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    Carbamic acid derivatives
    4.
    发明授权
    Carbamic acid derivatives 失效
    氨基甲酸衍生物

    公开(公告)号：US06596743B2

    公开(公告)日：2003-07-22

    申请号：US10008827

    申请日：2001-12-10

    申请人： Konrad Bleicher ,  Vincent Mutel ,  Eric Vieira ,  Jürgen Wichmann ,  Thomas Johannes Woltering

    发明人： Konrad Bleicher ,  Vincent Mutel ,  Eric Vieira ,  Jürgen Wichmann ,  Thomas Johannes Woltering

    IPC分类号： A61K31421

    CPC分类号： C07D213/30 ,  C07C233/91 ,  C07C271/64 ,  C07C333/10 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07D213/61 ,  C07D263/48 ,  C07D271/07 ,  C07D271/113 ,  C07D295/088 ,  C07D311/84 ,  C07D333/16 ,  C07D335/14 ,  C07D413/12

    摘要： The present invention is a compound of formula: wherein R1, R2, R2′, X, A1/A2 and B are as defined in the specification. These compounds may be used in the control or prevention of acute and/or chronic neurological disorders such as restricted brain function caused by bypass operations or transplants, poor blood supply to the brain, spinal cord injuries, head injuries, hypoxia caused by pregnancy, cardiac arrest, hypoglycaemia, Alzheimer's disease, Huntington's chorea, ALS, dementia caused by AIDS, eye injuries, retinopathy, cognitive disorders, memory deficits, schizophrenia, idiopathic parkinsonism or parkinsonism caused by medicaments as well as conditions which lead to glutamate deficiency functions, such as e.g. muscle spasms, convulsions, migraine, urinary incontinence, nicotine addiction, psychoses, opiate addiction, anxiety, vomiting, acute and chronic pain, dyskinesia and depression.

    摘要翻译： 本发明是下式的化合物：其中R1，R2，R2'，X，A1 / A2和B如本说明书中所定义。这些化合物可用于控制或预防急性和/或慢性神经障碍，例如 作为由旁路手术或移植引起的限制性脑功能，脑供血不足，脊髓损伤，头部损伤，怀孕引起的缺氧，心脏骤停，低血糖，阿尔茨海默病，亨廷顿舞蹈症，ALS，艾滋病引起的痴呆，眼睛损伤 ，视网膜病变，认知障碍，记忆缺陷，精神分裂症，由药物引起的特发性帕金森综合症或帕金森综合征以及导致谷氨酸缺乏功能的病症，例如 肌肉痉挛，抽搐，偏头痛，尿失禁，尼古丁成瘾，精神病，鸦片成瘾，焦虑，呕吐，急性和慢性疼痛，运动障碍和抑郁症。