公开(公告)号：US20230287086A1

公开(公告)日：2023-09-14

申请号：US18005543

申请日：2021-07-13

申请人： YANG SHENG TANG COMPANY, LTD. ,  XIAMEN UNIVERSITY

发明人： Quan YUAN ,  Shaojuan WANG ,  Sheng NIAN ,  Min WEI ,  Yali ZHANG ,  Kai WANG ,  Yixin CHEN ,  Tianying ZHANG ,  Shengxiang GE ,  Ningshao XIA

IPC分类号： C07K16/10 ,  C07K14/005 ,  C12N15/70

CPC分类号： C07K16/10 ,  C07K14/005 ,  C12N15/70 ,  C07K2319/10 ,  C07K2319/81 ,  C12N2800/101

摘要： Provided is a cell-penetrating peptide, which can deliver a variety of biological macromolecules, such as proteins, antibodies, nucleic acids and so on into cells across a membrane. In addition, further provided are a fusion protein, conjugate and complex containing the cell-penetrating peptide, and a use of the cell-penetrating peptide.

公开(公告)号：US20220110988A1

公开(公告)日：2022-04-14

申请号：US16966345

申请日：2019-02-01

申请人： XIAMEN UNIVERSITY ,  YANG SHENG TANG COMPANY, LTD.

发明人： Yixin CHEN ,  Guosong WANG ,  Quan YUAN ,  Jiali CAO ,  Lina LIN ,  Ningshao XIA

IPC分类号： A61K35/763 ,  C12N7/00 ,  A61P35/00

摘要： A pseudorabies virus (PRV) or a modified form thereof, or a genome sequence or a cDNA sequence containing the PRV or the modified form thereof, or nucleic acid molecules of a complementary sequence of the cDNA sequence, for treating tumors of subjects and/or reducing or inhibiting tumor recurrence, and for preparation of a pharmaceutical composition used for treating the tumors of the subjects and/or reducing or inhibiting the tumor recurrence. A method for treating tumors and/or reducing or inhibiting tumor recurrence, comprising a step of administering, on a subject having a need, the PRV or the modified form thereof, or nucleic acid molecules of the genome sequence containing the PRV or the modified form thereof.

公开(公告)号：US20230057621A1

公开(公告)日：2023-02-23

申请号：US17786937

申请日：2020-10-26

申请人： XIAMEN UNIVERSITY ,  YANG SHENG TANG COMPANY, LTD.

发明人： Yixin CHEN ,  Guosong WANG ,  Pengfei HUANG ,  Ruiqi CHEN ,  Lina LIN ,  Qiangyuan HAN ,  Ningshao XIA

IPC分类号： A61K31/675 ,  A61P31/22 ,  A61K38/21 ,  A61K31/7056 ,  A61K31/522 ,  A61K31/192 ,  A61K31/616 ,  A61K31/405

摘要： The present invention relates to the medical field, and in particular to the use of adefovir dipivoxil and a structural analog thereof for treating pseudorabies virus. In particular, the invention relates to the use of a compound as shown in formula (I), a stereoisomer thereof, a solvate thereof, a pharmaceutically acceptable salt thereof or a solvate of the pharmaceutically acceptable salt thereof for inhibiting the pseudorabies virus, treating pseudorabies virus infections or treating diseases related to pseudorabies virus infections.

公开(公告)号：US20160145320A1

公开(公告)日：2016-05-26

申请号：US14781391

申请日：2014-04-02

申请人： XIAMEN UNIVERSITY

发明人： Yixin CHEN ,  Qingbing ZHENG ,  Rui LI ,  Chenguang SHEN ,  Shaojun KE ,  Wenxin LUO ,  Honglin CHEN ,  Ningshao XIA

IPC分类号： C07K16/10 ,  G01N33/569

CPC分类号： C07K16/1018 ,  A61K2039/505 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/76 ,  G01N33/56983 ,  G01N2333/11 ,  G01N2469/10

摘要： The invention relates to antibodies recognizing epitopes on HA1 domain of hemagglutinin (HA) protein of influenza virus, cell lines for producing the antibodies, and uses thereof. The antibodies according to the invention can specifically bind to HA1 domain of different HA subtypes and specifically bind to HA1 domain of hemagglutinin (HA) protein of H1 subtype (including seasonal H1N1 and 2009 pandemic H1N1) and H5 subtype of influenza viruses. Therefore, the invention also relates to vaccines or pharmaceutical compositions for preventing and/or treating infection of H1 subtype and H5 subtype influenza virus and/or a disease caused by the infection (e.g. influenza), comprising the antibodies according to the invention.

摘要翻译： 本发明涉及识别流感病毒血凝素（HA）蛋白HA1结构域上的抗原表位的抗体，用于产生抗体的细胞系及其用途。 根据本发明的抗体可以特异性结合不同HA亚型的HA1结构域，并特异性结合H1亚型（包括季节性H1N1和2009大流行H1N1）和流感病毒H5亚型的血凝素（HA）蛋白的HA1结构域。 因此，本发明还涉及用于预防和/或治疗H1亚型和H5亚型流感病毒感染的疫苗或药物组合物和/或由包含本发明的抗体的感染（例如流感）引起的疾病。

公开(公告)号：US20240123058A1

公开(公告)日：2024-04-18

申请号：US18276700

申请日：2022-01-29

申请人： XIAMEN UNIVERSITY ,  SUN YAT-SEN UNIVERSITY CANCER CENTER (SUN YAT-SEN UNIVERSITY CANCER CENTER HOSPITAL, SUN YAT-SEN ,  SUN YAT-SEN UNIVERSITY

发明人： Yixin CHEN ,  Xiao ZHANG ,  Junping HONG ,  Miao XU ,  Qian WU ,  Ling ZHONG ,  Ningshao XIA

IPC分类号： A61K39/245 ,  A61P35/00 ,  C07K16/08 ,  C12N7/00

CPC分类号： A61K39/245 ,  A61P35/00 ,  C07K16/085 ,  C12N7/00 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2319/30

摘要： Provided are an epitope peptide (or a variant thereof) that can be used for preventing or treating an EBV infection, a recombinant protein containing the epitope peptide (or variant thereof) and a carrier protein, and the use of the epitope peptide (or variant thereof) and the recombinant protein. Further provided are an antibody against the epitope peptide, and the use thereof in the detection, prevention and/or treatment of an EBV infection and/or diseases caused by the infection.