公开(公告)号：US09995510B2

公开(公告)日：2018-06-12

申请号：US15418233

申请日：2017-01-27

Applicant: Bruker BioSpin GmbH

Inventor： Patrick Wikus ,  Steffen Bonn ,  Gerhard Roth

IPC: F25B9/14 ,  F25B9/10

CPC classification number: F25B9/145 ,  F25B9/10 ,  F25B2309/006 ,  F25B2309/1418 ,  F25B2309/14181 ,  F25B2500/13 ,  G01R33/3804 ,  G01R33/3815

Abstract: A connecting device in a pulse tube cooler system branches such that a first line branch (11) has a first flexible line segment (4a) and a second line branch (12) has a second flexible line segment (4b), the flexible line segments being arranged in parallel with and offset from one another. The flexible line segments each have a front segment end (17, 18) and a rear segment end (19, 20), the front segment end (17) of the first flexible line segment (4a) and the rear segment end (20) of the second flexible line segment (4b) are rigidly connected to one another, the rear segment end (19) of the first flexible line segment (4a) and the front segment end (18) of the second flexible line segment (4b) are rigidly connected to one another, and there is no continuous rigid connection between the control valve and the cold head.

公开(公告)号：US20180038925A1

公开(公告)日：2018-02-08

申请号：US15669465

申请日：2017-08-04

Applicant: Bruker BioSpin GmbH

Inventor： Michael MAIXNER

IPC: G01R33/36

CPC classification number: G01R33/3657 ,  G01R33/36 ,  G01R33/3607 ,  G01R33/3621 ,  G01R33/3628 ,  G01R33/3642

Abstract: A high-frequency interface circuit to direct transmitted signals to a connector (PR) for a HF arrangement in a transmit mode via an input (TX) of the high-frequency interface circuit and received signals from the connector (PR) to a receiver system in a receive mode via an output (RX) of the high-frequency interface circuit is presented. The circuit includes a transmit path (SP) linking the input (TX) to the connector (PR) and a receive path (EP) linking the connector (PR) to the output (RX). The receive path (EP) includes a first circuit (K1), with at least a first switching element (S1) that is electro-conductive in transmit mode and is electrically insulating in receive mode, connected to the connector (PR). In transmit mode, the first circuit (K1) forms two parallel resonance circuits connected in series, while in receive mode, the first circuit (K1) includes two series resonance circuits connected in parallel.

公开(公告)号：US20170322270A1

公开(公告)日：2017-11-09

申请号：US15587447

申请日：2017-05-05

Applicant: Bruker BioSpin GmbH

Inventor： Patrick WIKUS ,  Volker NIEMANN ,  Wolfgang FRANTZ ,  Michael DUMM ,  Michael WAGENKNECHT ,  Steffen BONN

IPC: G01R33/3873 ,  G01R33/3815 ,  G01R33/38

CPC classification number: G01R33/3873 ,  G01R33/28 ,  G01R33/3804 ,  G01R33/3815

Abstract: An arrangement for setting the spatial profile of a magnetic field in a working volume of a main field magnet (2), in particular a superconducting main field magnet, of a magnetic resonance installation. The main field magnet is arranged in a cryostat (1) and the spatial profile is set by a passive shim apparatus (3) with magnetic field forming elements which are arranged within the cryostat during operation and which have cryogenic temperatures. The magnetic resonance installation contains a room temperature tube (4), in which the sample volume is situated during operation. The passive shim apparatus is introduced into or removed from the cold region of the cryostat via a vacuum lock (5), without needing to ventilate the cold region of the cryostat. This provides a relatively simple, cost effective, and time-efficient method to carry out a stable field homogenization using a passive shim apparatus.

公开(公告)号：US09620273B2

公开(公告)日：2017-04-11

申请号：US13967380

申请日：2013-08-15

Applicant: Bruker BioSpin GmbH

Inventor： Arne Kasten

IPC: H01F6/06 ,  G01R33/3815

CPC classification number: H01F6/06 ,  G01R33/3815

Abstract: A magnet system generates a highly stable magnetic field at a sample location. The magnet system has a magnet cryostat housing a first superconducting magnet coil and a second magnet coil co-axial to the first magnet coil. The second magnet coil is short-circuited in a superconducting persistent mode during operation of the magnet system. An external power supply during operation supplies current to the first magnet coil via a current lead thereby generating a first magnetic field at the sample location that fluctuates according to the current noise of the power supply, wherein the second magnet coil is positioned and dimensioned in a way that it inductively couples to the first magnet coil such that it generates at the sample location a second magnetic field that compensates the fluctuations of the first magnetic field.

公开(公告)号：US09476848B1

公开(公告)日：2016-10-25

申请号：US15071331

申请日：2016-03-16

Applicant: Bruker BioSpin GmbH

Inventor： Martin Hofmann

IPC: G01N24/08 ,  G01R33/31 ,  G01R33/30 ,  G01R33/46

CPC classification number: G01N24/08 ,  G01N24/088 ,  G01R33/307 ,  G01R33/31 ,  G01R33/46

Abstract: Monitoring cell (100) for performing an NMR measurement of a reaction fluid. The monitoring cell (100) has a hollow NMR sample probe (110) for receiving the reaction fluid. Inlet and outlet transport capillaries (112, 123) transport the reaction fluid to and from the sample probe (110). A feed line (306) and return line transport a temperature control fluid to and from the monitoring cell (100). An adapter head (108) couples the transport capillaries (112, 123) to the sample probe (110) and removably connects the sample probe (110) to an adapter section (106). The transport capillaries (112, 123) are positioned within the feed line (306) in parallel to one another. The feed and the return lines (306, 358) are attached to the adapter section (106) such that a reversal of the temperature control fluid stream occurs in the adapter section (106).

Abstract translation: 监测细胞（100），进行反应液的NMR测定。 监测电池（100）具有用于接收反应流体的中空NMR试样探针（110）。 入口和出口运输毛细管（112,123）将反应流体运送到样品探针（110）和从样品探针（110）传送。 馈送线（306）和返回线将温度控制流体传送到监测电池（100）和从监测电池（100）传送温度控制流体。 适配器头（108）将传送毛细管（112,123）耦合到样品探针（110）并将样品探针（110）可移除地连接到适配器部分（106）。 运输毛细管（112,123）彼此平行地定位在进料管线（306）内。 馈送和返回线（306,358）连接到适配器部分（106），使得温度控制流体流的逆转发生在适配器部分（106）中。

公开(公告)号：US20160274200A1

公开(公告)日：2016-09-22

申请号：US15063536

申请日：2016-03-08

Applicant: Bruker BioSpin GmbH

Inventor： Ion Prisecaru ,  Peter Hoefer

IPC: G01R33/343 ,  H01P7/10 ,  G01R33/60

CPC classification number: G01R33/343 ,  G01R33/345 ,  G01R33/60 ,  H01P7/10

Abstract: A microwave resonator for an EPR probe head has a metal cavity body (1) supporting an electromagnetic microwave resonance mode. The metal cavity body (1) has an opening for inserting a sample tube (2) to a center position of the resonator. The center of the opening and the center position of the resonator define an x-axis. The cavity body also has an opening for transmitting microwave radiation into the resonator. Two dielectric elements (4a, 4b) are located symmetrically to the E-field nodal plane containing the x-axis and a z-axis perpendicular to the x-axis. Each dielectric element is geometrically formed and positioned such that it provides an equal overlap with a local maximum of the microwave electric field energy. The microwave resonant cavity has a thin planar shape and the resonator is loaded with two dielectric elements, placed symmetrically relative to the central EPR sample.

Abstract translation: 用于EPR探针头的微波谐振器具有支撑电磁微波谐振模式的金属腔体（1）。 金属腔体（1）具有用于将样品管（2）插入到谐振器的中心位置的开口。 开口的中心和谐振器的中心位置定义了x轴。 空腔体还具有用于将微波辐射传输到谐振器中的开口。 两个电介质元件（4a，4b）对称地位于包含x轴和垂直于x轴的z轴的电场节点平面。 每个电介质元件被几何地形成和定位成使得其提供与微波电场能的局部最大值相等的重叠。 微波谐振腔具有薄的平面形状，并且谐振器装载有相对于中央EPR样本对称放置的两个电介质元件。

公开(公告)号：US20160195593A1

公开(公告)日：2016-07-07

申请号：US14910706

申请日：2014-07-23

Applicant: BRUKER BIOSPIN GMBH

Inventor： Armin Purea ,  Frank Engelke ,  Alexander Krahn

IPC: G01R33/345 ,  G01R33/28 ,  G01N24/08 ,  G01R33/30

CPC classification number: G01R33/345 ,  G01N24/08 ,  G01R33/282 ,  G01R33/307 ,  G01R33/62

Abstract: An NMR DNP-MAS probe head (10) has an MAS stator (2) for receiving an MAS rotor (3) having a sample substance in a sample volume (4), and a hollow microwave waveguide (5)′ for feeding microwave radiation through an opening (5a) of the microwave waveguide into the sample volume, an axially expanded rod-shaped microwave coupler (6) located in the opening made of dielectric material, characterized in that the microwave waveguide has a conically tapered hollow transition piece for coupling in an HE 11 mode, into which the microwave coupler projects at an all-round radial distance to the opening of the microwave waveguide. It is thus possible, in a surprisingly simple manner and by means of readily available technical means, to irradiate a considerably higher microwave energy in the HE 11 mode into the NMR measuring sample than by means of the known arrangements.

Abstract translation: NMR DNP-MAS探针头（10）具有用于接收具有样品体积（4）中的样品物质的MAS转子（3）的MAS定子（2）和用于馈送微波辐射的中空微波波导（5） 通过微波波导的开口（5a）进入样品体积，位于由电介质材料制成的开口中的轴向膨胀的棒状微波耦合器（6），其特征在于微波波导具有锥形锥形空心过渡件 在HE 11模式中，微波耦合器以与微波波导的开口全方位的径向距离突出。 因此，以令人惊讶的简单方式并且通过易于获得的技术手段，可以通过已知布置将HE 11模式中相当高的微波能量照射到NMR测量样品中。

公开(公告)号：US20040164736A1

公开(公告)日：2004-08-26

申请号：US10764981

申请日：2004-01-26

Applicant: Bruker BioSpin GmbH

Inventor： Gisela Guthausen ,  Arne Kasten

IPC: G01V003/00

CPC classification number: G01R33/44 ,  G01N24/08

Abstract: A description is given of a method for determining the content of a first component of a sample, which first component provides a first NMR signal and has a first self-diffusion coefficient D1, the sample additionally containing at least one further component which provides a further NMR signal and has a larger self-diffusion coefficient D2, in particular for determining the fat content of a hydrous sample, with the aid of a low-resolution nuclear magnetic resonance (NMR) pulse spectrometer, the sample being excited by a radio-frequency (RF) excitation pulse and being exposed to a magnetic gradient field and to a sequence of further refocusing RF pulses for generating spin echo signals, the spin echo signals being detected and their amplitude values being determined, from which a value for the content of the first component of the sample is determined. The magnetic gradient field is not switched off during the sequence of further refocusing RF pulses.

Abstract translation: 给出了用于确定样品的第一组分的含量的方法的描述，该第一组分提供第一NMR信号并且具有第一自扩散系数D1，该样品另外含有至少一个其它组分，其进一步提供 NMR信号，并且具有较大的自扩散系数D2，特别是用于通过低分辨率核磁共振（NMR）脉冲光谱仪来确定含水样品的脂肪含量，样品被射频激发 （RF）激发脉冲并且暴露于磁梯度场和进一步重新聚焦RF脉冲的序列以产生自旋回波信号，检测自旋回波信号并确定它们的振幅值，从而从其中检测出内容的值 确定样品的第一组分。 在进一步重新聚焦RF脉冲的序列期间，磁梯度场不被关闭。

公开(公告)号：US20020101240A1

公开(公告)日：2002-08-01

申请号：US10050996

申请日：2002-01-22

Applicant: Bruker BioSpin GmbH

Inventor： Arne Kasten

IPC: G01V003/00

CPC classification number: G01R33/389 ,  G01R33/3815

Abstract: The invention concerns a means and a method for stabilizing a magnetic field generated by a superconductingly short-circuited main coil located in a cryostat in the measuring volume of a high-resolution magnetic resonance spectrometer, which comprises compensation coils which are dimensioned and positioned such that they, in their entirety, are suited to largely compensate for field drifts of the superconductingly short-circuited main coil in the measuring volume. The drift compensation coils consist of HTS material and are disposed radially outside of the main coil at a higher temperature level.

Abstract translation: 本发明涉及一种用于稳定位于高分辨率磁共振光谱仪的测量体积中的低温恒温器中的超导短路主线圈所产生的磁场的方法和方法，该补偿线圈的尺寸和位置使得 它们整体上适合于大大地补偿测量体积中超导短路主线圈的场漂移。 漂移补偿线圈由HTS材料组成，并在较高的温度水平位于主线圈的径向外侧。

公开(公告)号：US20250044387A1

公开(公告)日：2025-02-06

申请号：US18793172

申请日：2024-08-02

Applicant: Bruker BioSpin GmbH

Inventor： Christian Fischer ,  Karl-Friedrich Ratzsch ,  Fabrice Moriaud

IPC: G01R33/46

Abstract: Fast quantitative NMR data acquisition for NMR scans performed on a sample is provided. Scan batches on the sample are performed, where each batch comprises a long delay scan, followed by a set of short delay scans. Each scan is associated with a corresponding scan time point in relation to the long delay scan time point of the respective scan batch. For each corresponding scan time point, aggregated NMR spectrum portions are determined showing a decay over time, which is fitted with an exponential decay function. An averaged integral loss is computed for each scan time point. For each NMR spectrum of the scan batches, an integral associated with a respective region of interest is multiplied with a corresponding correction factor. The integrals associated with the corrected NMR spectra are summed to obtain a representation of the NMR signal intensity in the region of interest for the sample.