公开(公告)号：US20050032820A1

公开(公告)日：2005-02-10

申请号：US10922869

申请日：2004-08-23

申请人： Takehiro Fukami ,  Akio Kanatani ,  Akane Ishihara ,  Yasuyuki Ishii ,  Toshiyuki Takahashi ,  Yuji Haga ,  Toshihiro Sakamoto ,  Takahiro Itoh ,  Masato Chiba

发明人： Takehiro Fukami ,  Akio Kanatani ,  Akane Ishihara ,  Yasuyuki Ishii ,  Toshiyuki Takahashi ,  Yuji Haga ,  Toshihiro Sakamoto ,  Takahiro Itoh ,  Masato Chiba

IPC分类号： C07D491/107 ,  A61K31/438 ,  A61P1/00 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P5/00 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P13/12 ,  A61P15/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/08 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30 ,  A61P25/32 ,  A61P27/06 ,  A61P29/00 ,  A61P43/00 ,  C07D213/61 ,  C07D307/94 ,  C07D405/12 ,  C07D471/10 ,  C07D491/10 ,  C07D519/00 ,  C07D487/14 ,  A61K31/4747 ,  A61K31/519

CPC分类号： C07D213/61 ,  C07D307/94 ,  C07D405/12 ,  C07D471/10 ,  C07D491/10

摘要： A Compound represented by the general formula (I): wherein AR1 represents an aryl or heteroaryl which may be substituted, the substituent being selected from the group consisting of hydroxy, halogen, nitro, lower alkyl, halo(lower)alkyl, hydroxy(lower)alkyl, cyclo(lower)alkyl, lower alkenyl, lower alkoxy, halo(lower)alkoxy, lower alkylthio, carboxyl, lower alkanoyl, lower alkoxycarbonyl, lower alkylene optionally substituted with oxo, and a group represented by the formula —Q—Ar2; Ar2represents an aryl or heteroaryl which may be substituted, the substituent being selected from the group consisting of halogen, cyano, lower alkyl, halo(lower)alkyl, hydroxy(lower)alkyl, hydroxy, lower alkoxy, halo(lower)alkoxy, lower alkylamino, di-lower alkylamino, lower alkanoyl and aryl; n represents 0 or 1; Q represents a single bond or carbonyl; T, U, V and W each independently represent a nitrogen atom or a methine group which may have a substituent selected from the group consisting of halogen, lower alkyl, hydroxy and lower alkoxy, wherein at least two of which represent said methine group; X represents methine, hydroxy substituted methine or nitrogen atom; Y represents an imino which may be substituted with lower alkyl, or oxygen; and a salt, ester or N-oxide derivative thereof exhibit NPY antagonistic activities and are useful as agents for the treatment of various diseases related to NPY, for example, cardiovascular disorders such as hypertension, nephropathy, heart disease, vasospasm, arteriosclerosis and the like, central nervous system disorders such as bulimia, depression, anxiety, seizure, epilepsy, dementia, pain, alcoholism, drug withdrawal and the like, metabolic diseases such as obesity, diabetes, hormone abnormality, hypercholesterolemia, hyperlipidemia and the like, sexual and reproductive dysfunction, gastro-intestinal disorder, respiratory disorder, inflammation or glaucoma, and the like.

公开(公告)号：US06704524B2

公开(公告)日：2004-03-09

申请号：US10323754

申请日：2002-12-20

申请人： Minoru Matsuguma ,  Yasuyuki Ishii

发明人： Minoru Matsuguma ,  Yasuyuki Ishii

IPC分类号： G03G1500

CPC分类号： G03G21/1889 ,  G03G15/75 ,  G03G2221/1663 ,  G03G2221/1823

摘要： A method of detecting the end of the life of an image bearing member has: a contact time detecting step of detecting the contact time when a developer carrying member that can be in contact with or have a clearance with an image bearing member contacts the image bearing member, the developer carrying member developing an electrostatic image formed in the image bearing member by a developer; and a determining step of determining the end of the life of the image bearing member in accordance with a parameter calculated by using the contact time detected in the contact time detecting step.

摘要翻译： 一种检测图像承载部件的寿命终止的方法具有：接触时间检测步骤，用于检测当与图像承载部件接触或具有间隙的显影剂承载部件与图像承载件接触时的接触时间 构件，显影剂承载构件通过显影剂显影形成在图像承载构件中的静电图像; 以及确定步骤，根据通过使用在接触时间检测步骤中检测到的接触时间计算出的参数来确定图像承载部件的寿命的结束。

公开(公告)号：US06647230B2

公开(公告)日：2003-11-11

申请号：US09942657

申请日：2001-08-31

申请人： Tetsuya Kobayashi ,  Yasuyuki Ishii ,  Tsuyoshi Nakagawa ,  Shinji Uehara

发明人： Tetsuya Kobayashi ,  Yasuyuki Ishii ,  Tsuyoshi Nakagawa ,  Shinji Uehara

IPC分类号： G03G1500

CPC分类号： G03G9/0918 ,  G03G9/08 ,  G03G9/08755 ,  G03G9/0904 ,  G03G9/092 ,  G03G9/097 ,  G03G9/09783 ,  G03G13/08

摘要： An image-forming apparatus includes an image-bearing member for holding thereon an electrostatic latent image; a charging device for electrostatically charging a surface of the image-bearing member; an exposure unit for forming the electrostatic latent image on the image-bearing member by exposing to light the image-bearing member having been charged by the charging device; and a developing unit which has at least a toner-carrying member for carrying and transporting a negatively-chargeable toner thereon and developing the electrostatic latent image by a contact developing system to form a toner image. In the triboelectric series relationship between the toner and a surface layer of the image-bearing member, the surface layer of the image-bearing member has a charge polarity which is a different polarity with respect to the charge polarity of the toner in the developing unit. The image-bearing member includes the electrostatic latent image including a surface potential, as a nonimage area potential (Vd) within a range of −500 to −800 V, and as an image area potential (Vl), at which the maximum toner image density is to be obtained, within a range of −50 to −200 V. A process cartridge includes the above-described image-bearing member.

摘要翻译： 图像形成装置包括用于保持静电潜像的图像承载部件; 用于对图像承载部件的表面进行静电充电的充电装置; 曝光单元，用于通过对由充电装置充电的图像承载部件进行曝光而在图像承载部件上形成静电潜像; 以及显影单元，该显影单元至少具有用于在其上承载和传送可带负电荷的调色剂的调色剂承载构件，并通过接触显影系统显影静电潜像以形成调色剂图像。 在调色剂和图像承载部件的表面层之间的摩擦系列关系中，图像承载部件的表面层具有相对于显影单元中的调色剂的电荷极性具有不同极性的电荷极性 。 图像承载部件包括包括表面电位的静电潜像，作为在-500至-800V的范围内的非图像区域电位（Vd），以及作为图像区域电位（V1），其中最大调色剂图像 要在-50至-200V的范围内获得密度。处理盒包括上述图像承载部件。

公开(公告)号：US06643484B2

公开(公告)日：2003-11-04

申请号：US10082203

申请日：2002-02-26

申请人： Katsuhiro Kojima ,  Tetsuya Kobayashi ,  Yasuyuki Ishii

发明人： Katsuhiro Kojima ,  Tetsuya Kobayashi ,  Yasuyuki Ishii

IPC分类号： G03G1501

CPC分类号： G03G15/0806 ,  G03G15/0126 ,  G03G2215/0119

摘要： An image forming apparatus includes an image bearing member and a developer carrying member, which carries a developer to develop an electrostatic image formed on the image bearing member with the developer. In a non-developmental time period, a peripheral velocity of the developer carrying member is slower than the peripheral velocity of the developer carrying member during a developmental time period. In addition, a peripheral velocity of the image bearing member during the non-developmental time period is slower than the peripheral velocity of the image bearing member during the development time period.

摘要翻译： 图像形成装置包括图像承载部件和显影剂承载部件，其承载显影剂以使显影剂形成在图像承载部件上形成的静电图像。 在非显影时间段中，显影剂承载构件的圆周速度比显影剂承载构件在显影时间段内的圆周速度慢。 此外，在显影时间段期间，图像承载部件的非显影时间段的圆周速度比图像承载部件的圆周速度慢。

公开(公告)号：US06638942B1

公开(公告)日：2003-10-28

申请号：US10228250

申请日：2002-08-26

申请人： Ying-Duo Gao ,  Douglas J. MacNeil ,  Lihu Yang ,  Nancy R. Morin ,  Takehiro Fukami ,  Akio Kanatani ,  Takahiro Fukuroda ,  Yasuyuki Ishii ,  Masaki Ihara

发明人： Ying-Duo Gao ,  Douglas J. MacNeil ,  Lihu Yang ,  Nancy R. Morin ,  Takehiro Fukami ,  Akio Kanatani ,  Takahiro Fukuroda ,  Yasuyuki Ishii ,  Masaki Ihara

IPC分类号： C07D47110

CPC分类号： C07D221/20 ,  C07D471/10

摘要： Compounds of general structural formula I are selective NPY Y5 receptor antagonists, useful in the treatment of obesity and the complications associated therewith.

摘要翻译： 通用结构式的化合物Iare选择性NPY Y5受体拮抗剂，可用于治疗肥胖及其相关并发症。

公开(公告)号：US06594462B2

公开(公告)日：2003-07-15

申请号：US09803968

申请日：2001-03-13

申请人： Yasuyuki Ishii ,  Tomomi Kakeshita

发明人： Yasuyuki Ishii ,  Tomomi Kakeshita

IPC分类号： G03G1508

CPC分类号： G03G9/0827 ,  G03G9/0825 ,  G03G9/09708 ,  G03G15/0806 ,  G03G15/0812 ,  G03G2215/0634

摘要： A developing apparatus, which can obtain a stable toner charging amount even if a developer charging member is contaminated by toner and reduce reversal fog to reduce toner consumption, has a developer carrying body for carrying a developer to a developing position, and a developer charging member contacted with the developer to charge the developer, wherein the developer includes toner and conductive particles.

摘要翻译： 即使显影剂充电构件被调色剂污染并且减少反转雾以减少调色剂消耗量，也可以获得稳定的调色剂充电量的显影装置具有用于将显影剂携带到显影位置的显影剂承载体和显影剂充电构件 与显影剂接触以对显影剂充电，其中显影剂包括调色剂和导电颗粒。

公开(公告)号：US06462053B1

公开(公告)日：2002-10-08

申请号：US10101221

申请日：2002-03-20

申请人： Takehiro Fukami ,  Akio Kanatani ,  Akane Ishihara ,  Yasuyuki Ishii ,  Toshiyuki Takahashi ,  Yuji Haga ,  Toshihiro Sakamoto ,  Takahiro Itoh

发明人： Takehiro Fukami ,  Akio Kanatani ,  Akane Ishihara ,  Yasuyuki Ishii ,  Toshiyuki Takahashi ,  Yuji Haga ,  Toshihiro Sakamoto ,  Takahiro Itoh

IPC分类号： A61K34355

CPC分类号： C07D405/12 ,  C07D213/61 ,  C07D307/94 ,  C07D471/10 ,  C07D491/10

摘要： A method for treating a cardiovascular disorder, which involves administering to a patient in need a therapeutically effective amount of a compound of formula (I): wherein Ar1 represents an aryl or heteroaryl which may be substituted, the substituent being selected from the group consisting of halogen, nitro, lower alkyl, halo(lower) alkyl, hydroxy(lower) alkyl, cyclo(lower) alkyl, lower alkenyl, lower alkoxy, halo(lower) alkoxy, lower alkylthio, carboxyl, lower alkanoyl, lower alkoxycarbonyl, lower alkylene optionally substituted with oxo, and a group represented by the formula —Q—Ar2; Ar2 represents an aryl or heteroaryl which may be substituted, the substituent being selected from the group consisting of halogen, cyano, lower alkyl, halo(lower) alkyl, hydroxy(lower) alkyl, hydroxy, lower alkoxy, halo(lower) alkoxy, lower alkylamino, di-lower alkylamino, lower alkanoyl and aryl: n represents 0 or 1; Q represents a single bond or carbonyl; T, U, V and W each independently represent a nitrogen atom or a methine group which may have a substituent selected from the group consisting of halogen, lower alkyl, hydroxy and lower alkoxy, wherein at least two of which represent said methine group; X represents methine; Y represents an imino which may be substituted with lower alkyl, or oxygen; or a salt or ester thereof.

摘要翻译： 一种治疗心血管疾病的方法，其涉及向需要的患者施用治疗有效量的式（I）化合物：其中Ar1表示可被取代的芳基或杂芳基，所述取代基选自 卤素，硝基，低级烷基，卤代（低级）烷基，羟基（低级）烷基，环（低级）烷基，低级烯基，低级烷氧基，卤代（低级）烷氧基，低级烷硫基，羧基，低级烷酰基，低级烷氧基羰基， 任选被氧代取代的基团和由式-Q-Ar 2表示的基团; Ar 2表示可被取代的芳基或杂芳基，所述取代基选自卤素，氰基，低级烷基，卤代（低级）烷基， 羟基（低级）烷基，羟基，低级烷氧基，卤代（低级）烷氧基，低级烷基氨基，二低级烷基氨基，低级烷酰基和芳基：n表示0或1; Q表示单键或羰基; T，U， W各自独立地表示硝基 可以具有选自卤素，低级烷基，羟基和低级烷氧基的取代基的次甲基，其中至少两个表示所述次甲基; X表示次甲基; Y表示可以被取代的亚氨基 与低级烷基或氧; 或其盐或酯。

公开(公告)号：US06170945B2

公开(公告)日：2001-01-09

申请号：US08901958

申请日：1997-07-29

申请人： Shinya Matsui ,  Toshimitsu Hirakue ,  Masakazu Ozawa ,  Junichi Asano ,  Masanori Morita ,  Eiichi Motai ,  Tetsuto Kageyama ,  Yasuyuki Ishii

发明人： Shinya Matsui ,  Toshimitsu Hirakue ,  Masakazu Ozawa ,  Junichi Asano ,  Masanori Morita ,  Eiichi Motai ,  Tetsuto Kageyama ,  Yasuyuki Ishii

IPC分类号： B41J2913

CPC分类号： B41J2/1752

摘要： An ink jet recording apparatus includes a recording head for effecting recording by ejecting ink onto a recording material and a holder for holding the recording head while it is not used for recording. The holder includes a cap for sealing an ejection outlet of the recording head, and the cap includes ink absorbing material for maintaining wetness of the ejection outlet.

摘要翻译： 一种喷墨记录装置，包括用于通过将油墨喷射到记录材料上进行记录的记录头和用于在不用于记录时保持记录头的保持器。 保持器包括用于密封记录头的喷射出口的帽，并且帽包括用于保持喷射出口的湿度的吸墨材料。

公开(公告)号：US5799233A

公开(公告)日：1998-08-25

申请号：US710998

申请日：1996-09-26

申请人： Yasuyuki Ishii ,  Hiroyuki Adachi ,  Hiroki Kisu ,  Hiroaki Ogata

发明人： Yasuyuki Ishii ,  Hiroyuki Adachi ,  Hiroki Kisu ,  Hiroaki Ogata

IPC分类号： G03G15/02 ,  G03G21/18

CPC分类号： G03G15/0241 ,  G03G2215/022

摘要： A charging apparatus includes a charging member contactable or proximatable to a member to be charged, the charging member being capable of being supplied with a voltage; wherein the charging member has a magnetic particle layer, and a magnetic force generator with a gap for generating magnetic force in the magnetic particles, the magnetic particle layer and magnetic force generator forming a magnetic circuit; and wherein the magnetic particle has a particle size of no less than 10 .mu.m and no more than 100 .mu.m, and the maximum magnetic flux density in the gap ranges 1,000.times.10.sup.-4 T-10,000.times.10.sup.-4 T.

摘要翻译： 充电装置包括可充电或可接近待充电构件的充电构件，充电构件能够被提供电压; 其中所述充电构件具有磁性颗粒层，以及具有用于在所述磁性颗粒中产生磁力的间隙的磁力发生器，所述磁性颗粒层和磁力发生器形成磁路; 并且其中所述磁性颗粒具有不小于10μm且不大于100μm的粒径，并且所述间隙中的最大磁通密度范围为1,000×10 -4 T-10,000×10 -4 T。

公开(公告)号：US5660489A

公开(公告)日：1997-08-26

申请号：US683129

申请日：1996-07-18

申请人： Yasuyuki Ishii ,  Toshimitsu Hirakue ,  Shigeru Yoshimura ,  Kenji Kurita ,  Masakazu Ozawa ,  Masanori Morita ,  Hiroaki Noaki ,  Eiichi Motai

发明人： Yasuyuki Ishii ,  Toshimitsu Hirakue ,  Shigeru Yoshimura ,  Kenji Kurita ,  Masakazu Ozawa ,  Masanori Morita ,  Hiroaki Noaki ,  Eiichi Motai

IPC分类号： B65H3/06 ,  B41J13/02 ,  B65H5/06 ,  B65H29/20

CPC分类号： B41J13/02

摘要： A roller comprises a rotary shaft, an outer peripheral wall member for defining an outer peripheral surface to be contacted with a sheet, and a support member for supporting the outer peripheral wall member so that the outer peripheral wall member surrounds the rotary shaft. The support member defines a space between the rotary shaft and the outer peripheral wall member and supports the outer peripheral wall member with maintaining a condition that the outer peripheral wall member is deformed to swell radially outwardly.

摘要翻译： 辊包括旋转轴，用于限定与片接触的外周面的外周壁构件和用于支撑外周壁构件的支撑构件，使得外周壁构件围绕旋转轴。 支撑构件限定了旋转轴和外周壁构件之间的空间，并且保持外周壁构件变形以径向向外膨胀的状态支撑外周壁构件。