公开(公告)号：US06765093B2

公开(公告)日：2004-07-20

申请号：US10052431

申请日：2002-01-18

Applicant: Mu-Ill Lim ,  Yuh-Guo Pan ,  James S. Anderson

Inventor： Mu-Ill Lim ,  Yuh-Guo Pan ,  James S. Anderson

IPC: C07C21568

CPC classification number: C07D295/088 ,  A61K8/411 ,  A61K8/415 ,  A61K8/49 ,  A61K8/4926 ,  A61K8/4946 ,  A61Q5/10 ,  C07C45/29 ,  C07C45/60 ,  C07C49/753

Abstract: Couplers for hair coloring compositions for oxidative dyeing of hair are compounds of the formula (1): where R1 and R2 are each individually selected from a hydrogen atom, a C1 to C3 alkyl group, a C1 to C5 mono or dihydroxyalkyl group; phenyl or benzyl optionally substituted with an alkoxy group, or R1 and R2 together with the nitrogen atom to which they are attached form a piperazine, piperidine, imidazole, or morpholine ring.

Abstract translation: 用于头发氧化染色的染发组合物的成色剂是式（1）的化合物：其中R 1和R 2各自独立地选自氢原子，C1至C3烷基，C1至C5单或二羟基烷基; 任选被烷氧基取代的苯基或苄基，或者R 1和R 2与它们所连接的氮原子一起形成哌嗪，哌啶，咪唑或吗啉环。

公开(公告)号：US06750337B2

公开(公告)日：2004-06-15

申请号：US10052362

申请日：2002-01-18

Applicant: Mu-Ill Lim ,  Yuh-Guo Pan ,  Gottfried Wenke

Inventor： Mu-Ill Lim ,  Yuh-Guo Pan ,  Gottfried Wenke

IPC: C07D27910

CPC classification number: C07C217/84 ,  A61K8/415 ,  A61K8/416 ,  A61K8/49 ,  A61K8/4906 ,  A61K8/4913 ,  A61K8/4926 ,  A61K8/494 ,  A61Q5/10 ,  C07C2601/14

Abstract: Couplers for hair coloring compositions for oxidative dyeing of hair are compounds of the formula (1): wherein X is selected from halogen and R5SO4 where the halogen is preferably Cl, Br or I; R, R1 and R2 are each individually selected from C1 to C22 alkyl and C1 to C22 mono or dihydroxyalkyl, or two of R, R1 and R2 together with the nitrogen atom to which they are attached form a C3 to C6 saturated or unsaturated ring optionally containing in the ring one or more additional hetero atoms selected from O, S and N atoms; R3 and R 4 are each individually selected from C1 to C6 alkyl, C1 to C6 hydroxyalkyl, C1 to C6 alkoxy, C1 to C6 aminoalkyl or R3 and R4 together form a C1 to C5 alkylene group; and R5 is selected from C1 to C22 alkyl and C1 to C22 mono or dihydroxyalkyl.

Abstract translation: 用于头发氧化染色的染发组合物的成色剂是式（1）的化合物：其中X选自卤素和R 5 SO 4，其中卤素优选为Cl，Br或I; R 1，R 2和R 2各自独立地选自C 1至C 22烷基和C 1至C 22单或二羟基烷基，或者R 1，R 2和R 2中的两个与它们的氮原子一起 连接形成任选地在环中含有一个或多个选自O，S和N原子的另外的杂原子的C 3至C 6饱和或不饱和环; R 3和R 4各自独立地选自C 1至C 6烷基，C 1至C 6羟基烷基，C 1至C 6烷氧基，C 1至C 6氨基烷基或R 3和R 4一起形成C 1至C 5亚烷基 组; 并且R 5选自C 1至C 22烷基和C 1至C 22单或二羟基烷基。

公开(公告)号：US06572665B2

公开(公告)日：2003-06-03

申请号：US09990749

申请日：2001-11-16

Applicant: Mu-Ill Lim ,  Yuh-Guo Pan ,  Margaret Popp

Inventor： Mu-Ill Lim ,  Yuh-Guo Pan ,  Margaret Popp

IPC: A61K713

CPC classification number: A61K8/4926 ,  A61K8/347 ,  A61K8/415 ,  A61Q5/10 ,  C07D213/38

Abstract: Couplers for hair coloring compositions for oxidative dyeing of hair are compounds of the formula (1): wherein X is selected from halogen and R2SO4; R3 is selected from C1 to C2 alkyl or hydroxyethyl; R2 is selected from C1 to C22 alkyl and C1 to C22 mono and dihydroxyalkyl; and R is selected from of C1 to C16 alkyl, C1 to C10 hydroxyalkyl, C1 to C6 alkoxyalkyl and benzyl.

Abstract translation: 用于头发氧化染色的染发组合物的成色剂是式（1）的化合物：其中X选自卤素和R 2 SO 4; R3选自C1至C2烷基或羟乙基; R2选自C1至C22烷基和C1至C22单和二羟基烷基; 且R选自C 1至C 16烷基，C 1至C 10羟基烷基，C 1至C 6烷氧基烷基和苄基。

公开(公告)号：US06409773B1

公开(公告)日：2002-06-25

申请号：US09736913

申请日：2000-12-14

Applicant: Mu-Ill Lim ,  Yuh-Guo Pan ,  Margaret Popp

Inventor： Mu-Ill Lim ,  Yuh-Guo Pan ,  Margaret Popp

IPC: A61K713

CPC classification number: C07C215/76 ,  A61K8/415 ,  A61Q5/10 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14

Abstract: Couplers for hair coloring compositions for oxidative dyeing of hair are compounds of the formula at least one coupler comprising a compound of the formula (1): wherein R is selected from of C1 to C2 alkyl and hydroxyethyl, R1 and R2 are each independently selected from the group consisting of C1 to C5 alkyl, C3 to C6 cycloalkyl, C1 to C5 alkoxy, C1 to C5 hydroxyalkyl, C1 to C5 hydroxyalkoxy, or R1 and R2 together with the carbon atom to which they are attached form a C3 to C6 cycloalkyl group.

Abstract translation: 用于头发氧化染色的染发组合物的成色剂是下式化合物：至少一种成色剂，其包含式（1）化合物：其中R选自C 1至C 2烷基和羟乙基，R 1和R 2各自独立地选自 由C1至C5烷基，C3至C6环烷基，C1至C5烷氧基，C1至C5羟基烷基，C1至C5羟基烷氧基或R1和R2与它们所连接的碳原子一起形成C 3至C 6环烷基 。

公开(公告)号：US06045590A

公开(公告)日：2000-04-04

申请号：US855550

申请日：1997-05-13

Applicant: Mu-Ill Lim ,  Yuh-Guo Pan ,  Linas R. Stasaitis ,  John D. O'Donoghue

Inventor： Mu-Ill Lim ,  Yuh-Guo Pan ,  Linas R. Stasaitis ,  John D. O'Donoghue

IPC: A61K7/13

CPC classification number: A61K8/347 ,  A61K8/37 ,  A61K8/69 ,  A61K8/70 ,  A61Q5/10

Abstract: Compounds of Formula II ##STR1## wherein R.sub.3 is --COOCH.sub.3, --COCH.sub.3 or --COCH.sub.2 CH.sub.3 and R.sub.4 is hydrogen or R.sub.3 is hydrogen and R.sub.4 is --OCH.sub.3, --OC.sub.2 CH.sub.3, --OCH.sub.2 CH.sub.2 OH or --OCH.sub.2 CH.sub.2 OCH.sub.3 are storage stable and can be used in oxidative hairdye systems in place of the storage unstable 2-methyl-1-naphthol. Advantageously, it has been found to produce the same colors as 2-methyl-1-naphthol.

Abstract translation: 其中R 3是-COOCH 3，-COCH 3或-COCH 2 CH 3和R 4是氢或R 3是氢，R 4是-OCH 3，-OC 2 CH 3，-OCH 2 CH 2 OH或-OCH 2 CH 2 OCH 3的式II化合物是保存稳定的，并且可以在氧化发粘体系中使用 的储存不稳定的2-甲基-1-萘酚。 有利地，已经发现产生与2-甲基-1-萘酚相同的颜色。

公开(公告)号：US5993491A

公开(公告)日：1999-11-30

申请号：US78264

申请日：1998-05-13

Applicant: Mu-Ill Lim ,  Margaret Popp ,  Yuh-Guo Pan

Inventor： Mu-Ill Lim ,  Margaret Popp ,  Yuh-Guo Pan

IPC: C07D207/08 ,  A61K8/00 ,  A61K8/22 ,  A61K8/49 ,  A61Q5/10 ,  C07D207/09 ,  C07D207/12 ,  C09B57/00 ,  A61K7/13

CPC classification number: C07D207/09 ,  C07D207/12

Abstract: Compositions and methods for the oxidative coloring of human hair, wherein the compositions contain as a novel primary dye intermediate a 1-(4-aminophenyl)-2-pyrrolidinemethanol, or a cosmetically acceptable salt thereof. The compositions may also contain at least one other primary intermediate and conventional coupling compounds, in addition to an oxidizing agent and other components typically used in oxidative hair dye preparations. A preferred dye intermediate in the composition is 1-(4-aminophenyl)-2-pyrrolidinemethanol or cosmetically acceptable salts thereof, which produce intense black colors when used in admixture with a suitable coupling agents, such as 3-aminophenol, in conventional hair dye base formulations.

Abstract translation: 用于人毛发氧化着色的组合物和方法，其中所述组合物含有1-（4-氨基苯基）-2-吡咯烷甲醇或其美容上可接受的盐作为新的初级染料中间体。 除了氧化剂和通常用于氧化性染发剂制剂的其它成分之外，组合物还可以含有至少一种其它初级中间体和常规偶联化合物。 组合物中优选的染料中间体是1-（4-氨基苯基）-2-吡咯烷甲醇或其美容上可接受的盐，当与常规染发剂中的合适偶联剂如3-氨基苯酚混合使用时，产生强烈的黑色 碱配方。

公开(公告)号：US5529583A

公开(公告)日：1996-06-25

申请号：US527911

申请日：1995-09-14

Applicant: Mu-Ill Lim ,  Yuh-Guo Pan ,  Linas R. Stasaitis ,  John D. O'Donoghue

Inventor： Mu-Ill Lim ,  Yuh-Guo Pan ,  Linas R. Stasaitis ,  John D. O'Donoghue

IPC: A61K7/13

CPC classification number: A61K8/347 ,  A61K8/37 ,  A61K8/69 ,  A61K8/70 ,  A61Q5/10

Abstract: Compounds of Formula II ##STR1## wherein R.sub.3 is --COCH.sub.3, --COCH.sub.3 or --COCH.sub.2 CH.sub.3 and R.sub.4 is hydrogen or R.sub.3 is hydrogen and R.sub.4 is --OCH.sub.3, --OCH.sub.2 CH.sub.3, --OCH.sub.2 CH.sub.2 OH or --OCH.sub.2 CH.sub.2 OCH.sub.3 are storage stable and can be used in oxidative hairdye systems in place of the storage unstable 2-methyl-1-naphthol. Advantageously, it has been found to produce the same colors as 2-methyl-1-naphthol.

Abstract translation: 式II的化合物其中R 3是-COCH 3，-COCH 3或-COCH 2 CH 3，R 4是氢或R 3是氢，R 4是-OCH 3，-OCH 2 CH 3，-OCH 2 CH 2 OH或-OCH 2 CH 2 OCH 3是保存稳定的并且可以用于氧化 发丝系统代替储存不稳定的2-甲基-1-萘酚。 有利地，已经发现产生与2-甲基-1-萘酚相同的颜色。

公开(公告)号：US5420362A

公开(公告)日：1995-05-30

申请号：US133352

申请日：1993-10-08

Applicant: Mu-Ill Lim ,  Linas Stasaitis ,  Yuo-Guo Pan ,  Alexander Chan

Inventor： Mu-Ill Lim ,  Linas Stasaitis ,  Yuo-Guo Pan ,  Alexander Chan

IPC: C07C37/00 ,  C07C37/11 ,  C07C39/14

CPC classification number: C07C37/11 ,  C07C37/001

Abstract: 4-Halo-1-naphthol is reacted with a secondary amine and formaldehyde to produce a reaction mixture containing a Mannich base which is hydrogenated to produce 2-methyl-1-naphthol. Advantageously, the procedure can be carried out in one pot.

Abstract translation: 4-卤-1-萘酚与仲胺和甲醛反应以产生含有曼尼希碱的反应混合物，氢化得到2-甲基-1-萘酚。 有利地，该程序可以在一个锅中进行。

公开(公告)号：US5186716A

公开(公告)日：1993-02-16

申请号：US759282

申请日：1991-09-13

Applicant: Mu-Ill Lim ,  Yuh-Guo Pan

Inventor： Mu-Ill Lim ,  Yuh-Guo Pan

IPC: A61K8/41 ,  A61K8/69 ,  A61Q5/06 ,  A61Q5/10 ,  C09B51/00

CPC classification number: A61K8/418 ,  A61K8/69 ,  A61Q5/065 ,  A61Q5/10 ,  C09B51/00

Abstract: N.sup.1 -Trifluoroalkyl substituted 2-nitro-p-phenylenediamines, compositions containing same, and their use as direct dyes for keratinous fibers are disclosed.

公开(公告)号：US5118323A

公开(公告)日：1992-06-02

申请号：US751459

申请日：1991-08-29

Applicant: Mu-Ill Lim ,  Nancy A. Botta

Inventor： Mu-Ill Lim ,  Nancy A. Botta

IPC: A61K8/49 ,  A61Q5/06 ,  C07D263/56 ,  C07D265/36 ,  C07D267/14 ,  C09B19/00

CPC classification number: A61Q5/065 ,  A61K8/49 ,  C07D263/56 ,  C07D265/36 ,  C07D267/14 ,  C09B19/00

Abstract: Novel benzoxazine compounds of the structure ##STR1## wherein X and Y are independently selected from the group hydrogen, alkyl, alkoxyalkyl, aminoalkyl, hydroxyalkyl and hydroxyaminoalkyl, each alkyl moiety having 1 to 6 carbons, and m=1, 2, or 3, have been found suitable as hair dyes.

Abstract translation: 结构式“IMAGE”的新型苯并恶嗪化合物，其中X和Y独立地选自氢，烷基，烷氧基烷基，氨基烷基，羟基烷基和羟基氨基烷基，每个烷基部分具有1至6个碳，m = 1,2或3， 已被发现适合作为染发剂。