公开(公告)号：US20200288680A1

公开(公告)日：2020-09-17

申请号：US16769325

申请日：2018-12-19

Applicant: Intervet Inc.

Inventor： Russel Howe ,  Zachary Lizer ,  James Wallace Sarrett ,  Peter Jon Abrahamson ,  Jascha Tucker Little

IPC: A01K61/13 ,  A01K61/60 ,  A01K63/06 ,  G05B15/02

Abstract: A method for external fish parasite monitoring in aquaculture, comprising the steps of: submerging a camera in a sea pen comprising fish; capturing images of the fish with the camera; and identifying external fish parasite on the fish by analyzing the captured images, characterized by the steps of: distinguishing between at least two different classes of external fish parasite which differ in the difficulty of recognizing the external fish parasite; calculating quality metrics for each captured image, the quality metrics permit-ting to identify the classes of external fish parasite for which the quality of the image is sufficient for lice detection.

公开(公告)号：US20200206340A1

公开(公告)日：2020-07-02

申请号：US16634756

申请日：2018-08-02

Applicant: Intervet Inc.

Inventor： Melanie SNO ,  Erik COX ,  Ruud Philip Antoon Maria SEGERS

IPC: A61K39/12

Abstract: The present invention pertains to a vaccine comprising an ORF2 encoded protein of porcine circo virus 2 (PCV2) and a pharmaceutically acceptable carrier, for use in a method to protect a pig against an infection with porcine circo virus type 2 by administering the vaccine to the pig, wherein the vaccine comprises less than 20 μg per dose of the ORF2 encoded protein, the protein being of a porcine circo virus of genotype 2b.

公开(公告)号：US20200206336A1

公开(公告)日：2020-07-02

申请号：US16634768

申请日：2018-08-02

Applicant: Intervet Inc.

Inventor： Antonius Arnoldus Christiaan JACOBS

IPC: A61K39/09

Abstract: The present invention pertains to a vaccine comprising an IgM protease antigen of Streptococcus suis, for use in a method for protecting piglets having maternally derived anti-Streptococcus suis antibodies against Streptococcus suis, by administering the vaccine to the piglets at an age of at most 28 days, preferably before the piglets are weaned.

公开(公告)号：US10689612B2

公开(公告)日：2020-06-23

申请号：US15300499

申请日：2015-04-02

Applicant: Intervet inc.

Inventor： Koen Gevers ,  Theodorus Petrus Maria Schetters

IPC: C12N1/10 ,  C12N1/02 ,  B07B1/18 ,  B07B1/22 ,  B07B1/10

Abstract: The invention pertains to a method to purify coccidial oocysts having dimensions between Dmin and Dmax from faeces comprising the steps of collecting the faeces containing the coccidial oocysts from host animals, diluting the faeces in an aqueous medium, separating a coarse fraction comprising macroscopic particulate matter from the diluted faeces and collecting an aqueous fraction containing the oocysts, characterised in that the method further comprises sieving the aqueous fraction over a first sieve deck having mesh openings to let the oocysts pass, to obtain an aqueous filtrate comprising the oocysts and a first residue comprising particles larger than the oocysts, and sieving the aqueous filtrate over a second sieve deck having mesh openings to obstruct passing of the oocysts through this sieve deck, to obtain a second residue comprising the purified oocysts and a waist filtrate comprising particles smaller than the oocysts. The invention also pertains to a system suitable for applying this method and to oocysts obtained therewith.

公开(公告)号：US10555998B2

公开(公告)日：2020-02-11

申请号：US15528549

申请日：2015-11-23

Applicant: Intervet Inc.

Inventor： Zhisong Qiao ,  Catherine M. Peters ,  Zhuyan Guo ,  Wendy Vaala ,  Craig Barnett

IPC: A61K39/145 ,  C12N7/00 ,  C07K14/005 ,  A61K39/00

Abstract: The present invention relates to equine influenza virus (EIV) isolates that when administered in vaccines to equine provide protection against currently emerging EIV strains in the U.S. The present invention also relates to inactivated EIV isolates. In addition, the present invention also relates to safe and efficacious vaccines that comprise the EIV isolates, as well as to corresponding subunit vaccines. The present invention further relates to methods of administering such safe and efficacious vaccines to equine.

公开(公告)号：US10550194B2

公开(公告)日：2020-02-04

申请号：US15514920

申请日：2015-09-29

Applicant: Intervet Inc.

Inventor： Mohamad Morsey ,  Yuanzheng Zhang ,  Denise Bartels-Morozov ,  Jason Erskine ,  Ian Tarpey

IPC: C07K16/28 ,  A61K39/00

Abstract: The present disclosure describes antibodies including caninized antibodies against canine PD-L1 with specific properties. The document relates to epitopes of canine PD-L1 that bind to these antibodies, as well as to anti-canine PD-L1 antibodies that bind these epitopes, and to the use of the caninized anti-canine PD-L1 antibodies in the treatment of cancer in dogs.

公开(公告)号：US10512685B2

公开(公告)日：2019-12-24

申请号：US16302891

申请日：2017-05-24

Applicant: Intervet Inc.

Inventor： Paul Vermeij ,  Ad Groof De ,  Carla Christina Schrier ,  Wannes Vogels

IPC: C07K14/005 ,  C07K14/08 ,  A61K39/00 ,  A61K39/29 ,  C12Q1/70 ,  A61K39/12 ,  A61P31/14 ,  A61K39/39

Abstract: The present invention relates to a vaccine comprising Open Reading Frame 2 (ORF2) protein of Swine Hepatitis E virus (HEV) and a pharmaceutically acceptable carrier, for use in the protection of anti-HEV MDA-positive piglets against HEV fecal shedding.

公开(公告)号：US10434168B2

公开(公告)日：2019-10-08

申请号：US15506898

申请日：2015-09-02

Applicant: Intervet Inc.

Inventor： Catherine M. Peters ,  Mark W. Mellencamp ,  Wenzhi Xue ,  Terri Wasmoen ,  Emilio Trigo

IPC: A61K39/215 ,  A61K39/12 ,  C07K14/005 ,  C12N7/00 ,  C12Q1/70 ,  A61K39/00

Abstract: The present invention discloses novel attenuated bovine coronavirus isolates, compositions comprising these isolate, and methods of using such compositions in vaccines, including in live vaccines. The present invention further discloses the administration of such vaccines, including the intranasal administration of such vaccines, to aid in the prevention of respiratory disease caused by bovine coronavirus.

公开(公告)号：US20190192486A1

公开(公告)日：2019-06-27

申请号：US16293024

申请日：2019-03-05

Applicant: Intervet Inc.

Inventor： Anja Regina Heckeroth ,  Hartmut Zoller ,  Annie Flochlay-Sigognault ,  Bruno Huyghe

IPC: A61K31/42 ,  A01N43/90 ,  A01N43/80 ,  A61K31/437 ,  A61K9/00 ,  A61K9/08 ,  A61K47/26 ,  A61K47/10 ,  A61K31/422

CPC classification number: A61K31/42 ,  A01N43/80 ,  A01N43/90 ,  A61K9/0053 ,  A61K9/08 ,  A61K31/422 ,  A61K31/437 ,  A61K47/10 ,  A61K47/26

Abstract: The present invention relates to methods of treating or preventing arthropod infestations of poultry animals and methods of controlling arthropod infestations in poultry animal's environment by administering an isoxazoline compound of formula (I) via drinking water.

公开(公告)号：US10308956B2

公开(公告)日：2019-06-04

申请号：US15110628

申请日：2015-12-23

Applicant: Intervet Inc.

Inventor： Iwan Verstegen ,  Paulus Jacobus Antonius Sondermeijer ,  Paul Vermeij

IPC: C12N15/86 ,  A61K39/12 ,  A61K39/17 ,  A61K39/295 ,  C07K14/005 ,  A61K39/00

Abstract: The present invention regards a new and Improved HVT-vectored ND-IBD vaccine, comprising a recombinant HVT comprising the VP2 gene from IBDV and the F gene from NDV to a target animal. The recombinant HVT can be used in a vaccine for poultry, which displayed good viral vector replication, effective expression of the NDV F- and IBDV VP2 genes, improved immunoprotection against ND and IBD, and improved genetic stability over prior art constructs.