公开(公告)号：US20130023558A1

公开(公告)日：2013-01-24

申请号：US13532272

申请日：2012-06-25

Applicant: Dieter KADEREIT ,  Matthias SCHAEFER ,  Stephanie HACHTEL ,  Thomas HUEBSCHLE ,  Katrin HISS

Inventor： Dieter KADEREIT ,  Matthias SCHAEFER ,  Stephanie HACHTEL ,  Thomas HUEBSCHLE ,  Katrin HISS

IPC: A61K31/437 ,  A61P3/10 ,  A61P9/00 ,  C07D498/04 ,  A61P17/02

CPC classification number: C07D498/04

Abstract: Carboxylic acid derivatives having an oxazolo[4,5-c]pyridine ringThe invention therefore relates to compounds of the formula I in which X, Y, R1, R2 and R3 have the given meanings. The compounds of the formula I are suitable, for example, for wound healing.

Abstract translation: 具有恶唑并[4,5-c]吡啶环的羧酸衍生物本发明涉及其中X，Y，R 1，R 2和R 3具有给定含义的式Ⅰ化合物。 式I的化合物适用于例如伤口愈合。

公开(公告)号：US20130023557A1

公开(公告)日：2013-01-24

申请号：US13532255

申请日：2012-06-25

Applicant: Dieter KADEREIT ,  Matthias SCHAEFER ,  Stephanie HACHTEL ,  Thomas HUEBSCHLE ,  Katrin HISS

Inventor： Dieter KADEREIT ,  Matthias SCHAEFER ,  Stephanie HACHTEL ,  Thomas HUEBSCHLE ,  Katrin HISS

IPC: A61K31/437 ,  A61P17/02 ,  A61P9/00 ,  C07D498/04

CPC classification number: C07D498/04

Abstract: The invention therefore relates to compounds of the formula I in which X, Y, R1, R2 and R3 have the given meanings. The compounds of the formula I are suitable, for example, for wound healing.

Abstract translation: 因此，本发明涉及其中X，Y，R 1，R 2和R 3具有给定含义的式I化合物。 式I的化合物适用于例如伤口愈合。

公开(公告)号：US20120264790A1

公开(公告)日：2012-10-18

申请号：US13461264

申请日：2012-05-01

Applicant: Josef PERNERSTORFER ,  Heinz-Werner KLEEMANN ,  Matthias SCHAEFER ,  Alena SAFAROVA ,  Marcel PATEK

Inventor： Josef PERNERSTORFER ,  Heinz-Werner KLEEMANN ,  Matthias SCHAEFER ,  Alena SAFAROVA ,  Marcel PATEK

IPC: C07C61/40 ,  C07D231/12 ,  A61K31/415 ,  C07D213/82 ,  A61K31/44 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P7/02 ,  A61P29/00 ,  A61P19/02 ,  A61P13/12 ,  A61P11/00 ,  A61P11/06 ,  A61P37/00 ,  A61P37/08 ,  A61P35/04 ,  A61P3/00 ,  A61P17/06 ,  A61P25/00 ,  A61P17/04 ,  A61P27/02 ,  A61P25/18 ,  A61P25/28 ,  A61P5/00 ,  A61P5/16 ,  A61P17/02 ,  A61P35/00 ,  A61K31/196

CPC classification number: C07C235/54 ,  C07C231/00 ,  C07C231/02 ,  C07C235/42 ,  C07C235/84 ,  C07C255/50 ,  C07C255/54 ,  C07C255/57 ,  C07C307/10 ,  C07C317/46 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/22 ,  C07C2602/50 ,  C07D213/16 ,  C07D213/64 ,  C07D213/69 ,  C07D213/81 ,  C07D213/82 ,  C07D231/12 ,  C07D231/18 ,  C07D305/04 ,  C07D305/06 ,  C07D305/08 ,  C07D309/04 ,  C07D309/08 ,  C07D309/14 ,  C07D313/04 ,  C07D317/06 ,  C07D317/68 ,  C07D317/72 ,  C07D333/16 ,  C07D333/32 ,  C07D335/02 ,  C07D335/14 ,  C07D335/18 ,  C07D493/10

Abstract: The present invention relates to compounds of the formula I, wherein A, Y, Z, R20 to R22 and R50 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they are inhibitors of the endothelial differentiation gene receptor 2 (Edg-2, EDG2), which is activated by lysophosphatidic acid (LPA) and is also termed as LPA1 receptor, and are useful for the treatment of diseases such as atherosclerosis, myocardial infarction and heart failure, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.

Abstract translation: 本发明涉及式I化合物，其中A，Y，Z，R20至R22和R50具有权利要求中所示的含义，它们是有价值的药物活性化合物。 具体来说，它们是由溶血磷脂酸（LPA）激活的内皮分化基因受体2（Edg-2，EDG2）的抑制剂，也被称为LPA1受体，可用于治疗动脉粥样硬化，心肌的疾病 梗死和心力衰竭。 本发明还涉及制备式I化合物的方法，其用途和包含它们的药物组合物。

公开(公告)号：US20110182134A1

公开(公告)日：2011-07-28

申请号：US12692009

申请日：2010-01-22

Applicant: Maria Pollard ,  Steven R. Strand ,  David A. Eversdyk ,  Matthias Schaefer

Inventor： Maria Pollard ,  Steven R. Strand ,  David A. Eversdyk ,  Matthias Schaefer

IPC: B01F5/06

CPC classification number: B01F5/0453 ,  B01F5/0451 ,  B01F5/0456

Abstract: A mixing system is disclosed comprising at least one extensional flow mixer comprising: a generally open and hollow body having a contoured outer surface and having: a single entrance port and a single exit port; a means for compressing a bulk stream flowing through the generally open and hollow body in a direction of flow and at least one injected additive stream introduced at the single entrance port in the direction of flow; and a means for broadening the bulk stream and the at least one injected additive stream such that an interfacial area between the bulk stream and the at least one injected additive stream is increased as the bulk stream and the at least one injected additive stream flow through the generally open and hollow body in the direction of flow to promote mixing of the bulk stream and the at least one injected additive stream, a flow conductor having an axis and having a generally open and hollow flow mixer body secured therein; and a primary additive stream injector positioned at the entrance port of the generally open and hollow flow mixer body, wherein the primary additive stream injector injects an additive stream into the interior of the flow mixer in the direction of flow when the bulk stream is flowing through the generally open and hollow flow mixer body to allow compression and broadening of the bulk stream and the additive stream together to facilitate mixing of the bulk stream and the primary additive stream at an exit of the extensional flow mixer, wherein the extensional flow mixer is followed by at least one of helical static mixing elements that is at least one half flow conductor diameter downstream of the exit of the extensional flow mixer.

Abstract translation: 公开了一种混合系统，该混合系统包括至少一个延伸流动混合器，包括：具有轮廓外表面的大致敞开且中空的主体，具有：单个入口和单个出口; 用于沿流动方向压缩流过大体上敞开的中空体的主体流和沿着流动方向在单个入口处引入的至少一个注入的添加剂流的装置; 以及用于使本体流和至少一个注入的添加剂流扩展的手段，使得当本体流和至少一个注入的添加剂流流过该流体流时，本体流和至少一个注入的添加剂流之间的界面面积增加 通常在流动方向上开放和中空的体，以促进本体流和至少一个注入的添加剂流的混合，具有轴线并具有固定在其中的大体上敞开且中空的流动混合器主体的流动导体; 以及位于大体上敞开的中空流动混合器主体的入口处的主要添加剂流注入器，其中当主体流流过时，主要添加剂流注入器将流动混合器的内部流向流动方向的内部注入流动混合器的内部 通常是开放和中空的流动混合器主体，以允许将本体流和添加剂流压缩和扩展在一起，以便于在延伸流动混合器的出口处混合本体流和初级添加剂流，其中遵循该拉伸流动混合器 通过至少一个螺旋静态混合元件，其是在延伸流动混合器的出口下游的至少一个半流动导体直径。