公开(公告)号：US20100221320A1

公开(公告)日：2010-09-02

申请号：US12672496

申请日：2009-07-29

申请人： Yasuki Kato ,  Mitsunori Harada ,  Hiroyuki Saito ,  Tatsuyuki Hayashi

发明人： Yasuki Kato ,  Mitsunori Harada ,  Hiroyuki Saito ,  Tatsuyuki Hayashi

IPC分类号： A61K9/48

CPC分类号： B82Y5/00 ,  A61K47/60 ,  A61K47/642 ,  A61K47/644 ,  A61K47/6845 ,  A61K47/6849 ,  A61K47/6905 ,  A61K47/6907

摘要： The present invention provides an active targeting polymer micelle encapsulating a drug, preventing an inappropriate release of a drug which may damage a normal cell. A polymer micelle 100 includes a backbone polymer unit 10 that has a target binding site 11 and a backbone polymer unit 20 that has a drug 14 and is free from the target binding site 11, such polymer units 10 and 20 being disposed in a radial arrangement in a state where the target binding site 11 is directed outward and the drug 14 is directed inward, in which: i) when the micelle is bound to a target 40 while maintaining the radial arrangement, the micelle is taken up into a cell 50 supplying the target 40 through endocytosis, and the drug 14 is released into the cell 50 by collapse of the radial arrangement in the cell 50; and ii) when the radial arrangement collapses in blood 60 before the micelle is bound to a target 40, the unit 20 is excreted through metabolism, to thereby prevent a normal cell from being damaged by the drug 14.

摘要翻译： 本发明提供了包封药物的活性靶向聚合物胶束，防止可能损害正常细胞的药物的不适当释放。 聚合物胶束100包括具有靶结合位点11的骨架聚合物单元10和具有药物14并且不含靶结合位点11的主链聚合物单元20，这样的聚合物单元10和20以径向排列 在靶结合位点11向外指向并且向内指向药物14的状态下，其中：i）当保持径向布置时胶束被结合到靶40上时，胶束被吸收到电池50中 靶40通过内吞作用，并且药物14通过细胞50中的径向排列的折叠而释放到细胞50中; 和ii）当胶束与靶标40结合之前径向布置在血液60中塌陷时，单元20通过代谢排泄，从而防止正常细胞被药物14损伤。

公开(公告)号：US20100045725A1

公开(公告)日：2010-02-25

申请号：US12542847

申请日：2009-08-18

申请人： Hiroyuki Saito ,  Takaaki Ishida ,  Koichiro Kawaguchi ,  Toshirou Yoshiike ,  Jun Yasutani ,  Shuichi Tokuda

发明人： Hiroyuki Saito ,  Takaaki Ishida ,  Koichiro Kawaguchi ,  Toshirou Yoshiike ,  Jun Yasutani ,  Shuichi Tokuda

IPC分类号： B41J29/38

CPC分类号： B41J13/0009 ,  B41J11/42 ,  B41J29/38

摘要： A recording apparatus has a controller that controls a conveying roller and a discharge roller for conveying a recording medium. The controller controls the rotation phases of the conveying roller and the discharge roller when the recording medium leaves the conveying roller before the recording medium enters the conveying roller.

摘要翻译： 记录装置具有控制输送辊和用于输送记录介质的排纸辊的控制器。 当记录介质在记录介质进入输送辊之前离开输送辊时，控制器控制输送辊和排出辊的旋转相位。

公开(公告)号：US20100044959A1

公开(公告)日：2010-02-25

申请号：US12543991

申请日：2009-08-19

申请人： Hiroyuki Saito ,  Takaaki Ishida

发明人： Hiroyuki Saito ,  Takaaki Ishida

IPC分类号： B65H5/06

CPC分类号： B65H7/02 ,  B41J11/42 ,  B41J13/02 ,  B65H7/20

摘要： The present invention is to provide a printing apparatus capable of correctly detecting an origin of a conveying roller for conveying a print medium at the time of its rotation with a simple configuration that does not accompany an increase of cost. For this purpose, the printing apparatus is equipped with a lock mechanism (a lock link lever) for stopping rotation of the conveying roller at a predetermined rotational position and saves a count value of a rotation amount of the conveying roller when the conveying roller is locked by the lock mechanism concerned as origin information. After this, driving of the conveying roller is controlled based on the saved origin information and a phase of rotation of the conveying roller obtained from the count value of the conveying roller.

摘要翻译： 本发明提供一种能够正确地检测用于在旋转时输送打印介质的输送辊的原点的打印装置，其具有不伴随成本增加的简单配置。 为此，打印装置配备有用于在输送辊被锁定时停止输送辊的旋转的锁定机构（锁定连杆杆），并且在输送辊被锁定时保存输送辊的旋转量的计数值 以锁机制为原点信息。 此后，基于保存的原始信息和从输送辊的计数值获得的输送辊的旋转相位来控制输送辊的驱动。

公开(公告)号：US20100044947A1

公开(公告)日：2010-02-25

申请号：US12544087

申请日：2009-08-19

申请人： Minoru Teshigawara ,  Jun Yasutani ,  Takeshi Yazawa ,  Hiroyuki Saito ,  Takaaki Ishida ,  Koichiro Kawaguchi ,  Toshiro Yoshiike ,  Shuichi Tokuda

发明人： Minoru Teshigawara ,  Jun Yasutani ,  Takeshi Yazawa ,  Hiroyuki Saito ,  Takaaki Ishida ,  Koichiro Kawaguchi ,  Toshiro Yoshiike ,  Shuichi Tokuda

IPC分类号： B65H7/02 ,  B65H5/06

CPC分类号： B41J3/4071 ,  B41J11/009 ,  B41J13/0027

摘要： A recording apparatus includes a conveying roller and an ejection roller for conveying a recording medium. The recording apparatus also includes a controller which controls the conveying roller and the ejection roller. The controller selectively performs a conveyance control process for the rollers when the recording medium leaves the conveying roller.

摘要翻译： 记录装置包括输送辊和用于输送记录介质的排出辊。 记录装置还包括控制输送辊和排出辊的控制器。 当记录介质离开输送辊时，控制器选择性地执行辊的输送控制处理。

公开(公告)号：US07517965B2

公开(公告)日：2009-04-14

申请号：US10522086

申请日：2003-07-17

申请人： Takaki Koga ,  Tsukasa Suzuki ,  Hiroyuki Saito

发明人： Takaki Koga ,  Tsukasa Suzuki ,  Hiroyuki Saito

IPC分类号： C07K16/00

CPC分类号： C07K16/40 ,  A61K2039/505 ,  C07K2317/565 ,  C07K2317/76

摘要： The present invention provides anti-aPC antibodies that suppress the inactivation of activated protein C (aPC), and uses thereof. The present inventors screened anti-aPC antibodies, and succeeded in isolating anti-aPC antibodies comprising the activity of suppressing aPC inactivation in blood. The antibodies of the present invention can be used to maintain aPC activity by suppressing aPC inactivation, and can thus be used to sustain aPC bioactivities, such as the activity of suppressing activation of the blood coagulation system, and anti-inflammatory activity. In addition, the present invention provides uses of the antibodies of the present invention in aPC therapy for diseases such as thrombosis and sepsis. The therapeutic effect of aPC can be prolonged in treatment that uses aPC administration by allowing an antibody of the present invention to bind with aPC. The antibodies of the present invention can be used in the treatment and prevention of diseases such as thrombosis and sepsis.

摘要翻译： 本发明提供抑制活化蛋白C（aPC）失活的抗-APC抗体及其用途。 本发明人筛选了抗-APC抗体，并成功地分离了包含抑制血液中的aPC失活活性的抗-APC抗体。 本发明的抗体可用于通过抑制aPC灭活来维持PCPC活性，因此可用于维持aPC生物活性，例如抑制血液凝固系统活化的活性和抗炎活性。 此外，本发明提供本发明的抗体在aPC治疗中用于血栓形成和败血症等疾病的用途。 通过使本发明的抗体与aPC结合，可以延长使用aPC施用的治疗中aPC的治疗效果。 本发明的抗体可用于治疗和预防诸如血栓形成和败血症等疾病。

公开(公告)号：US20090074874A1

公开(公告)日：2009-03-19

申请号：US12226693

申请日：2007-04-24

申请人： Yuko Amano ,  Yasuki Kato ,  Mitsunori Harada ,  Naoya Shibata ,  Hiroyuki Saito

发明人： Yuko Amano ,  Yasuki Kato ,  Mitsunori Harada ,  Naoya Shibata ,  Hiroyuki Saito

IPC分类号： A61K9/10

CPC分类号： A61K31/4745 ,  A61K9/1075 ,  A61K31/704 ,  A61K47/6907

摘要： The present invention provides a method of encapsulating a low molecular weight drug in a polymer micelle, the method comprising the steps of: (a) dissolving or dispersing the drug having an electric charge in an aqueous medium; (b) preparing an aqueous medium containing a polymer micelle comprising a block copolymer having an overall hydrophobic region and a hydrophilic region, the overall hydrophobic region containing hydrophobic side chains and side chains having an electric charge opposite to that of the low molecular weight drug in random order; (c) mixing the aqueous medium having the low molecular weight drug dissolved or dispersed therein and the aqueous medium containing the polymer micelle; and (d) adjusting the pH of the mixed aqueous medium to a pH at which the encapsulation of the low molecular weight drug is stabilized.

摘要翻译： 本发明提供一种将低分子量药物包封在聚合物胶束中的方法，该方法包括以下步骤：（a）将具有电荷的药物溶解或分散在水性介质中; （b）制备含有聚合物胶束的水性介质，所述聚合物胶束包含具有总疏水区域和亲水区域的嵌段共聚物，所述整个疏水区域含有疏水侧链和具有与低分子量药物相反的电荷的侧链 随机顺序; （c）将溶解或分散在其中的低分子量药物的水性介质和含有聚合物胶束的水性介质混合; 和（d）将混合水性介质的pH调节至低分子量药物的包封稳定的pH。

公开(公告)号：US07481506B2

公开(公告)日：2009-01-27

申请号：US11445286

申请日：2006-06-02

申请人： Hiroyuki Saito ,  Nobutsune Kobayashi

发明人： Hiroyuki Saito ,  Nobutsune Kobayashi

IPC分类号： B41J29/38

CPC分类号： B41J29/38

摘要： In a printing apparatus which prints using a printhead, a printing controller for feedback-controlling driving of a motor includes a control information generation unit which generates control information for a driving torque of the motor on the basis of a first driving pattern, a comparison unit which compares the control information and a threshold for determining an overload on driving of the motor, and a setting unit which sets a second driving pattern for changing a load on driving of the motor by the control information, instead of the first driving pattern, on the basis of the comparison result of the comparison unit. Control of the motor is switched in accordance with the load state.

摘要翻译： 在使用打印头进行打印的打印装置中，用于对马达进行反馈控制的打印控制器包括：控制信息生成单元，其基于第一驱动模式生成用于马达的驱动转矩的控制信息;比较单元 其比较控制信息和用于确定电动机的驱动过载的阈值;以及设定单元，其通过控制信息而不是第一驱动模式来设置用于改变电动机的驱动负载的第二驱动模式，而不是第一驱动模式 比较单位的比较结果的基础。 根据负载状态切换电动机的控制。

公开(公告)号：US20070036785A1

公开(公告)日：2007-02-15

申请号：US11585172

申请日：2006-10-24

申请人： Tadamitsu Kishimoto ,  Asao Katsume ,  Hiroyuki Saito

发明人： Tadamitsu Kishimoto ,  Asao Katsume ,  Hiroyuki Saito

IPC分类号： A61K39/395

CPC分类号： A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/01 ,  A61K38/00 ,  C07K16/2866 ,  C07K2317/24 ,  C07K2319/00 ,  C12N15/8509

摘要： Pharmaceutical compositions for prevention or treatment of diseases caused by interleukin-6 production, comprising an antibody to interleukin-6 receptor (IL-6R antibody). As the IL-6R antibody, an antibody of animals other than the human such as mice, rats, etc., a chimeric antibody between these and a human antibody, a reshaped human antibody, etc. may be used. The pharmaceutical compositions are useful for prevention or treatment of diseases caused by interleukin-6 production such as plasmacytosis, anti-IgGl-emia, anemia, nephritis, etc.

摘要翻译： 用于预防或治疗由白细胞介素-6产生引起的疾病的药物组合物，其包含白细胞介素-6受体抗体（IL-6R抗体）。 作为IL-6R抗体，除了人以外的动物的抗体，例如小鼠，大鼠等，可以使用它们与人抗体之间的嵌合抗体，重构的人抗体等。 药物组合物可用于预防或治疗由白细胞介素-6产生引起的疾病，如浆细胞病，抗IgG1-emia，贫血，肾炎等。

公开(公告)号：US20060269613A1

公开(公告)日：2006-11-30

申请号：US10570819

申请日：2004-09-06

申请人： Yasuaki Ogawa ,  Shoko Nagasaki ,  Chieko Tsuchiya ,  Sohei Higashi ,  Hiroyuki Saito

发明人： Yasuaki Ogawa ,  Shoko Nagasaki ,  Chieko Tsuchiya ,  Sohei Higashi ,  Hiroyuki Saito

IPC分类号： A61K9/16 ,  A61K9/50 ,  A61K38/17 ,  A61K31/4745

CPC分类号： A61K9/5153

摘要： A drug and a biodegradable polymer having at least one carboxyl group are encapsulated into nanoparticle which is formed by a block copolymer having a hydrophilic segment and a hydrophobic segment. This invention thus provides a drug-encapsulated nanoparticle which shows an increased in vivo drug-stability.

摘要翻译： 具有至少一个羧基的药物和可生物降解的聚合物被包封成由具有亲水链段和疏水链段的嵌段共聚物形成的纳米粒子。 因此，本发明提供了显示体内药物稳定性增加的药物包封的纳米颗粒。

公开(公告)号：US20060257169A1

公开(公告)日：2006-11-16

申请号：US11382817

申请日：2006-05-11

申请人： Hiroyuki Saito ,  Hidetaka Yamaguchi ,  Masatoshi Takano ,  Motohiro Maseki

发明人： Hiroyuki Saito ,  Hidetaka Yamaguchi ,  Masatoshi Takano ,  Motohiro Maseki

IPC分类号： G03G15/10

CPC分类号： G03G15/104

摘要： A wet type image forming apparatus having a developing solution container a preparatory developing solution container, which is adapted to store developing solution to be supplied to the developing solution container, and an attachment unit to which the preparatory developing solution container is attached, is provided. The preparatory developing solution container includes a coupling portion removably coupled to the attachment unit, a developing solution path being formed in the coupling portion to allow the developing solution to flow therein, a blocking system blocking the developing solution path, and a stirring unit stirring the developing solution in the preparatory developing solution container. The attachment unit includes a releasing system to open the developing solution path blocked by the blocking system when the coupling portion of the preparatory developing solution container is coupled to the attachment unit.

摘要翻译： 具有显影液容器的湿式图像形成装置，该显影液容器是适于存储供给到显影液容器的显影液的预备显影液容器，以及附着有显影液容器的安装单元。 预备显影液容器包括可拆卸地联接到附接单元的联接部分，形成在联接部分中以使显影液流动的显影液路径，阻挡显影液路径的阻挡系统和搅拌器 在准备开发解决方案容器中开发解决方案。 所述附接单元包括释放系统，用于当所述预备显影液容器的联接部分联接到所述附接单元时，打开由所述阻挡系统阻挡的所述显影液路径。