-
公开(公告)号：US10280226B2
公开(公告)日：2019-05-07
申请号：US16175453
申请日：2018-10-30
申请人： Agenus Inc. , Memorial Sloan-Kettering Cancer Center , Ludwig Institute for Cancer Research Ltd.
发明人： Volker Seibert , Olivier Léger , Marc Van Dijk , Taha Merghoub , David Schaer , Gerd Ritter , Takemasa Tsuji
摘要： The present disclosure provides antibodies that specifically bind to human glucocorticoid-induced TNFR family related receptor (GITR) and compositions comprising such antibodies. In a specific aspect, the antibodies specifically bind to human GITR and modulate GITR activity, e.g., enhance, activate or induce GITR activity, utilizing such antibodies. The present disclosure also provides methods for treating disorders, such as cancer and infectious diseases, by administering an antibody that specifically binds to human GITR and modulates GITR activity e.g., enhances, activates or induces GITR activity.
-
公开(公告)号：US20190062446A1
公开(公告)日：2019-02-28
申请号：US16175453
申请日：2018-10-30
申请人： Agenus Inc. , Memorial Sloan-Kettering Cancer Center , Ludwig Institute for Cancer Research Ltd.
发明人： Volker SEIBERT , Olivier LÉGER , Marc VAN DIJK , Taha MERGHOUB , David SCHAER , Gerd RITTER , Takemasa TSUJI
摘要： The present disclosure provides antibodies that specifically bind to human glucocorticoid-induced TNFR family related receptor (GITR) and compositions comprising such antibodies. In a specific aspect, the antibodies specifically bind to human GITR and modulate GITR activity, e.g., enhance, activate or induce GITR activity, utilizing such antibodies. The present disclosure also provides methods for treating disorders, such as cancer and infectious diseases, by administering an antibody that specifically binds to human GITR and modulates GITR activity e.g., enhances, activates or induces GITR activity.
-
公开(公告)号：US20190023783A1
公开(公告)日：2019-01-24
申请号：US16051250
申请日：2018-07-31
发明人： Andreas BEHREN , Jonathan CEBON , Christopher HUDSON , Katherine WOODS , Andrew HAMMET , Anne VERHAGEN , Eugene MARASKOVSKY , Con PANOUSIS
IPC分类号： C07K16/28 , C07K16/30 , A61K47/68 , C12N15/113
摘要： The present disclosure provides computer-implemented methods of organising the marketing of a compound that neutralises BTN2A1.
-
公开(公告)号：US10155818B2
公开(公告)日：2018-12-18
申请号：US14724452
申请日：2015-05-28
申请人： Agenus Inc. , Memorial Sloan-Kettering Cancer Center , Ludwig Institute for Cancer Research Ltd.
发明人： Volker Seibert , Olivier Léger , Marc Van Dijk , Taha Merghoub , David Schaer , Gerd Ritter , Takemasa Tsuji
摘要： The present disclosure provides antibodies that specifically bind to human glucocorticoid-induced TNFR family related receptor (GITR) and compositions comprising such antibodies. In a specific aspect, the antibodies specifically bind to human GITR and modulate GITR activity, e.g., enhance, activate or induce GITR activity, utilizing such antibodies. The present disclosure also provides methods for treating disorders, such as cancer and infectious diseases, by administering an antibody that specifically binds to human GITR and modulates GITR activity e.g., enhances, activates or induces GITR activity.
-
公开(公告)号：US20180057606A1
公开(公告)日：2018-03-01
申请号：US15661864
申请日：2017-07-27
发明人： Lloyd J. Old , Terrance Grant Johns , Con Panousis , Andrew M. Scott , Christoph Renner , Gerd Ritter , Achim Jungbluth , Elisabeth Stockert , Vincent Peter Collins , Webster K. Cavenee , Huei-Jen Su Huang , Antony Wilks Burgess , Edouard Collins Nice , Anne Murray , George Mark
IPC分类号： C07K16/40 , A61K31/495 , A61K39/395 , A61K51/10 , C07K16/30 , C07K16/42 , C07K16/28 , A61K39/00
CPC分类号： C07K16/40 , A61K31/495 , A61K39/39541 , A61K39/39558 , A61K47/6871 , A61K51/103 , A61K51/1045 , A61K51/1078 , A61K2039/505 , A61K2300/00 , C07K16/2863 , C07K16/30 , C07K16/4258 , C07K2317/24 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92
摘要： The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.
-
公开(公告)号：US09518112B2
公开(公告)日：2016-12-13
申请号：US14383602
申请日：2013-03-06
IPC分类号： C07K16/22 , A61K45/06 , G01N33/574 , A61K39/395 , A61K39/00
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/33 , C07K2317/565 , C07K2317/76 , G01N33/57488 , G01N2333/495 , G01N2800/52
摘要： Specific binding members, particularly antibodies and fragments thereof, which bind to transforming growth factor beta 1 (TGF-β1) are provided, particularly recognizing human and mouse TGF-β1 and not recognizing or binding TGF-β2 or TGF-β3. Particular antibodies are provided which specifically recognize and neutralize TGF-β1. These antibodies are useful in the diagnosis and treatment of conditions associated with activated or elevated TGF-β1, including cancer, and for modulating immune cells and immune response, including immune response to cancer or cancer antigens. The anti-TGF-β1 antibodies, variable regions or CDR domain sequences thereof, and fragments thereof may also be used in therapy in combination with chemotherapeutics, immune modulators, or anti-cancer agents and/or with other antibodies or fragments thereof. Antibodies of this type are exemplified by the novel antibodies hereof, including antibody 13A1, whose sequences are provided herein.
摘要翻译： 提供了与转化生长因子β1（TGF-β1）结合的特异性结合成员，特别是抗体及其片段，特别是识别人和小鼠TGF-β1，并且不识别或结合TGF-β2或TGF-β3。 提供特异性识别和中和TGF-β1的特异性抗体。 这些抗体可用于诊断和治疗与活化或升高的TGF-β1（包括癌症）和调节免疫细胞和免疫应答（包括对癌症或癌症抗原的免疫应答）相关的病症。 抗TGF-β1抗体，其可变区或CDR结构域序列及其片段也可用于与化学治疗剂，免疫调节剂或抗癌剂和/或与其它抗体或其片段组合的治疗中。 这种抗体的例子有本发明的抗体，包括抗体13A1，其序列在此提供。
-
公开(公告)号：US11447557B2
公开(公告)日：2022-09-20
申请号：US15781043
申请日：2016-12-02
申请人： Agenus Inc. , Memorial Sloan-Kettering Cancer Center , Ludwig Institute for Cancer Research Ltd.
发明人： Nicholas S. Wilson , Jeremy D. Waight , Gerd Ritter , David Schaer , Daniel Hirschhorn-Cymerman , Taha Merghoub , Ekaterina V. Breous-Nystrom , Volker Seibert , Takemasa Tsuji , Olivier Léger , Dennis J. Underwood , Marc Van Dijk
IPC分类号： C07K16/28 , A61K39/395 , A61K45/06
摘要： The present disclosure provides multispecific (e.g., bispecific) antibodies that specifically bind to human GITR and/or human OX40 as well as compositions comprising such antibodies. In a specific aspect, the multispecific antibodies specifically bind to human GITR and OX40 and modulate GITR and/or OX40 activity, e.g., enhance, activate, or induce GITR and/or OX40 activity, or reduce, deactivate, or inhibit GITR and/or OX40 activity. The present disclosure also provides methods for treating disorders, such as cancer, by administering a multispecific antibody that specifically binds to human GITR and/or OX40 and modulates GITR and/or OX40 activity, e.g., enhances, activates, or induces GITR and/or OX40 activity. Also provided are methods for treating autoimmune or inflammatory diseases or disorders, by administering a multispecific antibody that specifically binds to human GITR and/or OX40 and modulates GITR and/or OX40 activity, e.g., reduces, deactivates, or inhibits GITR and/or OX40 activity.
-
公开(公告)号：US11332536B2
公开(公告)日：2022-05-17
申请号：US16784469
申请日：2020-02-07
申请人： Agenus Inc. , Memorial Sloan-Kettering Cancer Center , Ludwig Institute for Cancer Research Ltd.
发明人： Marc Van Dijk , Ekaterina V. Breous-Nystrom , Gerd Ritter , David Schaer , Daniel Hirschhorn-Cymerman , Taha Merghoub , Hao Tang , David A. Savitsky , Nicholas S. Wilson
摘要： The present disclosure provides antibodies that specifically bind to human OX40 receptor (OX40) and compositions comprising such antibodies. In a specific aspect, the antibodies specifically bind to human OX40 and modulate OX40 activity, e.g., enhance, activate, or induce OX40 activity, or reduce, deactivate, or inhibit OX40 activity. The present disclosure also provides methods for treating disorders, such as cancer, by administering an antibody that specifically binds to human OX40 and modulates OX40 activity, e.g., enhances, activates, or induces OX40 activity. Also provided are methods for treating autoimmune or inflammatory diseases or disorders, by administering an antibody that specifically binds to human OX40 and modulates OX40 activity, e.g., reduces, deactivates, or inhibits OX40 activity.
-
公开(公告)号：US20220133706A1
公开(公告)日：2022-05-05
申请号：US17438610
申请日：2020-03-13
发明人： Paul S. MISCHEL , Bing REN , Vineet BAFNA , Sudhir CHOWDHRY
IPC分类号： A61K31/4545 , A61P35/00 , A61K31/455 , A61K31/63 , A61K45/06
摘要： There are provided, inter alia, methods for treatment of cancer. The methods include means of identifying the NAD biosynthetic pathway on which depend cancer cells in a tumor, in a subject suffering from cancer. The methods further include administering to a subject in need a therapeutically effective amount of an inhibitor of the NMRK1 enzyme pathway to a tumor where the cancer cells are dependent of the NAD salvage pathway, allowing to lower the of dose FK866 administered to the subject. The methods also include administering to a subject in need a therapeutically effective amount of a bacterial inhibitor of NADSYN1 to a tumor where the cancer cells depend on the Preiss Handler pathway.
-
公开(公告)号：US11253521B2
公开(公告)日：2022-02-22
申请号：US15762527
申请日：2016-09-26
发明人： Timothy Gahman , Andrew Shiau , Richard Kolodner
IPC分类号： A61K31/519 , A61K31/517 , A61K45/06 , C07D239/96 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： Described inter alia are compounds according to formula (I): or a pharmaceutically acceptable salt thereof, and uses in methods for the modulation of flap endonuclease 1 (FEN1), Xeroderma Pigmentosum Complementation Group G protein (XPG), Exonuclease 1 (EXO1) and/or GEN1.
-
-
-
-
-
-
-
-
-
搜索结果
137 条记录 (耗时 0.075 秒)
