公开(公告)号：US11497931B2

公开(公告)日：2022-11-15

申请号：US17304666

申请日：2021-06-24

Applicant: ACUCELA INC.

Inventor： Philip M. Buscemi ,  Ryo Kubota

IPC: A61N5/06

Abstract: A stimulus is configured to treat astigmatism with changes in retinal thickness, independently of, or in combination with, treatment for myopia. In some embodiments, a stimulus pattern is arranged with respect to an astigmatic axis of the eye to decrease ocular growth in relation to the astigmatic axis. In some embodiments, the apparatus is configured to direct light to regions of retina outside the macula in relation to the astigmatic axis of the eye. In some embodiments, the intensity is modulated to provide the effect. A lens, such as a contact lens or spectacle lens may be configured with a plurality of light sources, such as projection units having a light source and focusing optics that work together to project anteriorly or posteriorly defocused images onto the retina at locations eccentric to the fovea.

公开(公告)号：US11480813B2

公开(公告)日：2022-10-25

申请号：US17650134

申请日：2022-02-07

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Nabin Joshi ,  Arkady Selenow ,  Steven Ali ,  Stefan Bauer ,  Jean-Noël Fehr ,  Moritz Haeberli ,  Patrizia Weber ,  Julien Sauvet ,  Amitava Gupta

IPC: G02C7/02 ,  G02C7/04 ,  A61B3/00 ,  A61F9/00 ,  G02C7/06 ,  G02C11/04

Abstract: An apparatus to treat refractive error of the eye comprises one or more optics configured to project stimuli comprising out of focus images onto the peripheral retina outside the macula. While the stimuli can be configured in many ways, in some embodiments the stimuli are arranged to decrease interference with central vison such as macular vision. The stimuli can be out of focus images may comprise an amount of defocus within a range from about 3 Diopters (“D”) to about 6 D. In some embodiments, the brightness of the stimuli is greater than a brightness of background illumination by an appropriate amount such as at least 3 times the background brightness. In some embodiments, each of a plurality of stimuli comprises a spatial frequency distribution with an amplitude profile having spatial frequencies within a range from about range of 1×10−1 to 2.5×101 cycles per degree.

公开(公告)号：US11460720B1

公开(公告)日：2022-10-04

申请号：US17662805

申请日：2022-05-10

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Philip M. Buscemi ,  Pascal Loser ,  Ben Crook ,  Massimo Pinazza ,  Jim Niebanck ,  James Phillips ,  Stefan Bauer

IPC: G02C11/00 ,  G02C7/08 ,  G02C5/14

Abstract: An electronic case for electronic spectacles may include a base comprising a cavity formed therein. A first spectacle retention device may be located within the cavity. The first spectacle retention device may be configured to retain spectacles. An electrical control system may be included. An electrical connector may be configured to couple the electrical control system in electronic communication with the spectacles.

公开(公告)号：US20220265140A1

公开(公告)日：2022-08-25

申请号：US17662054

申请日：2022-05-04

Applicant: ACUCELA INC.

Inventor： Christian OGGENFUSS ,  Karim HAROUD ,  Lukas SCHEIBLER ,  Matthias PFISTER ,  Urban SCHNELL ,  Stefan TROLLER ,  Ryo KUBOTA ,  Philip M. BUSCEMI

IPC: A61B3/10 ,  A61B3/00 ,  A61B3/13

Abstract: Improved optical coherence tomography systems and methods to measure thickness of the retina are presented. The systems may be compact, handheld, provide in-home monitoring, allow the patient to measure himself or herself, and be robust enough to be dropped while still measuring the retina reliably.

公开(公告)号：US20220257972A1

公开(公告)日：2022-08-18

申请号：US17662098

申请日：2022-05-05

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Karim HAROUD ,  Beat WYSS ,  Hans BERNHARD ,  Jean-Noël FEHR ,  Patrizia WEBER ,  Moritz HAEBERLI ,  Amitava GUPTA

IPC: A61N5/06 ,  G02B27/30 ,  G02B27/01

Abstract: A device to stimulate the retina comprises one or more light sources coupled to one or more optical elements. The one or more optical elements is configured to illuminate the retina with one or more images at a location away from a fovea of a wearer. In some embodiments, each of the one or more images comprises a depth of focus and a spatial resolution. The one or more images can be formed at a distance anterior to the retina, at a distance posterior to the retina or on the retina. In some embodiments, the depth of focus is less than the distance, and the spatial resolution greater than a spatial resolution of the retina at the location.

公开(公告)号：US11366341B1

公开(公告)日：2022-06-21

申请号：US17302479

申请日：2021-05-04

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Philip M. Buscemi ,  Pascal Loser ,  Ben Crook ,  Massimo Pinazza ,  Jim Niebanck ,  James Phillips ,  Stefan Bauer

IPC: G02C5/14 ,  G02C7/08 ,  G02C11/00

Abstract: An electronic case for electronic spectacles may include a base comprising a cavity formed therein. A first spectacle retention device may be located within the cavity. The first spectacle retention device may be configured to retain spectacles. An electrical control system may be included. An electrical connector may be configured to couple the electrical control system in electronic communication with the spectacles.

公开(公告)号：USD950618S1

公开(公告)日：2022-05-03

申请号：US29718289

申请日：2019-12-23

Applicant: ACUCELA INC.

Designer： Karim Haroud ,  Matthias Pfister ,  Jean-Christophe Roulet ,  Stefan Troller ,  Jacob Schubert

公开(公告)号：US20220024915A1

公开(公告)日：2022-01-27

申请号：US17279422

申请日：2019-09-27

Applicant: ACUCELA INC.

Inventor： Mark W. ORME ,  Edison S. ZUNIGA ,  Vladimir A. KUKSA ,  Russell Stuart CRAFT ,  Eduardo Moreno SAVEEDRA ,  Johannes Wilhelm Georg MEISSNER ,  Jacobus Antonius Joseph den HARTOG ,  Albert Cornelis DROS

IPC: C07D471/04 ,  C07D487/04

Abstract: Provided herein are compounds and methods of use thereof for the modulation of VAP-1 activity.

公开(公告)号：US20210389607A1

公开(公告)日：2021-12-16

申请号：US17303889

申请日：2021-06-09

Applicant: ACUCELA INC.

Inventor： Philip M. BUSCEMI ,  Ryo KUBOTA

IPC: G02C7/04 ,  G02B27/01 ,  G02C7/14

Abstract: Systems, devices, apparatuses and methods for an active projection system that may be incorporated into spectacles, contact lenses or provided as an add-on layer to existing spectacles or lenses. The active projection system operates to generate a stimulus or stimuli for viewing by a person's eye. The stimulus or stimuli creates an image that is defocused in front of the person's retina and can assist in slowing or stopping the progression of myopia or other refractive errors in the person.

公开(公告)号：US20210382326A1

公开(公告)日：2021-12-09

申请号：US17304630

申请日：2021-06-23

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Philip M. BUSCEMI ,  Amitava GUPTA ,  Stefan BAUER ,  Benjamin CROOK ,  Julien SAUVET

IPC: G02C7/08 ,  G02C7/06 ,  G02C7/02 ,  G02C7/14 ,  G02C7/10

Abstract: An apparatus to treat refractive error of an eye comprises an optic comprising an optical zone and a peripheral defocus optical structure to form images of a plurality of stimuli anterior or posterior to a peripheral portion of a retina of the eye. In some embodiments, the peripheral defocus optical structure located outside the optical zone. In some embodiments, the peripheral defocus optical structure comprises optical power to focus light to a different depth of the eye than the optical zone. In some embodiments, the optic comprises one or more of a lens, an optically transparent substrate, a beam splitter, a prism, or an optically transmissive support.