公开(公告)号：US20210219881A1

公开(公告)日：2021-07-22

申请号：US16757490

申请日：2018-10-19

申请人： Universitat Zurich

发明人： Stefan KLEISER ,  Martin WOLF ,  Daniel OSTOJIC ,  Nassimsadat NASSERI

IPC分类号： A61B5/1455

摘要： A spectrophotometric apparatus for determining optical parameters in a scattering medium based on the measurement of attenuation of light propagating through said medium by diffusion. To eliminate the detrimental effect of light being guided in an intermediate optical layer between a surface of the medium and a contact surface of the apparatus, either a multitude of optical barriers may be formed in the contact surface or the angular range over which light is emitted or received by the apparatus may be limited by appropriate means. With both of these alternative approaches, light propagation in the intermediate layer can be suppressed, leading to increased measurement accuracy. This is particularly beneficial for building an oximeter with improved precision. Further aspects include features for improving the applicability of the apparatus on curved surfaces such as the strongly curved skulls of neonates.

公开(公告)号：US11006866B2

公开(公告)日：2021-05-18

申请号：US15326042

申请日：2015-07-14

申请人： UNIVERSITAT ZURICH ,  EIDGENOSSISCHE MATERIALPRUFUNGS—UND FORSCHUNGSANSTALT

发明人： Lukas Baumann ,  Katrin Scholler ,  Markus Rothmaier ,  Lukas Scherer ,  Rene Rossi ,  Damien Paul Joseph Henri De Courten ,  Martin Wolf

IPC分类号： A61B5/145 ,  A61B5/00

摘要： The invention relates to a device for measuring the concentration of an analyte in the blood or tissue of a an animal or a human, particularly a premature infant, wherein for measuring said concentration the device comprises a means (30) comprising at least a first and a second permeability with respect to said analyte, wherein the first permeability for said analyte differs from the second permeability for the analyte. Further, the invention relates to a corresponding method.

公开(公告)号：US10953140B2

公开(公告)日：2021-03-23

申请号：US15500106

申请日：2014-07-29

申请人： UNIVERSITAT ZURICH

发明人： Ernst Reichmann ,  Daniela Marino ,  Agnieszka Sylwia Klar

IPC分类号： A61L27/60 ,  A61L27/22 ,  A61L27/24 ,  A61L27/38 ,  A61L27/52 ,  A61L27/50 ,  A61L27/36 ,  G01N33/50

摘要： The present invention is directed to a method of producing a tissue graft, comprising at least steps of providing a gel, seeding the gel with cells of at least a first and/or cells of a second type, and culturing of the cells of the first and/or cells of the second type in said gel until the formation of at least one first biostructure in the gel by the cells of the first type and/or the cells of the second type.

公开(公告)号：US10786513B2

公开(公告)日：2020-09-29

申请号：US16045193

申请日：2018-07-25

申请人： UNIVERSITÄT ZÜRICH

发明人： Hanns Ulrich Zeilhofer ,  William Ralvenius

IPC分类号： A61K31/5517 ,  A61K31/53 ,  A61K31/519 ,  A61K31/437 ,  A61K31/4184 ,  A61K31/5025 ,  A61K31/5513 ,  A61P17/04 ,  A61K31/4188

摘要： A compound for use in the treatment of itch is provided, wherein the compound comprises the general formula (1a), general formula (1b) or general formula (1c). The compounds of the invention are positive allosteric α2 and/or α3 GABAA receptor modulators.

公开(公告)号：US20200062793A1

公开(公告)日：2020-02-27

申请号：US16609788

申请日：2018-05-01

申请人： WAYNE STATE UNIVERSITY ,  UNIVERSITAT ZURICH

发明人： Erik C. BOTTGER ,  Sven N. HOBBIE ,  Andrea VASELLA ,  David CRICH ,  Amr SONOUSI ,  Takayuki KATO ,  Jonathan QUIRKE ,  Parasuraman RAJASEKARAN ,  Vikram Ashok SARPE

IPC分类号： C07H5/06

摘要： The invention relates to derivatives of apramycin-based aminoglycoside antibacterial drugs modified in positions C5 and/or C6 and O5 and/or O6. The modifications impart favourable properties regarding increased selectivity and retention of activity in the presence of resistance determinants of the AAC(3) class. The invention further relates to said compounds for use in the therapy of bacterial infection by systemic administration, especially in instances where the infection is caused by a pathogen comprising a resistance determinant of the AAC(3) class, in particular AAC(3)-IV.

公开(公告)号：US20190256587A1

公开(公告)日：2019-08-22

申请号：US16269572

申请日：2019-02-07

申请人： UNIVERSITAT ZURICH

发明人： Burkhard Becher ,  Sonia Tugues

IPC分类号： C07K16/24 ,  A61P37/06 ,  C07K16/28 ,  A61P35/02

摘要： Described herein is the use of a non-agonist ligand, particularly an antibody, specifically binding to GM-CSF or one of CD116, CD131 and the GM-CSF receptor composed of CD116 and CD131 for use in treatment of leukemia in a patient having undergone allo-HCT or in treatment of other complications arising as a consequence of hematopoietic cell transplantation from an immunologically non-identical donor.

公开(公告)号：US10385170B2

公开(公告)日：2019-08-20

申请号：US15025559

申请日：2014-09-29

申请人： UNIVERSITAT ZURICH ,  ETH ZURICH

发明人： Vincent Milleret ,  Benjamin R. Simona ,  Janos Voros ,  Martin Ehrbar

IPC分类号： C12P7/18 ,  C25B3/00 ,  C25B3/10 ,  C25B9/12 ,  C08G65/08 ,  C08G65/26 ,  C08G65/32 ,  C08J3/075 ,  C12N11/04 ,  C25B11/02 ,  C25B11/04

摘要： The invention relates to a method, a device and a system for producing particularly a hydrogel (200) and for controlling an enzymatically catalyzed formation of a covalent bond in a solution, wherein said covalent bond is formed between a first compound (20) comprising a first moiety (21) and a second compound (22) comprising a second moiety (23), wherein the first and the second moiety (21, 23) are a substrate of an enzyme wherein said enzyme catalyzes the formation of a covalent bond between the first and the second moiety (21, 23), and wherein a voltage is applied to the solution for spatially controlling said formation, wherein said voltage is adjusted such that it induces electrolysis of said solution.

公开(公告)号：US10262207B2

公开(公告)日：2019-04-16

申请号：US15328084

申请日：2015-07-24

申请人： UNIVERSITAT ZURICH

发明人： Tobias Delbruck ,  Christian Brandli ,  Marc Osswald

IPC分类号： G06K9/00 ,  G06K9/46 ,  G06K9/60 ,  G06K9/62 ,  G06T7/246 ,  G06T7/73

摘要： The present invention relates to a method for tracking a position of at least one keypoint in an image of an object moving relative to an optical sensor, wherein light reflected from the object (12) is detected so as to generate an image of the object, and wherein a position of at least one keypoint (Kj) in said image is detected and updated using temporal contrast events (Ev) of the optical sensor. The invention also relates to a corresponding computer program and device.

公开(公告)号：US20180136298A1

公开(公告)日：2018-05-17

申请号：US15573284

申请日：2016-05-12

申请人： EIDGENOSSISCHE TECHNISCHE HOCHSCHULE ,  UNIVERSITAT ZURICH

发明人： Bertram Wilm ,  Christoph Barmet ,  Klaas P. Prussmann

IPC分类号： G01R33/565 ,  G01R33/389 ,  G01R33/58 ,  G01R33/46

CPC分类号： G01R33/56518 ,  G01R33/389 ,  G01R33/4625 ,  G01R33/58

摘要： A method of determining an actual gradient impulse response function during execution of a magnetic resonance (MR) imaging or spectroscopy sequence, wherein a main magnetic field is generated in a sample region of an MR apparatus by means of a main magnet and wherein superimposed time dependent gradient fields and radiofrequency fields in a first RF band are generated in the sample region according to a first MR sequence for forming images or spectra, the gradient fields being generated by gradient forming means of the MR apparatus operated according to a gradient forming sequence part of said first MR sequence, the MR apparatus further comprising at least one magnetic field probe. The method comprises the steps of: —operating said at least one magnetic field probe according to a second sequence, whereby a time dependent probe signal is repeatedly acquired from each magnetic field probe during a probe acquisition time window, thus providing at least one time dependent probe signal; —obtaining said actual gradient impulse response function by calculating an impulse response function from said at least one time dependent probe signal and from said gradient forming sequence part.

公开(公告)号：US09958374B2

公开(公告)日：2018-05-01

申请号：US14390034

申请日：2013-03-28

申请人： UNIVERSITAT ZURICH

发明人： Madhavi Krishnan

IPC分类号： G01N15/00 ,  G01N15/02 ,  G01N25/00 ,  G01N15/14 ,  B82Y35/00 ,  G01N15/10

CPC分类号： G01N15/10 ,  B82Y35/00 ,  G01N15/0211 ,  G01N15/0266 ,  G01N15/1031 ,  G01N15/1463 ,  G01N25/00 ,  G01N2015/0038 ,  G01N2015/1075 ,  G01N2015/1087

摘要： In a method for determining charge and/or size of an object (15) suspended in a fluid, the object (15) is introduced, together with the fluid, into an electrostatic trap (1) defining an electrostatic confining potential. The thermal motion of the object (15) in the fluid is observed under influence of the confining potential, and charge and/or size are determined from the observed thermal motion. In particular, the viscous drag on the object yields a measure of its size, while the stiffness of its confinement can be compared with a potential model to reveal the total charge it carries. Also disclosed are an apparatus and software for carrying out the method.