公开(公告)号：US11060975B2

公开(公告)日：2021-07-13

申请号：US16557340

申请日：2019-08-30

申请人： Kinetic River Corp.

发明人： Giacomo Vacca

IPC分类号： G01N21/65 ,  G01N15/14 ,  G01N15/10

摘要： An apparatus to provide a label-free or native particle analysis comprises a light generating system producing first light pulses at a first wavelength and second light pulses at a second wavelength; and a flow cell coupled to the light generating system to convey particles for analysis. The light generating system is configured to chirp at least one of the first light pulses and the second light pulses to analyze the particles.

公开(公告)号：US11035778B2

公开(公告)日：2021-06-15

申请号：US16876488

申请日：2020-05-18

申请人： Kinetic River Corp.

发明人： Giacomo Vacca

IPC分类号： G01N15/14 ,  G01N15/10

摘要： A particle analyzer, comprising a source of a substantially nondiffracting light beam; a flow path configured to produce in a flowcell a ribbon-like core stream having a specific cross-sectional aspect ratio; the flowcell being configured to expose a segment of the core stream to the light beam; a detector configured to receive a signal resulting from an interaction of a particle in the core stream with the light beam; a first sorting actuator connected with the flowcell, downstream of the exposed segment of core stream; a plurality of sorting channels in fluid connection with the flow path and downstream of the first actuator; the actuator having multiple actuation states, each state configured to direct at least one part of the core stream to a corresponding channel; a second sorting actuator connected with the flowcell, opposite the first actuator, and operable in coordination with the first actuator.

公开(公告)号：US09952133B2

公开(公告)日：2018-04-24

申请号：US15599834

申请日：2017-05-19

申请人： Kinetic River Corp.

发明人： Giacomo Vacca

IPC分类号： G01N15/14 ,  G01N15/10

CPC分类号： G01N15/14 ,  G01N15/1429 ,  G01N15/1434 ,  G01N15/1459 ,  G01N15/147 ,  G01N2015/1006 ,  G01N2015/1477 ,  G01N2015/1488 ,  G01N2015/149

摘要： A particle analyzer, comprising a source of a beam of pulsed optical energy; a detector comprising a number of spectral detection channels to detect optical signals resulting from interactions between the beam and particles in a sample (such as, e.g., fluorescence signals), and to convert the optical signals into respective electrical signals; optical paths from the source to the sample and from the sample to the detector; a flowcell connected with the optical paths and with a flow path for a suspension of particles; a signal processing module capable of: receiving the electrical signals from the detector; mathematically combining individual decay curves in the signals into a decay supercurve; allocating individual components of the supercurve to discrete bins of predetermined time constants; and quantifying the relative contribution of individual components to the supercurve; a particle sorting actuator; an actuator driver; and at least one particle collection receptacle.