公开(公告)号：US12129502B2

公开(公告)日：2024-10-29

申请号：US16589394

申请日：2019-10-01

申请人： NANOBACTERIE

发明人： Edouard Alphandery

IPC分类号： C12P3/00 ,  B82Y35/00 ,  B82Y40/00 ,  C01G49/08 ,  C12N1/20 ,  C12N1/38

CPC分类号： C12P3/00 ,  C01G49/08 ,  C12N1/20 ,  C12N1/38 ,  B82Y35/00 ,  B82Y40/00 ,  C01P2004/64

摘要： A method for removing at least one impurity from metal-based nanoparticles, including at least two heating steps. During step 1, the temperature of the nanoparticles is increased to a temperature T1, and is then maintained at T1 during a heating time that is included between 1 second and 20 years, where T1 is included between 50° C. and 300° C. During step 2, the temperature of the nanoparticles is increased to a temperature T2, and is then maintained at T2 during a heating time that is included between 1 second and 20 years, where T2 is included between 300° C. and 600° C.

公开(公告)号：US12038360B2

公开(公告)日：2024-07-16

申请号：US17289282

申请日：2019-10-30

申请人： CRAIF INC.

发明人： Takao Yasui ,  Yoshinobu Baba ,  Hirotaka Koga

IPC分类号： G01N1/40 ,  B82Y5/00 ,  B82Y35/00 ,  B82Y40/00 ,  C12N15/10 ,  D04H1/425

CPC分类号： G01N1/4077 ,  C12N15/1006 ,  D04H1/425 ,  B82Y5/00 ,  B82Y35/00 ,  B82Y40/00 ,  D10B2201/01 ,  G01N2001/4088

摘要： The present invention provides a novel miRNA extraction method and a method for analyzing miRNA extracted by using said miRNA extraction method. According to the present invention, provided is, for example, a method for extracting miRNA from extracellular vesicles in a sample solution, by using a device capable of capturing extracellular vesicles, the miRNA extraction method comprising: an extracellular vesicle capturing step for capturing extracellular vesicles in a sample solution onto a device by bringing the sample solution and the device in contact with each other; and a miRNA extraction step for homogenizing the extracellular vesicles by bringing the device having captured the extracellular vesicles in contact with a homogenization liquid for extracellular vesicles to extract miRNA from the extracellular vesicle into the homogenization liquid.

公开(公告)号：US20240219398A1

公开(公告)日：2024-07-04

申请号：US18407278

申请日：2024-01-08

申请人： Seer, Inc.

发明人： William Manning ,  Young Kim ,  Brandon Kwan-Leong ,  Hope Liou ,  Xiaoyan Zhao ,  Daniel Hornburg ,  Martin Goldberg

IPC分类号： G01N33/68 ,  B01L3/00 ,  B01L7/00 ,  B82Y5/00 ,  B82Y25/00 ,  B82Y30/00 ,  B82Y35/00 ,  B82Y40/00 ,  G01N1/34 ,  G01N1/44 ,  G01N33/543

CPC分类号： G01N33/6848 ,  B01L3/5085 ,  B01L7/00 ,  G01N1/34 ,  G01N1/44 ,  G01N33/54326 ,  G01N33/54346 ,  B01L2400/043 ,  B82Y5/00 ,  B82Y25/00 ,  B82Y30/00 ,  B82Y35/00 ,  B82Y40/00

摘要： Systems and methods for automated sample preparation and processing of protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic agents.

公开(公告)号：US12005448B2

公开(公告)日：2024-06-11

申请号：US17268955

申请日：2019-08-16

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Leonardo Scarabelli ,  Gail Vinnacombe ,  Liv Heidenreich ,  Naihao Chiang ,  Yao Gong ,  Paul S. Weiss ,  Steven J. Jonas

IPC分类号： B01L3/00 ,  C01G7/00 ,  G01N21/64 ,  G01N21/65 ,  G01N33/543 ,  G01N33/574 ,  G02B21/00 ,  G02B21/16 ,  B82Y35/00

CPC分类号： B01L3/50273 ,  B01L3/502761 ,  C01G7/00 ,  G01N21/6458 ,  G01N21/658 ,  G01N33/54346 ,  G01N33/57492 ,  G02B21/006 ,  G02B21/16 ,  B01L2300/0838 ,  B01L2300/0896 ,  B01L2400/0478 ,  B82Y35/00 ,  C01P2004/03 ,  C01P2004/30 ,  C01P2004/64 ,  G01N2021/656

摘要： Systems and methods are disclosed that utilize metal nanostructures that are synthesized in situ along the internal surfaces of a microfluidic device. The nanostructures are formed by initial deposition of metallic seeds followed by flowing growth and reducing agent solutions into the capillaries/microfluidic channels to grow the nanostars. The nanostructures may optionally be functionalized with a capture ligand. The capture ligand may be used to selectively bind to certain cells (e.g., circulating tumor cells). The cells may be removed by a beam of light (e.g., laser beam) that induces localized heating at the surface location(s) containing the nanostructures. The plasmonic nature of the nanostructures can be used to heat the nanostructure(s) locally for the selective removal of one or certain cells. The nanostructures may be used to acquire Raman spectra of molecules or other small objects that are bound thereto for identification and quantification.

公开(公告)号：US11961626B2

公开(公告)日：2024-04-16

申请号：US17585056

申请日：2022-01-26

申请人： Worcester Polytechnic Institute

发明人： Yuxiang Liu ,  Chaoyang Ti ,  Qi Wen

IPC分类号： G21K1/00 ,  B82Y35/00

CPC分类号： G21K1/006 ,  B82Y35/00

摘要： A fiber optic based particle manipulation system employs one or more optical fibers for emanating a refracted optical manipulation signal directed at a target particle for fixing or manipulating the particle for examination, research and manufacturing. A target particle may be a living cell or inanimate sample or compound of matter. An alignment linkage controls optical fibers carrying the manipulation signal for focusing one or more manipulation signals on the target particle. Manipulated particles occupy a fluid medium of either liquid or gas, and are responsive to the manipulation signal based on both photon bombardment and temperature differential from photon contact. The temperature differential is based on surface properties of the target particle, as smooth particles tend to exhibit a greater thermal differential for stronger displacement forces driving or affecting the target particle.

公开(公告)号：US11940461B2

公开(公告)日：2024-03-26

申请号：US18133054

申请日：2023-04-11

申请人： BRUKER NANO, INC.

发明人： Sergey Osechinskiy ,  Anthonius Ruiter ,  Bede Pittenger ,  Syed-Asif Syed-Amanulla

IPC分类号： G01Q60/38 ,  G01Q10/04 ,  G01Q20/04 ,  G01Q30/04 ,  B82Y35/00

CPC分类号： G01Q60/38 ,  G01Q10/04 ,  G01Q20/04 ,  G01Q30/04 ,  B82Y35/00

摘要： An atomic-force-microscope-based apparatus and method including hardware and software, configured to collect, in a dynamic fashion, and analyze data representing mechanical properties of soft materials on a nanoscale, to map viscoelastic properties of a soft-material sample. The use of the apparatus as an addition to the existing atomic-force microscope device.

公开(公告)号：US11906526B2

公开(公告)日：2024-02-20

申请号：US18365674

申请日：2023-08-04

申请人： Seer, Inc.

发明人： William Manning ,  Young Kim ,  Brandon Kwan-Leong ,  Hope Liou ,  Xiaoyan Zhao ,  Daniel Hornburg ,  Martin Goldberg

IPC分类号： G01N1/34 ,  G01N1/44 ,  G01N33/543 ,  B01L3/00 ,  B01L7/00 ,  G01N33/68 ,  B82Y5/00 ,  B82Y25/00 ,  B82Y30/00 ,  B82Y35/00 ,  B82Y40/00

CPC分类号： G01N33/6848 ,  B01L3/5085 ,  B01L7/00 ,  G01N1/34 ,  G01N1/44 ,  G01N33/54326 ,  G01N33/54346 ,  B01L2400/043 ,  B82Y5/00 ,  B82Y25/00 ,  B82Y30/00 ,  B82Y35/00 ,  B82Y40/00

摘要： Systems and methods for automated sample preparation and processing of protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic agents.

公开(公告)号：US11891652B2

公开(公告)日：2024-02-06

申请号：US16766029

申请日：2018-11-23

申请人： Queen Mary University of London

发明人： Matteo Palma ,  Xinzhao Xu ,  Pierrick Clement

IPC分类号： C12Q1/6825 ,  G01N33/543 ,  B82Y35/00 ,  B82Y40/00

CPC分类号： C12Q1/6825 ,  B82Y35/00 ,  B82Y40/00 ,  C12Q2500/00 ,  C12Q2560/00 ,  G01N2333/005 ,  G01N2333/195 ,  G01N2333/37 ,  G01N2458/00

摘要： The invention relates to a method of assembling a biosensor device comprising two or more biosensor units, wherein each unit comprises one or more biosensors comprising one or more carbon nanotubes (CNTs) coated with nucleic acid and one or more sensor molecules coupled to the nucleic acid, wherein each one of the one or more sensor molecules is capable of binding to a target molecule in a sample. Each biosensor unit is capable of detecting a different target molecule in a sample, and each unit comprises one or more biosensors each capable of detecting the same target molecule. The invention further relates to biosensor devices and methods for detecting target molecules in a sample using the same.

公开(公告)号：US11848117B2

公开(公告)日：2023-12-19

申请号：US17316876

申请日：2021-05-11

申请人： C3 Nano, Inc.

发明人： Yongxing Hu ,  Ying-Syi Li ,  Xiqiang Yang ,  Jing Shun Ang ,  Ajay Virkar

IPC分类号： H01B1/02 ,  H01B5/00 ,  H01B13/00 ,  B82Y40/00 ,  B82Y35/00

CPC分类号： H01B1/02 ,  H01B5/00 ,  H01B13/0006 ,  H01B13/0016 ,  B82Y35/00 ,  B82Y40/00 ,  H05K2201/026

摘要： Highly uniform and thin silver nanowires are described having average diameters below 20 nm and a small standard deviation of the diameters. The silver nanowires have a high aspect ratio. The silver nanowires can be characterized by a small number of nanowires having a diameter greater than 18 nm as well as with a blue shifted narrow absorption spectrum in a dilute solution. Methods are described to allow for the synthesis of the narrow uniform silver nanowires. Transparent conductive films formed from the thin, uniform silver nanowires can have very low levels of haze and low values of ΔL*, the diffusive luminosity, such that the transparent conductive films can provide little alteration of the appearance of a black background.

公开(公告)号：US11826955B2

公开(公告)日：2023-11-28

申请号：US17128345

申请日：2020-12-21

申请人： City University of Hong Kong

发明人： Dong Sun ,  Tanyong Wei ,  Lidai Wang ,  Dongfang Li ,  Yachao Zhang ,  Shuxun Chen

IPC分类号： B29C64/153 ,  A61B5/00 ,  A61B34/30 ,  B33Y70/10 ,  B33Y80/00 ,  C08K5/053 ,  C08K5/103 ,  H01F1/00 ,  H02K1/02 ,  B82Y25/00 ,  B82Y30/00 ,  B82Y35/00

CPC分类号： B29C64/153 ,  A61B5/0095 ,  A61B34/30 ,  B33Y70/10 ,  B33Y80/00 ,  C08K5/053 ,  C08K5/103 ,  H01F1/0054 ,  H02K1/02 ,  B82Y25/00 ,  B82Y30/00 ,  B82Y35/00 ,  C08K2201/01 ,  C08K2201/011 ,  C08K2201/018

摘要： A method of making a magnetically-drivable microrobot that is suitable for carrying and delivering cells includes photo-curing a photo-curable material composition to form a body of the magnetically-drivable microrobot. The photo-curable material composition includes a degradable component, a structural component, a magnetic component, and a photo-curing facilitation composition including a photoinitiator component and a photosensitizer component.