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32 条记录 (耗时 0.024 秒)

    Manufacturing method and apparatus of optical material
    3.
    发明授权
    Manufacturing method and apparatus of optical material 失效
    光学材料的制造方法和装置

    公开(公告)号：US08013084B2

    公开(公告)日：2011-09-06

    申请号：US12336934

    申请日：2008-12-17

    申请人： Masaki Ihara ,  Toru Saito ,  Akinori Yamamoto

    发明人： Masaki Ihara ,  Toru Saito ,  Akinori Yamamoto

    IPC分类号： C08G75/04 ,  C08G75/08 ,  C08L81/02

    CPC分类号： G02B1/04 ,  B29C39/006 ,  B29D11/00442 ,  B29L2011/0016 ,  C08G75/08 ,  C08K3/06 ,  C08K3/30 ,  C08L81/02 ,  C08L2666/54

    摘要： A manufacturing method of an optical material, the method including: blending an inorganic compound (a) containing at least one of a sulfur atom and a selenium atom and a compound (b) represented by a following formula (1) in a tank, the compound (a) and the compound (b) being blended at a ratio of 1 mass % or more and 50 mass % or less of the compound (a) and 50 mass % or more and 99 mass % or less of the compound (b) relative to a total mass of a mixture of the compound (a) and the compound (b); mixing a compound (c) containing at least one thiol (SH) group; preliminarily polymerizing the compounds; cooling the compounds; and deaerating the compounds, in which a viscosity of the composition stored in the tank is controlled during at least one of the preliminarily polymerizing, the cooling and the deaerating (m represents an integer of 0 to 4, and n represents an integer of 0 to 2).

    摘要翻译： 光学材料的制造方法，其特征在于，将含有硫原子和硒原子中的至少一种的无机化合物（a）和下述式（1）所示的化合物（b））混合在槽中， 化合物（a）和化合物（b）以化合物（a）的1质量％以上且50质量％以下的比例和50质量％以上且99质量％以下的化合物（b ）相对于化合物（a）和化合物（b）的混合物的总质量; 混合含有至少一个硫醇（SH）基团的化合物（c） 预先使化合物聚合; 冷却化合物; 在预聚合，冷却和脱气中的至少一种（m表示0〜4的整数，n表示0〜0的整数）中控制储存在罐中的组合物的粘度的化合物脱气 2）。

    Aminopyrazole derivatives
    5.
    发明授权
    Aminopyrazole derivatives 失效
    氨基吡唑衍生物

    公开(公告)号：US6166038A

    公开(公告)日：2000-12-26

    申请号：US319270

    申请日：1999-07-30

    申请人： Takehiro Fukami ,  Takahiro Fukuroda ,  Akio Kanatani ,  Masaki Ihara

    发明人： Takehiro Fukami ,  Takahiro Fukuroda ,  Akio Kanatani ,  Masaki Ihara

    IPC分类号： C07D231/40 ,  C07D401/12 ,  A61K31/445 ,  A61K31/415 ,  C07D231/38

    CPC分类号： C07D401/12 ,  C07D231/40

    摘要： The present invention relates to a compound represented by the general formula [I]: ##STR1## wherein Ar.sup.1 represents an aryl group which may have a substituent selected from the group consisting of a halogen atom and lower alkyl and lower haloalkyl groups; Ar.sup.2 represents an aryl or heteroaryl group which may have a substituent selected from the group consisting of a halogen atom and lower alkyl, lower alkenyl, lower haloalkyl, lower alkoxy, lower alkylthio, lower alkylamino, lower dialkylamino and aryl groups; R.sup.1 and R.sup.2 may be the same or different and each represents a hydrogen atom or a lower alkyl group; R.sup.3 and R.sup.4 may be the same or different and each represents a hydrogen atom or a lower alkyl group, or R.sup.3 and R.sup.4 are linked to each other to form an alkylene group containing 2 to 4 carbon atoms which may have a lower alkyl group; and R.sup.5 represents a hydrogen atom or a lower alkyl or lower alkoxy group,or its salt, a method for its preparation as well as an agent for the treatment of bulimia, obesity or diabetes comprising it as an active ingredient.

    摘要翻译： PCT No.PCT / JP97 / 04571 Sec。 371日期1999年7月30日第 102（e）1999年7月30日PCT 1997年12月12日PCT PCT。 公开号WO98 / 25908 日期：1998年6月18日本发明涉及由通式[I]表示的化合物：其中Ar1表示可具有选自卤素原子和低级烷基和低级卤代烷基的取代基的芳基; Ar2表示可以具有选自卤素原子和低级烷基，低级烯基，低级卤代烷基，低级烷氧基，低级烷硫基，低级烷基氨基，低级二烷基氨基和芳基的取代基的芳基或杂芳基; R 1和R 2可以相同或不同，各自表示氢原子或低级烷基; R 3和R 4可以相同或不同，各自表示氢原子或低级烷基，或者R 3和R 4相互连接形成可以具有低级烷基的含有2〜4个碳原子的亚烷基; R5代表氢原子或低级烷基或低级烷氧基，或其盐，其制备方法以及用于治疗贪食症，肥胖症或糖尿病的药物，其包含其作为活性成分。

    Pyrazole derivatives
    6.
    发明授权
    Pyrazole derivatives 失效
    吡唑衍生物

    公开(公告)号：US06057335A

    公开(公告)日：2000-05-02

    申请号：US319260

    申请日：1999-07-30

    申请人： Takehiro Fukami ,  Takahiro Fukuroda ,  Akio Kanatani ,  Masaki Ihara

    发明人： Takehiro Fukami ,  Takahiro Fukuroda ,  Akio Kanatani ,  Masaki Ihara

    IPC分类号： C07D231/40 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/12 ,  C07D487/04 ,  A61K31/473 ,  A61K31/4155 ,  A61K31/4439 ,  C07D401/14

    CPC分类号： C07D401/04 ,  C07D231/40 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/12 ,  C07D487/04

    摘要： The present invention relates to a compound represented by the general formula [I]: ##STR1## wherein A and B rings are ortho-condensed to each other, A ring represents an aromatic carbocyclic or heterocyclic ring and B ring represents an aliphatic four- to seven-membered carbocyclic or nitrogen-containing heterocyclic ring, said nitrogen atom being possible to present at only the position where the A ring is condensed; Ar represents an aromatic carbocyclic or heterocyclic ring group which may have a substituent selected from the group consisting of a halogen atom and lower alkyl, lower alkenyl, lower haloalkyl, lower alkoxy, lower alkylthio, lower alkylamino, lower dialkylamino and aromatic carbocyclic ring groups; and R represents a substituent selected from the group consisting of a halogen atom and nitro, lower alkyl, lower alkoxy, aromatic carbocyclic ring groups and a carbonyl group having an aromatic carbocyclic ring group, or a hydrogen atom, provided that when the group represented by ##STR2## is the group represented by ##STR3## Ar is not a phenyl group nor a 4-chlorophenyl group, or its salt, a method for its preparation as well as an agent for the treatment of bulimia, obesity or diabetes comprising it as an active ingredient.

    摘要翻译： 本发明涉及由通式[I]表示的化合物：其中A和B环彼此原子稠合，A环表示芳族碳环或杂环，B环表示脂族四至七元 碳环或含氮杂环，所述氮原子只能存在于A环稠合的位置; Ar表示可以具有选自卤素原子和低级烷基，低级烯基，低级卤代烷基，低级烷氧基，低级烷硫基，低级烷基氨基，低级二烷基氨基和芳族碳环基团的取代基的芳族碳环或杂环基团; R表示选自卤素原子和硝基，低级烷基，低级烷氧基，芳香族碳环基团和具有芳香族碳环基团的羰基或氢原子的取代基，条件是当以 是由Ar表示的基团不是苯基或4-氯苯基，或其盐，其制备方法以及用于治疗包含其作为活性成分的贪食症，肥胖症或糖尿病的药剂。

    Urea derivatives
    7.
    发明授权
    Urea derivatives 失效
    尿素衍生物

    公开(公告)号：US6043246A

    公开(公告)日：2000-03-28

    申请号：US308668

    申请日：1999-07-26

    申请人： Takehiro Fukami ,  Takahiro Fukuroda ,  Akio Kanatani ,  Masaki Ihara

    发明人： Takehiro Fukami ,  Takahiro Fukuroda ,  Akio Kanatani ,  Masaki Ihara

    IPC分类号： C07D231/40 ,  C07D401/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/04 ,  A61K31/415 ,  A61K31/496

    CPC分类号： C07D401/04 ,  C07D231/40 ,  C07D401/12 ,  C07D403/12 ,  C07D405/04

    摘要： The present invention relates to a compound represented by the general formula [I]: ##STR1## wherein A represents a nitrogen atom or a group represented by C--R.sup.5 ; Ar.sup.1 represents an aryl group which may have a substituent selected from the group consisting of a halogen atom and lower alkyl and lower haloalkyl groups; Ar.sup.2 represents an aryl or heteroaryl group which may have a substituent selected from the group consisting of a halogen atom and lower alkyl, lower alkenyl, lower haloalkyl, lower alkoxy, lower alkylthio, lower alkylamino, lower dialkylamino and aryl groups; R.sup.1 represents a hydrogen atom, a lower alkyl group or a bond formed by linking to R.sup.5 ; R.sup.2 represents a hydrogen atom or a lower alkyl group; R.sup.3 and R.sup.4 may be the same or different and each represents a hydrogen atom or a lower alkyl group, or R.sup.3 and R.sup.4 are linked to each other to form an alkylene group containing 2 to 4 carbon atoms which may have a lower alkyl group; and R.sup.5 represents a hydrogen atom or a hydroxyl, lower alkyl or lower alkoxy group or a bond formed by linking to R.sup.1,or its salt, a process for its preparation and an agent for the treatment of bulimia, obesity or diabetes comprising it as an active ingredient.

    摘要翻译： PCT No.PCT / JP97 / 04399 Sec。 371日期：1999年7月26日 102（e）日期1999年7月26日PCT 1997年12月2日PCT公布。 WO98 / 24768 PCT公开号 日期：1998年6月11日本发明涉及由通式[I]表示的化合物：其中A表示氮原子或C-R5表示的基团; Ar 1表示可以具有选自卤素原子和低级烷基和低级卤代烷基的取代基的芳基; Ar2表示可以具有选自卤素原子和低级烷基，低级烯基，低级卤代烷基，低级烷氧基，低级烷硫基，低级烷基氨基，低级二烷基氨基和芳基的取代基的芳基或杂芳基; R1表示氢原子，低级烷基或通过连接到R5形成的键; R2表示氢原子或低级烷基; R 3和R 4可以相同或不同，各自表示氢原子或低级烷基，或者R 3和R 4相互连接形成可以具有低级烷基的含有2〜4个碳原子的亚烷基; R5表示氢原子或羟基，低级烷基或低级烷氧基或通过连接R1或其盐形成的键，其制备方法和用于治疗贪食，肥胖或糖尿病的药物，其包含其作为 有效成分。

    Immobilization substrate and method for producing the same
    10.
    发明授权
    Immobilization substrate and method for producing the same 有权
    固定基质及其制备方法

    公开(公告)号：US09487592B2

    公开(公告)日：2016-11-08

    申请号：US13125478

    申请日：2009-10-23

    申请人： Koichi Minami ,  Hirohiko Tsuzuki ,  Hiroshi Ueda ,  Masaki Ihara

    发明人： Koichi Minami ,  Hirohiko Tsuzuki ,  Hiroshi Ueda ,  Masaki Ihara

    IPC分类号： C07K16/18 ,  C07K16/40

    CPC分类号： C07K16/40 ,  C07K16/18 ,  C07K2317/56 ,  Y10T428/269

    摘要： An antibody-fragment-immobilizing substrate includes a substrate and at least one set of antibody fragments, wherein the antibody fragments of each set includes at least two types of separate antibody fragments that are capable of recognizing one type of antigen and that are independently immobilized on the substrate in a positional relationship that allows each of the antibody fragments in one set to bind to the same antigen.

    摘要翻译： 抗体片段固定底物包括底物和至少一组抗体片段，其中每组的抗体片段包含能够识别一种类型的抗原并且独立地固定在其上的至少两种类型的分离的抗体片段 位置关系的底物允许一组中的每个抗体片段与相同的抗原结合。