摘要:
Systems and methods are disclosed for redirecting data. These systems and methods may include transmitting over a network an indication from a first node to a second node that a third node has failed. In addition, a first data may be reconfigured to be transmitted over the network between a fourth node and the first node after the indication has been received by the second node. The first data may be initially configured to be transmitted over the network between the second node and the third node. Furthermore, the disclosed systems and methods may include configuring the first node and the fourth node to send and receive the reconfigured first data as encrypted data via a first tunnel and configuring the second node and the third node to send and receive the first data as encrypted data via a second tunnel.
摘要:
There is disclosed an antibody drug conjugate (ADC) having an IgG antibody that binds to a c-Met target conjugated at both Cys sites in the hinge region of an IgG antibody. There is further disclosed a method for treating a breast cancer comprising providing an effective amount of a c-Met ADC.
摘要:
The present invention relates to oral formulations comprising an active agent comprising at least one of 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-propanoic acid, salts of 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-propanoic acid or buffered 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-propanoic acid.
摘要:
The invention provides a liquid aqueous pharmaceutical formulation comprising a human anti-TNFa antibody, or antigen-binding portion thereof, which reduces pain associated with injection in a subject by at least about 50% when compared to injecting an otherwise identical formulation comprising at least one salt and/or at least one buffer. The invention also provides a liquid aqueous pharmaceutical formulation comprising a human anti-TNFa antibody, or antigen-binding portion thereof, having increased bioavailability upon subcutaneous administration into a subject. The formulation may comprise a therapeutic protein, such as a human anti-TNF-alpha antibody, or an antigen-binding portion thereof, or a biosimilar thereof.
摘要:
In accordance with the present invention, novel multifunctional compounds have been developed which have orthogonal reactive groups thereon, thereby facilitating preparation of compounds having multiple functional properties (e.g., a targeting moiety and a biologically active moiety). Such constructs are useful for a variety of applications, e.g., for the delivery of biologically compatible materials, and release thereof in active form. Therefore, in accordance with the present invention, there are provided multifunctional linkers of defined structure, as well as various derivatives thereof bearing one or more biologically active components thereon. Also provided in accordance with the present invention are methods for the preparation of such constructs, as well as various uses thereof.
摘要:
Routing text messages. A mobile message (MM) is received from an application program or other message source, and includes a destination identifier, such as a phone number. Based on the destination identifier, a routing server determines whether the MM is to be locally routed to a destination carrier, or forwarded to a remote server that provides access to the destination carrier. For local routing, the routing server determines a channel to the carrier based on predefined carrier information, the destination user information, and the carrier gateway dynamic information. The predefined carrier information indicates predicted availability or reliability of each of a plurality of channels to the carrier. The destination user information indicates availability of the destination user to receive messages, and includes a destination user criterion for determining one of the channels. The carrier gateway dynamic information indicates current and statistical traffic information for each of the channels.
摘要:
Clusters of plant genes that are regulated in response to one or more stress conditions are provided, as are isolated plant stress-regulated genes, including portions thereof comprising a coding sequence or a regulatory element, and to consensus sequences comprising a plant stress-regulated regulatory element. In addition, a recombinant polynucleotide, which includes a plant stress-regulated gene, or functional portion thereof, operatively linked to a heterologous nucleotide sequence, is provided, as are transgenic plants, which contain a plant stress-regulated gene or functional portion thereof that was introduced into a progenitor cell of the plant. Also provided are methods of using a plant stress-regulated gene to confer upon a plant a selective advantage to a stress condition, methods of identifying an agent that modulates the activity of a plant stress-regulated regulatory element, and methods of determining whether a plant has been exposed to a stress.
摘要:
Routing text messages. A mobile message (MM) is received from an application program or other message source, and includes a destination identifier, such as a phone number. Based on the destination identifier, a routing server determines whether the MM is to be locally routed to a destination carrier, or forwarded to a remote server that provides access to the destination carrier. For local routing, the routing server determines a channel to the carrier based on predefined carrier information, the destination user information, and the carrier gateway dynamic information. The predefined carrier information indicates predicted availability or reliability of each of a plurality of channels to the carrier. The destination user information indicates availability of the destination user to receive messages, and includes a destination user criterion for determining one of the channels. The carrier gateway dynamic information indicates current and statistical traffic information for each of the channels.
摘要:
A system, apparatus, and method are directed towards managing abuse of text messages through controls on messages sent by an application to a mobile device (e.g., MT text messages). MT text messages sent from a defined application are intercepted by a Text Message SPAM Control Service (TMSCS). Various controls are determined for the sending application based on the application, level of user control on contents of the message, the user requesting the message to be sent (if any), and/or a destination address for the message. These controls may then be used in various combinations and/or various levels of constraint to determine whether to block transmission of the message to a destination mobile device. By monitoring messages from the application, abuse of the application may be minimized.