公开(公告)号：US20230039679A1

公开(公告)日：2023-02-09

申请号：US17939147

申请日：2022-09-07

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY ,  INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY

Inventor： Sung Youn CHANG ,  Hyuk LEE ,  Ki Young KIM ,  Bum Tae KIM ,  Sung Soo KIM ,  Seong Hwan KIM ,  Hwan Jung LIM ,  Jung Nyoung HEO ,  Sang Joon SHIN ,  Sang Youn PARK

IPC: C07D231/38 ,  A61P35/04 ,  C07D401/04 ,  C07D401/14 ,  C07D403/10 ,  C07D409/04 ,  C07D417/04

Abstract: The present disclosure provides the compound having inhibitory property against TNIK having a specific chemical structure or its pharmaceutically acceptable salt. The present disclosure also provides a composition comprising the compound or its pharmaceutically acceptable salt. The present disclosure also provides a medical use of the compound, its salt or the composition comprising the compound or its pharmaceutically acceptable salt for treating or preventing cancer. The present disclosure also provides a method of treatment or prevention of cancer comprising administering the compound, its salt or the composition comprising the compound or its salt to a subject in need of such treatment or prevention.

公开(公告)号：US20230026024A1

公开(公告)日：2023-01-26

申请号：US17858528

申请日：2022-07-06

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Young Kyu HWANG ,  Changho YOO ,  Dong Won HWANG ,  Do-Young HONG ,  Jaedeuk PARK ,  In Hyoup SONG ,  Maeum LEE ,  Kyung-Ryul OH ,  Anil Haribhau VALEKAR

IPC: C07C51/41 ,  C07C51/44 ,  C07C51/15

Abstract: Proposed is a two-pot-two-step simultaneous conversion system for carbon dioxide and a hydrocarbon containing at least one hydroxy group and a method thereof. The system integrates a process of producing a metal salt that is a dehydrogenated form of the hydrocarbon, hydrogen, and water by reacting a hydrocarbon containing at least one hydroxy group in the presence of water and a metal oxalate, and a process of converting carbon dioxide or carbon dioxide-derived carbonate into formate by hydrogenation, thereby increasing energy efficiency while maintaining a higher hydrocarbon conversion rate and a higher carbon dioxide conversion rate than the one-pot conversion system for hydrocarbon and carbon dioxide.

公开(公告)号：US20230025531A1

公开(公告)日：2023-01-26

申请号：US17367254

申请日：2021-07-02

Applicant: Korea Research Institute of Chemical Technology

Inventor： Myung-Ae BAE ,  Dae-Seop SHIN ,  Jung Yoon YANG ,  Kyu Seok HWANG ,  Seong Soon KIM ,  Byung Hoi LEE ,  Ki Young KIM ,  Won Hoon JUNG ,  Jae Chun WOO

IPC: A61K31/472 ,  A61K9/00 ,  A61P17/00 ,  A61K31/47 ,  A61P29/00 ,  A61P1/16

Abstract: The present invention relates to a novel isoquinoline derivative, a preparing method thereof, and a pharmaceutical composition for preventing or treating autophagy related diseases containing the same as an active ingredient. The novel isoquinoline furanone derivative according to the present invention is capable of regulating autophagy activity, and thus, by using this derivative as an active ingredient, there is a useful effect that can be used as a pharmaceutical composition for preventing or treating autophagy-related diseases such as neurodegenerative diseases, cancer, metabolic diseases, inflammatory diseases or melanogenesis-related diseases, a health functional food composition for ameliorating thereof, or a cosmetic composition with a whitening function.

公开(公告)号：US20230002680A1

公开(公告)日：2023-01-05

申请号：US17664301

申请日：2022-05-20

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Young-Pyo JEON ,  Seung Jae HA ,  Min Seong JO ,  Hyunsig KIL ,  Hyo Cheol LEE ,  Seung Hyun KO

IPC: C10C3/08 ,  C10C3/00 ,  C10C3/02

Abstract: Provided are a method for manufacturing a high yield and high performance mesophase pitch and a high yield and high performance mesophase pitch manufactured therefrom by hydrogenating, mesophase formation, thin film evaporation, solvent-extracting, filtering and then drying to obtain only mesogen components in flow-domained mesophase pitch and then mixing the mesogen components with an isotropic pitch as a solvent component. Further, the high yield mesophase pitch of the present disclosure exhibits high spinnability while maintaining whole anisotropy and exhibits a much higher production yield than existing mesophase pitches.

公开(公告)号：US20220386607A1

公开(公告)日：2022-12-08

申请号：US17770681

申请日：2020-10-21

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY ,  FARMHANNONG CO., LTD.

Inventor： Young Kwan KO ,  Eun Ae KIM ,  Ill Young LEE ,  Hee Nam LIM ,  Jung Sub CHOI ,  Jee Hee SUH ,  Nack Jeong KIM ,  Dong Wan KOO ,  Hyun Jin KIM ,  Gyu Hwan YON ,  Jae Deok KIM ,  Seungae OH ,  So-Young LEE ,  Chan Yong PARK ,  Yun Kyoung HWANG ,  Byung Hoon AHN ,  Ah Reum KIM ,  Hye Ji HAN ,  Sungjun PARK ,  Junhyuk CHOI ,  Jisoo LIM ,  Mi Sook HONG

IPC: A01N43/40 ,  A01N43/713 ,  A01P13/00

Abstract: The present invention relates to a novel nicotinamide compound, a method for preparing the same, and a herbicide comprising the compound. The compound of the present invention is useful as a herbicide for foliar treatment or soil treatment because it has high safety for wheat or corn and has excellent herbicidal activity against grassy weeds, sedge weeds or broadleaf weeds.

公开(公告)号：US11485711B2

公开(公告)日：2022-11-01

申请号：US16967844

申请日：2019-01-31

Applicant: Korea Research Institute of Chemical Technology ,  Industry-Academic Cooperation Foundation, Yonsei University

Inventor： Sung Youn Chang ,  Hyuk Lee ,  Ki Young Kim ,  Bum Tae Kim ,  Sung Soo Kim ,  Seong Hwan Kim ,  Hwan Jung Lim ,  Jung Nyoung Heo ,  Sang Joon Shin ,  Sang Youn Park

IPC: C07D231/38 ,  A61P35/04 ,  C07D401/04 ,  C07D401/14 ,  C07D403/10 ,  C07D409/04 ,  C07D417/04 ,  A61K31/4745

Abstract: The present disclosure provides the compound having inhibitory property against TNIK having a specific chemical structure or its pharmaceutically acceptable salt. The present disclosure also provides a composition comprising the compound or its pharmaceutically acceptable salt. The present disclosure also provides a medical use of the compound, its salt or the composition comprising the compound or its pharmaceutically acceptable salt for treating or preventing cancer. The present disclosure also provides a method of treatment or prevention of cancer comprising administering the compound, its salt or the composition comprising the compound or its salt to a subject in need of such treatment or prevention.

公开(公告)号：US20220323931A1

公开(公告)日：2022-10-13

申请号：US17641975

申请日：2020-08-28

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Jong-San CHANG ,  Kyung Ho CHO ,  U Hwang LEE ,  Young Kyu HWANG ,  Ji Woong YOON

IPC: B01J20/22 ,  C07F5/06 ,  B01J20/28

Abstract: The present invention relates to a metal-organic framework (MOF) having a three-dimensional porous structure and being represented by the chemical formula of [Al8(OH)a(BTC)b(IPA)c(L)d], a preparation method therefor, and a use thereof as an adsorbent and a catalyst.

公开(公告)号：US11447469B2

公开(公告)日：2022-09-20

申请号：US16967825

申请日：2019-01-31

Applicant: Korea Research Institute of Chemical Technology ,  Industry-Academic Cooperation Foundation, Yonsei University

Inventor： Sung Youn Chang ,  Hyuk Lee ,  Ki Young Kim ,  Bum Tae Kim ,  Sung Soo Kim ,  Seong Hwan Kim ,  Hwan Jung Lim ,  Jung Nyoung Heo ,  Sang Joon Shin ,  Sang Youn Park

IPC: C07D403/12 ,  C07D401/12 ,  C07D403/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14

Abstract: The present disclosure provides the compound having inhibitory property against TNIK having a specific chemical structure or its pharmaceutically acceptable salt. The present disclosure also provides a composition comprising the compound or its pharmaceutically acceptable salt. The present disclosure also provides a medical use of the compound, its salt or the composition comprising the compound or its pharmaceutically acceptable salt for treating or preventing cancer. The present disclosure also provides a method of treatment or prevention of cancer comprising administering the compound, its salt or the composition comprising the compound or its salt to a subject in need of such treatment or prevention.

公开(公告)号：US11446384B2

公开(公告)日：2022-09-20

申请号：US16482444

申请日：2019-03-12

Applicant: Korea Research Institute of Chemical Technology ,  Korea Advanced Institute of Science and Technology

Inventor： Ki-Suk Kim ,  Hyang-Ae Lee ,  Sun Hyun Park ,  Haeshin Lee ,  Mikyung Shin

IPC: A61P9/10 ,  A61K47/54 ,  A61K38/18

Abstract: The present invention relates to a heart targeting agent comprising tannic acid, in which the agent aids a heart disease therapeutic drug to be delivered to the heart and bind to the cardiac myocardium by inducing tannylation of the drug so as to make heart targeting and accumulation of the drug possible. Unlike the conventional invasive method used for the traditional drugs to be able to target the heart, the agent of the present invention can help a drug to target the heart with high efficiency just via non-invasive intravenous administration.

公开(公告)号：US20220282048A1

公开(公告)日：2022-09-08

申请号：US17597430

申请日：2020-05-28

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Sung Yeon HWANG ,  Jeyoung PARK ,  Dong Yeop OH ,  Tae Ho KIM ,  Si Gyeong LEE ,  Myung Suk SHIN ,  Jong Geon JEGAL

IPC: C08J5/04 ,  C08G63/81 ,  C08G63/12 ,  C08K7/02

Abstract: A biodegradable composite material which is produced by polymerizing a mixture of an aqueous dispersion of a natural polymer nanofiber including any one or more of a chitin nanofiber and a cellulose nanofiber, a dicarboxylic acid or a derivative thereof, and a diol. The biodegradable composite material has excellent biodegradable and mechanical properties.