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    PSEUDORABIES VIRUS FOR TREATING TUMORS
    34.
    发明申请
    PSEUDORABIES VIRUS FOR TREATING TUMORS 有权

    公开(公告)号：US20220110988A1

    公开(公告)日：2022-04-14

    申请号：US16966345

    申请日：2019-02-01

    Applicant: XIAMEN UNIVERSITY ,  YANG SHENG TANG COMPANY, LTD.

    Inventor： Yixin CHEN ,  Guosong WANG ,  Quan YUAN ,  Jiali CAO ,  Lina LIN ,  Ningshao XIA

    IPC: A61K35/763 ,  C12N7/00 ,  A61P35/00

    Abstract: A pseudorabies virus (PRV) or a modified form thereof, or a genome sequence or a cDNA sequence containing the PRV or the modified form thereof, or nucleic acid molecules of a complementary sequence of the cDNA sequence, for treating tumors of subjects and/or reducing or inhibiting tumor recurrence, and for preparation of a pharmaceutical composition used for treating the tumors of the subjects and/or reducing or inhibiting the tumor recurrence. A method for treating tumors and/or reducing or inhibiting tumor recurrence, comprising a step of administering, on a subject having a need, the PRV or the modified form thereof, or nucleic acid molecules of the genome sequence containing the PRV or the modified form thereof.

    MUTANT OF L1 PROTEIN OF HUMAN PAPILLOMAVIRUS TYPE 51
    35.
    发明申请
    MUTANT OF L1 PROTEIN OF HUMAN PAPILLOMAVIRUS TYPE 51 有权

    公开(公告)号：US20220001002A1

    公开(公告)日：2022-01-06

    申请号：US17280805

    申请日：2019-09-26

    Applicant: XIAMEN UNIVERSITY ,  XIAMEN INNOVAX BIOTECH CO., LTD.

    Inventor： Shaowei LI ,  Daning WANG ,  Jie CHEN ,  Ying GU ,  Jun ZHANG ,  Ningshao XIA

    IPC: A61K39/12 ,  C07K14/015 ,  C12N7/00 ,  A61P31/20

    Abstract: Provided are a mutated HPV51 L1 protein or a variant thereof, a coding sequence thereof, a preparation method therefor, and a virus-like particle containing same, wherein the protein or the variant and the virus-like particle thereof are capable of inducing neutralizing antibodies against at least two types of HPV (for example, HPV51 and HPV69, or HPV51, HPV69 and HPV26). Also provided is the use of the above-mentioned protein and the virus-like particle for preparing a pharmaceutical composition or a vaccine, wherein the pharmaceutical composition or the vaccine can be used to prevent infections of the at least two types of HPV and diseases caused by the infections, such as cervical cancer and condyloma acuminatum.

    Mutant of L1 Protein of Human Papillomavirus Type 39
    36.
    发明申请
    Mutant of L1 Protein of Human Papillomavirus Type 39 有权

    公开(公告)号：US20210198322A1

    公开(公告)日：2021-07-01

    申请号：US15734715

    申请日：2019-06-04

    Applicant: Xiamen University ,  Xiamen Innovax Biotech Co., Ltd.

    Inventor： Shaowei LI ,  Daning WANG ,  Zhiping WANG ,  Xinlin LIU ,  Jun ZHANG ,  Ningshao XIA

    IPC: C07K14/025 ,  C12N7/00 ,  C12N15/70 ,  A61K39/12

    Abstract: The invention relates to a mutated HPV39 L1 protein (or a variant thereof), a sequence encoding the same, a method for preparing the same, and a virus-like particle comprising the same, wherein the protein (or a variant thereof) and the virus-like particle can induce the generation of neutralizing antibodies against at least two HPV types (e.g. HPV39 and HPV68, or HPV39, HPV68 and HPV70), and therefore can be used to prevent infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum. The invention further relates to the use of the protein and the virus-like particle in the manufacture of a pharmaceutical composition or a vaccine for preventing infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum.

    MUTANT OF L1 PROTEIN OF HUMAN PAPILLOMAVIRUS TYPE 16
    37.
    发明申请
    MUTANT OF L1 PROTEIN OF HUMAN PAPILLOMAVIRUS TYPE 16 有权

    公开(公告)号：US20210000938A1

    公开(公告)日：2021-01-07

    申请号：US16630673

    申请日：2018-07-13

    Applicant: XIAMEN UNIVERSITY ,  XIAMEN INNOVAX BIOTECH CO., LTD.

    Inventor： Ying GU ,  Shaowei LI ,  Shuo SONG ,  Maozhou HE ,  Zhihai LI ,  Ningshao XIA

    IPC: A61K39/12 ,  A61P31/20 ,  A61K39/39

    Abstract: Provided are a mutated HPV16 L1 protein (or a variant thereof), a sequence encoding the same and a method for preparing the same, as well as a virus-like particle comprising the same. The protein (or variant thereof) and the virus-like particle are capable of inducing neutralizing antibodies against at least two types of HPV (e.g., HPV16 and HPV35, or HPV16, HPV35, and HPV31), and therefore can be used to prevent infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum. Also provided are a use of the above protein and virus-like particle in the manufacture of a pharmaceutical composition or vaccine for preventing infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum.

    POLYPEPTIDE CARRIER FOR PRESENTING TARGET POLYPEPTIDE AND USES THEREOF
    40.
    发明申请
    POLYPEPTIDE CARRIER FOR PRESENTING TARGET POLYPEPTIDE AND USES THEREOF 审中-公开

    公开(公告)号：US20200147205A1

    公开(公告)日：2020-05-14

    申请号：US16484366

    申请日：2018-02-05

    Applicant: XIAMEN UNIVERSITY ,  YANG SHENG TANG COMPANY, LTD.

    Inventor： Tianying ZHANG ,  Quan YUAN ,  Xueran GUO ,  Minxi WEI ,  Xiaozhen KANG ,  Jun ZHANG ,  Ningshao XIA

    IPC: A61K39/29 ,  C07K14/005 ,  C12N7/00 ,  A61P31/20

    Abstract: The invention relates to a polypeptide carrier for presenting a target polypeptide, and use thereof. In particular, the invention relates to a nucleic acid molecule, comprising a nucleotide sequence encoding a polypeptide carrier, and being used for insertion of a nucleotide sequence encoding a target polypeptide. In addition, the invention further relates to a recombinant protein comprising the polypeptide carrier and a target polypeptide. Furthermore, the invention further relates to use of the nucleic acid molecule and the recombinant protein. In addition, the invention further relates to a vaccine or a pharmaceutical composition useful for preventing, alleviating or treating HBV infection or a disease associated with HBV infection (e.g., hepatitis B), comprising a recombinant protein comprising the polypeptide carrier of the invention and an epitope from HBV.

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