公开(公告)号：US06551619B1

公开(公告)日：2003-04-22

申请号：US09674417

申请日：2001-01-22

Applicant: Lawrence John Penkler ,  Rainer Helmut Müller ,  Stephan Anton Runge ,  Vittorino Ravelli

Inventor： Lawrence John Penkler ,  Rainer Helmut Müller ,  Stephan Anton Runge ,  Vittorino Ravelli

IPC: A61K914

CPC classification number: A61K9/5123 ,  A61K9/1075 ,  A61K9/1617 ,  A61K38/13 ,  Y10S514/951 ,  Y10S514/969 ,  Y10S514/975 ,  Y10S977/906

Abstract: The invention relates to solid, particulate lipid-based excipients which are loaded with cyclosporine. Said excipients have improved biopharmaceutical properties for cyclosporines in vivo, are of a better quality (in terms of fineness, homogeneity of the particles, inclusion of the medicament) and are more physically stable in the particulate formulation (no aggregation or gel formation). The invention also relates to a therapeutic treatment with cyclosporine formulations which produce an average blood level concentration in the steady state range of 300 ng/ml to over 1000 ng/ml, preferably over 800 ng/ml, especially up to 900 ng/ml, preferably 400 ng/ml to 800 ng/ml in the absence of high initial blood level concentrations essentially over 1500 ng/ml, especially over 1200 ng/ml. This blood level concentration is preferably maintained for an extended period of at least 5 hours, preferably at least 7 hours.

Abstract translation: 本发明涉及负载有环孢菌素的固体颗粒状基于脂质的赋形剂。 所述赋形剂在体内具有改善的环孢菌素的生物药物性质，具有更好的质量（在细度，颗粒的均匀性，药物的包合性方面），并且在颗粒制剂中更具物理稳定性（无聚集或凝胶形成）。 本发明还涉及使用环孢菌素制剂的治疗性治疗，其在300ng / ml至超过1000ng / ml，优选超过800ng / ml，特别是至多900ng / ml的稳态范围内产生平均血液浓度， 优选400ng / ml至800ng / ml，在不存在高的初始血液浓度基本上超过1500ng / ml，特别是超过1200ng / ml的情况下。 该血液浓度优选保持至少5小时，优选至少7小时的延长时间。

公开(公告)号：US06441195B1

公开(公告)日：2002-08-27

申请号：US09710079

申请日：2000-11-09

Applicant: Klaus-Helmut Müller ,  Mark Wilhelm Drewes ,  Kurt Findeisen ,  Ernst Rudolf F. Gesing ,  Johannes R. Jansen ,  Rolf Kirsten ,  Joachim Kluth ,  Ulrich Philipp ,  Hans-Jochem Riebel ,  Markus Dollinger ,  Hans-Joachim Santel

Inventor： Klaus-Helmut Müller ,  Mark Wilhelm Drewes ,  Kurt Findeisen ,  Ernst Rudolf F. Gesing ,  Johannes R. Jansen ,  Rolf Kirsten ,  Joachim Kluth ,  Ulrich Philipp ,  Hans-Jochem Riebel ,  Markus Dollinger ,  Hans-Joachim Santel

IPC: C07D33326

CPC classification number: C07D263/34 ,  A01N43/76 ,  A01N43/82 ,  A01N43/90 ,  A01N47/38 ,  C07D249/12 ,  C07D271/06 ,  C07D333/38 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D487/04

Abstract: The invention relates to novel substituted sulphonylamino(thio)carbonyl compounds of the formula (I) in which A represents oxygen, sulphur, NH, N-alkyl, N-aryl, —CH═N—, or —N═CH— or —CH═CH—, Q represents oxygen or sulphur, R1 represents respectively optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heterocyclyl or heterocyclylalkyl, R2 represents cyano, nitro, halogen or represents respectively optionally substituted alkyl, alkoxy, alkoxycarbonyl, alkylthio, alkylsulphinyl, alkylsulphonyl, alkenyl, alkinyl, alkenyloxy or alkinyloxy, and R3 represents respectively optionally substituted heterocyclyl having 5 ring members of which at least one represents oxygen, sulphur or nitrogen and a further one to three may represent nitrogen, (except for certain individual prior art compounds), furthermore to salts of novel compounds of the formula (I), to various processes and novel intermediates for preparing the novel compounds and to their use as herbicides.

Abstract translation: 本发明涉及式（I）的新型取代磺酰基氨基（硫代）羰基化合物，其中A代表氧，硫，NH，N-烷基，N-芳基，-CH = N-或-N = CH-或-CH R 2代表氰基，硝基，卤素或分别表示任意取代的烷基，烷氧基，烷氧基羰基，烷氧基羰基，烷氧基羰基，烷氧基羰基， ，烷硫基，烷基亚磺酰基，烷基磺酰基，烯基，炔基，烯氧基或烷氧基，R 3分别表示具有5个环成员的任选取代的杂环基，其中至少一个表示氧，硫或氮，另外一个至三个可以代表氮， 各种现有技术化合物），还有式（I）的新化合物的盐，各种方法和用于制备新化合物的新中间体及其作为除草剂的用途。

公开(公告)号：US06200931B1

公开(公告)日：2001-03-13

申请号：US09242253

申请日：1999-05-13

Applicant: Klaus-Helmut Müller ,  Mark Wilhelm Drewes ,  Kurt Findeisen ,  Ernst Rudolf F. Gesing ,  Johannes Rudolf Jansen ,  Rolf Kirsten ,  Joachim Kluth ,  Ulrich Philipp ,  Hans-Jochem Riebel ,  Klaus König ,  Markus Dollinger ,  Hans-Joachim Santel

Inventor： Klaus-Helmut Müller ,  Mark Wilhelm Drewes ,  Kurt Findeisen ,  Ernst Rudolf F. Gesing ,  Johannes Rudolf Jansen ,  Rolf Kirsten ,  Joachim Kluth ,  Ulrich Philipp ,  Hans-Jochem Riebel ,  Klaus König ,  Markus Dollinger ,  Hans-Joachim Santel

IPC: A01N4388

CPC classification number: C07D413/12 ,  A01N47/38 ,  C07D413/14

Abstract: The invention relates to novel substituted sulphonylamino(thio)carbonyl compounds of the formula (I) in which A represents a single bond, represents oxygen, imino (NH), alkanediyl (alkylene) or alkylimino (N-alkyl), J represents a (hetero)aryl grouping selected from the series phenyl, pyridyl, pyrazolyl, thienyl which is substituted by a 5,6-dihydro-[1,4,2]-dioxazin-3-yl group (which may for its part be substituted by halogen, alkyl or halogenoalkyl) and optionally by one or two further radicals selected from the series cyano, halogeno, alkyl, halogenoalkyl, phenyl, pyridyl, Q represents oxygen or sulphur and, R represents optionally substituted heterocyclyl having 5 ring members of which at least one is oxygen, sulphur or nitrogen and one to three more may be nitrogen, and salts of compounds of the formula (I), processes and specific novel intermediates for their preparation and their use as herbicides.

Abstract translation: 本发明涉及式（I）的新型取代磺酰基氨基（硫代）羰基化合物，其中A代表单键，代表氧，亚氨基（NH），烷二基（亚烷基）或烷基亚氨基（N-烷基），J代表 ）芳基，其选自苯并吡啶基，吡唑基，噻吩基，其被5,6-二氢 - [1,4,2] - 二恶嗪-3-基（其可以被卤素取代）取代， 烷基或卤代烷基）和任选地一个或两个选自氰基，卤代，烷基，卤代烷基，苯基，吡啶基，Q代表氧或硫的其它基团，R代表任选取代的具有5个环成员的杂环基，其中至少一个是 氧，硫或氮，一至三个可以是氮，以及式（I）化合物的盐，其制备方法和具体的新型中间体及其作为除草剂的用途。

公开(公告)号：US09173396B2

公开(公告)日：2015-11-03

申请号：US13878193

申请日：2011-10-17

Applicant: Thomas Bretschneider ,  Adeline Köhler ,  Joachim Kluth ,  Martin Füβlein ,  Peter Jeschke ,  Reiner Fischer ,  Friedrich August Mühlthau ,  Olga Malsam ,  Arnd Voerste ,  Klaus-Helmut Müller ,  Yoshitaka Sato

Inventor： Thomas Bretschneider ,  Adeline Köhler ,  Joachim Kluth ,  Martin Füβlein ,  Peter Jeschke ,  Reiner Fischer ,  Friedrich August Mühlthau ,  Olga Malsam ,  Arnd Voerste ,  Klaus-Helmut Müller ,  Yoshitaka Sato

IPC: C07D413/14 ,  A01N43/40 ,  A01N43/54 ,  C07D401/04 ,  C07D401/14 ,  C07D413/04 ,  A01N43/56 ,  A01N43/76 ,  A01N43/78 ,  A01N43/80 ,  A01N43/82 ,  C07D403/04

CPC classification number: A01N43/76 ,  A01N43/40 ,  A01N43/54 ,  A01N43/56 ,  A01N43/647 ,  A01N43/653 ,  A01N43/78 ,  A01N43/80 ,  A01N43/82 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/14

Abstract: The present application relates to novel heterocyclic compounds, to processes for preparation thereof and to the use thereof for controlling animal pests, which also include arthropods and especially insects.

Abstract translation: 本申请涉及新型杂环化合物，其制备方法及其用于控制​​动物害虫的用途，其还包括节肢动物，特别是昆虫。

公开(公告)号：US08840909B2

公开(公告)日：2014-09-23

申请号：US13130654

申请日：2009-11-16

Applicant: Claude Taranta ,  Thomas Bork ,  Gerhard Schnabel ,  Helmut Müller ,  Sarah Thompson ,  Clark D. Klein ,  Nigel Armes ,  Tiffany Hennessey

Inventor： Claude Taranta ,  Thomas Bork ,  Gerhard Schnabel ,  Helmut Müller ,  Sarah Thompson ,  Clark D. Klein ,  Nigel Armes ,  Tiffany Hennessey

IPC: A01N25/34 ,  A01N25/00 ,  A01N43/56 ,  A01N47/34

CPC classification number: A01N25/006 ,  A01N43/56 ,  A01N47/34 ,  A01N47/02 ,  A01N2300/00

Abstract: Subject of the present invention is a solid ant bait comprising an insecticide and a bait composition. Another subject is a process for the preparation of said ant bait, comprising extruding a mixture, which contains the insecticide and the bait composition. Yet another subject is a method for controlling ants, comprising offering to said ants the ant bait according to the invention. Finally, a subject is a use of the ant bait according to the invention for controlling ants.

Abstract translation: 本发明的主题是包含杀虫剂和诱饵组合物的固体蚂蚁诱饵。 另一个主题是制备所述蚂蚁诱饵的方法，包括挤出含有杀虫剂和诱饵组合物的混合物。 另一个主题是用于控制蚂蚁的方法，包括向所述蚂蚁提供根据本发明的蚂蚁诱饵。 最后，受试者是使用根据本发明的蚂蚁诱饵来控制蚂蚁。

公开(公告)号：US20120198924A1

公开(公告)日：2012-08-09

申请号：US13502632

申请日：2010-09-09

Applicant: Bernd Last ,  Christian Pottiez ,  Bernd Uwe Stoller ,  Georg Rixecker ,  Helmut Müller

Inventor： Bernd Last ,  Christian Pottiez ,  Bernd Uwe Stoller ,  Georg Rixecker ,  Helmut Müller

IPC: G01M15/08

CPC classification number: G01L19/04 ,  G01L19/14 ,  G01L19/147 ,  G01M15/08

Abstract: The invention relates to a cylinder pressure sensor comprising a housing for clamping into a cylinder head, which carries a sensor element at a front end. According to the invention, the cylinder pressure sensor has a conical seat at the front end thereof.

Abstract translation: 本发明涉及一种气缸压力传感器，其包括用于夹紧到气缸盖中的壳体，其在前端承载传感器元件。 根据本发明，气缸压力传感器在其前端具有锥形座。

公开(公告)号：US20110190365A1

公开(公告)日：2011-08-04

申请号：US13058767

申请日：2009-08-01

Applicant: Stefan Werner ,  Klaus-Helmut Müller ,  Hans-Georg Schwarz ,  Tetsuya Murata ,  Klaus Raming ,  Ulrich Görgens ,  Angela Becker ,  Eva-Maria Franken ,  Elichi Shimojo ,  Katsuhiko Shibuya ,  Ulrich Ebbinghaus-Kintscher ,  Teruyuki Chihara ,  Masashi Ataka ,  Olga Malsam ,  Arnd Voerste

Inventor： Stefan Werner ,  Klaus-Helmut Müller ,  Hans-Georg Schwarz ,  Tetsuya Murata ,  Klaus Raming ,  Ulrich Görgens ,  Angela Becker ,  Eva-Maria Franken ,  Elichi Shimojo ,  Katsuhiko Shibuya ,  Ulrich Ebbinghaus-Kintscher ,  Teruyuki Chihara ,  Masashi Ataka ,  Olga Malsam ,  Arnd Voerste

IPC: A01N43/56 ,  C07D231/12 ,  A01P15/00

CPC classification number: C07D249/08 ,  C07C243/22 ,  C07D231/12 ,  C07D231/16 ,  C07D231/18 ,  C07D231/38 ,  C07D403/10

Abstract: The present invention relates to novel 4-phenyl-1H-pyrazoles and their use as insecticides and/or parasiticides and also to processes for their preparation and to compositions comprising such phenylpyrazoles.

Abstract translation: 本发明涉及新的4-苯基-1H-吡唑及其作为杀虫剂和/或杀寄生虫剂的用途，以及其制备方法以及包含这种苯基吡唑的组合物。

公开(公告)号：US20100279863A1

公开(公告)日：2010-11-04

申请号：US12769400

申请日：2010-04-28

Applicant: Klaus-Helmut MÜLLER ,  Christian WALDRAFF ,  Ernst Rudolf GESING ,  Guido BOJACK ,  Heinz KEHNE ,  Christopher Hugh ROSINGER ,  Dieter FEUCHT

Inventor： Klaus-Helmut MÜLLER ,  Christian WALDRAFF ,  Ernst Rudolf GESING ,  Guido BOJACK ,  Heinz KEHNE ,  Christopher Hugh ROSINGER ,  Dieter FEUCHT

IPC: A01N43/88 ,  C07D413/14 ,  C07D413/04 ,  C07D498/04 ,  A01N43/66 ,  A01N25/32 ,  A01P13/00

CPC classification number: C07D498/04 ,  A01N43/88 ,  A01N47/36 ,  C07D413/04 ,  C07D413/14

Abstract: There are described compounds of the formula (I) in which the respective substituents have the meanings given in the description. The compounds of the formula (I) can be used for example as herbicides and plant growth regulators.

Abstract translation: 描述了式（I）的化合物，其中各取代基具有在说明书中给出的含义。 式（I）化合物可用作例如除草剂和植物生长调节剂。

公开(公告)号：US20100267703A1

公开(公告)日：2010-10-21

申请号：US12654177

申请日：2009-12-11

Applicant: Bernd Alig ,  Klaus-Helmut Müller ,  Eva-Maria Franken ,  Ulrich Görgens ,  Arnd Voerste

Inventor： Bernd Alig ,  Klaus-Helmut Müller ,  Eva-Maria Franken ,  Ulrich Görgens ,  Arnd Voerste

IPC: A01N43/88 ,  C07D291/08 ,  A01P7/02 ,  A01P5/00 ,  A01P3/00 ,  A01P7/00 ,  C12P17/14

CPC classification number: C07D291/08 ,  A01N37/50 ,  A01N43/88 ,  C07D419/04

Abstract: The present invention relates to novel benzoxathiazine derivatives of the formula (I) in which R1, R2, R3, R4, R5 and R6 are each as defined in the description, to several processes for preparation thereof and to the use thereof as insecticides and/or acaricides in combination with further compositions such as penetrants and/or ammonium or phosphonium salts.

Abstract translation: 本发明涉及式（I）的新的苯并噻嗪衍生物，其中R 1，R 2，R 3，R 4，R 5和R 6各自如说明书中所定义，其几种制备方法及其作为杀虫剂和/ 或杀螨剂与其它组合物如渗透剂和/或铵或鏻盐的组合。

公开(公告)号：US20100044402A1

公开(公告)日：2010-02-25

申请号：US11916743

申请日：2006-06-14

Applicant: Manfred Winkelmann ,  Erika Winkelmann ,  Markus Fauhl ,  Jürgen Pernot ,  Helmut Müller

Inventor： Manfred Winkelmann ,  Erika Winkelmann ,  Markus Fauhl ,  Jürgen Pernot ,  Helmut Müller

IPC: B22D41/18

CPC classification number: B22D41/186

Abstract: The invention relates to a stopper for a metallurgical melting pot with. Stoppers of this type serve to control the discharge of a molten metal in the area of an outlet of an associated melting pot, for example, a tundish.

Abstract translation: 本发明涉及一种用于冶金熔化罐的塞子。 这种止动器用于控制熔融金属在相关联的熔炉例如中间包的出口区域中的排放。