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公开(公告)号：US20220024915A1
公开(公告)日：2022-01-27
申请号：US17279422
申请日：2019-09-27
申请人： ACUCELA INC.
发明人： Mark W. ORME , Edison S. ZUNIGA , Vladimir A. KUKSA , Russell Stuart CRAFT , Eduardo Moreno SAVEEDRA , Johannes Wilhelm Georg MEISSNER , Jacobus Antonius Joseph den HARTOG , Albert Cornelis DROS
IPC分类号： C07D471/04 , C07D487/04
摘要： Provided herein are compounds and methods of use thereof for the modulation of VAP-1 activity.
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公开(公告)号：US20210387975A1
公开(公告)日：2021-12-16
申请号：US17279382
申请日：2019-09-27
申请人： ACUCELA INC.
发明人： Mark W. ORME , Edison S. ZUNIGA , Vladimir A. KUKSA , Russell Stuart CRAFT , Eduardo Moreno SAVEEDRA , Johannes Wilhelm Georg MEISSNER , Jacobus Antonius Joseph den HARTOG , Albert Cornelis DROS
IPC分类号： C07D413/12 , C07D263/56 , C07D277/64 , C07D263/58 , C07D277/82 , C07D261/20 , C07D235/08 , C07D413/04 , C07D491/107 , C07D249/18
摘要： Provided herein are compounds and methods of use thereof for the modulation of VAP-1 activity.
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公开(公告)号：US20160145198A1
公开(公告)日：2016-05-26
申请号：US14946721
申请日：2015-11-19
申请人： Acucela Inc.
发明人： Ian L. SCOTT , Vladimir A. KUKSA , Feng HONG , Ryo KUBOTA , Jennifer GAGE
IPC分类号： C07C233/25 , C07C225/06 , C07C215/08
CPC分类号： C07C233/25 , A61K31/167 , A61K31/18 , C07B59/001 , C07B2200/05 , C07C211/49 , C07C211/52 , C07C215/08 , C07C215/14 , C07C215/42 , C07C215/68 , C07C217/08 , C07C217/10 , C07C217/58 , C07C225/06 , C07C225/22 , C07C233/36 , C07C233/43 , C07C233/62 , C07C275/40 , C07C311/08 , C07C311/10 , C07C311/14 , C07C311/21 , C07C311/24 , C07C335/18 , C07C2601/08 , C07C2601/14 , C07D277/28
摘要： Provided are compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.
摘要翻译： 提供了化合物，其药物组合物，以及使用所述化合物和组合物治疗眼科疾病和病症如老年性黄斑变性和Stargardt氏病的方法。
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公开(公告)号：US20230218549A1
公开(公告)日：2023-07-13
申请号：US17817927
申请日：2022-08-05
申请人： Acucela Inc.
发明人： Ian L. SCOTT , Vladimir A. KUKSA , Mark W. ORME , Thomas L. LITTLE, JR. , Anna GALL , Feng HONG
IPC分类号： A61K31/137 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C317/28 , C07C323/25 , C07D277/24 , C07D309/06 , C07C217/20 , C07C215/20 , C07C309/06 , C07C217/84 , C07C323/33 , A61K31/165 , A61K31/222
CPC分类号： A61K31/137 , A61K31/165 , A61K31/222 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C217/84 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C309/06 , C07C317/28 , C07C323/25 , C07C323/33 , C07D277/24 , C07D309/06 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42
摘要： The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt’s Disease.
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公开(公告)号：US20210077427A1
公开(公告)日：2021-03-18
申请号：US16865195
申请日：2020-05-01
申请人： Acucela Inc.
发明人： Ian L. SCOTT , Vladimir A. KUKSA , Mark W. ORME , Thomas L. LITTLE, Jr. , Anna GALL , Feng HONG
IPC分类号： A61K31/137 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C317/28 , C07C323/25 , C07D277/24 , C07D309/06 , C07C217/20 , C07C215/20 , C07C309/06 , C07C217/84 , C07C323/33 , A61K31/165 , A61K31/222
摘要： The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
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公开(公告)号：US20180346407A1
公开(公告)日：2018-12-06
申请号：US15967080
申请日：2018-04-30
申请人： Acucela Inc.
IPC分类号： C07C215/08 , A61K31/765 , A61K31/35 , A61K31/137 , A61K45/06 , A61K31/138 , C07C323/32 , C07C217/20 , C07C211/27 , C07D309/06
摘要： Methods are provided herein for the treatment of ophthalmic diseases or conditions such as an ophthalmic disease or disorder associated with diabetes in a patient. Also provided herein are methods of treating retinopathy of prematurity in a patient. Further, provided herein are methods for treating wet age-related macular degeneration in a patient. The methods comprise administration of compounds disclosed herein to a patient in need thereof that inhibit or slow one or more signs or symptoms of such conditions.
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公开(公告)号：US20240308951A1
公开(公告)日：2024-09-19
申请号：US18379142
申请日：2023-10-11
申请人： Acucela Inc.
IPC分类号： C07C215/08 , A61K31/137 , A61K31/138 , A61K31/35 , A61K31/765 , A61K45/06 , C07C211/27 , C07C217/20 , C07C323/32 , C07D309/06
CPC分类号： C07C215/08 , A61K31/137 , A61K31/138 , A61K31/35 , A61K31/765 , A61K45/06 , C07C211/27 , C07C217/20 , C07C323/32 , C07D309/06
摘要： Methods are provided herein for the treatment of ophthalmic diseases or conditions such as an ophthalmic disease or disorder associated with diabetes in a patient. Also provided herein are methods of treating retinopathy of prematurity in a patient. Further, provided herein are methods for treating wet age-related macular degeneration in a patient. The methods comprise administration of compounds disclosed herein to a patient in need thereof that inhibit or slow one or more signs or symptoms of such conditions.
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公开(公告)号：US20230295140A1
公开(公告)日：2023-09-21
申请号：US18201715
申请日：2023-05-24
申请人： Acucela Inc.
发明人： Mark W. ORME , Edison S. ZUNIGA , Vladimir A. KUKSA , Russell Stuart CRAFT , Eduardo Moreno SAVEEDRA , Johannes Wilhelm Georg MEISSNER , Jacobus Antonius Joseph den HARTOG , Albert Cornelis DROS
IPC分类号： C07D413/12 , C07D235/08 , C07D249/18 , C07D261/20 , C07D263/56 , C07D263/58 , C07D277/64 , C07D277/82 , C07D413/04 , C07D491/107
CPC分类号： C07D413/12 , C07D235/08 , C07D249/18 , C07D261/20 , C07D263/56 , C07D263/58 , C07D277/64 , C07D277/82 , C07D413/04 , C07D491/107
摘要： Provided herein are compounds and methods of use thereof for the modulation of VAP-1 activity.
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公开(公告)号：US20210171435A1
公开(公告)日：2021-06-10
申请号：US16934715
申请日：2020-07-21
申请人： Acucela Inc.
IPC分类号： C07C215/08 , C07C323/32 , A61K31/35 , A61K31/138 , A61K45/06 , C07C211/27 , A61K31/765 , C07C217/20 , C07D309/06 , A61K31/137
摘要： Methods are provided herein for the treatment of ophthalmic diseases or conditions such as an ophthalmic disease or disorder associated with diabetes in a patient. Also provided herein are methods of treating retinopathy of prematurity in a patient. Further, provided herein are methods for treating wet age-related macular degeneration in a patient. The methods comprise administration of compounds disclosed herein to a patient in need thereof that inhibit or slow one or more signs or symptoms of such conditions.
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公开(公告)号：US20190183816A1
公开(公告)日：2019-06-20
申请号：US16043019
申请日：2018-07-23
申请人： Acucela Inc.
发明人： Ian L. SCOTT , Vladimir A. KUKSA , Mark W. ORME , Thomas L. LITTLE, JR. , Anna GALL , Feng HONG
IPC分类号： A61K31/137 , C07C317/28 , C07C217/84 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , A61K31/222 , A61K31/165 , C07C323/33 , C07C215/20 , C07D309/06 , C07D277/24 , C07C323/25 , C07C309/06 , C07C279/08 , C07C251/86 , C07C235/08 , C07C233/18 , C07C229/38 , C07C225/16 , C07C217/72
CPC分类号： A61K31/137 , A61K31/165 , A61K31/222 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C217/84 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C309/06 , C07C317/28 , C07C323/25 , C07C323/33 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07D277/24 , C07D309/06
摘要： The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
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