公开(公告)号：US08601544B1

公开(公告)日：2013-12-03

申请号：US13333233

申请日：2011-12-21

申请人： Peter A. Robinson ,  Eric Andrew Young ,  Michael Foley

发明人： Peter A. Robinson ,  Eric Andrew Young ,  Michael Foley

IPC分类号： H04L29/06

CPC分类号： H04L63/101 ,  G06F21/44

摘要： A first machine (e.g., server VM) authenticates an untrusted second machine (e.g., new client VM) as a condition to performing or allowing a protected operation. An authentication identifier is written to a file of a file system using one mechanism, and then read from the file using another mechanism. One of the mechanisms is an untrusted mechanism employing the untrusted second machine, while the other is a trusted mechanism performed by the first machine either alone or in combination with a trusted management component that has privileged access to the file system. If the written and read values match, it can be inferred that the second machine is authentic, because the trusted management component has identified and accessed an existing file system that is also separately accessed by the second machine.

摘要翻译： 第一机器（例如，服务器VM）将不可信的第二机器（例如，新的客户机VM）认证为执行或允许受保护的操作的条件。 使用一种机制将认证标识符写入文件系统的文件，然后使用其他机制从文件读取。 其中一种机制是采用不受信任的第二机器的不受信任的机制，而另一种是由第一机器单独执行或与具有对文件系统的特权访问的可信管理组件的可信机制。 如果写入和读取值匹配，则可以推断出第二机器是真实的，因为可信管理组件已经识别并访问也被第二机器单独访问的现有文件系统。

公开(公告)号：US20130034428A1

公开(公告)日：2013-02-07

申请号：US13197532

申请日：2011-08-03

申请人： Daniel Edward Jordy ,  William Edward Adis ,  Bernard Arthur Couture, JR. ,  Dexter Andrew Young

发明人： Daniel Edward Jordy ,  William Edward Adis ,  Bernard Arthur Couture, JR. ,  Dexter Andrew Young

IPC分类号： F04D29/08

CPC分类号： F01D11/02 ,  F01D11/025 ,  F05D2220/31 ,  F05D2230/642 ,  F05D2250/37 ,  F05D2260/36 ,  F16J15/442

摘要： Systems and devices for sealing portions of a rotary machine are disclosed. In one embodiment, a seal assembly element includes: a head flange; an axial neck connected to the head flange, wherein the axial neck includes a mating flange extending circumferentially from a distal end of the seal assembly element, the mating flange configured to form a multidirectional seal with a recessed portion of a complementary seal assembly element; and a set of axial seal teeth connected to the axial neck.

摘要翻译： 公开了用于密封旋转机器的部分的系统和装置。 在一个实施例中，密封组件元件包括：头凸缘; 连接到头部凸缘的轴向颈部，其中所述轴向颈部包括从所述密封组件元件的远端周向延伸的配合凸缘，所述配合凸缘被配置成与互补密封组件元件的凹部形成多向密封; 以及一组轴向密封齿连接到轴向颈部。

公开(公告)号：US08366650B2

公开(公告)日：2013-02-05

申请号：US12084069

申请日：2006-10-24

申请人： Andrew Young

发明人： Andrew Young

IPC分类号： A61M5/00

CPC分类号： A61M27/002 ,  A61F2002/041 ,  A61M27/008

摘要： Provided is a shunt device that promotes stimulation of secretion of intestinal L-cells and other enteroendocrine cell types. Enteroendocrine secretion is stimulated directly or indirectly by shunting bile and/or pancreatic secretion to segments of the gut more distal than would normally occur The shunt device may be a flexible catheter that is impervious to such secretions, with a proximal end draining the pancreatic/bile duct, and a distal end residing distally within the lumen of the small or large intestine. The shunt may be inserted with minimally invasive techniques, such as by endoscopy.

摘要翻译： 提供了促进肠L细胞和其他肠内分泌细胞类型的分泌刺激的分流装置。 通过将胆汁和/或胰腺分泌物分流到比通常发生的更远端的肠段，直接或间接刺激肠内分泌分泌。分流装置可以是不透过这种分泌物的柔性导管，其中近端排出胰腺/胆汁 导管，以及远端位于小肠或大肠的内腔内的远端。 分流可以用微创技术插入，例如通过内窥镜检查。

公开(公告)号：US20100106475A1

公开(公告)日：2010-04-29

申请号：US12375354

申请日：2007-08-03

申请人： Nicolas Peter Smith ,  David Mortimer Budgett ,  Peter John Hunter ,  Duane Tearaitoa Kingwell Malcolm ,  Leo Koon-Wah Cheng ,  Martyn Peter Nash ,  Poul Michael Fonss Nielsen ,  Andrew John Pullan ,  Alistair Andrew Young ,  Oliver Roehrle

发明人： Nicolas Peter Smith ,  David Mortimer Budgett ,  Peter John Hunter ,  Duane Tearaitoa Kingwell Malcolm ,  Leo Koon-Wah Cheng ,  Martyn Peter Nash ,  Poul Michael Fonss Nielsen ,  Andrew John Pullan ,  Alistair Andrew Young ,  Oliver Roehrle

IPC分类号： G06F17/30 ,  G06G7/60

CPC分类号： G16H50/50 ,  G06F19/321 ,  G16H10/60

摘要： A biophysical virtual model of a body or body section of a human subject contains measured parameter values, scan data and images from surface or full body imaging systems, and also descriptive and subject identification data. Data in the model are applied to customize external objects ergonomically to fit a subject, by adjustment or by selection when the objects are configured for one or a group of subjects. The database can be centralized and/or mobile devices carried by users can supply model data to external apparatus. Where a parameter value needed for a subject is unknown, the statistical distribution of the database and the correlation of parameters can supply a probable value and level of certainty. In connection with values that are known for an individual, complexities inherent in the combination of plural parameters can be collected in the model and used in later security screens to confirm the identity of a subject.

摘要翻译： 人类受试者身体或身体部位的生物物理虚拟模型包含来自表面或全身成像系统的测量参数值，扫描数据和图像，以及描述性和主体识别数据。 模型中的数据应用于根据人体工程学来定制外部对象，以便在对象配置为一个或一组主题时通过调整或通过选择来适应主体。 数据库可以是集中式的和/或用户携带的移动设备可以将模型数据提供给外部设备。 如果一个主题所需的参数值是未知的，数据库的统计分布和参数的相关性可以提供可能的价值和确定性水平。 关于个人已知的值，可以在模型中收集多个参数的组合中固有的复杂性，并在后来的安全屏幕中使用以确认主体的身份。

公开(公告)号：US07285324B1

公开(公告)日：2007-10-23

申请号：US09670529

申请日：2000-09-27

申请人： Yannick Albertone ,  Mark Andrew Young ,  Jacques Gilbert ,  George Ostapchenko

发明人： Yannick Albertone ,  Mark Andrew Young ,  Jacques Gilbert ,  George Ostapchenko

IPC分类号： B32B7/02 ,  B32B27/32 ,  B32B5/18 ,  B32B27/12

CPC分类号： B32B27/12 ,  Y10T428/2495 ,  Y10T442/2139 ,  Y10T442/2738 ,  Y10T442/3854 ,  Y10T442/3862 ,  Y10T442/3886 ,  Y10T442/674 ,  Y10T442/675 ,  Y10T442/676 ,  Y10T442/678

摘要： A substantially liquid impermeable moisture vapor permeable laminate structure comprising: (i) a substrate layer comprising a woven or non-woven material, (ii) a moisture vapor control layer attached to said substrate, (iii) a tie layer comprising one or more copolymers comprising from about 30 to about 90 weight percent ethylene co-monomer units and from about 10 to about 70 weight percent vinyl acetate co-monomer units, and (iv) a layer comprising one or more copolyetherester(s) in an amount of at least 50 weight percent based on the total amount of polymer in the layer. The moisture vapor transmission rate (MVTR) in the direction away from the copolyetherester-containing layer and tie layer and towards the substrate is preferably greater than the MVTR in the direction away from the substrate layer and towards the tie layer and copolyetherester-containing layer.

摘要翻译： 一种基本上液体不透水蒸气渗透层压结构，包括：（i）包含织造或非织造材料的基底层，（ii）附着到所述基底上的湿气控制层，（iii）包含一种或多种共聚物 包含约30至约90重量％的乙烯共聚单体单元和约10至约70重量％的乙酸乙烯酯共聚单体单元，和（iv）至少包含一种或多种共聚醚酯的层 基于该层中聚合物的总量的50重量％。 在离开含有共聚醚酯层的层和粘结层和朝向衬底的方向上的湿气透过率（MVTR）优选大于在远离衬底层的方向并且朝向粘结层和含共聚醚酯的层的MVTR。

公开(公告)号：US20060183677A1

公开(公告)日：2006-08-17

申请号：US10522103

申请日：2003-05-28

申请人： Andrew Young ,  Orville Kolterman

发明人： Andrew Young ,  Orville Kolterman

IPC分类号： A61K38/22 ,  A61K9/22

CPC分类号： A61K9/0019 ,  A61K9/0043 ,  A61K9/0056 ,  A61K9/006 ,  A61K9/0073 ,  A61K38/00 ,  C07K14/57563

摘要： Novel exendin and exendin agonist compound formulations and dosages and methods of administration thereof are provided. These compositions and methods are useful in treating diabetes and conditions that would be benefited by lowering plasma glucose or delaying and/or slowing gastric emptying or inhibiting food intake.

公开(公告)号：US20060106705A1

公开(公告)日：2006-05-18

申请号：US11319981

申请日：2005-12-28

申请人： Andrew Young ,  Evan Tick ,  Robert Towse ,  Yoon Chang ,  Roy Campbell ,  Joan Tse ,  Stephen Reddy ,  Young-Sup Lee ,  John Scowcroft

发明人： Andrew Young ,  Evan Tick ,  Robert Towse ,  Yoon Chang ,  Roy Campbell ,  Joan Tse ,  Stephen Reddy ,  Young-Sup Lee ,  John Scowcroft

IPC分类号： G06Q40/00

CPC分类号： G06Q40/00 ,  G06Q40/04 ,  G06Q40/06

摘要： Computer technology for substantially optimizing portfolios of multiple participants is disclosed. Preferably the portfolios of such multiple participants comprise fixed income instruments. The disclosed systems and methods include using at least one computer system for storing digital data representing portfolio holdings of multiple parties and, in particular, for each participant storing in the computer memory data representing constraints with respect to the desired portfolio. The method and system comprise optimizing using an optimization engine portfolio and constraint information of multiple participants so as to generate a set of trades that would substantially optimize participants portfolios with respect to a known objective.

公开(公告)号：US20050267034A1

公开(公告)日：2005-12-01

申请号：US11174089

申请日：2005-06-30

申请人： Kathryn Prickett ,  Andrew Young

发明人： Kathryn Prickett ,  Andrew Young

IPC分类号： A61K38/22 ,  A61K47/48 ,  C07K14/47

CPC分类号： C07K14/605 ,  A61K47/60

摘要： Novel modified exendins and exendin agonists having an exendin or exendin agonist linked to one or more polyethylene glycol polymers, for example, and related formulations and dosages and methods of administration thereof are provided. These modified exendins and exendin agonists, compositions and methods are useful in treating diabetes and conditions that would be benefited by lowering plasma glucose or delaying and/or slowing gastric emptying or inhibiting food intake.

摘要翻译： 提供了具有与一种或多种聚乙二醇聚合物连接的毒蜥外泌肽或毒蜥外泌激素的新型修饰的毒蜥外泌肽和毒蜥外泌肽激动剂，以及相关的制剂和剂量以及施用方法。 这些修饰的毒蜥外泌肽和毒蜥外泌肽激动剂，组合物和方法可用于治疗通过降低血浆葡萄糖或延迟和/或减缓胃排空或抑制食物摄取而受益的糖尿病和病症。

公开(公告)号：US20050070472A1

公开(公告)日：2005-03-31

申请号：US10671304

申请日：2003-09-24

申请人： Bronislava Gedulin ,  Andrew Young

发明人： Bronislava Gedulin ,  Andrew Young

IPC分类号： A61K20060101 ,  A61K38/00 ,  A61K38/17 ,  A61K38/22

CPC分类号： A61K38/22

摘要： The disclosed invention provides for the treatment of pancreatitis, and the alleviation of pain associated therewith, with amylin, amylin agonists and amylin analogs.

摘要翻译： 所公开的发明提供胰岛淀粉样多肽，胰岛淀粉样多肽激动剂和胰岛淀粉样多肽类似物治疗胰腺炎和与之相关的疼痛的缓解。

公开(公告)号：US20050043238A1

公开(公告)日：2005-02-24

申请号：US10895909

申请日：2004-07-20

申请人： Andrew Young ,  Sunil Bhavsar ,  Bronislava Gedulin

发明人： Andrew Young ,  Sunil Bhavsar ,  Bronislava Gedulin

IPC分类号： A61K45/00 ,  A61K35/56 ,  A61K38/00 ,  A61K38/17 ,  A61K38/22 ,  A61K38/23 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/00 ,  C07K14/575

CPC分类号： A61K9/0019 ,  A61K38/00 ,  A61K38/22 ,  A61K38/2207 ,  A61K38/2264 ,  A61K38/23 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/26 ,  A61K47/44 ,  C07K14/57563 ,  Y10S514/866 ,  A61K2300/00

摘要： Methods for treating conditions or disorders which can be alleviated by reducing food intake are disclosed which comprise administration of an effective amount of an exendin or an exendin agonist, alone or in conjunction with other compounds or compositions that affect satiety. The methods are useful for treating conditions or disorders, including obesity, Type II diabetes, eating disorders, and insulin-resistance syndrome. The methods are also useful for lowering the plasma glucose level, lowering the plasma lipid level, reducing the cardiac risk, reducing the appetite, and reducing the weight of subjects. Pharmaceutical compositions for use in the methods of the invention are also disclosed.

摘要翻译： 公开了通过减少食物摄入可以缓解的病症或病症的方法，其包括单独施用有效量的毒蜥外泌肽或毒蜥外泌肽激素，或与影响饱腹感的其它化合物或组合物联合施用。 该方法可用于治疗条件或障碍，包括肥胖，II型糖尿病，进食障碍和胰岛素抵抗综合征。 该方法对于降低血浆葡萄糖水平，降低血浆脂质水平，降低心脏风险，降低食欲和降低受试者的体重也是有用的。 还公开了用于本发明方法的药物组合物。