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    Fluorination of acrylate esters and derivatives
    32.
    发明授权
    Fluorination of acrylate esters and derivatives 有权

    公开(公告)号：US10138198B2

    公开(公告)日：2018-11-27

    申请号：US15680325

    申请日：2017-08-18

    申请人： Relypsa, Inc.

    发明人： YongQi Mu

    IPC分类号： C07C51/62 ,  C07C51/363 ,  C07C53/21 ,  C07C53/50 ,  C07C67/307 ,  C07C69/63 ,  C07C253/30 ,  C07C255/03 ,  C07C51/36 ,  C07C67/22 ,  C07C253/32 ,  C07C51/50 ,  C07C51/64 ,  C07C67/03 ,  C07C67/62

    摘要： The present disclosure generally relates to processes for converting acrylate esters or a derivative thereof to difluoropropionic acid or a derivative thereof. This process is generally performed using fluorine gas in a hydrofluorocarbon solvent. In particular, a continuous process for fluorinating a double bond is disclosed, the process comprising forming a reaction stream comprising a compound of formula 1 or formula 5 dissolved in a hydrofluorocarbon or fluorocarbon solvent, wherein R1 is hydroxy, alkoxy, chloro, or —OC(O)CH═CH2; the reaction stream flowing through a continuous fluorination reactor at a flow rate of from about 0.2 mL/minute to about 2 mL/minute and fluorine gas flows through the continuous fluorination reactor at a gas flow rate of from about 0.2 mmol/minute to about 2 mmol/minute; whereby reaction of the compound of formula 1 or formula 5 with the fluorine gas forms a compound of formula 2 or formula 6 wherein R2 is hydroxy, alkoxy, chloro, or —OC(O)CHFCH2F.

    Process for preparing amino acids or esters comprising a metathesis step
    34.
    发明授权
    Process for preparing amino acids or esters comprising a metathesis step 有权
    制备包含复分解步骤的氨基酸或酯的方法

    公开(公告)号：US09221745B2

    公开(公告)日：2015-12-29

    申请号：US14234818

    申请日：2012-07-27

    申请人： Jean-Luc Couturier ,  Jean-Luc Dubois

    发明人： Jean-Luc Couturier ,  Jean-Luc Dubois

    IPC分类号： C07C227/04 ,  C07C253/32 ,  C08G69/08

    CPC分类号： C07C227/04 ,  C07C253/32 ,  C08G69/08 ,  C07C229/08 ,  C07C255/23

    摘要： A process for synthesizing a long-chain saturated α,ω-amino ester (acid) including from 6 to 17 carbon atoms, said process including a first step of cross metathesis between a first acrylic compound chosen from acrylonitrile, acrylic acid or an acrylic ester and a second monounsaturated compound including at least one nitrile, acid or ester trivalent function, one of these compounds including a nitrile function and the other an acid or ester function, in the presence of a ruthenium carbene metathesis catalyst, and a second step of hydrogenation of the monounsaturated nitrile-ester (acid) obtained, wherein said monounsaturated compound including at least one nitrile, acid or ester trivalent function has previously been subjected to a purification by thermal and/or chemical treatment.

    摘要翻译： 一种合成包含6至17个碳原子的长链饱和α，ω-氨基酯（酸）的方法，所述方法包括在选自丙烯腈，丙烯酸或丙烯酸酯的第一丙烯酸化合物之间进行交叉复分解的第一步 以及第二单不饱和化合物，其包含至少一种腈，酸或酯三价官能团，这些化合物中的一种，包括腈官能团，另一种是酸或酯官能团，在钌卡宾复分解催化剂的存在下，和第二步氢化 所得的单不饱和腈 - 酯（酸），其中包括至少一种腈，酸或酯三价官能团的所述单不饱和化合物已经经过热和/或化学处理的纯化。

    Use of substituted phenols to inhibit polymer formation during the manufacture of acrylonitrile
    38.
    发明授权
    Use of substituted phenols to inhibit polymer formation during the manufacture of acrylonitrile 失效
    在制备丙烯腈期间使用取代酚抑制聚合物形成

    公开(公告)号：US6025515A

    公开(公告)日：2000-02-15

    申请号：US755891

    申请日：1996-09-23

    申请人： Muslim D. Shahid

    发明人： Muslim D. Shahid

    IPC分类号： C07C253/32 ,  C07C255/08 ,  C07C255/00

    CPC分类号： C07C253/32 ,  C07C255/08

    摘要： The present invention provides substituted phenols which are effective to inhibit polymer formation during the manufacture of acrylonitrile. Preferred substituted phenols are (a) hindered phenols, nonhindered phenols, and partially hindered phenols, or (b) combinations of hindered phenols with nonhindered or partially hindered phenols. A most preferred substituted phenol is p-nitrosophenol. In a preferred embodiment, the substituted phenols (with the exception of p-nitrosophenol) are combined with hydrogen transfer agents.

    摘要翻译： 本发明提供了在制造丙烯腈期间有效抑制聚合物形成的取代酚。 优选的取代酚是（a）受阻酚，非阻碍酚和部分受阻酚，或（b）受阻酚与非阻碍或部分受阻酚的组合。 最优选的取代苯酚是对亚硝基苯酚。 在优选的实施方案中，取代的酚（除对亚硝基苯酚除外）与氢转移剂组合。