公开(公告)号：US11536642B2

公开(公告)日：2022-12-27

申请号：US17328331

申请日：2021-05-24

申请人： Kinetic River Corp.

发明人： Giacomo Vacca ,  Ralph Jimenez

IPC分类号： G01N15/14 ,  G01N15/10

摘要： Described herein are apparatuses for analyzing an optical signal decay. In some embodiments, an apparatus includes: a source of a beam of pulsed optical energy; a sample holder configured to expose a sample to the beam; a detector comprising a number of spectral detection channels configured to convert the optical signals into respective electrical signals; and a signal processing module configured to perform a method. In some embodiments, the method includes: receiving the electrical signals from the detector; mathematically combining individual decay curves in the electrical signals into a decay supercurve, the supercurve comprising a number of components, each component having a time constant and a relative contribution to the supercurve; and numerically fitting a model to the supercurve.

公开(公告)号：US20220113239A1

公开(公告)日：2022-04-14

申请号：US17559379

申请日：2021-12-22

申请人： Kinetic River Corp.

发明人： Giacomo Vacca ,  Ralph Jimenez

IPC分类号： G01N15/14 ,  G01N15/10

摘要： Described herein are apparatuses and methods for analyzing an optical signal decay. In some embodiments, an apparatus includes: a source of a beam of pulsed optical energy; a sample holder configured to expose a sample to the beam; a detector comprising a number of spectral detection channels configured to convert the optical signals into respective electrical signals; and a signal processing module configured to perform a method. In some embodiments, the method includes: receiving the electrical signals from the detector; mathematically combining individual decay curves in the electrical signals into a supercurve, the supercurve comprising a number of components, each component having a time constant and a relative contribution to the supercurve; and quantifying a relative contribution of each component to the supercurve.

公开(公告)号：US11249004B2

公开(公告)日：2022-02-15

申请号：US17209057

申请日：2021-03-22

申请人： Kinetic River Corp.

发明人： Giacomo Vacca ,  Ralph Jimenez

IPC分类号： G01N15/14 ,  G01N15/10

摘要： Described herein are apparatuses for analyzing an optical signal decay. In some embodiments, an apparatus includes: a source of a beam of pulsed optical energy; a sample holder configured to expose a sample to the beam; a detector comprising a number of spectral detection channels configured to convert the optical signals into respective electrical signals; and a signal processing module configured to perform a method. In some embodiments, the method includes: receiving the electrical signals from the detector; mathematically combining individual decay curves in the electrical signals into a decay supercurve, the supercurve comprising a number of components, each component having a time constant and a relative contribution to the supercurve; and numerically fitting a model to the supercurve.

公开(公告)号：US20210341391A1

公开(公告)日：2021-11-04

申请号：US17363907

申请日：2021-06-30

申请人： Kinetic River Corp.

发明人： Giacomo Vacca

IPC分类号： G01N21/65 ,  G01N15/14

摘要： An apparatus to provide a label-free or native particle analysis comprises a light generating system producing first light pulses at a first wavelength and second light pulses at a second wavelength; and a flow cell coupled to the light generating system to convey particles for analysis. The light generating system is configured to chirp at least one of the first light pulses and the second light pulses to analyze the particles.

公开(公告)号：US20210302301A1

公开(公告)日：2021-09-30

申请号：US17346893

申请日：2021-06-14

申请人： Kinetic River Corp.

发明人： Giacomo Vacca

IPC分类号： G01N15/14

摘要： A particle analyzer, comprising a source of a substantially nondiffracting light beam; a flow path configured to produce in a flowcell a ribbon-like core stream having a specific cross-sectional aspect ratio; the flowcell being configured to expose a segment of the core stream to the light beam; a detector configured to receive a signal resulting from an interaction of a particle in the core stream with the light beam; a first sorting actuator connected with the flowcell, downstream of the exposed segment of core stream; a plurality of sorting channels in fluid connection with the flow path and downstream of the first actuator; the actuator having multiple actuation states, each state configured to direct at least one part of the core stream to a corresponding channel; a second sorting actuator connected with the flowcell, opposite the first actuator, and operable in coordination with the first actuator.

公开(公告)号：US20210278332A1

公开(公告)日：2021-09-09

申请号：US17326662

申请日：2021-05-21

申请人： Kinetic River Corp.

发明人： Giacomo Vacca ,  Ralph Jimenez

IPC分类号： G01N15/14

摘要： Described herein are apparatuses for analyzing an optical signal decay. In some embodiments, an apparatus includes: a source of a beam of pulsed optical energy; a sample holder configured to expose a sample to the beam; a detector comprising a number of spectral detection channels configured to convert the optical signals into respective electrical signals; and a signal processing module configured to perform a method. In some embodiments, the method includes: receiving the electrical signals from the detector; mathematically combining individual decay curves in the electrical signals into a decay supercurve, the supercurve comprising a number of components, each component having a time constant and a relative contribution to the supercurve; and numerically fitting a model to the supercurve.

公开(公告)号：US20210270716A1

公开(公告)日：2021-09-02

申请号：US17307975

申请日：2021-05-04

申请人： Kinetic River Corp.

发明人： Giacomo Vacca ,  Ralph Jimenez

IPC分类号： G01N15/14

摘要： Described herein are apparatuses for analyzing an optical signal decay. In some embodiments, an apparatus includes: a source of a beam of pulsed optical energy; a sample holder configured to expose a sample to the beam; a detector comprising a number of spectral detection channels configured to convert the optical signals into respective electrical signals; and a signal processing module configured to perform a method. In some embodiments, the method includes: receiving the electrical signals from the detector; mathematically combining individual decay curves in the electrical signals into a decay supercurve, the supercurve comprising a number of components, each component having a time constant and a relative contribution to the supercurve; and numerically fitting a model to the supercurve.

公开(公告)号：US10955330B2

公开(公告)日：2021-03-23

申请号：US16725332

申请日：2019-12-23

申请人： Kinetic River Corp.

发明人： Giacomo Vacca ,  Ralph Jimenez

IPC分类号： G01N15/14 ,  G01N15/10

摘要： Described herein are apparatuses for analyzing an optical signal decay. In some embodiments, an apparatus includes: a source of a beam of pulsed optical energy; a sample holder configured to expose a sample to the beam; a detector comprising a number of spectral detection channels configured to convert the optical signals into respective electrical signals; and a signal processing module configured to perform a method. In some embodiments, the method includes: receiving the electrical signals from the detector; mathematically combining individual decay curves in the electrical signals into a decay supercurve, the supercurve comprising a number of components, each component having a time constant and a relative contribution to the supercurve; and numerically fitting a model to the supercurve.

公开(公告)号：US20190383746A1

公开(公告)日：2019-12-19

申请号：US16557340

申请日：2019-08-30

申请人： Kinetic River Corp.

发明人： Giacomo Vacca

IPC分类号： G01N21/65 ,  G01N15/14

摘要： An apparatus to provide a label-free or native particle analysis comprises a light generating system producing first light pulses at a first wavelength and second light pulses at a second wavelength; and a flow cell coupled to the light generating system to convey particles for analysis. The light generating system is configured to chirp at least one of the first light pulses and the second light pulses to analyze the particles.

公开(公告)号：US20180299383A1

公开(公告)日：2018-10-18

申请号：US15723088

申请日：2017-10-02

申请人： Kinetic River Corp.

发明人： Giacomo Vacca

IPC分类号： G01N21/65 ,  G01N15/14 ,  G01N15/10

摘要： An apparatus to provide a label-free or native particle analysis comprises a light generating system producing first light pulses at a first wavelength and second light pulses at a second wavelength; and a flow cell coupled to the light generating system to convey particles for analysis. The light generating system is configured to chirp at least one of the first light pulses and the second light pulses to analyze the particles.