公开(公告)号：US20220404641A1

公开(公告)日：2022-12-22

申请号：US17823208

申请日：2022-08-30

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Philip M. BUSCEMI ,  Amitava GUPTA ,  Stefan BAUER ,  Benjamin CROOK ,  Julien SAUVET

IPC: G02C7/08 ,  G02C7/06 ,  G02C7/14 ,  G02C7/10 ,  G02C7/02

Abstract: An apparatus to treat refractive error of an eye comprises an optic comprising an optical zone and a peripheral defocus optical structure to form images of a plurality of stimuli anterior or posterior to a peripheral portion of a retina of the eye. In some embodiments, the peripheral defocus optical structure located outside the optical zone. In some embodiments, the peripheral defocus optical structure comprises optical power to focus light to a different depth of the eye than the optical zone. In some embodiments, the optic comprises one or more of a lens, an optically transparent substrate, a beam splitter, a prism, or an optically transmissive support.

公开(公告)号：US20220390768A1

公开(公告)日：2022-12-08

申请号：US17821079

申请日：2022-08-19

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Amitava GUPTA

IPC: G02C7/08 ,  G02F1/29

Abstract: An apparatus to treat refractive error of an eye comprises an electroactive component configured to switch between a light scattering or optical power providing configuration to treat refractive error of the eye and a substantially transparent configuration to allow normal viewing. The electroactive component can be located on the lens away from a central axis of the lens to provide light to a peripheral region of the retina to decrease the progression of myopia. The electroactive component can be located on the lens away from the central axis of the lens in order for the wearer to view objects through an optical zone while the electroactive component scatters light. The electroactive component can be configured to switch to the substantially transparent configuration to allow light to pass through the electroactive component and to allow the lens to refract light to correct vision and allow normal viewing through the lens.

公开(公告)号：US20210382325A1

公开(公告)日：2021-12-09

申请号：US17304691

申请日：2021-06-24

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Nabin JOSHI ,  Arkady SELENOW ,  Steve ALI ,  Stefan BAUER ,  Jean-Noël FEHR ,  Moritz HAEBERLI ,  Patrizia WEBER ,  Julien SAUVET ,  Amitava GUPTA

IPC: G02C7/06 ,  G02C11/04 ,  G02C7/02

Abstract: An apparatus to treat refractive error of the eye comprises one or more optics configured to project stimuli comprising out of focus images onto the peripheral retina outside the macula. While the stimuli can be configured in many ways, in some embodiments the stimuli are arranged to decrease interference with central vison such as macular vision. The stimuli can be out of focus images may comprise an amount of defocus within a range from about 3 Diopters (“D”) to about 6 D. In some embodiments, the brightness of the stimuli is greater than a brightness of background illumination by an appropriate amount such as at least 3 times the background brightness. In some embodiments, each of a plurality of stimuli comprises a spatial frequency distribution with an amplitude profile having spatial frequencies within a range from about range of 1×10−1 to 2.5×101 cycles per degree.

公开(公告)号：US20230324717A1

公开(公告)日：2023-10-12

申请号：US18330010

申请日：2023-06-06

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Philip M. BUSCEMI ,  Amitava GUPTA ,  Stefan BAUER ,  Benjamin CROOK ,  Julien SAUVET

IPC: G02C7/08 ,  G02C7/06 ,  G02C7/14 ,  G02C7/10 ,  G02C7/02

CPC classification number: G02C7/08 ,  G02C7/06 ,  G02C7/14 ,  G02C7/10 ,  G02C7/022 ,  G02C2202/24

Abstract: An apparatus to treat refractive error of an eye comprises an optic comprising an optical zone and a peripheral defocus optical structure to form images of a plurality of stimuli anterior or posterior to a peripheral portion of a retina of the eye. In some embodiments, the peripheral defocus optical structure located outside the optical zone. In some embodiments, the peripheral defocus optical structure comprises optical power to focus light to a different depth of the eye than the optical zone. In some embodiments, the optic comprises one or more of a lens, an optically transparent substrate, a beam splitter, a prism, or an optically transmissive support.

公开(公告)号：US20230144121A1

公开(公告)日：2023-05-11

申请号：US18153000

申请日：2023-01-11

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Karim HAROUD ,  Beat WYSS ,  Hans BERNHARD ,  Jean-Noel FEHR ,  Patrizia WEBER ,  Moritz HAEBERLI ,  Amitava GUPTA

IPC: A61N5/06 ,  G02B27/30 ,  G02B27/01

CPC classification number: A61N5/0622 ,  G02B27/30 ,  G02B27/0172 ,  A61N2005/063 ,  A61N2005/0648 ,  A61N2005/0652 ,  A61N2005/0663 ,  G02B2027/0178

Abstract: A device to stimulate the retina comprises one or more light sources coupled to one or more optical elements. The one or more optical elements is configured to illuminate the retina with one or more images at a location away from a fovea of a wearer. In some embodiments, each of the one or more images comprises a depth of focus and a spatial resolution. The one or more images can be formed at a distance anterior to the retina, at a distance posterior to the retina or on the retina. In some embodiments, the depth of focus is less than the distance, and the spatial resolution greater than a spatial resolution of the retina at the location.

公开(公告)号：US20230063265A1

公开(公告)日：2023-03-02

申请号：US17904450

申请日：2021-02-19

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Patrizia WEBER ,  Marco BURGENER ,  Jonas BUTSCHER ,  Praveenth SANMUGARAJAH ,  Hans BERNHARD ,  Amitava GUPTA

IPC: H02J50/10 ,  H02J50/40 ,  H02J7/00 ,  G02C7/04 ,  G02C11/00 ,  A45C11/00 ,  A45C15/00

Abstract: A contact lens charging case comprises a container sized and shaped to receive an electronic contact lens (“eCL”) and charging coil to couple to a coil of the eCL. In some embodiments, the charging coil comprises a diameter larger than a diameter of the coil of the eCL, so as to decrease sensitivity of the location and orientation of the eCL in the container and improve coupling between the coils. In some embodiments, the charging coil is dimensioned so as to extend at least partially around the container that receives the eCL.

公开(公告)号：US20220382076A1

公开(公告)日：2022-12-01

申请号：US17753773

申请日：2020-09-15

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Jean-Noël FEHR ,  Hans BERNHARD ,  Patrizia WEBER ,  Alain SAURER ,  Amitava GUPTA

IPC: G02C7/04 ,  G02C11/00 ,  G02C11/04

Abstract: An opto-electronic module is configured to fit between anterior and posterior surfaces of a contact lens. The opto-electronics module may comprise a plurality of light sources configured to direct a plurality of light beams to a region of the retina away from the fovea and in some embodiments away from the macula. Each of the plurality of light sources may comprises an LED and one or more projection optics. Each of the projection optics can be coupled to an LED with an adhesive prior to placing the opto-electronics module on a layer of contact lens material. The opto-electronics module may comprise a flex PCB with the plurality of light sources, an antenna, a battery, a capacitor and a processor supported on the flex PCB.

公开(公告)号：US20220257972A1

公开(公告)日：2022-08-18

申请号：US17662098

申请日：2022-05-05

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Karim HAROUD ,  Beat WYSS ,  Hans BERNHARD ,  Jean-Noël FEHR ,  Patrizia WEBER ,  Moritz HAEBERLI ,  Amitava GUPTA

IPC: A61N5/06 ,  G02B27/30 ,  G02B27/01

Abstract: A device to stimulate the retina comprises one or more light sources coupled to one or more optical elements. The one or more optical elements is configured to illuminate the retina with one or more images at a location away from a fovea of a wearer. In some embodiments, each of the one or more images comprises a depth of focus and a spatial resolution. The one or more images can be formed at a distance anterior to the retina, at a distance posterior to the retina or on the retina. In some embodiments, the depth of focus is less than the distance, and the spatial resolution greater than a spatial resolution of the retina at the location.

公开(公告)号：US20210382326A1

公开(公告)日：2021-12-09

申请号：US17304630

申请日：2021-06-23

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Philip M. BUSCEMI ,  Amitava GUPTA ,  Stefan BAUER ,  Benjamin CROOK ,  Julien SAUVET

IPC: G02C7/08 ,  G02C7/06 ,  G02C7/02 ,  G02C7/14 ,  G02C7/10

Abstract: An apparatus to treat refractive error of an eye comprises an optic comprising an optical zone and a peripheral defocus optical structure to form images of a plurality of stimuli anterior or posterior to a peripheral portion of a retina of the eye. In some embodiments, the peripheral defocus optical structure located outside the optical zone. In some embodiments, the peripheral defocus optical structure comprises optical power to focus light to a different depth of the eye than the optical zone. In some embodiments, the optic comprises one or more of a lens, an optically transparent substrate, a beam splitter, a prism, or an optically transmissive support.

公开(公告)号：US20230414097A1

公开(公告)日：2023-12-28

申请号：US18452350

申请日：2023-08-18

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Philip M. BUSCEMI ,  Matthias PFISTER ,  Stephan WYDER ,  Amitava GUPTA

IPC: A61B3/10 ,  G01B9/02091

CPC classification number: A61B3/102 ,  G01B9/02091 ,  G01B2290/45

Abstract: An OCT axial length measurement device is configured to measure an area of the retina within a range from about 0.05 mm to about 2.0 mm. The area can be measured with a scanned measurement beam or plurality of substantially fixed measurement beams. The OCT measurement device may comprise a plurality of reference optical path lengths, in which a first optical path length corresponds to a first position of a cornea, and a second optical path length corresponds to a second position of the retina, in which the axial length is determined based on a difference between the first position and the second position. An axial length map can be generated to determine alignment of the eye with the measurement device and improve accuracy and repeatability of the measurements. In some embodiments, the OCT measurement device comprises a swept source vertical cavity surface emitting laser (“VCSEL”).