/5759 ,  A61K38/00

摘要： The present invention provides anti-obesity proteins, which when administered to a patient regulate fat tissue. Accordingly, such agents allow patients to overcome their obesity handicap and live normal lives with much reduced risk for type II diabetes, cardiovascular disease and cancer.

公开(公告)号：US5569744A

公开(公告)日：1996-10-29

申请号：US383632

申请日：1995-02-06

申请人： Margret B. Basinski ,  Richard D. DiMarchi ,  David B. Flora ,  William F. Heath, Jr. ,  James A. Hoffmann ,  Brigitte E. Schoner ,  James E. Shields ,  David L. Smiley

发明人： Margret B. Basinski ,  Richard D. DiMarchi ,  David B. Flora ,  William F. Heath, Jr. ,  James A. Hoffmann ,  Brigitte E. Schoner ,  James E. Shields ,  David L. Smiley

IPC分类号： A61K38/00 ,  C07K14/575 ,  C07K14/00

CPC分类号： C07K14/5759 ,  A61K38/00

摘要： The present invention provides anti-obesity proteins, which when administered to a patient regulate fat tissue. Accordingly, such agents allow patients to overcome their obesity handicap and live normal lives with much reduced risk for type II diabetes, cardiovascular disease and cancer.

公开(公告)号：US5691309A

公开(公告)日：1997-11-25

申请号：US383650

申请日：1995-02-06

申请人： Margret B. Basinski ,  Richard D. DiMarchi ,  David B. Flora ,  William F. Heath, Jr. ,  James A. Hoffmann ,  Brigitte E. Schoner ,  James E. Shields ,  David L. Smiley

发明人： Margret B. Basinski ,  Richard D. DiMarchi ,  David B. Flora ,  William F. Heath, Jr. ,  James A. Hoffmann ,  Brigitte E. Schoner ,  James E. Shields ,  David L. Smiley

IPC分类号： A61K38/00 ,  C07K14/575 ,  C07K1/00 ,  C07K5/00 ,  C07K7/00

CPC分类号： C07K14/5759 ,  A61K38/00

摘要： The present invention provides anti-obesity proteins, which when administered to a patient regulate fat tissue. Accordingly, such agents allow patients to overcome their obesity handicap and live normal lives with much reduced risk for type II diabetes, cardiovascular disease and cancer.

摘要翻译： 本发明提供了抗肥胖蛋白质，其在施用于患者时调节脂肪组织。 因此，这样的药物允许患者克服其肥胖障碍和生活正常生活，其中II型糖尿病，心血管疾病和癌症风险大大降低。

公开(公告)号：US5851995A

公开(公告)日：1998-12-22

申请号：US905694

申请日：1997-08-04

申请人： Margret B. Basinski ,  Richard D. DiMarchi ,  David B. Flora ,  William F. Heath, Jr. ,  James A. Hoffmann ,  Brigitte E. Schoner ,  James E. Shields ,  David L. Smiley

发明人： Margret B. Basinski ,  Richard D. DiMarchi ,  David B. Flora ,  William F. Heath, Jr. ,  James A. Hoffmann ,  Brigitte E. Schoner ,  James E. Shields ,  David L. Smiley

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61P3/00 ,  A61P3/08 ,  A61P3/10 ,  C07K14/47 ,  C07K14/575 ,  C12P21/02 ,  C12R1/19

CPC分类号： C07K14/5759 ,  A61K38/00

摘要： The present invention provides anti-obesity proteins, which when administered to a patient regulate fat tissue. Accordingly, such agents allow patients to overcome their obesity handicap and live normal lives with much reduced risk for type II diabetes, cardiovascular disease and cancer.

公开(公告)号：US5580954A

公开(公告)日：1996-12-03

申请号：US381057

申请日：1995-01-31

申请人： Richard D. DiMarchi ,  David B. Flora ,  William F. Heath, Jr. ,  James A. Hoffmann ,  James E. Shields ,  David L. Smiley

发明人： Richard D. DiMarchi ,  David B. Flora ,  William F. Heath, Jr. ,  James A. Hoffmann ,  James E. Shields ,  David L. Smiley

IPC分类号： A61K38/00 ,  C07K14/575 ,  C07K14/00

CPC分类号： C07K14/5759 ,  A61K38/00

摘要： The present invention provides anti-obesity proteins, which when administered to a patient regulate fat tissue. Accordingly, such agents allow patients to overcome their obesity handicap and live normal lives with much reduced risk for type II diabetes, cardiovascular disease and cancer.

公开(公告)号：US5532336A

公开(公告)日：1996-07-02

申请号：US381034

申请日：1995-01-31

申请人： Richard D. DiMarchi ,  David B. Flora ,  William F. Heath, Jr. ,  James A. Hoffmann ,  James E. Shields ,  David L. Smiley

发明人： Richard D. DiMarchi ,  David B. Flora ,  William F. Heath, Jr. ,  James A. Hoffmann ,  James E. Shields ,  David L. Smiley

IPC分类号： A61K38/00 ,  C07K14/575 ,  C07K14/00

CPC分类号： C07K14/5759 ,  A61K38/00

摘要： The present invention provides anti-obesity proteins, which when administered to a patient regulate fat tissue. Accordingly, such agents allow patients to overcome their obesity handicap and live normal lives with much reduced risk for type II diabetes, cardiovascular disease and cancer.

公开(公告)号：US5574133A

公开(公告)日：1996-11-12

申请号：US381049

申请日：1995-01-31

申请人： Richard D. DiMarchi ,  David B. Flora ,  William F. Heath, Jr. ,  James A. Hoffmann ,  James E. Shields ,  David L. Smiley

发明人： Richard D. DiMarchi ,  David B. Flora ,  William F. Heath, Jr. ,  James A. Hoffmann ,  James E. Shields ,  David L. Smiley

IPC分类号： A61K38/00 ,  C07K14/575 ,  C07K7/00 ,  C07K7/10

CPC分类号： C07K14/5759 ,  A61K38/00

摘要： The present invention provides anti-obesity proteins, which when administered to a patient regulate fat tissue. Accordingly, such agents allow patients to overcome their obesity handicap and live normal lives with much reduced risk for type II diabetes, cardiovascular disease and cancer.

公开(公告)号：US5563245A

公开(公告)日：1996-10-08

申请号：US381163

申请日：1995-01-31

申请人： Richard D. DiMarchi ,  David B. Flora ,  William F. Heath, Jr. ,  James A. Hoffmann ,  James E. Shields ,  David L. Smiley

发明人： Richard D. DiMarchi ,  David B. Flora ,  William F. Heath, Jr. ,  James A. Hoffmann ,  James E. Shields ,  David L. Smiley

IPC分类号： A61K38/00 ,  C07K14/575 ,  C07K7/10

CPC分类号： C07K14/5759 ,  A61K38/00

摘要： The present invention provides anti-obesity proteins, which when administered to a patient regulate fat tissue. Accordingly, such agents allow patients to overcome their obesity handicap and live normal lives with much reduced risk for type II diabetes, cardiovascular disease and cancer.